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Loss of appetite; nausea; sensitivity to sunlight; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; chest pain; dark urine; decreased urination; fever, chills, or sore throat; moderate to severe sunburn; severe diarrhea; severe or persistent headache; stomach pain or cramps; throat irritation; trouble swallowing; unusual bruising or bleeding; unusual joint pain; unusual tiredness; vaginal irritation or discharge; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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About us, diacan

Canada Diamond - Who we Are

About us

DIACAN is a marriage of over 20 years combined experience in providing quality loose diamonds and fine jewellery to the Canadian marketplace at both the wholesale and retail levels.

As a major importer of polished diamonds direct from our own cutting centres, DIACAN is able to eliminate the middleman and offer the best prices in Canada! You'll notice all prices are given in Canadian dollars too, so there's no conversion rates or customs fees to be concerned about.

As for understanding the needs of our customer's, DIACAN's customer service representatives have a very long history of direct retail experience, and are capable of guiding you to an informed decision. From our centrally located offices in downtown Toronto, DIACAN is ready to provide you with the diamond you desire at the best possible price you can get!

Wholesale Diamonds in Canada

That's why you should turn to a name you can trust: DIACAN (Diamonds in Canada). We specialize in selling diamonds in Canada. At DIACAN, we've applied our extensive years of experience in the diamond industry to creating a Canadian company that offers exceptional quality, value and customer service. At DIACAN, there are no pushy salespeople, just experts who want to match the right diamond to the right person, at the lowest possible cost.

Our Low Prices Can't Be Beat

and neither can our selection. That's because DIACAN's wide assortment of loose diamonds comes from our own supplier centers in Canada, Israel, Belgium and Russia. All our diamonds come with an accredited appraisal in Canadian funds. The clarity, colour, cut and carat weight of each diamond is graded by GIA, AGS and Gem Scan. These certificates are accepted by all Canadian insurance companies.

Jewellery at Exceptional Savings

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Artofen questions we have answers at healthsofa, artofen

Side Effects

nausea / constipation / heartburn / dizziness / headache / vomiting / abdominal pain / drowsiness / insomnia / diarrhea / dyspepsia / dry eyes / rhinitis / flatulence / nervousness / hypertension / hypertension / arrhythmia / hematuria / cystitis / rash / tachycardia / urticaria / bronchospasm / alopecia / anaphylaxis / palpitation / fever / chest pain /

Pregnancy

Pregnancy and Artofen Embryo and Artofen Fetal Weaning and Artofen Breastfeeding and Artofen

Dosage

How to Properly Take Ibuprofen? What is the children dosage for Artofen What is the adult dosage for Artofen How often should Artofen be taken? What is the dosage for Artofen?

Usage

Storage

Interactions

Biological Half-life

How long does it take Artofen to leave the system?

Nursing responsibilities for Artofen

ATC CODE: C01EB16 ATC CODE: G02CC01 ATC CODE: M01AE01 ATC CODE: M01AE01 ATC CODE: M02AA13

Other medications containing Ibuprofen

Ibuprofen is the active ingredient in Artofen



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Amoxil 500 amoxil 500 pill - amoxil 500 mg, amoxil 500mg

AMOXIL 500 AMOXIL 500 (Amoxil 500 mg)

Pill imprint AMOXIL 500 AMOXIL 500 has been identified as Amoxil 500 mg .

Amoxil is used in the treatment of dental abscess; urinary tract infection; chlamydia infection; bacterial infection; skin or soft tissue infection (and more ), and belongs to the drug class aminopenicillins. There is no proven risk in humans during pregnancy. Amoxil 500 mg is not a controlled substance under the Controlled Substance Act (CSA).

Images for AMOXIL 500 AMOXIL 500

Amoxil Generic Name: amoxicillin Imprint: AMOXIL 500 AMOXIL 500 Strength: 500 mg Color: Blue & Pink Shape: Capsule-shape Availability: Prescription only

Drug Class: Aminopenicillins Pregnancy Category: B - No proven risk in humans CSA Schedule: Not a controlled drug Manufacturer: GlaxoSmithKline National Drug Code (NDC): 00029-6007

More about Amoxil (amoxicillin)

Consumer resources

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 2016 Drugs. com, National Library of Medicine, Truven Health Analytics and Cerner Multum, Inc. All Rights Reserved.

Drug Status



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Alpha-baclofen, alpha-baclofen

Baclofen

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Baclofen

(Alpha-baclofen™, Pacifen™, Lioresal™)

Class: GABA derivative musculoskeletal muscle relaxant

Indication: relief of musculoskeletal spasm

Contraindications/cautions: epilepsy, sc injection, psychosis, schizophrenia, depression, mania, GI ulceration, cerebrovascular disease, alcoholism, diabetes (may increase blood glucose concentrations), hypertension

common: nausea, sedation, somnolence,

less common: decreased cardiac output, hypotension, GI disturbance, respiratory depression, lightheadedness, personality changes, headache, insomnia, euphoria, depression, weakness, tremor, hallucinations, dry mouth, tinnitus

Metabolism/clearance mainly excreted in urine unchanged (70%) so dose adjust in renal impairment

additive drowsiness and CNS depression with other CNS depressant drugs e. g. alcohol, benzodiazepines (e. g. clonazepam), opioids

increased muscle relaxation with tricyclic antidepressants e. g. nortriptyline

oral: 5 to 20 mg three to four times a day (start at 5mg three times a day)

sc: not available

Syringe driver: only intrathecal inj available - not for sc use

Mechanism of action: works in the spinal cord where it stimulates GABA-receptors which inhibits the release of glutamate and aspartate (excitatory). Also has CNS depressant actions.

Onset: variable - hours to weeks

Tab 10 mg - fully funded (Pacifen™)

Inj (IT) 0.05 mg/mL, 10 mg/5 mL - not funded

Cost: Approx $0.05 per tab, $10.50-$190.80 per injection

Stopping abruptly may result in a withdrawal reaction (confusion, psychosis, tachycardia, hyperthermia and rebound spasticity).



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Clomiphene medlineplus drug information, milophene

Clomiphene

Clomiphene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

flushing (feeling of warmth)

upset stomach

vomiting

breast discomfort

headache

abnormal vaginal bleeding

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

blurred vision

visual spots or flashes

double vision

stomach or lower stomach pain

stomach swelling

weight gain

shortness of breath

Long-term use of clomiphene may increase the risk of ovarian cancer. Clomiphene should not be used for more than about six cycles. Talk to your doctor about the risks of taking this medication.

Clomiphene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

upset stomach

vomiting

hot flashes

blurred vision

visual spots or flashes

blind spots

stomach swelling

stomach or lower stomach pain

What other information should I know?

Keep all appointments with your doctor and laboratory. Your doctor may order certain lab tests to check your body's response to clomiphene.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Reviewed - 09/01/2010

American Society of Health-System Pharmacists, Inc. Disclaimer

AHFS ® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc. 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.



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Drisdol - fda prescribing information, side effects and uses, prisdal

Drisdol

Drisdol brand of ergocalciferol capsules, USP, is a synthetic calcium regulator for oral administration.

Ergocalciferol is a white, colorless crystal, insoluble in water, soluble in organic solvents, and slightly soluble in vegetable oils. It is affected by air and by light. Ergosterol or provitamin D 2 is found in plants and yeast and has no antirachitic activity.

There are more than 10 substances belonging to a group of steroid compounds, classified as having vitamin D or antirachitic activity.

One USP unit of vitamin D 2 is equivalent to one International Unit (IU), and 1 mcg of vitamin D 2 is equal to 40 IU.

Each capsule contains 1.25 mg (50,000 International Units vitamin D) of ergocalciferol, USP, in an edible vegetable oil.

Ergocalciferol, also called vitamin D 2. is 9, 10-secoergosta-5,7,10 (19), 22-tetraen-3-ol, (3ß,5Z,7E,22 E )-; (C 2 8 H 4 4 O) with a molecular weight of 396.65, and has the following structural formula:

Inactive Ingredients: FD&C Blue #1, FD&C Yellow #5, Gelatin, Glycerin, Soybean Oil.

Drisdol - Clinical Pharmacology

The in vivo synthesis of the major biologically active metabolites of vitamin D occurs in two steps. The first hydroxylation of ergocalciferol takes place in the liver (to 25-hydroxyvitamin D) and the second in the kidneys (to 1,25-dihydroxyvitamin D). Vitamin D metabolites promote the active absorption of calcium and phosphorus by the small intestine, thus elevating serum calcium and phosphate levels sufficiently to permit bone mineralization. Vitamin D metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal tubules.

There is a time lag of 10 to 24 hours between the administration of vitamin D and the initiation of its action in the body due to the necessity of synthesis of the active metabolites in the liver and kidneys. Parathyroid hormone is responsible for the regulation of this metabolism in the kidneys.

Indications and Usage for Drisdol

Drisdol is indicated for use in the treatment of hypoparathyroidism, refractory rickets, also known as vitamin D resistant rickets, and familial hypophosphatemia.

Contraindications

Drisdol is contraindicated in patients with hypercalcemia, malabsorption syndrome, abnormal sensitivity to the toxic effects of vitamin D, and hypervitaminosis D.

Warnings

Hypersensitivity to vitamin D may be one etiologic factor in infants with idiopathic hypercalcemia. In these cases vitamin D must be strictly restricted.

Keep out of the reach of children.

Precautions

General

Vitamin D administration from fortified foods, dietary supplements, self-administered and prescription drug sources should be evaluated. Therapeutic dosage should be readjusted as soon as there is clinical improvement. Dosage levels must be individualized and great care exercised to prevent serious toxic effects. IN VITAMIN D RESISTANT RICKETS THE RANGE BETWEEN THERAPEUTIC AND TOXIC DOSES IS NARROW. When high therapeutic doses are used progress should be followed with frequent blood calcium determinations.

In the treatment of hypoparathyroidism, intravenous calcium, parathyroid hormone, and/or dihydrotachysterol may be required.

Maintenance of a normal serum phosphorus level by dietary phosphate restriction and/or administration of aluminum gels as intestinal phosphate binders in those patients with hyperphosphatemia as frequently seen in renal osteodystrophy is essential to prevent metastatic calcification.

Adequate dietary calcium is necessary for clinical response to vitamin D therapy.

This product contains FD&C Yellow No. 5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible individuals. Although the overall incidence of FD&C Yellow No. 5 (tartrazine) sensitivity in the general population is low, it is frequently seen in patients who also have aspirin hypersensitivity.

Protect from light.

Drug Interactions

Mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin D preparations.

Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with Drisdol may cause hypercalcemia.

Carcinogenesis, Mutagenesis, Impairment of Fertility

No long-term animal studies have been performed to evaluate the drug’s potential in these areas.

Pregnancy Category C

Animal reproduction studies have shown fetal abnormalities in several species associated with hypervitaminosis D. These are similar to the supravalvular aortic stenosis syndrome described in infants by Black in England (1963). This syndrome was characterized by supravalvular aortic stenosis, elfin facies, and mental retardation. For the protection of the fetus, therefore, the use of vitamin D in excess of the recommended dietary allowance during normal pregnancy should be avoided unless, in the judgment of the physician, potential benefits in a specific, unique case outweigh the significant hazards involved. The safety in excess of 400 IU of vitamin D daily during pregnancy has not been established.

Nursing Mothers

Caution should be exercised when Drisdol is administered to a nursing woman. In a mother given large doses of vitamin D, 25-hydroxycholecalciferol appeared in the milk and caused hypercalcemia in her child. Monitoring of the infant’s serum calcium concentration is required in that case (Goldberg, 1972).

Pediatric Use

Pediatric doses must be individualized (see DOSAGE AND ADMINISTRATION ).

Geriatric Use

Clinical studies of Drisdol did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. A few published reports have suggested that the absorption of orally administered vitamin D may be attenuated in elderly compared to younger individuals. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Adverse Reactions

Hypervitaminosis D is characterized by effects on the following organ system:

Renal. Impairment of renal function with polyuria, nocturia, polydipsia, hypercalciuria, reversible azotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or irreversible renal insufficiency which may result in death.

CNS. Mental retardation.

Soft Tissues. Widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs.

Skeletal. Bone demineralization (osteoporosis) in adults occurs concomitantly.

Decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism) vague aches, stiffness, and weakness.

Gastrointestinal. Nausea, anorexia, constipation.

Metabolic. Mild acidosis, anemia, weight loss.

Overdosage

The effects of administered vitamin D can persist for two or more months after cessation of treatment.

Hypervitaminosis D is characterized by:

1. Hypercalcemia with anorexia, nausea, weakness, weight loss, vague aches and stiffness, constipation, mental retardation, anemia, and mild acidosis.

2. Impairment of renal function with polyuria, nocturia, polydipsia, hypercalciuria, reversible azotemia, hypertension, nephrocalcinosis, generalized vascular calcification, or irreversible renal insufficiency which may result in death.

3. Widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs. Bone demineralization (osteoporosis) in adults occurs concomitantly.

4. Decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism).

The treatment of hypervitaminosis D with hypercalcemia consists in immediate withdrawal of the vitamin, a low calcium diet, generous intake of fluids, along with symptomatic and supportive treatment. Hypercalcemic crisis with dehydration, stupor, coma, and azotemia requires more vigorous treatment. The first step should be hydration of the patient. Intravenous saline may quickly and significantly increase urinary calcium excretion. A loop diuretic (furosemide or ethacrynic acid) may be given with the saline infusion to further increase renal calcium excretion. Other reported therapeutic measures include dialysis or the administration of citrates, sulfates, phosphates, corticosteroids, EDTA (ethylenediaminetetraacetic acid), and mithramycin via appropriate regimens. With appropriate therapy, recovery is the usual outcome when no permanent damage has occurred. Deaths via renal or cardiovascular failure have been reported.

The LD 50 in animals is unknown. The toxic oral dose of ergocalciferol in the dog is 4 mg/kg.

Drisdol Dosage and Administration

THE RANGE BETWEEN THERAPEUTIC AND TOXIC DOSES IS NARROW.

Vitamin D Resistant Rickets: 12,000 to 500,000 IU units daily.

Hypoparathyroidism: 50,000 to 200,000 IU units daily concomitantly with calcium lactate 4 g, six times per day.

DOSAGE MUST BE INDIVIDUALIZED UNDER CLOSE MEDICAL SUPERVISION.

Calcium intake should be adequate. Blood calcium and phosphorus determinations must be made every 2 weeks or more frequently if necessary.

X-rays of the bones should be taken every month until condition is corrected and stabilized.

How is Drisdol Supplied

Capsules of 1.25 mg (50,000 IU vitamin D) of ergocalciferol, USP are green and oval shaped, imprinted with a circled W and "D 92" on one side and plain on the other.

HDPE plastic bottles of 100 capsules (NDC 30698-393-01).

Store at 25° C (77° F); excursions permitted between 15° - 30° C (59° - 86°F) [see USP Controlled Room Temperature].

Rx Only Distributed by:

Validus Pharmaceuticals LLC

Parsippany, New Jersey 07054 info@validuspharma. com www. validuspharma. com 1-866-982-5438 (1-866-9VALIDUS)

© 2016 Validus Pharmaceuticals LLC 60042-00 (Rev April 2016)

PRINCIPAL DISPLAY PANEL

NDC 30698-393-01 100 capsules

Drisdol ® (ergocalciferol, USP) 1.25 mg (50,000 IU vitamin D) Rx only



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Furazolidone (oral-local), furazolidone

Furazolidone (Oral-Local)

Commonly used brand name(s): Furoxone; Furoxone Liquid.

Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s).

† Not commercially available in Canada.

antiprotozoal— Note: Furazolidone is a broad-spectrum anti-infective that is effective against most gastrointestinal tract pathogens.

Diarrhea, bacterial (treatment)—Furazolidone is indicated as a secondary agent in the treatment of bacterial diarrhea caused by susceptible organisms. Furazolidone is active in vitro against Campylobacter jejuni, Enterobacter aerogenes, Escherichia coli, Proteus species, Salmonella species, Shigella species, and staphylococci. However, clinical studies on the effectiveness of furazolidone in some types of bacterial diarrhea have been inconclusive or conflicting.

—Not all species or strains of a particular organism may be susceptible to furazolidone.

Physicochemical characteristics: Molecular weight— 225.16 Mechanism of action/Effect:

Microbicidal. Furazolidone interferes with several bacterial enzyme systems. It neither significantly alters normal bowel flora nor results in fungal overgrowth.

Furazolidone also acts as a monoamine oxidase inhibitor (MAOI). MAOIs prevent the inactivation of tyramine by hepatic and gastrointestinal monoamine oxidase. Tyramine in the bloodstream releases norepinephrine from the sympathetic nerve terminals and produces a sudden increase in blood pressure. Absorption:

Radiolabeled drug studies indicate that furazolidone is well absorbed following oral administration. Distribution:

Limited pharmacokinetic information is available in humans; however, recent data have reported that variable plasma concentrations were measured in subjects given therapeutic doses. One study of 8 meningitis patients showed that cerebral spinal fluid (CSF) concentrations reached levels comparable to serum concentrations. Also, significant concentrations have been measured in the bile of rats. Biotransformation:

Furazolidone is rapidly and extensively metabolized; the primary metabolic pathway identified begins with nitro-reduction to the aminofuran derivative. Elimination: Radiolabeled drug studies showed that more than 65% of an oral dose was recovered in the urine of humans and animals. Also found in feces.

Precautions to Consider Cross-sensitivity and/or related problems

Patients hypersensitive to other nitrofurans may be hypersensitive to this medication also. Carcinogenicity/Tumorigenicity

Several studies in rodents, given chronic, high-dose furazolidone orally, have shown that this medication is tumorigenic. Furazolidone has been shown to cause mammary neoplasia in two strains of rats. In addition, furazolidone has been shown to cause pulmonary tumors in mice. Pregnancy/Reproduction

Pregnancy— Studies in humans have not been done. However, teratogenic effects on the human fetus or newborn infants have not been reported.

Studies in animals have not shown that furazolidone, given in doses far exceeding recommended human doses for long periods of time, causes adverse effects on the fetus. Breast-feeding

It is not known whether furazolidone is distributed into breast milk. However, breast-feeding is not recommended in nursing infants up to 1 month of age because of the possibility of hemolytic anemia due to glutathione instability in the early neonatal period. Pediatrics

Use of furazolidone is not recommended in infants up to 1 month of age because of the possibility of hemolytic anemia due to immature enzyme systems (glutathione instability) in the early neonatal period.

No information is available on the relationship of age to the effects of furazolidone in geriatric patients. Drug interactions and/or related problems The following drug interactions and/or related problems have been selected on the basis of their potential clinical significance (possible mechanism in parentheses where appropriate)—not necessarily inclusive ( » = major clinical significance):

Note: Combinations containing any of the following medications, depending on the amount present, may also interact with this medication.

» Alcohol (concurrent use of alcohol with furazolidone may rarely result in a disulfiram-like reaction, characterized by facial flushing, difficult breathing, slight fever, and tightness of the chest; these effects usually subside spontaneously within 24 hours with no lasting ill effects; patients should be advised not to drink alcoholic beverages while taking furazolidone and for 4 days after discontinuing it )

» Antidepressants, tricyclic or » Monoamine oxidase (MAO) inhibitors, other or » Sympathomimetics, direct - or indirect-acting, such as amphetamines, ephedrine, or phenylephrine or » Tyramine - or other high pressor amine–containing foods and beverages, such as aged cheese; beer; reduced-alcohol and alcohol-free beer and wine; red and white wine; sherry; liqueurs; yeast or protein extracts; fava or broad bean pods; smoked or pickled meat, poultry, or fish; fermented sausage (bologna, pepperoni, salami, summer sausage) or other fermented meat; and any overripe fruit (concurrent use of these medications, foods, and beverages with furazolidone may theoretically precipitate sudden and severe hypertensive reactions due to furazolidone's MAO inhibitory properties; a dose of 400 mg daily for 5 days was required to experimentally enhance tyramine and amphetamine sensitivity by 2- to 3-fold; this dose does not usually cause an undue risk of hypertensive crises in adults due to MAO inhibition, and no clinical reports of this interaction have been reported; however, if furazolidone is given in larger-than-recommended doses or for more than 5 days, there may be an increased risk of hypertensive crises due to accumulation of monoamine oxidase )

(because of furazolidone's MAO inhibitory properties, dietary restrictions must be continued for at least 2 weeks after the medication is discontinued; other tyramine - or high pressor amine–containing foods, such as yogurt, sour cream, cream cheese, cottage cheese, chocolate, and soy sauce, if eaten when fresh and in moderation, are considered unlikely to cause serious problems )

Medical considerations/Contraindications The medical considerations/contraindications included have been selected on the basis of their potential clinical significance (reasons given in parentheses where appropriate)— not necessarily inclusive ( » = major clinical significance).

Risk-benefit should be considered when the following medical problems exist Glucose-6-phosphate dehydrogenase (G6PD) deficiency (mild, reversible, hemolytic anemia may occur in G6PD-deficient patients; it is recommended that furazolidone be discontinued if hemolytic anemia occurs in patients with G6PD deficiency )

Hypersensitivity to furazolidone or other nitrofurans Patient monitoring The following may be especially important in patient monitoring (other tests may be warranted in some patients, depending on condition; » = major clinical significance):

Glucose-6-phosphate dehydrogenase (G6PD) determinations (recommended prior to treatment in Caucasians of Mediterranean and Near Eastern origin, Orientals, and blacks; if a deficiency is found, furazolidone should be given with caution since hemolytic effects may be exacerbated in these patients; dosage adjustments and/or discontinuation of the medication may be required )

For giardiasis » Stool examinations (3 stool examinations, taken several days apart, beginning 3 to 4 weeks following treatment are recommended if symptoms persist; however, in some successfully treated patients, the lactose intolerance brought on by infection may persist for a period of some weeks or months, mimicking the symptoms of giardiasis; in cases of treatment failure, alternate medications may be used )

Note: Furazolidone may cause mild, reversible hemolytic anemia in G6PD-deficient patients. Furazolidone should be discontinued if hemolytic anemia occurs in these patients.

The following side/adverse effects have been selected on the basis of their potential clinical significance (possible signs and symptoms in parentheses where appropriate)—not necessarily inclusive: Those indicating need for medical attention Incidence rare Hypersensitivity reactions (fever; itching; joint pain; skin rash or redness) —incidence approximately 0.6% leukopenia (sore throat and fever) —incidence approximately 0.2%

Patient Consultation As an aid to patient consultation, refer to Advice for the Patient, Furazolidone (Oral) .

In providing consultation, consider emphasizing the following selected information ( » = major clinical significance): Before using this medication » Conditions affecting use, especially: Sensitivity to furazolidone or other nitrofurans

Breast-feeding—Not recommended in infants up to 1 month of age because of possibility of hemolytic anemia

Use in children—Not recommended in infants up to 1 month of age because of possibility of hemolytic anemia

Other medications, especially direct-acting and indirect-acting sympathomimetics, other MAO inhibitors, or tricyclic antidepressants Proper use of this medication » Not giving to infants up to 1 month of age; may cause hemolytic anemia

May be taken with food to reduce gastrointestinal irritation

Proper administration technique for oral suspension: Using a specially marked measuring spoon or other device

» Compliance with full course of therapy

» Proper dosing Missed dose: Taking as soon as possible; not taking if almost time for next dose; not doubling doses

» Proper storage Precautions while using this medication Regular visits to physician to check progress

Checking with physician if no improvement within a week

» Avoiding alcoholic beverages or other alcohol-containing preparations while taking, and for 4 days after discontinuing, furazolidone

» Avoiding tyramine - and other high pressor amine–containing foods and beverages, OTC appetite suppressants, cough and cold medications, and other medications unless prescribed by physician; also avoiding these products for at least 2 weeks after discontinuing furazolidone; asking health care professional to provide list of products that may or may not cause serious problems with furazolidone

Side/adverse effects Signs of potential side effects, especially hypersensitivity reactions and leukopenia

Dark yellow to brown discoloration of urine may be alarming to patient, although medically insignificant

General Dosing Information Furazolidone has been used as adjunctive therapy with other antibacterial agents or bismuth salts with no problems reported. Diet/Nutrition Gastrointestinal intolerance may be decreased if furazolidone is taken with food or if the dose is reduced.

After discontinuation of furazolidone, the MAO inhibiting effects may persist for at least 2 weeks. During this time, food, beverage, and medication precautions must be observed by patients receiving larger-than-recommended doses or prolonged therapy (See Drug interactions and/or related problems ).

For treatment of adverse effects Recommended treatment consists of the following

• Administering direct-acting vasopressor agents (e. g. norepinephrine) to counteract hypotensive episodes. Avoiding indirect-acting vasopressor agents. • Administering phentolamine or parenteral chlorpromazine to counteract hypertensive crises.

Note: Some medical experts recommend shorter courses of treatment (e. g. two to five days) for the above-listed infections.

Usual pediatric dose Cholera or Diarrhea, bacterial Infants up to 1 month of age: Use is not recommended because of the possibility of hemolytic anemia due to immature enzyme systems (glutathione instability) in these infants.

Infants and children 1 month of age and over: Oral, 1.25 mg per kg of body weight four times a day for five to seven days.

Giardiasis Infants up to 1 month of age: Use is not recommended because of the possibility of hemolytic anemia due to immature enzyme systems (glutathione instability) in these infants.

Infants and children 1 month of age and over: Oral, 1.25 to 2 mg per kg of body weight four times a day for seven to ten days.

Note: The maximum dose for children should not exceed 8.8 mg per kg of body weight daily because of the possibility of nausea or vomiting.

Strength(s) usually available U. S.—

50 mg per 15 mL (Rx) [ Furoxone Liquid (methyparaben) (propylparaben)]

Canada— Not commercially available.

Packaging and storage: Store below 40 °C (104 °F) in a tight, light-resistant container. Protect from freezing. Auxiliary labeling: • Shake well. • Avoid alcoholic beverages. • Continue medication for full time of treatment. • May discolor urine.

Canada— Not commercially available.

Packaging and storage: Store below 40 °C (104 °F) in a tight, light-resistant container. Preparation of dosage form: For patients who cannot take oral solids —Furazolidone tablets may be crushed and given in a teaspoonful of corn syrup. Auxiliary labeling: • Avoid alcoholic beverages. • Continue medication for full time of treatment. • May discolor urine.

References

Furoxone package insert (Norwich Eaton—US), Rev 4/85, Rec 1/89.

DuPont HL, Ericsson CD, Galindo E, et al. Furazolidone versus ampicillin in the treatment of traveler's diarrhea. Antimicrob Agents Chemother 1984 Aug; 26: 160-3.

AMA Drug evaluations. 6th ed. Chicago: American Medical Association, September 1986: 140-1, 156, 1578-9.

Reynolds JEF, editor. Martindale, the extra pharmacopeia. 28th ed. London: The Pharmaceutical Press, 1982: 979-80.

Rakel RE, editor. Conn's current therapy 1988. Philadelphia: W. B. Saunders Company, 1988: 58-9, 454-7.

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