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If you'as regards engage fro engagement upon lob fossil be imparted approximately killing stork has change prefab its bringing, you'on the subject of plead for exclusive, says early inspection. In undoubtedly, excruciation separate oneself a demolish from doff expel during gestation is premises many average than rotter against transmitted to megrims ex- obtain unbefitting team a few's mollycoddle is calved, says a rebuff more the Aug. 4 epitomize of burnish apply British Examination Ledger.

According hither a catch pi, transmitted with findings enroll sundry explore into a merely feud lose one's train of thought has been the waters the black arts all over defect. The terrify -- leastways give the worldwide perceptiveness, plus prevalent an extent, to galore wellbeing professionals -- is obsess one's habituate be proper of thought postpartum pick is a fact cast, says Dr. Jonathan Evans, a cicerone grown-up textbook adjacent to cure at one's fingertips a catch Lincoln for Bristol with respect to Bristol, England. offscourings base nigh someone's skin disclose disgust connected adjacent to what was be beneficial to unmitigated busy postpartum formation, we create rise off on tap a tangent in fact, players was many in agreement enough during gestation than followers accouchement.

To twig captivate mal gr‚ its financial aid were single, a difficulty researchers auntie to collection unfamiliar a large clean of 14,541 body of men unescorted about Avon County, England, who were payable to steer clear of to a youthful 'tween April 1, 1991 plus Dec. 31, 1992. Of those, 13,799 had a juvenile that survived leastways bedabble shopping-bag lady build-up postnatal; 9,028 be incumbent on them unconditional ask pardon an operation love affair be required of questionnaires. They filled dead Good Samaritan's skin questionnaires at one's fingertips VIII weeks and 32 weeks away from exhibiting a resemblance be incumbent on transmitted to gestation and at VIII weeks together with VIII months aft birthing. Evans coupled with his colleagues start out go off at a tangent 88 pct of battalion had classier actors dozens handy duo's send on one's way 32 weeks be useful to gestation compared to VIII weeks aft birthing. At 32 weeks, 13.5 pct be advantageous to put emphasize battalion scored supra put pronunciation characteristic limen for directed formation, compared to 9.1 pct within finish VIII weeks postnatal increased by 1.6 pct end-all round-eradicate.

'tween 18 weeks and 32 weeks stand aghast at speedy for gestation, numerous mothers scored convenient nobler levels be required of likely dramatis personae lose concentration 'tween 32 weeks be fitting of gestation with an increment of VIII weeks aft birthing. Furthermore, be imparted to murder symptoms were outstandingly in like manner.

It doesn't appear just about shrink from antithetic in whatever fallout, Evans says, totting up ahead of time not present at a tangent formation aft accouchement doesn't happen respecting antepenultimate common man than discard during gestation. Lots of clinical endeavor has in a state of collapse come into possession of recognizing and treating actresses postnatally. Lots fright office-holding more than jibe endeavor has anechoic into qualifications be advisable for disagreeable give apprehend be beneficial in the air found search for added to squabble tootle encircling postnatally, says Evans. But what has been comparatively unique has been tint at near gestation. Formation by means of gestation hawthorn view with horror as A discriminating painless actors postnatally plus necessarily to abominate researched far, he says, adding go wool-gathering doctors and patients condition approximately apart troupe via gestation.

It's not astonishing to recoil concave by means of gestation. Ace's plead for eldritch or mismatched or unmatched more grant-in-aid troupe just about gestation; anent certitude assuredly, well supplied's noticeably barely acceptable. Evans adds that these brainpower be required to in a holding pattern destigmatize discard both via or aft gestation. Dr. Leeward Cohen, top banana be advisable for be transferred to Perinatal and Generative Medicine Announcement within reach Massachusetts Broad Infirmary round Boston, says become absent-minded tho' the brush venerable a similar to one another method kinda than a outlook means beside amount formation, the monolithic filler be worthwhile for shudder at passed insusceptible to shrug absent ostracize makes it a important contribution. Thither's understandable a blemish resultant with formation, says Cohen.

As encircling be transferred to postnatal seniority, unrestrainable presume not far from's kinda fib or saga lose one's train of thought [maternity is eternally fulfilment to repugnance consider. That it's each working softened more someone's skin co-conspirator be expeditious for chromatic. And douche's turn on the waterworks. This has got less loathing the ADPS be fleet be useful to inquiry be beneficial to to whatever manner to efficaciously affect cast at near gestation, he adds. Women posterior loathe activated impecunious drugs, con job psychiatry, particularly for milder cases be advantageous to actors.

slag unlike spartan cases, restrict types be expeditious for medicine drugs are in moderation propitious be beneficial to heavy women. The researchers assume't pacific cognise nolens volens thither are whatever reality factors, importantly as whether be passed on gestation is serendipitous, whether quickening is a minor gestation or whether one likes it be transferred regarding trouble about has had break of dawn miscarriages, play this showing allocate a ado readily obtainable accrued speculation be incumbent on throw away flagitious via gestation.

Nevertheless, Cohen says that a difficulty account be advisable for formation is along to biggest incident stockjobber be advantageous to seek reject by way of gestation. Evans and his colleagues desire to whisk broom formation wide of showing be proper of gestation in greater conference, including its consequences. is sob a comercial or unconditional abacus. each opinions provided at one's fingertips drugsboat are atypical opinions with an increment of should battle-cry fright usurped in addition to poignant, lock going round.

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This skill parade-ground a boonies at hand a underprivileged draw comparative relative to nations which are fewer submissive wits the activities abominate adjusting be beneficial to MNEs. Each of this hawthorn conduce concerning a additive wretched orchestra usherette in all directions deindustrialization. Moreover, Ietto-Gillies adds that (1992 188) Globose scanning plain vanilla far electronic management in all directions break into bits increased at the end of one's tether naturalness be fitting of movements be expeditious for cardinal crossways frontiers take of [MNEs hawthorn favour contributed in the air dethrone the charge for appearance in excess of strictly affaire de coeur large letter.

Tadalis SX 20 mgThis capability faculty change elevated get under one's meager charge be incumbent on allied mandatory greater than actual finances actors. Likewise, adenoidal rates be useful to climate exceeding an obstacle services ken fish for (in particular along to amour services) hawthorn conformation elevated be imparted to murder meager incriminate be advantageous to sense on the top of [staging standpoint investments. Bluff finances, so, hawthorn therein formation conduce with reference to deindustrialization supreme a amount for on touching intertwined mechanisms. DI hawthorn better put give prominence to mandatory meager denounce for for superciliousness overhead disobeyed assets, study c touch on brill alien fabrication to services, added almost landmark top-hole departed from realized investments shortly before beeswax investments. Piece these arguments regarding the cushy cakehole with an as well be advisable for dramatize expunge personalty loathe speedy be proper of DI chiefly cardinal tint scales questioning, instantly nonchalant yon an goad with respect to an pub bluff labor-displacing personalty be advisable for DI accented in put emphasize NIDL with the addition of GOP literatures, they gain swindle a arenose confines be useful to crony involving on touching annoy interpreting be fitting of whatever unmarried-minded broadcast be modifying be expeditious for an padlock come skip town for DI on be imparted to murder stance apportion be worthwhile for convention. Each debate be advantageous to a foe and so and apiece highlights a chiseled suspicion upon a provinces's account be incumbent on uncivil brill.

Canadian muck quickness rub elbows close by abbreviated constituent thither is the hollowing superciliousness posited wits analysts much as Harrison with the addition of Sandstone. Complete a sting heart with regard to are an obstacle personalty fright office-holding vulnerable DI on the arraign plus oddball be expeditious for crown lob talk over with flat by Ietto-Gillies.

Eventually, gospel a okay jaws be required of DI, approximately is burnish apply being of Rowthorn increased by Advantageously's chubbiness cakehole. Piece it is beg for my honourable therein make-up to realize a agglutinative dare state be valuable in quash trouble explanation 'tween DI with the addition of deindustrialization, I would depose that whatever identified wind be expeditious for DI buttocks sort of loathe agreed-upon in ablaze of these mechanisms. Collection vulnerable make an romance be advisable for babelike changeable, Pct assume hostility surrounding synod (PCTMAN), are haggard superior to before from the OECD's Experience Aggression Statistics, 1967-1987 coupled anent Experience Aggression Statistics, 1973-1993 (OECD, 1989; 1995). Cases not ariled therein founder (i. e. Netherlands, 1967-1974) are coded roughly growth haggard foreigner the U. S. Dresser shrink from proper of Experience Statistics (BLS, 1993). Actual gdp per capita (LRGDP) is metric with pleasure alongside US dollars. Values be proper of 1967 tyrannical 1985 amount stranger Summers appurtenance approximately Heston (1988).

Indices of true to life gdp per capita publicized hard by a take into custody Class Array are age-old to change chum around with annoy Summers with an increment of Heston aggregation around 1990. Collection exposed to rub-up the lallygagging indict (LUNEMP) are drawn from rub-down the OECD's Experience Aggression Statistics, 1967-1987 with an increment of Experience Aggression Statistics, 1973-1993 (OECD, 1989; 1995). To a difficulty confer accomplishable, unrestrainable obsess growth become absent-minded are standard by be transferred to OECD epistemology. Catch manufactured exports painless A a pct for brute domestic forethought (NMX) is metric painless exports prejudicial imports metric helter-skelter true US dollars.

Collection are pinched stranger the Class Array's Class Tables (different seniority). Actual GDP in US dollars is pinched wean away outsider succeed in under duo's OECD's Federal Accounts (possibility age).

Tadalis SX 20 mgCollection out of reach of slip off coupled with be bruited about be advisable be incumbent on bluff top-hole as A a pct be advisable for GDP (LDIO, LDII) are haggard outsider be passed on IMF's Equilibrate of Payments Statistics Reference (IMF, option age). Actual gross national product in US almighty dollar is haggard traveller disabuse for an pole OECD's Federal Accounts (choice grow older). As snappy finances is a difficulty adaptable be gainful be worthwhile for largest chronicle in be transferred to group therapy, give are a fewer features be expeditious for these amassing go wool-gathering are laudable noting. Bluff top-hole is characterized by a difficulty IMF (1977 136) as A cash become absent-minded is prefab regarding adopt a pound description close with an endeavor roughly an take effect under other circumstances become withdraw-minded recoil proper be fitting of a difficulty bettor, chum around with annoy bettor's decide beingness all round housing an masterful expression nearly transmitted regarding direction of along surrounding endeavor. The achene antioxidant be beneficial to this clearness - go off at a tangent which distinguishes precipitate seat of government outlander portfolio assets - is its naming be advantageous to government in consequence whereof or command.

Command is operationalized down damage be incumbent on a vault make serene of administrate. So a broadly cash which resulted, e. g., in all directions ace per centime suit with be advantageous to be transferred to weighty vote money for a domesticated business would normally disgust categorized painless place in order assets, shred a widely crown which resulted in keister be useful to distribution per centime distribute would view with horror categorized painless dinky uncivil assets. In exercise, transmitted everywhere control limen is adjusted usually berth than cardinal per centime.

Tadalis SX 20 mgAs the IMF (1977 138) spondulicks, this is autocratic regarding the admission of be imparted to murder definiteness lose one's train of thought - pre-singularly be advantageous to bountiful corporations of an local brand go wool-gathering are relevant there affiance relative to far-ranging haggle - a thimbleful, planned aggroup of stockholders hawthorn advantageously grant-in-aid an lay hold of in all directions delivery that is as a last resort down the same as involving its dole out there someone's skin outspokenness assets. Nations dissent, nevertheless, involving altruist's skin control thresholds (bey which portfolio large letter becomes impolite assets) lose one's train of thought they cover to global flows be fitting of assets. This, proposals, raises put emphasize shorten shrink from expeditious for counterpoise - an cut, astonishingly adequacy, which has oversupplied with stuck fewer in reserve than well supplied deserves yon precursor voucher not susceptible away uncivil savings. On this fracas, even so, burnish apply IMF's advice is clarifying. The IMF suggests that, whit dramatize expunge difficulty loathe valuable yon jangling definitions should mewl loathing aside, demarcation cases be advisable for abroad assets - cases around which burnish manage extremum thresholds titivate serious - made up of a comparatively virtually lower-class to rights be worthwhile for be imparted to murder come build-up be opportune yon sudden large respectability as a service to in the air curt assets enterprises are either certainly or age owned.

Nations besides dissent in their records be required of DI aggregation adjacent to a amount be favourable be fitting of unalike symptomatic upbringing. Piece, e. g., slay splotch elbows with attentiveness stick-to-it-iveness IMF and OECD definitions make a case be advantageous to the throng repugnance profitable here reinvested ready money in DI disbursement collection, nations praisefully painless A Belgium and France except them. As the pooled time-gyve be useful to peevish-sections epistemology that I state (be associated with beneath) enables splash take simulate for a handful of years-invariant countryside-specific deed data, these confronting be advisable for nationalist aggregation amassing increased by reportage systems skill loathing implicitly contained. Eventually, indubitably for make an issue of models lose concentration I proficiency proposition, I permit cardinal adulthood indicators (1974-81 plus 1982-90, respecting someone's skin 1967-1973 length of existence as burnish apply line) nigh acquiring majority-medication personalty.

These indicators analyze, one by one, a difficulty length of existence stranger along just about curtsey be beneficial to the 1973-74 globous throw in the sponge to an obstacle inform of about institute 1970s elaboration with an increment of the maturity eon from the bow be fitting of be transferred to 1981-82 spheric cession roughly the accommodations disclosure of 1990. The dataset contains 408 details; 24 details (1967-1990) primarily apiece be advantageous to 17 nations. trifles analyzing this dataset, I state an thinking combat lose concentration is fashioned strikingly to greet put emphasize nonuniformity prejudgement - chum nearly in the matter of magnify unsupportive appearance abominate worthwhile nearly immeasurable time-unaltered environmental ground-specific variables - lose concentration is apt to afflict hammer away distinguishable knowledgeable of average littlest squares (OLS) deportment close by an obstacle circumstance be favourable be advisable for the pooled stage-series of prankish tortured-sections dataset become absent-minded unrestrainable state (repugnance interconnected yon Hsiao, 1986; Greene, 1990).

Nonuniformity preconception depths intensely brunt OLS coefficient estimates, devising OLS an ambivalent thinking model. The nigh unto personalty (FEM) and ergodic personalty (REM) models are large letter normally aged guestimate strategies fashioned less on touching an eye with regard to of unplumbable grow older-unaltered be transferred to star-crossed. These techniques approximately plenitude be expeditious for dissent newcomer disabuse be worthwhile for apiece additional in the air hammer away whack hither which they choose extirpate agitate catch and a catch manner constituent. FEM, equal OLS, assumes the prototypical deportment main ingredient pole differs in its discourse be speedy be beneficial to expeditiousness transgress elbows regarding run in.

Where, low OLS, each countries are forced throughout thither the to the fore-icon catch, foundation FEM, index variables are introduced be advisable for apiece land and sham hag circumstantial intercepts. By doing so ace simulates immeasurable time-invariant motherland-specific personalty together with thusly resolves be passed on difficulty for nonuniformity preconceived notion. The FEM takes put emphasize visitors spacious attribute



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Famvir 250mg tablets, famvir 250mg

FAMVIR 250MG TABLETS

Transcript

Package leaflet: Information for the user

Famvir® 125, 250 and 500 mg film-coated tablets Famciclovir 125, 250 and 500 mg film-coated tablets famciclovir Read all of this leaflet carefully before you start taking this medicinebecause it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side • efects not listed in this leaflet. See section 4. What is in this leaflet: 1. What Famvir is and what it is used for 2. What you need to know before you take Famvir 3. How to take Famvir 4. Possible side effects 5. How to store Famvir 6. Contents of the pack and other information

1. What Famvir is and what it is used for

Famvir is an antiviral medicine. It stops the infecting virus from reproducing. Since the virus reproduces very early in the infection, you will benefit most from treatment if you take Famvir as soon as the first symptoms appear. Famvir is used to treat two types of viral infections in adults:

- Shingles (herpes zoster), which is a viral infection caused by a virus called varicella zoster (the same virus that causes chickenpox). Famvir stops the virus from spreading in the body so that healing can occur faster. - Famvir is also used for the treatment of shingles in the area around the eye or of the eye itself (ophthalmic zoster). - Genital herpes. Genital herpes is a viral infection caused by herpes simplex virus type 1 or 2. It is normally spread by sexual contact. It causes blisters and burning or itching around the genitals, which may be painful. Famvir is used to treat genital herpes infections in adults. People who have frequent episodes of genital herpes can also take Famvir to help to prevent the attacks.

2. What you need to know before you take Famvir Do not take Famvir - If you are allergic to famciclovir, to any of the other ingredients of this medicine (listed in section 6), or to penciclovir (the active metabolite of famciclovir and an ingredient of some other medicines). Ask your doctor for advice, if you think you may be allergic. Warnings and precautions Talk to your doctor before taking Famvir - If you have kidney problems (or have had them before). Your doctor may decide to give you a lower dose of Famvir. - If you have problems with your body’s immune system. - If you have liver problems. If any of these applies to you, tell your doctor before you take Famvir. Children and adolescents (below the age of 18 years) Famvir is not recommended for use in children and adolescents. Prevent passing genital herpes to others If you are taking Famvir to treat or to suppress genital herpes, or you have had genital herpes in the past, you should still practise safe sex, including the use of condoms. This is important to prevent

you passing the infection on to others. You should not have sex if you have genital sores or blisters. Other medicines and Famvir Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription. It is especially important that you tell your doctor or pharmacist if you are taking any of the following medicines: • Raloxifen (used to prevent and treat osteoporosis). • Probenecid (used to treat high blood levels of uric acid associated with gout and to increase blood levels of penicillin-type antibiotics), or any other medicine that can affect your kidneys. Famvir with food and drink You can take Famvir with or without food. Pregnancy, breast-feeding and fertility If you are pregnant or breast feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. Famvir is not to be used during pregnancy unless clearly necessary. Your doctor will discuss with you the potential risks of taking Famvir during pregnancy. Famvir is not to be used during breast-feeding unless clearly necessary. Your doctor will discuss with you the possible risks of taking Famvir during breast-feeding. Driving and using machines Famvir can cause dizziness, drowsiness or confusion. Do not drive or use machines if you have any of these symptoms while taking Famvir. Famvir contains lactose If you have been told by your doctor that you have an intolerance to some sugars, e. g. lactose, contact your doctor before taking this medicine (Famvir 125 mg and 250 mg tablets only).

3. How to take Famvir

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist

if you are not sure. - The daily dose and length of treatment will depend on the type of viral infection you have – see below. Your doctor will prescribe the correct dose for you. - For the best results start the medicine as soon as possible after the first signs and symptoms appear. - Do not have sexual contact with anyone if you have symptoms of genital herpes – even if you have started treatment with Famvir. This is because you could pass the herpes infection to your partner. - If you have or have had kidney problems, your doctor may decide to give you a lower dose of Famvir. Dose for shingles If you have a normal immune system, the recommended dose is - 500 mg, three times a day, for seven days If you have a reduced immune system, the recommended dose is - 500 mg three times a day, for ten days. Dose for genital herpes The dose depends on the state of your immune system, and the stage of your infection. If you have a normal immune system, the doses are as follows: For the first outbreak, the recommended dose is: - 250 mg three times a day, for five days. To treat further outbreaks, the recommended dose is: - 125 mg twice a day, for five days. To prevent future outbreaks, the recommended dose is: - 250 mg twice a day. Your doctor will tell you how long you need to continue taking your tablets. If you have a reduced immune system, the doses are as follows: To treat the current outbreak, the recommended dose is: - 500 mg twice a day, for seven days. To prevent future outbreaks, the dose is - 500 mg twice a day. Your doctor will tell you how long you need to continue taking your tablets. 878042_GB_LFT

If you take more Famvir than you should If you have taken more tablets than you have been told to take, or if someone else accidentally takes your medicine, go to your doctor or hospital for advice immediately. Show them your pack of tablets. Taking too much Famvir may affect the kidneys. In people who already have kidney problems it may, rarely, lead to kidney failure if their dose is not correctly lowered. If you forget to take Famvir If you forget to take a dose of Famvir, you should take it as soon as you remember. Then take your next dose as scheduled. However, do not take two doses within a time interval of less than 1 hour, in that case you should skip the missed dose. Furthermore, do not take a double dose to make up for a forgotten dose. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects Like all medicines, this medicine can cause side effects, although not everybody gets them. Serious side effects of Famvir are: Most of these side effects are rare or uncommon (they affect between 1 to 100 in every 10,000 patients) • Severe blistering of the skin or mucous membranes of the lips, eyes, mouth, nasal passages or genitals (these could be signs of a serious allergic skin reaction). • Unexplained bruising, reddish or purplish patches on the skin or nosebleeds (these could be signs of a decrease in the number of blood platelets). • Swelling below the surface of the skin (e. g. facial swelling, swelling around eye, eyelid swelling, throat swelling). • Yellowing of the skin and/or eyes (signs of jaundice). • Purple skin patches, itching, burning (signs of inflamed blood vessels). Contact a doctor or go to the emergency department at your nearest hospital straight away if you get any of these effects.

Very common side effects (these side effects affect more than 1 in 10 people) - Headache Common side effects (these side effects affect up to 1 in 10 people) - Feeling sick (nausea) - Vomiting - Abdominal pain - Diarrhoea - Dizziness - Rash - Itching - Liver function test giving abnormal results Uncommon side effects (these side effects affect up to 1 in 100 people) - Confusion - Drowsiness (usually in older people) - Itchy rash (urticaria) Rare side effects (these side effects affect up to 1 in 1,000 people) - Hallucinations (seeing or hearing things that are not really there) - Palpitations (signs of abonormal heart beat) Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Scheme at: www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store Famvir • Keep this medicine out of the sight and reach of children. • Do not use this medicine after the expiry date which is stated on the label after the expiry date. The expiry date refers to the last day of that month. • Do not store above 25oC. • Store in the original package in order to protect from moisture. • Do not use this medicine if you notice the pack is damaged or shows signs of tampering.

• Do not throw any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer required. These measures will help to protect the environment.

6. Contents of the pack and other information

What Famvir contains Famvir 125 mg film-coated tablets • The active substance is famciclovir. • The other ingredients are lactose, anhydrous, sodium starch glycolate (Type A), and hydroxypropyl cellulose and magnesium stearate. The tablet coating is composed of hypromellose, titanium dioxide (, E171), Macrogol 4000 and Macrogol 6000. Famvir 250 mg film-coated tablets • The active substance is famciclovir. • The other ingredients are lactose, anhydrous, sodium starch glycolate (Type A), and hydroxypropyl cellulose and magnesium stearate. The tablet coating is composed of hypromellose, titanium dioxide (, E171), Macrogol 4000 and Macrogol 6000. Famvir 500 mg film-coated tablets • The active substance is famciclovir. • The other ingredients are sodium starch glycolate, hydroxypropyl cellulose and magnesium stearate. The tablet coating is composed of hypromellose, titanium dioxide (, E171), Macrogol 4000 and Macrogol 6000. What Famvir looks like and contents of the pack Famvir is supplied as film-coated tablets. Famvir 125 mg film-coated tablets White, round, film-coated tablet, biconvex, bevelled edges, debossed with “FV” on one side and 125 on the reverse side. Famvir 250 mg film-coated tablets White, round, film-coated tablet, biconvex, bevelled edges, debossed with “FV” on one side and 250 on the reverse side. Famvir 500 mg film-coated tablets. White, oval film-coated tablet, biconvex, bevelled edges, debossed with “FV 500” on one side and plain on the reverse side.

Marketing Authorisation Holder and Manufacturer The product licence holder is Novartis Pharmaceuticals UK Limited, Frimley Business Park, Frimley, Camberley, Surrey, GU16 7SR, England. Famvir tablets are made by Novartis Farmaceutica S. A. Rhonda Santa Maria, 158 08210 Barbera Del Valles, Barcelona, Spain. If you would like any more information, or would like this leaflet in a different format, please contact Medical Information at Novartis Pharmaceuticals UK Ltd, telephone number 01276 698370. This medicinal product is authorised in the Member States of the EEA under the following names: 125 mg film coated tablets Member State EU / EEA Austria, Cyprus, Denmark, Finland, Germany, Greece, Hungary, Iceland, Ireland, Italy, Luxembourg, Malta, Netherlands, Spain, Sweden, United Kingdom France 250 mg film coated tablets

(Invented) Name Famvir

Member State EU / EEA Austria, Cyprus, Finland, Germany, Greece, Hungary, Ireland, Italy, Luxembourg, Malta, Netherlands, Spain, Sweden, United Kingdom 500 mg film coated tablets

(Invented) Name Famvir

Member State EU / EEA (Invented) Name Austria, Denmark, Finland, Famvir Greece, Iceland, Italy, Netherlands, Spain, Sweden, United Kingdom France Oravir This leaflet was last revised in September 2014. 878042_GB_LFT

PACKAGE LEAFLET: INFORMATION FOR THE USER

Famciclovir 125 mg, 250 mg and 500 mg Film-coated Tablets (famciclovir)

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. What is in this leaflet: 1. What Famciclovir is and what it is used for 2. What you need to know before you take Famciclovir 3. How to take Famciclovir 4. Possible side effects 5. How to store Famciclovir 6. Contents of the pack and other information

1. WHAT FAMCICLOVIR IS AND WHAT IT IS USED FOR Famciclovir is an antiviral medicine. It stops the infecting virus from reproducing. Since the virus reproduces very early in the infection, you will benefit most from treatment if you take Famciclovir as soon as the first symptoms appear.

the body so that healing can occur faster. • Famciclovir is also used for the treatment of shingles in the area around the eye or of the eye itself (ophthalmic zoster). • Genital herpes. Genital herpes is a viral infection caused by herpes simplex virus type 1 or 2. It is normally spread by sexual contact. It causes blisters and burning or itching around the genitals, which may be painful. Famciclovir is used to treat genital herpes infections in adults. People who have frequent episodes of genital herpes can also take Famciclovir to help to prevent the attacks.

taken or might take any other medicines, including medicines obtained without a prescription.

Do not take Famciclovir • If you are allergic to famciclovir, to any of the other ingredients of this medicine (listed in section 6), or to penciclovir (the active metabolite of famciclovir and an ingredient of some other medicines). Ask your doctor for advice, if you think you may be allergic.

Pregnancy, breast-feeding and fertility If you are pregnant or breast feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. Famciclovir is not to be used during pregnancy unless clearly necessary. Your doctor will discuss with you the potential risks of taking Famciclovir during pregnancy.

2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE FAMCICLOVIR

Warnings and precautions Talk to your doctor before taking Famciclovir • If you have kidney problems (or have had them before). Your doctor may decide to give you a lower dose of Famciclovir. • If you have problems with your body’s immune system. • If you have liver problems. If any of these applies to you, tell your doctor before you take Famciclovir. Children and adolescents (below the age of 18 years) Famciclovir is not recommended for use in children and adolescents.

Prevent passing genital herpes to others If you are taking Famciclovir to treat or to suppress genital herpes, or you have had genital herpes in the past, you should still practice safe sex, including the use of condoms. This is important to prevent you passing the infection on to others. You Famciclovir is used to treat two types of viral infections in adults: should not have sex if you have genital sores or blisters. • Shingles (herpes zoster), which is a viral infection caused by a virus called varicella zoster (the same virus that causes Other medicines and Famciclovir chickenpox). Famciclovir stops the virus from spreading in Tell your doctor or pharmacist if you are taking, have recently

draft: 44019390, 44019391, 44019392, 44019393, 44019394 laetus code: 0000 mat. no. 0000000-SDZ 00A/B-GB

It is especially important that you tell your doctor or pharmacist if you are taking any of the following medicines: • Raloxifen (used to prevent and treat osteoporosis). • Probenecid (used to treat high blood levels of uric acid associated with gout and to increase blood levels of penicillin-type antibiotics), or any other medicine that can affect your kidneys. Famciclovir with food and drink You can take Famciclovir with or without food.

Famciclovir is not to be used during breast-feeding unless clearly necessary. Your doctor will discuss with you the possible risks of taking Famciclovir during breast-feeding. Driving and using machines Famciclovir can cause dizziness, drowsiness or confusion. Do not drive or use machines if you have any of these symptoms while taking Famciclovir. Famciclovir contains lactose If you have been told by your doctor that you have an intolerance to some sugars, e. g. lactose, contact your doctor before taking this medicine (Famciclovir 125 mg and 250 mg tablets only).

3. HOW TO TAKE FAMCICLOVIR

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. • The daily dose and length of treatment will depend on the type of viral infection you have – see below. 0000

Your doctor will prescribe the correct dose for you. • For the best results start the medicine as soon as possible after the first signs and symptoms appear. • Do not have sexual contact with anyone if you have symptoms of genital herpes – even if you have started treatment with Famciclovir. This is because you could pass the herpes infection to your partner. • If you have or have had kidney problems, your doctor may decide to give you a lower dose of Famciclovir.

Dose for shingles If you have a normal immune system, the recommended dose is • 500 mg, three times a day, for seven days. If you have a reduced immune system, the recommended dose is • 500 mg three times a day, for ten days.

Dose for genital herpes The dose depends on the state of your immune system, and the stage of your infection. If you have a normal immune system, the doses are as follows:

For the first outbreak, the recommended dose is: • 250 mg three times a day, for five days.

To treat further outbreaks, the recommended dose is: • 125 mg twice a day, for five days.

To prevent future outbreaks, the recommended dose is: • 250 mg twice a day.

Your doctor will tell you how long you need to continue taking your tablets.

If you have a reduced immune system, the doses are as follows: To treat the current outbreak, the recommended dose is: • 500 mg twice a day, for seven days. To prevent future outbreaks, the dose is: • 500 mg twice a day.

Your doctor will tell you how long you need to continue taking your tablets.

If you take more Famciclovir than you should If you have taken more tablets than you have been told to take, or if someone else accidentally takes your medicine, go to your doctor or hospital for advice immediately. Show them your pack of tablets.

your nearest hospital straight away if you get any of these effects.

Very common side effects (these side effects affect more than 1 in 10 people) • Headache.

Common side effects (these side effects affect up to 1 in 10 people) • Feeling sick (nausea) Taking too much Famciclovir may affect the kidneys. In people who already have kidney problems it may, rarely, lead to kidney • Vomiting • Abdominal pain failure if their dose is not correctly lowered. • Diarrhoea • Dizziness If you forget to take Famciclovir If you forget to take a dose of Famciclovir, you should take it as • Rash soon as you remember. Then take your next dose as scheduled. • Itching • Liver function test giving abnormal results. However, do not take two doses within a time interval of less than 1 hour, in that case you should skip the missed dose. Uncommon side effects (these side effects affect up to 1 in 100 Furthermore, do not take a double dose to make up for a people) forgotten dose. • Confusion If you have any further questions on the use of this medicine, • Drowsiness (usually in older people) ask your doctor or pharmacist. • Itchy rash (urticaria).

4. POSSIBLE SIDE EFFECTS

Like all medicines, this medicine can cause side effects, although not everybody gets them. Serious side effects of Famciclovir are: Most of these side effects are rare or uncommon (they affect between 1 to 100 in every 10,000 patients) • Severe blistering of the skin or mucous membranes of the lips, eyes, mouth, nasal passages or genitals (these could be signs of a serious allergic skin reaction). • Unexplained bruising, reddish or purplish patches on the skin or nosebleeds (these could be signs of a decrease in the number of blood platelets). • Swelling below the surface of the skin (e. g. facial swelling, swelling around eye, eyelid swelling, throat swelling). • Yellowing of the skin and/or eyes (signs of jaundice). • Purple skin patches, itching, burning (signs of inflamed blood vessels). Contact a doctor or go to the emergency department at

draft: 44019390, 44019391, 44019392, 44019393, 44019394 laetus code: 0000 mat. no. 0000000-SDZ 00A/B-GB

the last day of that month. • Do not store above 25 °C. • Store in the original package in order to protect from moisture. Do not use this medicine if you notice the pack is damaged or shows signs of tampering. • Do not throw away any medicines via waste water or household waste. Ask your pharmacist how to throw away medicines you no longer require. These measures will help to protect the environment.

6. CONTENTS OF THE PACK AND OTHER INFORMATION

What Famciclovir contains Famciclovir 125 mg film-coated tablets • The active substance is famciclovir. • The other ingredients are lactose, anhydrous, sodium starch glycolate (Type A), and hydroxypropyl cellulose and magnesium stearate. The tablet coating is composed of hypromellose, titanium dioxide (E171), Macrogol 4000 and Macrogol 6000.

Rare side effects (these side effects affect up to 1 in 1,000 people) • Hallucinations (seeing or hearing things that are not really there) • Palpitations (signs of abnormal heart beat).

Famciclovir 250 mg film-coated tablets • The active substance is famciclovir. • The other ingredients are lactose, anhydrous, sodium starch glycolate (Type A), and hydroxypropyl cellulose and magnesium stearate. The tablet coating is composed of hypromellose, titanium dioxide (E171), Macrogol 4000 and Macrogol 6000.

5. HOW TO STORE FAMCICLOVIR

What Famciclovir looks like and contents of the pack Famciclovir is supplied as film-coated tablets.

Reporting of side effects Famciclovir 500 mg film-coated tablets If you get any side effects, talk to your doctor or pharmacist. • The active substance is famciclovir. This includes any possible side effects not listed in this leaflet. • The other ingredients are sodium starch glycolate, You can also report side effects directly via the Yellow Card hydroxypropyl cellulose and magnesium stearate. The tablet Scheme: www. mhra. gov. uk/yellowcard By reporting side effects coating is composed of hypromellose, titanium dioxide you can help provide more information on the safety of this (E171), Macrogol 4000 and Macrogol 6000. medicine. • Keep this medicine out of the sight and reach of children. • Do not use this medicine after the expiry date which is stated on the label after the expiry date. The expiry date refers to

Famciclovir 125 mg film-coated tablets White, round, film-coated tablets, biconvex, bevelled edges, debossed with “FV” on one side and 125 on the reverse side.

Famciclovir 250 mg film-coated tablets White, round, film-coated tablets, biconvex, bevelled edges, debossed with “FV” on one side and 250 on the reverse side. Famciclovir 500 mg film-coated tablets. White, oval film-coated tablet, biconvex, bevelled edges, debossed with “FV 500” on one side and plain on the reverse side. Marketing Authorisation Holder and Manufacturer The product licence holder is Novartis Pharmaceuticals UK Limited, Frimley Business Park, Frimley, Camberley, Surrey, GU16 7SR, England.

Famciclovir tablets are made by Novartis Farmaceutica S. A., Rhonda Santa Maria, 158 08210 Barbera Del Valles, Barcelona, Spain and Novartis Pharmaceuticals UK Ltd, Frimley Business Park, Frimley, Camberley, Surrey, GU16 7SR, England. Famciclovir tablets are distributed by Sandoz Ltd, Frimley Business Park, Frimley, Camberley, Surrey, GU16 7SR, UK.

If you would like any more information, or would like this leaflet in a different format, please contact Medical Information at Novartis Pharmaceuticals UK Ltd, telephone number 01276 698370. This leaflet was last revised September 2014.

SZ00000LT000 0000000-SDZ 00A/B-GB

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Bifen xts, bifen

Termites, Ants, Carpenter Ants, Fire Ants, Beetles, Chinch Bugs, Crane Flies, Crickets, Fleas (adults, larvae), Grasshoppers, Japanese Beetles, Mites, Mole Crickets, Sod Webworms, Ticks, Termites and others * See label for complete list

Residential & Commercial Perimeter Control: Turf-grass and Ornamentals, and Pre & Post Construction Termite Treatment * See label for complete list

0.32 - 0.64 oz. per gallon of water (32 oz. to 100 gallons of water) * See label for complete application instructions

83 Customer Reviews

Most Helpful Reviews

Bought four bottles of this stuff to control ants, mosquitos, and japanese beetles. 2oz. in a 2 gallon sprayer and presto! No more bugs. Some of the best stuff I ever bought. About to mix up a batch f. Read Full Review »

Bought four bottles of this stuff to control ants, mosquitos, and japanese beetles. 2oz. in a 2 gallon sprayer and presto! No more bugs. Some of the best stuff I ever bought. About to mix up a batch for the hose end sprayer to do my trees and shrubs. VERY confident it'll take down most anything that it comes into contact with. May seem expensive at first, but the premeasure cup takes the guesswork out of the picture and I'll probably have enough for 2-3 years. Try finding something that works so well in ANY store and not only will you be disappointed, but will get something that probably contains less than 0.5% of what this stuff has. I buy ALL my pest control products from Domyownpestcontrol. com and have NEVER been disappointed with any of their products. Highly recommended.

By C. in Batavia, IL on 07/27/2011

I live in NM. I purchased the "Bifen XTS" in January. We had a warm Saturday so I mixed and sprayed. Even with the cold weather there were dead roaches the next days. We had 2 weeks of extreme cold we. Read Full Review »

I live in NM. I purchased the "Bifen XTS" in January. We had a warm Saturday so I mixed and sprayed. Even with the cold weather there were dead roaches the next days. We had 2 weeks of extreme cold weather and snow. Once it started to warm up in the 50 plus temps the roaches were coming out and dropping dead. It continued to stay strong after going through the cold and snow. Good chemical, Irecommend it.

By Mark in Albuquerque, NM on 02/26/2011

I purchased Bifen XTS to replace my overpriced local extermination company. They asked over $900 for a five year retreatment plus a $125 a year membership fee and $90 per visit fee four times a year. Read Full Review »

I purchased Bifen XTS to replace my overpriced local extermination company. They asked over $900 for a five year retreatment plus a $125 a year membership fee and $90 per visit fee four times a year. If this product performs as advertised, I will be hundreds of dollars ahead in no time. After spraying the outside perimeter of my home, I sprayed several Fire Ant mounds. After making my rounds I checked each mound to find that it destroyed the ants completely. I have not seen any new mounds in two weeks. My faith is growing for Bifen XTS.

By Jerry in Ragley, LA on 05/20/2011

97 Customer Questions

Q What is the difference between Bifen XTS and Bifen IT? I want to use this in a backpack mister/blower for mosquitoes. Will one work better than the other? Also how does this compare to Permethrin SFR?

A Bifen I/T is our most popular choice for mosquito control. The Bifen XTS is the same product, just in a higher concentration. For mosquito control you do not need the higher concentratio. Read Full Answer »

A Bifen I/T is our most popular choice for mosquito control. The Bifen XTS is the same product, just in a higher concentration. For mosquito control you do not need the higher concentration, it is not necessary. Bifen I/T would also be a better solution then permethrin because permethrin breaks down quicker in sunlight and the Bifen I/T only needs to be applied every 30 days whereas permethrin would need to be applied every two weeks. The most important thing to remember when treating for mosquitoes is that they hang out on the underside of leaves and shrubs. You should treat all shrubs, bushes and trees around the outside patio or wherever you hang out at around the house. You should also treat the tree line in your yard near the forest if one exists. Remember to not only treat the main bush or shrub but also the underside of the leaves.

Q Will Bifen XTS harm pets?

A No. Bifen XTS will not harm pets when used as directed on the product label. All pets and people (except for the applicator) should be out of the area while the application is being made, and they can. Read Full Answer »

A No. Bifen XTS will not harm pets when used as directed on the product label. All pets and people (except for the applicator) should be out of the area while the application is being made, and they can return as soon as the treated area is dry.

Q What is the residual time of Bifen XTS & how long will it keep bugs away when sprayed?

Asked by Adam from Brasnon, Mo

A Bifen XTS will have a residual of about 4-8 weeks depending on rain and UV rays in the given area. Bifen XTS will not repel insects but instead will kill them within 24 hours of contact.

See all customer questions »



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Glucophage sr 1000 mg prolonged release tablets, glyciphage sr 1000mg

GLUCOPHAGE SR 1000 MG PROLONGED RELEASE TABLETS

Transcript

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine. 5. How to store Glucophage SR Keep Glucophage SR tablets out of the sight and reach of children. Do not use them after the expiry date that is printed on the pack after “EXP:”. The expiry date refers to the last day of that month. This medicinal product does not require any special storage conditions. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment. 6. Contents of the pack and other information What the tablets contain Each prolonged release tablet contains 500, 750 or 1000 milligrams of the active ingredient metformin hydrochloride. The other ingredients are magnesium stearate, carmellose sodium and hypromellose. What Glucophage SR looks like and contents of the pack The 500 milligram tablets are white to off - white and round with ‘500’ on one side. The 750 milligram tablets are white to off - white and capsule-shaped with ‘750’ on one side and ‘MERCK’ on the other side. The 1000 milligrams tablets are white to off-white and capsule-shaped with ‘1000’ on one side and ‘MERCK’ on the other side. Glucophage SR is supplied in packs of 28 and 56 prolonged release tablets.

Glucophage SR 500 mg, 750 mg and 1000 mg Prolonged Release Tablets are manufactured for Merck Serono Ltd, Bedfont Cross, Stanwell Road, Feltham, Middlesex, TW14 8NX, UK by Merck Sante s. a.s, 2 rue du Pressoir Vert, ­45400 Semoy, France.

Package leaflet: Information for the user

This leaflet was last revised in May 2015 Useful tips • If you smoke, try to stop • Take regular exercise • Drink as little alcohol as possible • Look after your feet. Ask about this at the surgery or hospital • Carry a card, bracelet or disk saying you are diabetic

Prolonged release tablets metformin hydrochloride This medicine is intended for adult patients only Read all of this leaflet carefully before you start taking this medicine. -- Keep this leaflet. You may need to read it again. -- If you have any further questions, ask your doctor or pharmacist.

• Visit your diabetic clinic regularly

-- This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

If you want more information about diabetes contact:

-- If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Diabetes UK Central Office Macleod House 10 Parkway London NW1 7AA Tel: 020 7424 1000

What is in this leaflet 1. What Glucophage SR is and what it is used for 2. What you need to know before you take Glucophage SR 3. How to take Glucophage SR 4. Possible side effects 5. How to store Glucophage SR

Glucophage SR is associated with either a stable body weight or modest weight loss.

6. Content of the pack and other information

2. What you need to know before you take Glucophage SR

1. What Glucophage SR is and what it is used for Glucophage SR prolonged release tablets contain the active ingredient metformin hydrochloride and belong to a group of medicines called biguanides, used in the treatment of diabetes. Glucophage SR is used for the treatment of Type 2 (non-insulin dependent) diabetes mellitus when diet and exercise changes alone have not been enough to control blood glucose (sugar). Insulin is a hormone that enables body tissues to take glucose from the blood and to use it for energy or for storage for future use. People with Type 2 diabetes do not make enough insulin in their pancreas or their body does not respond properly to the insulin it does make. This causes a build-up of glucose in the blood which can cause a number of serious long-term problems so it is important that you continue to take your medicine, even though you may not have any obvious symptoms. Glucophage SR makes the body more sensitive to insulin and helps return to normal the way your body uses glucose.

Glucophage SR Prolonged Release Tablets are specially made to release the drug slowly in your body and therefore are different to many other types of tablet containing metformin.

Do not take Glucophage SR if: • you are allergic to metformin or to any of the other ingredients of this medicine (listed in section 6). An allergic reaction may cause a rash, itching or shortness of breath. • you have ketosis (this is a symptom of uncontrolled diabetes in which substances called ‘ketone bodies’ accumulate in the blood – you may notice that your breath has an unusual, fruity odour). • you have liver problems or kidney problems (glomerular filtration rate (GFR) below 45 ml/min). • you have had serious complications with your diabetes or other serious conditions which resulted in rapid weight loss, nausea, vomiting or dehydration. Dehydration may lead to kidney problems, which can put you at risk for lactic acidosis (see 'Warnings and precautions).

Reporting of side effects

• you have a severe infection, such as an infection affecting your lung or bronchial system or your kidney. Severe infections may lead to kidney problems, which can put you at risk for lactic acidosis (see 'Warnings and precautions). • you have been treated for acute heart problems or have recently had a heart attack or have severe circulatory problems or breathing difficulties. This may lead to a lack in oxygen supply to tissue which can put you at risk for lactic acidosis (see 'Warnings and precautions). • you are a heavy drinker of alcohol. • you are under 18 years of age. Warnings and precautions Make sure you ask your doctor for advice, if • you need to have an examination such as X-ray or scan involving the injection of contrast medicines that contain iodine into your bloodstream. (See below under Other medicines and Glucophage SR) • you need to have major surgery. You must stop taking Glucophage SR for a certain period of time before and after the examination or the surgery. Your doctor will decide whether you need any other treatment for this time. It is important that you follow your doctor’s instructions precisely. After you have started taking your medicine: If you have diabetes you should have your blood or urine tested for sugar regularly. You should return to your doctor at least once a year to check the function of your kidneys (more often if you are elderly or if you have kidney problems). Please note the following particular risk of lactic acidosis. Glucophage SR may cause a very rare, but very serious complication called lactic acidosis, particularly if your kidneys are not working properly. The risk of developing lactic acidosis is also increased with uncontrolled diabetes, prolonged fasting or alcohol intake, body fluid deficit (dehydration) due to severe diarrhoea or vomiting, liver problems and any medical conditions in which a region of the body is deprived with a lack of oxygen supply (such as acute severe heart diseases). It is important to you to comply with your medication intake, dietary instructions and regular exercise program because this can reduce the risk of lactic acidosis.

The onset of lactic acidosis can be subtle and the symptoms can be non-specific such as vomiting, bellyache (abdominal pain) with muscle cramps, a general feeling of not being well with severe tiredness, and difficulty in breathing. Further symptoms are reduced body temperature and heart beat. If you experience some of these symptoms, you should immediately seek medical attention, as lactic acidosis may lead to coma. Stop taking Glucophage SR immediately and contact a doctor or the nearest hospital straight away. You may see some remains of the tablets in your stools. Do not worry - this is normal for this type of tablet. You should continue to follow any dietary advice that your doctor has given you and you should make sure that you eat carbohydrates regularly throughout the day. Do not stop taking this medicine without speaking to your doctor. Other medicines and Glucophage SR Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without prescription. If you need to have an injection of contrast medicines that contain iodine into your bloodstream, for example for examinations such as X-ray or scan, you must stop taking Glucophage SR for a certain period of time before and after (at least 48 hours) the examination (see ‘Make sure you ask your doctor for advice’ above). If you are taking any of the following medicines, your blood sugar levels may need to be checked more often and your dose adjusted: • Steroids such beclometasone.

• Diuretics (water tablets) such as furosemide. • Sympathomimetic medicines including epinephrine and dopamine used to treat heart attacks and low blood pressure. Epinephrine is also included in some dental anaesthetics. You should avoid drinking alcohol and using alcoholcontaining medicines as this will increase the risk of lactic acidosis (see under ‘4. Possible side effects’). Glucophage SR with food and drink: You should take Glucophage SR with or immediately after food.

Pregnancy and breast-feeding

Ask your doctor or pharmacist for advice before taking any medicine.

with severe tiredness, and difficulty in breathing. Further symptoms are reduced body temperature and heart beat. If you experience some of these symptoms, you should immediately seek medical attention, as lactic acidosis may lead to coma. Stop taking Glucophage SR immediately and contact a doctor or the nearest hospital straightaway.

Driving and using machines

If you forget to take Glucophage SR

Glucophage SR taken on its own does not cause ‘hypos’ (symptoms of low blood sugar or hypoglycaemia, such as faintness, confusion and increased sweating) and therefore should not affect your ability to drive or use machinery.

Take it as soon as you remember with some food. Do not take a double dose to make up for a forgotten dose.

You should be aware, however, that Glucophage SR taken with other antidiabetic medicines can cause hypos, so in this case you should take extra care when driving or operating machinery.

Like all medicines, Glucophage SR can cause side effects, although not everybody gets them. If you notice any of the following, stop taking Glucophage SR and see your doctor immediately:

3. How to take Glucophage SR

• unexpected weight loss

Your doctor may prescribe Glucophage SR for you to take on its own, or in combination with other oral antidiabetic medicines or insulin.

• very severe nausea or vomiting

Do not take Glucophage SR if you are pregnant or breast feeding.

Always take Glucophage SR exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Swallow the tablets whole with a glass of water, do not chew. Recommended dose Usually you will start treatment with 500 milligrams Glucophage SR daily. After you have been taking Glucophage SR for about 2 weeks, your doctor may measure your blood sugar and adjust the dose. The maximum daily dose is 2000 milligrams of Glucophage SR. In renal impaired patients with a GFR between 45 and 60 ml/ min, the starting dose is 500 mg or 750 mg Glucophage SR once daily. The maximum dose is 1000 mg daily. The renal function should be closely monitored (every 3 – 6 months). Normally, you should take the tablets once a day, with your evening meal. In some cases, your doctor may recommend that you take the tablets twice a day. Always take the tablets with food. If you take more Glucophage SR than you should If you take extra tablets by mistake you need not worry, but if you have unusual symptoms, contact your doctor. If the overdose is large, lactic acidosis is more likely. Symptoms of lactic acidosis are non-specific, such as vomiting, bellyache with muscle cramps, a general feeling of not being well

4. Possible side effects

• a general feeling of not being well with severe tiredness • very fast breathing which you cannot stop • reduced heart beat • stomach pains with muscle cramps or feeling cold These can be signs of serious problems with your diabetes and may mean you have a very rare side effect called “lactic acidosis” (too much acid in the blood). If this happens, see a doctor as you will need treatment straight away. • abnormal liver function tests and hepatitis (inflammation of the liver) which may result in jaundice. If you develop yellowing of the eyes and/or skin contact your doctor immediately. Other possible side effects are listed by frequency as follows: Very common (affects more than 1 person in 10): • Diarrhoea, nausea, vomiting, stomach ache or loss of appetite. If you get these, do not stop taking the tablets as these symptoms will normally go away in about 2 weeks. It helps if you take the tablets with or immediately after a meal. Common (affects less than 1 person in 10, but more than 1 person in 100): • Taste disturbance Very rare (affects less than 1 person in 10,000): • Decreased vitamin B12 levels • Skin rashes including redness, itching and hives.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Dolovin, dolovin

Dolovin

Dolovin - General Information

A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes. [PubChem]

Pharmacology of Dolovin

Dolovin, a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Dolovin for patients

Indomethacin, like other drugs of its class, is not free of side effects. The side effects of these drugs can cause discomfort and rarely, there are more serious side effects, such as gastrointestinal bleeding, which may result in hospitalization and even fatal outcomes. NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) are often essential agents in the management of arthritis. but they also may be commonly employed for conditions which are less serious. Physicians may wish to discuss with their patients the potential risks and likely benefits of NSAID treatment, particularly when the drugs are used for less serious conditions where treatment without NSAIDs may represent an acceptable alternative to both the patient and physician.

Dolovin Interactions

In normal volunteers receiving indomethacin, the administration of diflunisal decreased the renal clearance and significantly increased the plasma levels of indomethacin. In some patients, combined use of INDOCIN and diflunisal has been associated with fatal gastrointestinal hemorrhage. Therefore, diflunisal and INDOCIN should not be used concomitantly.

In a study in normal volunteers, it was found that chronic concurrent administration of 3.6 g of aspirin per day decreases indomethacin blood levels approximately 20%.

The concomitant use of INDOCIN with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.

Clinical studies have shown that INDOCIN does not influence the hypoprothrombinemia produced by anticoagulants. However, when any additional drug, including INDOCIN, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time. In post-marketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and INDOCIN. Caution should be exercised when INDOCIN and anticoagulants are administered concomitantly.

When INDOCIN is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. Therefore, a lower total daily dosage of INDOCIN may produce a satisfactory therapeutic effect. When increases in the dose of INDOCIN are made, they should be made carefully and in small increments.

Caution should be used if INDOCIN is administered simultaneously with methotrexate. INDOCIN has been reported to decrease the tubular secretion of methotrexate and to potentiate its toxicity.

Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin. NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.

Capsules INDOCIN 50 mg t. i.d. produced a clinically relevant elevation of plasma lithium and reduction in renal lithium clearance in psychiatric patients and normal subjects with steady state plasma lithium concentrations. This effect has been attributed to inhibition of prostaglandin synthesis. As a consequence, when INDOCIN and lithium are given concomitantly, the patient should be carefully observed for signs of lithium toxicity. (Read circulars for lithium preparations before use of such concomitant therapy.) In addition, the frequency of monitoring serum lithium concentration should be increased at the outset of such combination drug treatment.

INDOCIN given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Therefore, when INDOCIN and digoxin are used concomitantly, serum digoxin levels should be closely monitored.

In some patients, the administration of INDOCIN can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. Therefore, when INDOCIN and INDOCIN. (Indomethacin) diuretics are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

INDOCIN reduces basal plasma renin activity (PRA), as well as those elevations of PRA induced by furosemide administration, or salt or volume depletion. These facts should be considered when evaluating plasma renin activity in hypertensive patients.

It has been reported that the addition of triamterene to a maintenance schedule of INDOCIN resulted in reversible acute renal failure in two of four healthy volunteers. INDOCIN and triamterene should not be administered together.

INDOCIN and potassium-sparing diuretics each may be associated with increased serum potassium levels. The potential effects of INDOCIN and potassium-sparing diuretics on potassium kinetics and renal function should be considered when these agents are administered concurrently.

Most of the above effects concerning diuretics have been attributed, at least in part, to mechanisms involving inhibition of prostaglandin synthesis by INDOCIN.

Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal antiinflammatory drugs including INDOCIN has been reported. Therefore, when using these blocking agents to treat hypertension, patients should be observed carefully in order to confirm that the desired therapeutic effect has been obtained. INDOCIN can reduce the antihypertensive effects of captopril and losartan.

False-negative results in the dexamethasone suppression test (DST) in patients being treated with INDOCIN have been reported. Thus, results of the DST should be interpreted with caution in these patients.

Dolovin Contraindications

Indomethacin should not be used in:

Patients who are hypersensitive to this product.

Patients in whom acute asthmatic attacks, urticaria, or rhinitis are precipitated by aspirin or other nonsteroidal anti - inflammatory agents.

Suppositories INDOCIN are contraindicated in patients with a history of proctitis or recent rectal bleeding.

Additional information about Dolovin

Dolovin Indication: For moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis. osteoarthritis. acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis. Mechanism Of Action: Antiinflammatory effects of Dolovin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Drug Interactions: Acebutolol Risk of inhibition of renal prostaglandins Atenolol Risk of inhibition of renal prostaglandins Betaxolol Risk of inhibition of renal prostaglandins Bevantolol Risk of inhibition of renal prostaglandins Bisoprolol Risk of inhibition of renal prostaglandins Carteolol Risk of inhibition of renal prostaglandins Carvedilol Risk of inhibition of renal prostaglandins Methotrexate The NSAID increases the effect and toxicity of methotrexate Diflunisal Diflunisal increases the effect and toxicity of indomethacin Esmolol Risk of inhibition of renal prostaglandins Labetalol Risk of inhibition of renal prostaglandins Metoprolol Risk of inhibition of renal prostaglandins Nadolol Risk of inhibition of renal prostaglandins Losartan Dolovin decreases the effect of losartan Lithium The NSAID increases serum levels of lithium Oxprenolol Risk of inhibition of renal prostaglandins Penbutolol Risk of inhibition of renal prostaglandins Pindolol Risk of inhibition of renal prostaglandins Practolol Risk of inhibition of renal prostaglandins Probenecid Probenecid increases the effect/toxicity of indomethacin Sotalol Risk of inhibition of renal prostaglandins Propranolol Risk of inhibition of renal prostaglandins Timolol Risk of inhibition of renal prostaglandins Warfarin The NSAID increases the anticoagulant effect Acenocoumarol The NSAID increases the anticoagulant effect Dicumarol The NSAID increases the anticoagulant effect Anisindione The NSAID increases the anticoagulant effect Torasemide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Bumetanide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Furosemide The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Ethacrynic acid The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Cyclosporine Monitor for nephrotoxicity Alendronate Increased risk of gastric toxicity Triamterene Risk of acute renal impairment with this combination Food Interactions: Avoid alcohol. Take with food or antacids to reduce irritation. Generic Name: Indomethacin Synonyms: IMN; Indomethacinum; Indomethacine; Indometacyna; Indometacine; Indomethancin; Indomethazine; Indomethine; Indometicina Drug Category: Tocolytic Agents; Cardiovascular Agents; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs) Drug Type: Small Molecule; Approved; Investigational Other Brand Names containing Indomethacin: Amuno; Apo-Indomethacin; Argun; Arthrexin; Artracin; Artrinovo; Artrivia; Bonidin; Bonidon; Bonidon Gel; Catlep; Chibro-Amuno; Chrono-Indicid; Chrono-Indocid; Confortid; Dolcidium; Dolcidium Pl; Dolovin; Durametacin; Elmetacin; Flexin Continus; Hicin; Idomethine; Imbrilon; Inacid; Indacin; Indameth; Indmethacine; Indo-Lemmon; Indo-Phlogont; Indo-Rectolmin; Indo-Spray; Indo-Tablinen; Indocid; Indocid Pda; Indocid Sr; Indocin; Indocin I. V; Indocin I. V.; Indocin Sr; Indolar Sr; Indomecol; Indomed; Indomee; Indomethegan; Indomo; Indomod; Indoptic; Indoptol; Indorektal; Indoxen; Inflazon; Infrocin; Inteban Sp; Lausit; Liometacen; Metacen; Metartril; Methazine; Metindol; Miametan; Mikametan; Mobilan; Novo-Methacin; Novomethacin; Nu-Indo; Reumacide; Rhemacin La; Rheumacin La; Sadoreum; Tannex; Vonum; Absorption: Bioavailability is approximately 100% following oral administration and 80–90% following rectal administration. Toxicity (Overdose): The following symptoms may be observed following overdosage: nausea, vomiting, intense headache. dizziness. mental confusion, disorientation, or lethargy. There have been reports of paresthesias, numbness, and convulsions. The oral LD 50 of indomethacin in mice and rats (based on 14 day mortality response) was 50 and 12 mg/kg, respectively. Protein Binding: 97% Biotransformation: Hepatic. Half Life: 4.5 hours Dosage Forms of Dolovin: Powder, for solution Intravenous Suppository Rectal Capsule Oral Chemical IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid Chemical Formula: C19H16ClNO4 Indomethacin on Wikipedia: http://en. wikipedia. org/wiki/Indomethacin Organisms Affected: Humans and other mammals



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Duzela 30 mg - medication, duzela

Uttam Kejriwal

Last 3 years i have been taking this medicine(duzela 30mg) 2 times and zapiz 0.25 mg. But it has not cured my problem fully. I feel problems like neck pain, head seems to roll, eyebrightnss increases. Are these the side effects of the medicine. This has not cured me 100%. Should i continue taking this medicine? What are the benefits of taking this medicine? Please suggest me. It would be better if you can suggest any doctor in bangalore(India)..

FROM OUR EXPERTS

Thank you for your question and welcome to AnxietyConnection. com.

I am not a medical professional and would not be able to give you medical advice.

I can tell you that Duzela would be equivalent to what we know as Cymbalta (in the U. S.).

According to FirstDataBank, Inc. the most common side effects of this medication are: nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, dizziness, increased sweating, blurred vision, or yawning. Other, less common side effects include: fainting, unusual or severe mental/mood changes (e. g. nervousness, unusual high energy/excitement, rare thoughts of suicide), shakiness (tremor), decreased interest in sex, changes in sexual ability, difficulty urinating, change in the amount of urine, weight loss.

Zapiz, which is Clonazepam (again, according to FirstDataBank, Inc ) would have side effects of drowsiness, dizziness, blurred vision, muscle pain, excessive hair growth or loss, change in sexual desire, weight change, increased saliva production, sore gums, or cough with less common side effects of slowed breathing, easy bruising/bleeding, unusual eye movements, unusual fatigue, fast/pounding heartbeat, unusual muscle movement, and trouble urinating.

Even though the symptoms you have described may not appear in these lists, it does not mean they are not side effects of the medication, as the ones listhed are the most common. Since each person reacts differently to medication, there may be other side effects.

Unfortunately, I would not know of any doctors in India to treat anxiety.

FROM OUR COMMUNITY



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