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Product Description

Augmentin belongs to the group of broad-spectrum antibiotics. Such antibiotic works destroying bacteria. The medicine is prescribed for treatment of pneumonia and other infectious diseases of respiratory, gastrointestinal systems, urogenital systems, infections which appear after surgery and others. Its component Clavulanate potassium provides resistance of Augmentin to activity of bacterial beta-lactamases.

It is recommended to take the medicine as it was prescribed by your doctor. Dosage depends of your condition and other circumstances. Do not exceed your recommended dose.

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Possible side effect

Side effects can be the following: dyspepsia, abdominal discomfort, bloating, gas, nausea, vomiting, liver function disorders, hepatitis, jaundice caused by stagnation of bile, vaginal itching and also symptoms of allergy.

Augmentin can interact with other antibiotics changing the normal bacteria flora of the colon and permitting overgrowth of C. difficile, a bacteria which causes pseudomembranous colitis.

Take the missed dose as soon as possible. If it is almost time of the next intake just skip it and go back to your schedule.

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The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.

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Inflama Relief Capsules

Anti-inflammatory and anti-spasmodic activity with strong analgesic herbs help to break the pain-spasm cycle.*

DIRECTIONS Take 2 caps every 4 - 6 hours as needed.

INGREDIENTS White Willow Bk. ( Salix a. ); Jamaican Dogwood Bk. ( Piscidia e. ); St. John’s Wort Lf. ( Hypericum p. ); White Pine Bk. ( Pinus s. ); Echinacea a. Rt. ; Echinacea p. Rt.; Gotu Kola Hrb. ( Centella a. ); Devil’s Claw Rt. ( Harpagophytum p. ); Red Clover Blsm. ( Trifolium p. ); Turmeric Rt. ext. ( Curcuma l. ); Licorice Rt. ( Glycyrrhiza g. ); Burdock Rt. ( Arctium l. ); Meadowsweet Hrb. ( Filipendula u. ); Alfalfa Lf. ( Medicago s. ); Chamomile Blsm. ( Matricaria r. ); Dandelion Rt. ( Taraxacum o. ); Ginger Rt. ( Zingiber o. ); Uva Ursi Lf. ( Arctostaphylos u. ); Bromelain.

What is it? A Combination Herbal Remedy Formula designed to reduce inflammation caused from injury or internal body distress.

What does it do? Inflammation is a normal and healthy body response to infection or injury through the local natural chemical changes, the heat produced and broader eliminations and immune system responses. The inflammatory reaction is a result of tissue damage. Anti-Flam™ helps encourage the body's system to work together to reduce inflammation and swelling, thereby eliminating the associated pain.

What are The Features and Benefits?

White Willow Bark

This analgesic herb helps to break the pain-spasm cycle, often associated with inflammation.

Known as the only herb with the ability to ease nervous system inflammation.

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Diflucan is a medication that is used for the treatment of the fungal infection or infection of yeast. It is a medicine that is in the group of antifungal drugs. Its active ingredient is fluconazole that has the effect of inhibiting or preventing the growth and multiplication of fungal cells. The drug is used to treat various fungal infections in human beings. Diflucan can be used by people of various ages and different weight since they are manufactured considering all those factors. It is used for people with the weak immune system because they are mostly prone to fungal infections. The drug was first marketed in 1990 and was discovered by a scientist called Pfizer. The drug is now distributed in the world as a generic medicine. The largest producers of the medicine are in India. Some of the companies involved in the manufacture of the drug are like Ultimate Chem. in Mumbai, and Chandigarh. The drug is now in the list of the World Health Organization as one of the important medicine in human health.

Purpose: Fungal Treatment

Prescription Required: No

Where is this medicine indicated?

Fluconazole has a wide range of spectrum and it is used to treat a lot of fungal infections. It is very active and kills the susceptible fungal cells in the patient and has been proven to have a very high efficacy. The medicine has been indicated to treat the following conditions.

It is used to clear the candida infections in the throat, vagina and mouth. Candida infection is a fungal infection that mostly occurs in some designated parts of the body like the ones mentioned above. They grow rapidly, and they produce undesirable effects to the patient. For example, when the candida cells grow in the mouth, the tongue appears white and makes the patient uncomfortable. The medicine has been clinically proven to clear this.

It also prevents the growth of candida in the body of the patient with weak immune system. Patients who are undergoing chemotherapy are prone to fungal infections, and the drug is used to reduce and prevent the growth of the fungal.

Diflucan is also used to prevent people from suffering from cryptococcal. This is a condition where the central nervous system is infected by fungal.

How to take this medicine?

Just like any other medicine, proper care should be taken before taking the medicine. One must read the instructions and directions for use from the sachet. Before using the medicine, clear prescriptions must be taken from medical practitioners to avoid misusing the drug. The dose to be taken depends on the type of infection. For vaginal infection, one pill is used to treat the condition while for the other infections; the first dose is the double dose. The drug should be taken with a glass full of water. If the drug is in a form of suspension, it should be shaken well before use and the drug measured with the marked medicine cup. The drug should be taken for the time prescribed because failure to do so may lead to resistance. However, if the conditions persist, consultation should be made with the doctor.

How does this medicine work?

Like any other antifungal medicine, Diflucan inhibits the cytochrome P450 enzyme. Inhibition of this enzyme prevents the conversion of lanosterol to ergosterol. Ergosterol is a the major components of the cytoplasmic membrane of the fungal cells, and when it is not there, the cell membrane does not function as required. This leads to accumulation of methyl sterols and hence destruction of the cell membrane. The cell membrane becomes permeable, and there is no proper exchange of water and other nutrients in the cell leading to its death. Diflucan is fungistatic meaning that it is used to prevent the growth and development of fungal cells. However, it may be fungicidal against some fungal cells, i. e. it can target susceptible fungal cells.

When should this medicine NOT be taken?

The medicine was found to have some implications for some set of people and, therefore, recommended consulting a doctor before using the drug.

The drug should not be used by the following:

Lactating mothers. From the clinical tests done, it was found that there was a percentage of the drug that was excreted in the human milk. Mothers are therefore advised not to use the drug because it can harm the child. The concentration of the medicine in the milk is enough to harm the child because their immune system is not well developed to resist that concentration.

People who are allergic. The bodies of some patients may consider the drug as an allergen and produce the antibodies to fight the drug. This will reduce the efficacy and distribution of the drug to the affected sites and hence fungal infections will not be cleared. The patient should first be well diagnosed by the doctor to avoid developing cases of resistance.

Pregnant mothers should not use it. Pregnant mothers should not use the drug because fluconazole can cause detrimental effect to the child.

How this drug interacts with other medicines?

Diflucan can favor or inhibit the functioning of other drugs when taken together. Interestingly the drug can increase the concentration of other drugs such as medicines metabolized by cytochrome P450. We are going to analyze how this drug interacts with others.

Berberine. This drug acts in synergy with Diflucan. They interact very well in that the concentration of one drug leads to an increase in the efficiency of the other. The introduction of berberine leads to increase the efficiency of fluconazole.

Benzodiazepine. These are drugs that are used to treat depression. Interaction of this drug with the fungal drug leads to decreased metabolism of benzodiazepine. If the metabolism of the drug is not efficient, it might lead to other complications.

Erythromycin. The drug is used to treat of sexually transmitted diseases. The fungal medicine increases the serum concentration of the drug, and this has the fatal effect on the patient.

Fungal drugs have an effect of increasing the concentration of drugs metabolized by cytochrome P450 and decreasing their metabolism. This has an effect of increasing the efficiency of these drugs.

What can be the possible side effects?

Common ones (greater than 1% patients): nausea, headache, abdominal pain, and vomiting.

Infrequent (0.1-1%): fatigue and constipation.

Rare (less than 0.1%): liver problems and seizure.

What precautions you must take?

The medicine should not be taken when driving or operating heavy machines because it is associated with dizziness and seizure. This is to avoid accidents that may lead to injuries or deaths.

The suspension that contains sucrose should not be administered to patients who have fructose malabsorption.

The drug should be used cautiously in patients who have QT prolonged intervals. Prolongation of QT intervals leads to cardiac arrhythmias. Therefore, this drug should be used with much care to such patients.

Where can I buy Diflucan?

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Generic Name: Clopidogrel

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Anginine tablets, anginine


Consumer Medicine Information

Please read this leaflet carefully before you start Anginine.

What is in this leaflet

This leaflet answers some common questions about Anginine. It does not contain all of the available information.

It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your doctor has weighed the risks of you using Anginine against the benefits this medicine is expected to have for you.

If you have any concerns about using this medicine, ask your doctor or pharmacist.

Keep this leaflet with the medicine. You may need to read it again.

What Anginine is used for

Anginine is used for angina. Angina is a pain or discomfort in the chest, often spreading to the arms or neck and sometimes to the shoulders and back. This is usually caused by too little blood and oxygen getting to the heart muscle. The pain of angina is usually brought on by exercise or stress. Other factors may also cause angina. Anginine is used to treat an angina attack or to prevent one developing.

Anginine belongs to a group of medicines called nitrates. It lets more blood and oxygen reach the heart muscle.

Your doctor may have prescribed Anginine for another reason.

Ask your doctor if you have any questions about why Anginine has been prescribed for you.

There is no evidence that Anginine is addictive or habit forming.

Before you use Anginine

When you must not use it

Do not use Anginine if you have ever had an allergic reaction to:

glyceryl trinitrate, the active ingredient in Anginine.

other medicines containing glyceryl trinitrate

For example skin patches (such as Deponit, Minitran, Nitradisc, Nitro-Dur, Transiderm-Nitro), and sprays (such as Nitrolingual Spray).

any medicine or food containing nitrates or nitrites.

any of the ingredients listed at the end of this leaflet.

Symptoms of an allergic reaction may be mild or severe. They usually include some or all of the following:

asthma, wheezing or shortness of breath

swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing

hayfever, lumpy rash ("hives") or itching


Do not use Anginine if you are pregnant, trying to become pregnant or breast-feeding, unless your doctor says you should.

Not all heart problems are suitable for treatment with Anginine.

Do not use Anginine if you have a heart condition known as hypertrophic obstructive

cardiomyopathy (HOCM).

Do not use Anginine if you have or have had a head injury.

Do not use Anginine if you have suffered a stroke due to a haemorrhage in the past.

Do not use Anginine if you are taking Phosphodiesterase 5 inhibitors such as sildenafil (Viagra®), tadalafil (Cialis®) and vardenafil (Levitra®)

Do not use Anginine after the expiry date (EXP) printed on the pack, or more than three months after you first open your bottle.

If you use the tablets after the expiry date has passed, they may not work as well.

Do not use Anginine if the packaging is torn or shows any signs of tampering.

Do not take Anginine if the tablets show any visible signs of deterioration (e. g. broken or discoloured).

If you're not sure whether you should be using Anginine, talk to your doctor.

Before you start to use it

You must tell your doctor if you have:

an allergy to foods, dyes, preservatives or any other medicines

poor blood supply to the brain

a blood condition, such as anaemia (reduced red blood count)

lung problems

glaucoma - may be worsened by nitrates

a recent heart attack - nitrates may lower blood pressure and cause a fast heart beat which may aggravate problems associated with heart attack.

heart problems as a complication of lung problems

severe coronary artery problems as a complication of lung problems

poor liver function

an overactive thyroid gland (hyperthyroidism)

any other medical condition.

Taking other medicines

Tell your doctor if you are taking or using any other medicines, including medicines you buy without a prescription from a pharmacy, supermarket or health food shop. Some medicines may affect the way other medicines work. Your doctor or pharmacist will be able to tell you what to do when using Anginine with other medicines.

It is especially important that your doctor knows if you are taking any of the following:

medicines for high blood pressure

medicines for heart conditions

medicines for depression


you must not use phosphodiesterase 5 inhibitors such as sildenafil (Viagra®), tadalafil (Cialis®) and vardenafil (Levitra®) if you are taking Anginine

Use in Children

Do not give Anginine tablets to children. We do not have enough information on use in children so it is not recommended for that age group.

Use in Elderly

Elderly patients may be more sensitive to the side effects of Anginine tablets. It is advisable to take half a tablet as a starting dose.

How to use Anginine

The pharmacist's label on the pack will tell you how to use Anginine. If there is something you do not understand, ask your doctor or pharmacist.

How much to use

At the first sign of an attack, sit down and place 1(one) Anginine tablet under your tongue or in your cheek, and allow it to dissolve.

If the Angina is not relieved within 5 minutes, take another dose of Anginine. You may use up to 2 tablets to relieve the angina pain or discomfort, but if a total of 2 fresh tablets and rest do NOT relieve your angina within 10 minutes, then you should immediately call an ambulance or the nearest hospital.

Anginine tablets are scored, so you can break or cut them in half. You should discuss your overall dose with your doctor.

How to use

Anginine is absorbed through the lining of your mouth.

Place your Anginine tablet under your tongue, or in your cheek and allow to dissolve. It will dissolve more easily if your mouth is not dry.

DO NOT SWALLOW, CHEW OR CRUSH your Anginine tablet, as swallowed Anginine tablets are NOT EFFECTIVE.

While the tablet is dissolving, avoid any eating, drinking or smoking until the tablet has completely dissolved.

Sometimes you may feel tingling in your mouth when using Anginine. However, the tablet still works even if you do not feel tingling.

When to use it

Use Anginine tablets at the first symptom of an angina attack.

Your doctor may also advise you to use Anginine just before exercise or stressful situations to stop you getting an angina attack.

How long to use it

After using Anginine, you should get relief of your angina pain or discomfort within a few minutes. When this occurs you may spit out any of the tablet which remains in your mouth to avoid side effect such as headache.

If your angina pain or discomfort is not relieved by a total of 2 fresh Anginine tablets within 10 minutes, then you should immediately call an ambulance or nearest hospital.

If you use too much (overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, if you think you or anyone else may have taken too much Anginine, even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

Keep telephone numbers for these places handy.

Too much Anginine may cause bluish-coloured lips, fingernails or palms of hands; dizziness or fainting; feeling of extreme pressure in head; shortness of breath.

If you are not sure what to do, contact your doctor or pharmacist.

While you are using Anginine

Things you must do

Use Anginine exactly as your doctor has prescribed. If you do not follow your doctor's instructions, you may not get relief from your attacks of angina.

Always carry your Anginine with you.

Tell all doctors, dentists, pharmacists and health professionals involved in your care that you are using Anginine.

Tell your doctor or pharmacist that you are using Anginine if you are about to be started on any new medicines.

Tell your doctor if you become pregnant or are trying to become pregnant.

Tell your doctor if, for any reason, you have not used your tablets exactly as prescribed. Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily.

Keep a record of the number of angina attacks, when they happen and the possible cause (e. g. during exercise).

Tell your doctor if you continue to have angina attacks or if your angina attacks seem worse when using Anginine. This helps your doctor give you the best possible treatment.

Things you must not do

Do not stop using Anginine, or change the dose without first checking with your doctor.

Do not give this medicine to anyone else, even if his or her symptoms seem similar to yours.

Do not use Anginine to treat any other complaints unless your doctor says so.

Things to be careful of

Be careful driving or operating machinery until you know how Anginine affects you. Anginine may cause dizziness or faintness in some people. Make sure you know how you react to Anginine before you drive a car, operate machinery or do anything else that could be dangerous if you become dizzy or faint.

Get up slowly when getting out of bed or standing up, as you may feel light-headed, dizzy or faint. You may feel light-headed, dizzy or faint after using Anginine. This is because your blood pressure drops. While the medicine is working, it is better for you to sit down and rest for a while. Especially if you are feeling dizzy or faint. Standing up slowly, especially when you get up from lying or sitting, will help your body get used to the change in position and blood pressure.

Be careful when drinking alcohol while you are using Anginine. If you drink alcohol whilst using Anginine, your blood pressure may drop, making you feel dizzy or faint.


Check with your doctor as soon as possible if you have any problems while using Anginine, even if you do not think the problems are connected with the medicine or are not listed in this leaflet. Like all medicines, Anginine can cause some side-effects. If they occur, they are most likely to be minor and temporary. However, some may be serious and need medical attention.

The most usual side-effects are:


low blood pressure, feeling faint or dizzy

flushing (redness) of the face

fast heart beat

If you are troubled by a throbbing headache when you use Anginine, you may remove the remaining part of the tablet from your mouth once the angina pain is relieved. Ask your doctor or pharmacist to answer any questions you may have.

Rarely reported side-effects are:

blurred vision

dry mouth

severe and prolonged headache

slow heart beat

skin rash

Ask your doctor or pharmacist to answer any questions you may have.

If you think you are having an allergic reaction to Anginine, tell your doctor immediately or go to the casualty department at your nearest hospital. Symptoms usually include some or all of the following:

asthma, wheezing or shortness of breath

swelling of the face, lips or tongue

difficulty in swallowing

difficulty in breathing

hay fever


lumpy rash ("hives")


Tell your doctor or pharmacist immediately if you notice any of the following:

severe nausea (feeling sick) and vomiting

swelling of the face

severe rash, hives, or itching of the skin

shortness of breath or other breathing problems

bluish colour of lips, nails or palms of the hands

severe dizziness or fainting (caused by impaired blood circulation to the brain)

weak or unusually fast heartbeat

severe headache

unusual tiredness or weakness


worsening of your angina pain

This is not a complete list of all possible side-effects. Others may occur in some people and there may be some side-effects not yet known.

Tell your doctor if you notice anything else that is making you feel unwell, even if it is not on this list.

Ask your doctor or pharmacist if you don't understand anything in this list.

Do not be alarmed by this list of possible side-effects. You may not experience any of them.

After using Anginine


Anginine tablets can easily lose their strength if not stored properly. Glyceryl trinitrate, the active ingredient in Anginine tablets, becomes less effective very easily.

Keep your Anginine tablets in a cool, dry and dark place where it stays below 25 deg C.

Do not carry the tablets close to your body where they become warm.

Keep your supply of Anginine tablets in the original glass bottle.

Always keep the lid tightly closed or your tablets will lose strength more quickly.

Obtain a fresh supply of Anginine within THREE months after you first open the bottle, even if you have not used all the tablets.

It is helpful to write the date of opening on the label of the bottle.

Do not use Anginine tablets after the expiry date on the bottle.

Do not store your Anginine tablets mixed with any other tablets.

Always keep Anginine tablets out of reach of children.

A locked cupboard a least one and a half metres above the ground is a good place to store medicines which you do not need to carry.

Do not store it, or any other medicine, in a bathroom or near a sink.

Heat and dampness can destroy some medicines.

Do not leave Anginine in the car or on windowsills.

Keep your Anginine tablets out of direct sunlight.


If your doctor tells you to stop using Anginine, or the Anginine has passed its expiry date, ask your pharmacist what to do with any Anginine left over.

Product description

What Anginine looks like

Anginine tablets are square flat white to off-white tablet scored on one face and plain on the other face

Each bottle contains 100 tablets.


Anginine contains 600 microgram of the active ingredient glyceryl trinitrate.

Anginine tablets also contain:

Anginine tablets contain gluten and lactose.


Sigma Pharmaceuticals (Australia) Pty Ltd A. C.N. 004 118 594 96 Merrindale Drive Croydon, Victoria, 3136 Australia Telephone: (03) 9839-2800

Further Information

Pharmaceutical companies are not in a position to give people an individual diagnosis or medical advice. Your doctor or pharmacist is the best person to give you advice on the treatment of your condition. You may also be able to find general information about your disease and its treatment from books, for example in public libraries.

Do not throw this leaflet away. You may need to read it again.

This leaflet was prepared on 20 September 2000 and updated in November 2007.

The information provided applies only to: Anginine.

Anginine: AUST R 11086

This leaflet is subject to copyright.

Published by MIMS January 2008

Consumers should be aware that the information provided by the Consumer Medicines Information (CMI) search (CMI Search) is for information purposes only and consumers should continue to obtain professional advice from a qualified healthcare professional regarding any condition for which they have searched for CMI. CMIs are provided by MIMS Australia. CMI is supplied by the relevant pharmaceutical company for each consumer medical product. All copyright and responsibility for CMI is that of the relevant pharmaceutical company. MIMS Australia uses its best endeavours to ensure that at the time of publishing, as indicated on the publishing date for each resource (e. g. Published by MIMS/myDr January 2007), the CMI provided was complete to the best of MIMS Australia's knowledge. The CMI and the CMI Search are not intended to be used by consumers to diagnose, treat, cure or prevent any disease or for any therapeutic purpose. Cirrus Media Pty Limited, its servants and agents shall not be responsible for the continued currency of the CMI, or for any errors, omissions or inaccuracies in the CMI and/or the CMI Search whether arising from negligence or otherwise or from any other consequence arising there from.

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Dofixim (Cefpodoxime) is an orally administered prodrug that is de-esterified in the intestinal wall to release Cefpodoxime a broad spectrum, semisynthetic 3rd generation cephalosporin antibiotic. Like other beta-lactam antibiotics it is bactericidal and acts by inhibiting cell wall synthesis. It is more active than other oral cephalosporin against respiratory bacterial pathogens.


Dofixim Capsule: Each capsule contains Cefpodoxime 100 mg as Cefpodoxime Proxetil INN. Dofixim Tablet: Each tablet contains Cefpodoxime 200 mg as Cefpodoxime Proxetil INN. Dofixim Suspension: Each 5 ml reconstituted suspension contains Cefpodoxime 40 mg Cefpodoxime Proxetil INN.

Indications And Uses

Upper respiratory tract infection: Acute otitis media, Acute maxillary sinusitis, Pharyngitis, Tonsilitis. Lower respiratory tract infection: Acute community acquired pneumonia, acute bacterial exacerbation of chronic bronchitis. Uncomplicated urinary tract infection: Cystitis, Pyuria. Skin and soft tissue infection: Furuncle, Cellulitis, Subcutaneous abscess, infectious atheroma. Sexually transmitted disease: Acute uncomplicated urethral and cervical gonorrhoea. Gastrointestinal tract infection: Typhoid fever.

Dosage And Administration

"Dofixim capsule should be administered only with food to enhance absorption but suspension may be given without regard to food. Adults (Age 13 years and older):Type of Infection, Dose and Duration Upper respiratory tract infection including tonsillitis and pharyngitis 100 mg 12 hourly for 5-10 days Acute exacerbation of chronic bronchitis 200 mg 12 hourly for 10 days Acute community acquired pneumonia 200 mg 12 hourly for 14 days Uncomplicated gonorrhoea 200 mg Single dose Uncomplicated urinary tract infection 100 mg 12 hourly for 7 days Skin and soft tissue infection 200-400 mg 12 hourly for 7-14 days Acute maxillary sinusitis 200 mg 12 hourly for 10 days. Children (Age 15 days to 9 years): Type of Infection and Dose Duration 6 months-2 years 40 mg every 12 hours 15 days-6 months 4 mg/kg every 12 hours 3 years-8 years 80 mg every 12 hours Over 9 years 100 mg every 12 hours "

Side Effect

Dofixim has very few side effects. Diarrhoea and rarely antibiotic associated with colitis, nausea, vomiting, abdominal discomfort etc. may occur. Other side effects include rashes, pruritus, urticaria, serum sickness, chest pain, myalgia, dyspepsia, dizziness, and vertigo, fungal and vaginal infection.

Use In Pregnancy Lactation

There is no well-controlled and sufficient study of Cefpodoxime Proxetil regarding its use in pregnancy. It was neither teratogenic nor embryocidal in animal trial. This drug should be given during pregnancy only if clearly needed. Because Cefpodoxime is excreted in human milk, a decision should be made whether to discontinue breast feeding or to discontinue the drug.

Drug Interactions

Antacids: Concomitant administration of high doses of antacids or H2- Blocker reduces peak plasma level by 24% to 42% and the extent of absorption by 27% to 30% respectively. Probenecid: It inhibits the excretion of Cefpodoxime. Nephrotoxic drugs: Close monitoring of renal function is advised when Cefpodoxime is administered concomitantly with compounds of known nephrotoxic potential.


Dofixim is contraindicated in patient with known hypersensitivity to it or to other cephalosporin antibiotics

How Supplied

Dofixim Capsule: Box contains 08 (2x4’s) capsules in alu-alu blister strip. Dofixim Tablet: Box contains 12 (3x4’s) tablets in alu-alu blister strip. Dofixim Suspension: Bottle contains dry powder for 50 ml & 100 ml oral suspension.

Download Dofixim

Elatrol, elatrol



a tricyclic antidepressant.

indication It is prescribed in the treatment of depression and has unlabeled uses for treating neuropathic pain and headaches.

contraindications Concomitant administration of monoamine oxidase inhibitors, recent myocardial infarction, or known hypersensitivity to this drug or to other tricyclic medications prohibits its use. It is used with caution in patients who have a seizure disorder or cardiovascular disease or who are at risk for suicide.

adverse effects Among the more common adverse reactions are sedation and anticholinergic effects. A variety of cardiovascular and central nervous system effects may occur. This agent interacts with many other drugs.


Elavil Neuropharmacology A tricyclic antidepressant, with sedative and anticholinergic properties, which may be used for peripheral neuropathy Adverse effects Rash, nausea, weight gain/loss, drowsiness, nervousness, insomnia, confusion, seizures, coma, orthostatic hypotension


A tricyclic antidepressant drug. The drug is on the WHO official list. A brand name is Triptafen.


tricyclic antidepressant drug used as an adjuvant analgesic for chronic pain states


a tricyclic antidepressant in humans; used in dogs and cats to treat psychodermatosis and as an antipruritic.

Link to this page:

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Amoxaren, amoxaren

Comprar AMOXAREN ? Precio & Efectos Adversos

Por favor ayudenos Califica este articulo Medicina

Comprar AMOXAREN 500 MG 12 CAPSULAS from AREU. Precio AMOXAREN es €2.4. Efectos adversos del AMOXAREN se deben a Anatomico Accion terapeutica. que podemos encontrar en su codigo atc. AMOXAREN 500 MG 12 CAPSULAS dosis – especificada por el medico. Usos de AMOXAREN 500 MG 12 CAPSULAS se encuentran en diversas complicaciones relacionadas con la ATA (accion terapeutica anatomica). Aprobado nombre universal por la FDA (Nombre generico) para el medicamento es el AMOXICILINA 500 MG 12 CAPSULAS.

AMOXAREN Detalles breves.

Nombre generico – AMOXICILINA 500 MG 12 CAPSULAS

Laboratorio – AREU

Dosis y Embalaje – 500 MG 12 CAPSULAS

Empresa fabricante – AREU

Pais de Fabricacion – Espana

Mercado Medicina – Espana

Medicine Market Espana

N ? de registro – 705327

Precios de los Medicamentos Para Publica – € 2.4

Importador de Drogas – AREU

estado en el mercado – ALTA

Disponibilidad Juridico de publico – Por prescripcion.

Realizar Medicina AMOXICILINA 500 MG 12 CAPSULAS

Estado de licencia – Aprobado por la FDA

Medicina del estado de disponibilidad – En Mercado.


esta disponible en el Espana y se vende en casi todas las tiendas de medicina, no se puede comprar sin receta AMOXAREN . Usted puede comprar desde AREU. Forma fisica vendida es la 500 MG 12 CAPSULAS.

Comprar en el precio barato

En el mercado internacional se puede comprar 500 MG 12 CAPSULAS en diferentes marcas y fuerzas, AREU ventas de TI en Espana. No se puede comprar sin receta AMOXAREN . Usted puede comprar AMOXAREN en linea tambien desde AREU. Para comprar AMOXAREN linea que usted necesita receta.

Comprar en linea

Para comprar AMOXAREN en linea con tarjeta de credito es posible que necesite una receta de los medicos, Varios sitios de ventas en linea con los principios activos – AMOXICILINA 500 MG 12 CAPSULAS. A comprar AMOXAREN en linea en el precio bajo que usted debe considerar las diferentes marcas de los ingredientes genericos. Para la entrega rapida usted puede considerar AREU. Lo puedes comprar en linea desde AREU Espana. Tasa de compra AMOXAREN mantendra fluctuante con el tiempo y la demanda y esta tasa se ??define el precio de mercado de la marca. Los datos historicos de la demanda de drogas de fluctuacion con ano se dan aqui.

El aumento de la edad de AMOXAREN % Compre precio online – Comprar por ano

Aumento o disminucion de la demanda de drogas

Aumento de la demanda en 2010

Compre en Argentina.

En Argentina se encuentra disponible en diferentes marcas cuyos ingredientes centrales son. AMOXAREN. paracetamol en Argentina es relativamente mejor calidad y de almacenamiento que cualquier otro pais. AREU puede suministrar AMOXAREN en todo el Argentina. Para comprar AMOXAREN en Argentina necesitara receta. En Argentina 500 MG 12 CAPSULAS fisica esta disponible facilmente.

% edad de comprar en Argentina por ano

Aumento o disminucion de la demanda de drogas

Aumento de la demanda en Argentina 2010

Comprar en Colombia y Venezuela

Colombia y Venezuela paises comparativamente caros para comprar AMOXAREN. usted puede comprar AMOXAREN en Colombia de AREU. AREU tambien AMOXAREN ventas en Venezuela relativamente mejor precio. Contacto Farmacias en Bogota y Medellin para comprar al mejor precio en Colombia. En Venezuela para comprar esta droga puede comunicarse directamente Farmacia AREU en Caracas y Maracaibo.

Demanda La rebelion de AMOXAREN en Colombia y Venezuela

Porcentaje de incremento en la demanda de AMOXAREN compra al ano.

Demanda Comprar en Colombia

Comprar en Venezuela

Comprar en Chile y Mexico

Sin embargo AMOXAREN en Chile y Mexico se encuentra disponible en todas las tiendas de un medico si usted tiene un problema de compra en Mexico y Chile puede comunicarse AREU. AREU suministrar AMOXAREN en Chile y Mexico a mejores precios. Para comprar AMOXAREN en Mexico contacto AREU Pharma en la Ciudad de Mexico o en Ecatepec. Para comprar en Chile desde AREU contacto farmaceutica respectiva farmacia en Puente Alto. Usted necesitara una receta para ordenar AMOXAREN en Chile .

Porcentaje de incremento en la demanda de AMOXAREN compra al ano.

Demanda Comprar en Mexico

Comprar en chile

Comprar AMOXAREN sin receta.

AMOXAREN es legalmente disponible solo con receta medica. Usted necesitara una receta de medico autorizado en el Espana para comprar en cualquier lugar. Tiendas en linea tambien requieren receta medica para comprar AMOXAREN. No se puede comprar AMOXAREN sin receta.


AMOXAREN lista de precios mantendra fluctuante, sin embargo el precio de AMOXAREN en Espana se fija por gob de Espana. Sin embargo diferentes marcas tienen diferentes precios. En la marca de AREU – AMOXAREN, el precio de AMOXAREN es – € 2.4.

Precio en Espana

Precio AMOXAREN en Espana es inferior a AMOXAREN de precios en el Chile y precio en la Venezuela. Esta diferencia en AMOXAREN precio es debido a la demanda del mercado, Coste de produccion y los impuestos aplicados por diferentes gbno on AREU. Precio de AMOXAREN en Espana – 2.4 €.

Sin embargo el precio real continuen fluctuando con el tiempo y la demanda, los datos historicos de AMOXAREN precio.

AMOXAREN Precio en la Espana por ano

Precio en linea AMOXAREN

En linea puede encontrar mejor y mas valiosa precio de AMOXAREN, AREU AMOXAREN precio es 2.4 € para la entrega del Espana para todos los paises (chile, colombia, venezuela o argentina) AREU puede cobrar extra. AMOXAREN ingredientes activos son – AMOXICILINA 500 MG 12 CAPSULAS. Para comprar AMOXAREN en el precio bajo tratar de comparar los ingredientes para diferentes marcas.

Precio en Chile, Mexico y Colombia.

En chile AMOXAREN es caro comparativamente colombia y Espana, AREU precio de la marca es muy superior a la mexico y colombia. Precio en Chile 2.414 . Precio en Mexico es inferior a Chile. AMOXAREN de precios en Mexico es €.Chile Gobierno tiene comision especial para regular los precios, pero debido a los costes laborales, etc el precio en chile es mas alta. AMOXAREN de precios en Colombia es – € 2.8. en Colombia varias otras empresas de ventas AMOXICILINA 500 MG 12 CAPSULAS. Calidad de la fabricacion de AMOXAREN en colombia es mejor por lo tanto hay diferencia de precio colombia .

AMOXAREN Precio Por ano

Precio en Chile

Precio en Mexico

Price in chile, mexico y colombia.

AMOXAREN efectos adversos.

Cada medicamento que contiene AMOXICILINA 500 MG 12 CAPSULAS como su ingrediente tiene efectos secundarios, la principal causa de los efectos secundarios causados ??por su ingrediente AMOXICILINA 500 MG 12 CAPSULAS. AMOXAREN efecto secundario es debido Anatomico Accion terapeutica del ingrediente. Los efectos secundarios del AMOXAREN se pueden minimizar si el medicamento se toma exactamente de acuerdo con la recomendacion del medico. Medico tambien puede prescribir algunos medicamentos de venta libre para contrarrestar los efectos secundarios.

Sin embargo especifico efecto secundario dosis potencia de AMOXAREN.

AMOXAREN Los efectos secundarios Potencia por mismo tamano de dosificacion.

Side efecto Potencialidad en Mujeres Embarazadas

En el varon adulto y hembra

Specific Dosage Potential Side Effects in different Age group.

AMOXAREN efectos secundarios en el embarazo

El uso de AMOXAREN durante el embarazo puede aumentar el riesgo de los ninos en desarrollo algun trastorno (commpon para algunos este tipo de drogas), sin embargo, depende de la forma en AMOXAREN ingredientes atravesar la placenta y pueden tener efecto en el bebe – fortaleza de la AMOXAREN es un factor importante en la determinacion de dichos efectos secundarios, el posible peligro en el embarazo estan bajo investigacion. AREU Espana publicar folleto sobre AMOXAREN cada actualizacion para describir los posibles riesgos del uso de AMOXAREN efecto secundario en el embarazo y las mujeres embarazadas . Usted puede descargar AREU emitido folleto acerca de los efectos secundarios de la AMOXAREN – 500 MG 12 CAPSULAS.

Los efectos secundarios en los ninos y el bebe

Evaluacion FDA todavia esta incompleto. AMOXAREN efectos secundarios comunes son Sin embargo.

1. Cambios en la actividad mental por AMOXICILINA 500 MG 12 CAPSULAS.

2. Los cambios metabolicos: Debido a AMOXAREN.

3. AMOXAREN causado alteracion Tasa de crecimiento.

Efectos exacta depende del modo de accion terapeutica en los ninos.


Dosificacion exacta de AMOXAREN – 500 MG 12 CAPSULAS es recetado por el medico Dependiendo de la edad, peso, sexo y tipo de enfermedad, etc Sin embargo sobredosis pueden causar AMOXAREN toxicidad.

En caso de sobredosis La toxicidad de AMOXAREN de contacto Spain – 112

el Centro de Toxicologia colombia – 123 or 112

el Centro de Toxicologia venezuela – 171

el Centro de Toxicologia mexico – 911

Argentina – 107

Nombre generico y de marca

Nombre generico es el nombre universal aprobado por la FDA de la droga o producto quimico sin marca. Marca es el nombre propio de la empresa para la comercializacion de la droga por una patente nombre especial para ellos. AMOXAREN en si es una marca .

?Que es la AMOXAREN nombre generico?

Los ingredientes activos de la AMOXAREN son AMOXICILINA 500 MG 12 CAPSULAS y su nombre generico es – AMOXICILINA 500 MG 12 CAPSULAS.

Dosis y via de administracion.

Exact Dosis (cuanto AMOXAREN paciente tiene que tomar.), La forma de dosificacion (Formulario de AMOXICILINA 500 MG 12 CAPSULAS Medicine.) y la via de administracion (?Como AMOXICILINA 500 MG 12 CAPSULAS que ser administrado).

Via de administracion

La medicina AMOXAREN se debe dar al paciente como el medico especifique. sin embargo, la via de administracion depende de la forma fisica de AMOXAREN y es – 500 MG 12 CAPSULAS.

Detalle Dosis

Dosis de AMOXAREN – AMOXICILINA 500 MG 12 CAPSULAS 500 MG 12 CAPSULAS es del volumen o tamano. La dosis clinica se especifica por el medico.

Periodo de caducidad.

AMOXICILINA 500 MG 12 CAPSULAS – AMOXAREN periodo de caducidad es el periodo de tiempo tras el cual AMOXAREN no es medicamente utilizables o caducados. El periodo de caducidad exacta despues de la fabricacion es de 48 meses. Despues de 48 meses AMOXAREN medicamente no es utilizable. Para mantener el AMOXAREN en mejor condicion mantengalo siempre a 25 grados centigrados.

Interacciones medicamentosas

AMOXAREN puede interactuar con algun otro medicamento o puede tener efectos secundarios. Los efectos secundarios y la interaccion de drogas causado por AMOXAREN en diferentes organos puede calcularse utilizando ATC ??codigo.

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Buy advil 400mg



Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



Advil 400mg Tablets 0140_PIL_15 080_v1 PL 0165/0140 PACKAGE LEAFLET: INFORMATION FOR THE USER Advil 400 mg Tablets Contains ibuprofen Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. This medicine is available without prescription, for you to treat a mild illness without a doctor’s help. Nevertheless, you still need to use your medicine carefully to get the best results - Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. - Keep this leaflet, you may need to read it again. - Ask your pharmacist if you need more information or advice. - If you get any side effects, or if any of the side effects gets serious, please tell your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. - You must see a doctor if your symptoms worsen or persist. See section 3. What is in this leaflet: 1. What Advil 400 mg is and what it is used for 2. What you need to know before you take Advil 400 mg 3. How to take Advil 400 mg 4. Possible side effects 5. How to store Advil 400 mg 6. Contents of the pack and other information 1. WHAT ADVIL 400 MG IS AND WHAT IT IS USED FOR Each tablet contains 400 mg of ibuprofen. Ibuprofen belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) that work by relieving pain and reducing inflammation, swelling and fever. Advil 400 mg is for the relief of mild to moderate pain including: rheumatic and muscular pain, backache, headache, toothache, dysmenorrhoea, feverishness, symptoms of colds and influenza. 2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE ADVIL 400 MG Please read the following information. Do not give to children under 12 years of age, except on the advice of a doctor. Do not take Advil 400 mg if you: • are suffering from or have had two or more separate occurrences of stomach ulcers or bleeding. • have suffered in the past from stomach bleeding or perforation because of treatment with this medicine or any other NSAID. • suffer from other bleeding conditions or blood disease. • are allergic to ibuprofen or any of the other ingredients of this product, aspirin, or any other NSAID painkiller. • suffer from severe liver, kidney or heart failure. • are in the last 3 months of pregnancy. Warnings and Precautions Talk to your pharmacist or your doctor if you : • are asthmatic or suffer from hayfever. • are suffering from liver or kidney problems.

Advil 400mg Tablets 0140_PIL_15 080_v1 PL 0165/0140 • are suffering from autoimmune diseases including Systemic Lupus Erythematosus (SLE), a condition of the immune system affecting connective tissue resulting in joint pain, skin changes and disorders of other organs. • are suffering from or have a history of gastro-intestinal disorders, such as ulcerative colitis or Crohn’s Disease, because medicines such as ibuprofen may make these conditions worse. ? are in the first 6 months of pregnancy. ? are 12-18 years old as there is a risk of renal impairment. Therefore ask a doctor before use if a child or adolescent between 12-18 years of age has not been drinking fluids or has lost fluids due to continuous vomiting or diarrhoea. ? have heart problems including heart failure, angina (chest pain) or if you have had a heart attack, bypass surgery, peripheral artery disease (poor circulation in the legs of feet due to narrow or blocked arteries), or any kind of stroke (including ‘mini-stroke’ or transient ischaemic attack “TIA”). ? have high blood pressure, diabetes, high cholesterol, have a family history of heart disease or stroke, or if you are a smoker. Medicines such as Advil 400 mg Tablets may be associated with a small increased risk of heart attack (“myocardial infarction”) or stroke. Any risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment. See section 3. Other medicines and Advil 400 mg Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. Do not use this medicine if you are taking aspirin/acetylsalicylic acid with a daily dose above 75 mg, or other NSAID painkillers. Talk to you doctor or pharmacist if you are taking: • medicines that are anti-coagulants (i. e thin blood/prevent clotting, e. g. aspirin/acetylsalicylic acid, warfarin, ticlopidine), diuretics (water tablets - increase the amount of urine you produce) ? medicines that reduce high blood pressure (ACE-inhibitors such as captopril, beta-blockers such as atenolol, angiotensin-II receptor antagonists such as losartan), or other medicines, as these may affect or be affected by treatment with ibuprofen. • other medicines such as corticosteroids (used in the management of asthma and to treat skin diseases and other conditions), anti-platelet agents (generally used to thin the blood to help prevent stroke or heart problems), cardiac glycosides (used in patients with heart problems), selective serotonin reuptake inhibitors (SSRIs) or lithium (used to treat depression), methotrexate (used in the treatment of some cancers, and to treat psoriasis or rheumatoid arthritis), ciclosporin or tacrolimus (used in patients receiving organ transplants, and to treat some skin disorders), zidovudine (used to treat HIV infection), quinolone antibiotics (a class of antibiotics used to treat some infections), phenytoin (used in the treatment of epilepsy) or antacids (used to treat indigestion). Some other medicines may also affect or be affected by the treatment of Advil 400mg. You should therefore always seek the advice of a doctor or pharmacist before you take Advil 400mg with other medicines. Pregnancy and breastfeeding Ibuprofen belongs to a group of medicines, NSAIDs, which may impair fertility in women. This effect is reversible upon stopping the medicine. It is unlikely that ibuprofen, used occasionally, will affect your chances of becoming pregnant, however tell your doctor before using this medicine if you have problems becoming pregnant or are trying to become pregnant. If you are in the first 6 months of pregnancy talk to your doctor before taking ibuprofen.

Advil 400mg Tablets 0140_PIL_15 080_v1 PL 0165/0140 Do not take ibuprofen during the last 3 months of pregnancy, Ibuprofen appears in breast milk in very low concentrations, but this is unlikely to adversely affect the breast-fed infant. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. 3. HOW TO TAKE ADVIL 400 MG This product is intended for short term use only. You should only take the lowest dose for the shortest time necessary to relieve your symptoms. If you are aged between 12 and 18 years and the product is required for more than 3 days or if the symptoms worsen, you should contact your doctor. If you are 18 years or older, you should not take this medicine for longer than 10 days unless your doctor tells you to. If symptoms persist or worsen consult your doctor. The recommended dose for Adults, older people and children and adolescents between 12-18 years of age: 1 tablet up to 3 times a day as required. The recommended interval between doses is approximately 6 to 8 hours, and you must leave at least 4 hours between doses. Do not take more than 3 tablets in any 24 hour period. The tablet should be taken with water. Do not chew. If you take more Advil 400 mg than you should If you take too many tablets, contact your doctor or hospital immediately. Bring the remaining tablets with you to show the doctor. If you forget to take Advil 400 mg Do not take a double dose to make up for a forgotten dose If you have questions regarding the use of Advil 400 mg, ask your doctor or pharmacist

Advil 400mg Tablets 0140_PIL_15 080_v1 PL 0165/0140 4. POSSIBLE SIDE EFFECTS Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects are very rare (less than 1 in 10,000 people) but if you experience any of these STOP taking this medicine immediately and contact your doctor or pharmacist: • Stomach ulceration or perforation. Symptoms could include severe abdominal pain, vomiting blood (or liquid with what looks like coffee grounds), blood in the faeces (stools/motions) or passing black tarry stools. • Inflammation of the brain lining (meningitis). Symptoms could include stiff neck, headache, feeling or being sick, fever, or feeling disorientated. • Severe allergic reactions (could be life-threatening). Symptoms may include sudden signs of allergy such as rash, itching, or hives on the skin, fainting, low blood pressure, faster heart rate, swelling of the face, tongue and throat, shortness of breath, wheezing or trouble breathing. • Asthma / worsening of asthma and other breathing difficulties. • Severe conditions of the skin that may affect the mouth and other parts of the body. This may progress to a severe skin reaction which starts with painful red areas, then large blisters, and ends up with peeling of layers of skin around the mouth, nose, eyes or genitals. This may be accompanied by fever and chills, aching muscles and generally feeling unwell. • Liver problems. Symptoms could include yellowing of the skin or the whites of the eyes. Medicines such as ibuprofen may be associated with a small increased risk of heart attack (“myocardial infarction”) or stroke. Other possible side effects If any of the following side effects gets serious, or if you notice any side effect not listed in this leaflet, please tell your doctor or pharmacist. Less than 1 in 100 people may experience the following uncommon side effects: • Allergic reactions such as hives, skin rashes and itching (or Systemic Lupus Erythematosus SLE). • Abdominal pain, indigestion, heartburn and feeling sick. • Headache or dizziness. Less than 1 in 1,000 people may experience the following rare side effects: • Diarrhoea, wind, constipation or being sick. Less than 1 in 10,000 people may experience the following very rare side effects: • Reduction in blood cells, which can make the skin pale or yellow, cause fever, sore throat, mild mouth ulcers, flu-like symptoms, exhaustion or weakness, easy bruising, or bleeding from the skin or nose. • High blood pressure, heart failure or chest pain. • Nervousness, visual disturbance, ringing in the ears and dizziness. • Kidney problems. Symptoms could include swelling of the ankles. • Severe skin reactions. Symptoms could include blistering. • Blood in urine, or foamy appearance of urine. Other very rare side effects with unknown frequency: • Worsening of symptoms of colitis and Crohn’s disease. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet.

Advil 400mg Tablets 0140_PIL_15 080_v1 PL 0165/0140

You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine. 5. HOW TO STORE YOUR MEDICINE • • •

Do not use this medicine after the expiry date stated on the side of the carton. The expiry date refers to the last day of the month. Do not store your medicine above 30°C. Keep this medicine out of the sight and reach of children.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment 6. CONTENTS OF THE PACK AND OTHER INFORMATION What Advil 400mg contains The active substance is ibuprofen. Each tablet contains 400 mg of ibuprofen. The other ingredients are maize starch, pregelatinised starch, croscarmellose sodium, colloidal silicon dioxide, stearic acid, sodium lauryl sulfate, hydroxypropyl methylcellulose, macrogol 6000, titanium dioxide (E171), iron oxide (E172), talc, black ink (black iron oxide (E172), shellac, propylene glycol and ammonium hydroxide (E527)). What Advil 400mg looks like and contents of the pack Advil 400 mg Tablets are brown, film-coated capsule-shaped tablets, printed on one side in black. ink. The blister packs contain 10, 12, 20, 24, 30, 36, 40, 48, 50, or 60 tablets. The bottles contain 20 or 50 tablets. (Not all pack sizes may be marketed.) Who your medicine is made by The Marketing Authorisation holder is: Pfizer Consumer Healthcare Ltd, Sandwich, Kent, CT13 9NJ, UK. The manufacturer is: Pfizer Consumer Manufacturing Italy S. r.l. Via Nettunense, 90 – 04011 Aprilia (LT), Italy. This medicinal product is authorised in the Member States of the EEA under the following names: Ireland – Seclodin 400 mg Tablets Netherlands – Advil Oval-Tabs 400, filmomhulde tabletten 400 mg United Kingdom – Advil 400 mg Tablets This leaflet was last revised in: September 2015. PL 0165/0140

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

What are the active ingredients in Advil ® PM caplets?

Each Advil ® PM caplet contains 200 mg of ibuprofen and 38 mg of diphenhydramine citrate, a gentle sleep aid. The ibuprofen relieves pain, while the diphenhydramine helps you get a full night’s sleep. The combination of these ingredients not only reduces your pain, it shortens the time it takes to fall asleep and increases the duration of your sleep. The result: a better night's sleep.

What is the recommended dosage for Advil ® PM caplets?

The recommended dose of Advil ® PM caplets is two caplets at bedtime, for adults and children 12 years and older. The two caplet dose contains a combined total of 400 mg of ibuprofen and 76 mg of diphenhydramine citrate. You should not take more than 2 capsules in 24 hours. Stop use and ask a doctor if: pain gets worse or lasts more than 10 days or if sleeplessness persists continuously for more than 2 weeks.

Can I take Advil ® PM caplets with alcohol?

Avoid drinking alcohol. Advil ® PM contains diphenhydramine, which may cause drowsiness - alcohol may intensify this side effect temporarily.

Is Advil ® PM addictive?

Like any drug you become dependent on, Advil ® PM can cause addiction problems. While the drug itself is not considered to be "addictive", the associations people can form with the drug and its results can create a dependency.

Single 400mg Dose OTC Ibuprofen Superior to 200mg for Pain Relief

LAS VEGAS, NV — A meta-analysis presented at PAINWeek 2012 of two standard single over-the-counter (OTC) doses of immediate-release ibuprofen showed that 400 mg provided significantly better overall pain relief compared with 200 mg over a 6-hour period. Both doses of ibuprofen provided significantly better overall pain relief compared with placebo over the 6-hour period.

Drs. Shyamalie Jayawardena and Paul Butkerait, from Pfizer Consumer Healthcare, Madison, NJ, reported the results of their analysis at PAINWeek 2012. The researchers designed the meta-analysis to investigate the analgesic dose-response relationship between 200 mg and 400 mg doses of immediate-release ibuprofen in oral surgery studies. The researchers noted that current OTC dosing instructions for ibuprofen state that adults and children > 12 years may take 1 tablet (200 mg) every 4–6 hours while symptoms persist or for up to 10 days. If pain does not respond to 1 tablet, 2 tablets (40 0mg) may be used (maximum 6 tablets/day).

To compare the efficacy of the two OTC doses, the researchers used Total Pain Relief scores over 6 hours (TOTPAR6), the maximum labeled dosing interval for OTC ibuprofen. Pain relief was measured using a categorical scale from 0 (no pain relief) to 4 (complete pain relief) at prespecified time points. A separate analysis was conducted for each comparison (400 mg vs. placebo, 200 mg vs. placebo, and 400 mg vs. 200 mg), using only those studies that concurrently evaluated the doses being compared.

The search identified 931 clinical studies, and 38 unique studies were included in the meta-analysis. Of these, 13 evaluated 200 mg ibuprofen, 32 evaluated 400 mg ibuprofen, and seven evaluated both 200- and 400-mg doses of ibuprofen. The pooled estimate for the treatment difference for the 400mg (n=2,890) vs. placebo (n=1,486) comparison was 9.58 (95% CI; 8.80–10.36). The pooled estimate for the treatment difference for the 200mg (n=1,036) vs. placebo (n=653) comparison was 6.89 (95% CI; 5.42–8.35). Both the 400mg and 200mg vs. placebo comparisons were statistically significant ( P <0.001). For the 400mg (n=716) vs. 200mg (n=714) comparison, the pooled estimate for the treatment difference was 1.39 (95% CI; 0.41–2.37). This comparison was also statistically significant ( P= 0.013). Both the 400-mg and 200-mg doses of ibuprofen were well tolerated across all studies and the incidence of adverse events was similar for both doses.

In conclusion, the study investigators' results were confirmed by data from the seven studies that simultaneously evaluated both doses of ibuprofen. The results of this meta-analysis are consistent with other reports in the literature on the efficacy and safety of OTC ibuprofen for pain relief following oral surgery.

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Disulfiram oral uses, side effects, interactions, pictures, warnings - dosing, disulfiramum


This medication should not be given to a patient without their knowledge. Do not take this medication if you are under the influence of alcohol or have drunk alcohol in the last 12 hours.


This medication is used along with counseling and support to treat alcoholism. Disulfiram works by blocking the processing of alcohol in the body. This causes you to have a bad reaction when you drink alcohol.

How to use disulfiram

See also Precautions section.

Take this medication by mouth with or without food, usually once daily in the morning or as directed by your doctor. If this medication causes drowsiness, take it at bedtime .

Dosage is based on your medical condition and response to therapy. The maximum recommended daily dose is 500 milligrams.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Side Effects

Drowsiness, tiredness, headache. acne. and metallic/garlic-like taste in the mouth may occur as your body gets used to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: decreased sexual ability, vision changes, numbness/tingling of arms/legs, muscle weakness. mental/mood changes (e. g. agitation, extreme excitement/confusion), seizures. confusion.

This drug may rarely cause serious (rarely fatal) liver disease. If you notice any of the following unlikely but very serious side effects, tell your doctor right away: persistent nausea /vomiting. severe stomach /abdominal pain. dark urine, yellowing eyes /skin .

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before taking disulfiram, tell your doctor or pharmacist if you are allergic to it; or to thiuram or thiuram-related chemicals (found in pesticides and rubber); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe heart /blood vessel disease (e. g. coronary artery disease ), certain mental/mood condition (psychosis ).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes. underactive thyroid (hypothyroidism ), brain disorders (e. g. seizures, brain damage ), kidney disease. liver disease, personal or family history of regular use/abuse of drugs.

Avoid all alcoholic beverages or alcohol-containing products/foods (e. g. cough and cold syrups, mouthwash, aftershave, sauces, vinegars) while taking this medication and for 2 weeks after stopping the medication. Check all product labels carefully to make sure that there is no alcohol in the product. Using alcohol, even a small amount, while taking this medication can lead to a reaction that may include flushing, throbbing headache. breathing problems (e. g. shortness of breath, fast breathing), nausea, vomiting, dizziness, extreme tiredness, fainting. fast/irregular heartbeat. or blurred vision. These symptoms can last from 30 minutes to several hours. Tell your doctor right away if these symptoms occur, especially if they persist or worsen.

A more serious reaction with this medication and alcohol may include trouble breathing, seizures, loss of consciousness, chest/jaw/left arm pain. Seek immediate medical attention if you have these symptoms.

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast - feeding.


Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medications because very serious interactions may occur: alcohol-containing products (e. g. cough and cold syrups, aftershave), metronidazole .

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting disulfiram.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: amitriptyline, "blood thinners " (e. g. warfarin), certain medications for seizures (e. g. hydantoins such as phenytoin/fosphenytoin), isoniazid, theophylline.

This medication can increase the side effects of caffeine. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas) or eating large amounts of chocolate.

This medication may interfere with certain laboratory tests (including urine VMA/HVA tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.


If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: vomiting, drowsiness, loss of coordination, loss of consciousness.


Do not share this medication with others.

Laboratory and/or medical tests (e. g. liver function test, complete blood count) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

It is recommended that you carry an identification card stating that you are taking this medication and describing the possible reaction that may occur if you consume alcohol.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.


Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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