Buy generic for hibadren 1mg, hibadren

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Generic Name: Doxazosin

Generic for Hibadren* (Doxazosin) is prescribed to treat high blood pressure and enlarged prostate gland. Generic for Hibadren* relaxes and expands blood vessels, which in turn improves blood flow and results in lowered blood pressure. Besides, by relaxing muscles in the prostate and bladder neck, Generic for Hibadren* also treats the prostate enlargement symptoms such as burning during urination, frequent urination, urinary hesitancy, and incomplete emptying of the bladder. This medicine may also be used to treat other conditions as determined by your doctor. Read More>>

We sell only Doxazosin . the generic version of Hibadren *. Buy Now and Save with Generics.

*We do not sell Hibadren brand.

Facts about Generic Drugs

Generic drugs are chemically identical to brand-name drugs in terms of active ingredient(s), intended use, quality, dosage, safety, bioavailability and effectiveness.

Generic drugs are cheaper than brand-name drugs.

What is Generic for Hibadren* used for?

Generic for Hibadren* (Doxazosin) is prescribed to treat high blood pressure and enlarged prostate gland. Generic for Hibadren* relaxes and expands blood vessels, which in turn improves blood flow and results in lowered blood pressure. Besides, by relaxing muscles in the prostate and bladder neck, Generic for Hibadren* also treats the prostate enlargement symptoms such as burning during urination, frequent urination, urinary hesitancy, and incomplete emptying of the bladder. This medicine may also be used to treat other conditions as determined by your doctor.

What is the recommended dosage of Generic for Hibadren*?

The dosage of Generic for Hibadren* prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label. The following dosage information includes the common dose of Generic for Hibadren* If your dose is different, do not follow the dosage described below unless your physician has approved.

The recommended dose of Generic for Hibadren* for hypertension is 1–16 mg a day and that for enlarged prostate gland is 1–8 mg a day. Take each dose with a full glass of water. This medication can be taken with or without food.

What if you miss a dose of Generic for Hibadren*?

If your physician has instructed or directed you to take Generic for Hibadren* medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.

What if you overdose on Generic for Hibadren*?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Generic for Hibadren*, seek medical attention immediately. Some of the overdose symptoms of this drug are seizures, drowsiness, and fainting.

What other drugs could interact with Generic for Hibadren*?

It may be noted that drugs other than those listed above may also interact with Generic for Hibadren*

Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Generic for Hibadren*, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions.

Generic for Hibadren* can interact with medications that lower blood pressure, sedatives, and narcotic pain medicines.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Generic for Hibadren*?

Like other medicines, Generic for Hibadren* can cause some side effects. If they do occur, the side effects of Generic for Hibadren* are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Generic for Hibadren* cannot be anticipated. If any side effects of Generic for Hibadren* develop or change in intensity, the doctor should be informed as soon as possible.

Generic for Hibadren* can cause side effects such as dizziness, weakness, nervousness, restlessness, headache, trouble sleeping, nausea, and runny nose. Some of the serious side effects of this drug are chest pain, depression, fast heartbeats, sexual problems, and swelling of hands or feet. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Generic for Hibadren*

What are the questions to ask your doctor before taking Generic for Hibadren*?

Is it possible for me to take Generic for Hibadren* with other drugs? Should certain beverages, foods and other products be avoided when I take Generic for Hibadren*? What are the possible drug interactions of Generic for Hibadren*? How will Generic for Hibadren* work in my body? How should Generic for Hibadren* be taken? How to reduce the risk of Generic for Hibadren* drug interactions and side effects?

Note

The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Generic for Hibadren* is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

Before using Generic for Hibadren*, tell your doctor if you have liver or kidney disease. Also inform your doctor if you are pregnant, plan to become pregnant or breast-feeding. While using this medication, limit your intake of alcohol. Avoid any activity that requires full mental alertness. Do not get up too fast from a sitting or lying position.

Hoodia gordonii, hoodia gordonii

Hoodia

Hoodia gordonii is a cactus-like succulent plant, native to the Kalahari Desert in southern Africa. 1 Due to over harvest and slow growth, Hoodia is now considered an endangered species. Hoodia grows in clumps of upright stems with tan flowers and thorns, and a strong, unpleasant odor.

Hoodia has received publicity in recent times for its natural appetite suppressant properties.

What is the most important information I should know about Hoodia?

Patients should not take Hoodia without first talking to their doctor if they

have diabetes or are taking a medicine to control blood sugar levels,

have any heart problems or take any heart medicines,

have a bleeding or blood clotting disorder or are taking a medicine to increase or decrease the clotting of their blood such as aspirin. warfarin (Coumadin), or heparin ,

have anorexia, bulimia or any other eating disorder.

Patients may not be able to take Hoodia, or may require special monitoring during treatment if they have any of the conditions or are taking any of the medicines listed above.

Hoodia has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/ or advantages of Hoodia may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/ health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/ health supplements should be purchased from a reliable source to minimize the risk of contamination.

Hoodia is available for purchase in retail stores and online; however, clinical trials have not proven Hoodia effectiveness or safety. Actual amounts of hoodia in advertised products cannot always be confirmed, and products may be counterfeit or contaminated. Because many of these products are promoted for weight loss, but have not been clinically evaluated, the manufacturers are in violation of the Federal Food, Drug, and Cosmetic Act.

In October, 2011 the FDA notified consumers that the “P57 Hoodia” product marketed by Huikng Pharmaceutical was found to contain sibutramine. a controlled substance that was removed from the U. S. market in October 2010 for safety reasons. Sibutramine may substantially increase blood pressure and/or pulse rate in some patients and may present a significant risk for patients with a history of coronary artery disease, congestive heart failure, arrhythmia, or stroke. This product may also interact in life threatening ways with other medications a consumer may be taking. 2

How does Hoodia work?

The appetite suppressant effects of Hoodia were first observed in 1937 by a Dutch anthropologist studying the primitive San Bushmen of the Kalahari Desert.

It was noticed that the nomadic Bushmen, (who call it Xhoba) ate the stem of the Hoodia plant to stave off hunger during long hunting trips in the sparsely vegetated area.

The active ingredient in Hoodia is the appetite-suppressing molecule, P57, or oxypregnane steroidal glycoside P57AS3. 3 In scarce clinical studies, P57 has been researched to evaluate its potential as an anti-obesity drug.

It is theorized that P57 acts on the brain in a manner similar to glucose. It tricks the brain into thinking one is full even when they have not eaten, reduces interest in food and delays the time before hunger sets in. It appears to work at the level of the hypothalamus to inhibit hunger signals.

Who should not take Hoodia?

Patients should not take Hoodia without first talking to their doctor if they have

Patients should talk to their doctor before taking Hoodia if they have any other medical conditions, allergies (especially to plants), or if they take other medicines or herbal/ health supplements.

Patients should not take Hoodia without first talking to their doctor if they are pregnant or could become pregnant.

Patients should not take Hoodia without first talking to their doctor if they are breast-feeding.

There is no information available regarding the use of Hoodia by children. Do not give any herbal/ health supplement to a child without first talking to the child's doctor.

How should I take Hoodia?

The use of Hoodia in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/ health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

Take Hoodia only as directed by a doctor, pharmacist, or other health care provider.

Store Hoodia as directed on the package.

What happens if I miss a dose?

No information is available regarding a missed dose of Hoodia. Consult with a doctor, pharmacist, or health care provider if additional information is required.

What happens if I overdose?

Seek emergency medical attention.

What should I avoid?

There are no known restrictions on food, beverages, or activity while taking Hoodia, unless otherwise directed by a health care provider.

What are the possible side effects of Hoodia?

Patients should talk to their doctor about any side effects they may develop.

What other drugs will affect Hoodia?

There is limited drug interaction information available between Hoodia and other medicines. It is recommended that patients talk to their doctor, pharmacist, or health care provider before taking any prescription or over-the-counter medicines or other herbal/ health supplements .

An in-vitro clinical trial has shown that intestinal transport of P57 was mediated by P-glycoprotein and multidrug resistance proteins MRP1/MRP2. P57 exhibited weak inhibition of the liver cytochrome P450 3A4 enzyme. 3 The potential for clinically significant drug interactions is unknown.

What are the results of Hoodia clinical trials?

Published, peer-reviewed, randomized controlled clinical trials evaluating the efficacy of Hoodia gordonii are lacking.

A 15-day, randomized clinical trial published in 2011 evaluated Hoodia gordonii purified extract (HgPE) relative to placebo. Healthy, overweight women (n=64) received 1,110 milligram HgPE or placebo formulated in a yogurt drink one hour before breakfast and dinner. Menus otherwise were unchanged and portions were not controlled. HgPE was less well-tolerated than placebo due to episodes of nausea, vomiting, and skin sensations. Blood pressure, pulse, heart rate, bilirubin and alkaline phosphatase were significantly increased in the HgPE group. No significant effects on energy intakes or weight relative to placebo were demonstrated.

References

van Heerden FR. Hoodia gordonii: a natural appetite suppressant. J Ethnopharmacol 2008:119;434-7.

U. S. Department of Health and Human Services. U. S. Food and Drug Administration. Public Notification: “P57 Hoodia” Contains Undeclared Drug Ingredient. Accessed 01/28/2012. http: / / www. fda. gov / Drugs / ResourcesForYou / Consumers / BuyingUsingMedicineSafely / MedicationHealthFraud / ucm276074.htm

Madgula VL. Avula B. Pawar RS, et al. In vitro metabolic stability and intestinal transport of P57AS3 (P57) from Hoodia gordonii and its interaction with drug metabolizing enzymes. Planta Med 2008:74:1269-75.

Blom WA. Abrahamse SL. Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthly, overweight women: a randomized controlled trial. Am J Clin Nutr. 2011:94;1171-81; Clinical trial available at http://clinicaltrials. gov/ct2/show/NCT01306422?term=hoodia&rank=1 Accessed 1/28/2012.

HOODIA

Overview

Hoodia is a cactus-type plant from the Kalahari desert in Africa.

People use hoodia to curb their appetite so they are able to lose weight. According to some claims, San bushmen in Africa eat hoodia to fight off hunger during long hunts.

Be careful when buying hoodia products. According to news reports, some samples of hoodia sold on the Internet do not contain any hoodia at all. You might not get what’s listed on the label.

How does it work?

A chemical in hoodia called P57 is thought to decrease feelings of hunger. But it is not known if hoodia has this effect when used in people.

Uses

Insufficient Evidence for

Suppressing appetite or weight loss .

More evidence is needed to rate the effectiveness of hoodia for this use.

Side Effects

There isn’t enough information to know if hoodia is safe.

Special Precautions & Warnings:

Pregnancy and breast - feeding . Not enough is known about the use of hoodia during pregnancy and breast - feeding. Stay on the safe side and avoid use.

Interactions

No data available at this time.

Dosing

The appropriate dose of hoodia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hoodia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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Fluticasone nasal medical facts from, flucosan

fluticasone nasal

What is fluticasone nasal?

Fluticasone is a steroid. It prevents the release of substances in the body that cause inflammation.

Fluticasone nasal (for the nose) is used to treat nasal congestion, sneezing, runny nose, and itchy or watery eyes caused by seasonal or year-round allergies.

The Flonase brand of this medicine for use in adults and children who are at least 4 years old. Veramyst may be used in children as young as 2 years old. Flonase is available without a prescription.

Fluticasone nasal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about fluticasone nasal?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What should I discuss with my healthcare provider before using fluticasone nasal?

You should not use fluticasone nasal if you are allergic to it.

Fluticasone can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

To make sure you can safely use fluticasone nasal, tell your doctor if you have any of these other conditions:

tuberculosis or any other infection or illness;

glaucoma or cataracts;

herpes simplex virus of your eyes;

sores or ulcers inside your nose; or

if you have recently had injury of or surgery on your nose.

If you use Flonase without a prescription and you have any medical conditions, ask a doctor or pharmacist if this medicine is safe for you.

Also tell your doctor if you have diabetes. Steroid medicines may increase the glucose (sugar) levels in your blood or urine. You may also need to adjust the dose of your diabetes medications.

It is not known whether fluticasone nasal will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant or plan to become pregnant.

It is not known whether fluticasone nasal passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

Steroid medicine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

How should I use fluticasone nasal?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Do not share this medicine with another person, even if they have the same symptoms you have.

The usual dose of fluticasone nasal is 1 to 2 sprays into each nostril once per day. Your dose may change after your symptoms improve. Follow all dosing instructions very carefully.

Do not use Flonase in a child younger than 4 years old. Do not use Veramyst in a child younger than 2 years old.

Any child using fluticasone nasal should be supervised by an adult while using the nasal spray.

This medication comes with patient instructions for safe and effective use, and directions for priming the inhaler device. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

If you use Flonase . shake the inhaler device gently before each use. If you use Veramyst . shake the device vigorously before each use.

Before your first use, prime the nasal spray pump by shaking the medicine well and spraying 6 test sprays into the air (away from your face), until a fine mist appears. Prime the Flonase spray pump any time you have not used it for 7 days or longer. Prime the Veramyst spray pump any time you have not used it for longer than 30 days, or if you have left the cap off for 5 days or longer.

If you switched to fluticasone from another steroid medicine, do not stop using the other steroid suddenly or you may have unpleasant withdrawal symptoms. Talk with your doctor about tapering your steroid dose before stopping completely.

To be sure fluticasone nasal is not causing harmful effects on your nose or sinuses, your doctor may need to check your progress on a regular basis.

It may take up to several days before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after a week of treatment.

Store fluticasone nasal in an upright position at room temperature, away from moisture and heat. Throw the spray bottle away after you have used 120 sprays, even if there is still medicine left in the bottle.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

An overdose of fluticasone nasal is not expected to produce life threatening symptoms. However, long term use of high steroid doses can lead to symptoms such as thinning skin, easy bruising, changes in the shape or location of body fat (especially in your face, neck, back, and waist), increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex.

What should I avoid while using fluticasone nasal?

Avoid getting the spray in your eyes or mouth. If this does happen, rinse with water.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using fluticasone nasal.

Fluticasone nasal side effects

Get emergency medical help if you have signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe or ongoing nosebleeds;

noisy breathing, runny nose, or crusting around your nostrils;

redness, sores, or white patches in your mouth or throat;

fever, chills, weakness, nausea, vomiting, flu symptoms;

any wound that will not heal; or

blurred vision, eye pain, or seeing halos around lights.

Common side effects may include:

minor nosebleed, burning or itching in your nose;

sores or white patches inside or around your nose;

cough, trouble breathing;

headache, back pain;

sinus pain, sore throat, fever; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Fluticasone nasal dosing information

Usual Adult Dose for Rhinitis:

Fluticasone furoate: 2 sprays (27.5 mcg/spray) in each nostril once a day Fluticasone propionate: 1 or 2 sprays (50 mcg/spray) in each nostril once a day as needed

Comments: Fluticasone furoate: - When maximum benefit has been achieved and symptoms have been controlled, reducing the dosage to 55 mcg (1 spray in each nostril) once a day may be effective.

Use: Treatment of symptoms of seasonal and perennial allergic rhinitis

Usual Pediatric Dose for Rhinitis:

2 to 11 years: Fluticasone furoate: 1 spray (27.5 mcg/spray) in each nostril once a day

4 to 11 years: Fluticasone propionate: 1 spray (50 mcg/spray) in each nostril once a day

12 years or older: Fluticasone furoate: 2 sprays (27.5 mcg/spray) in each nostril once a day Fluticasone propionate: 1 or 2 sprays (50 mcg/spray) in each nostril once a day as needed

Comments: Fluticasone furoate: - Children between 2 to 11 years not adequately responding to 55 mcg may use 110 mcg (2 sprays in each nostril) once a day. - When maximum benefit has been achieved and symptoms have been controlled, reducing the dosage to 55 mcg (1 spray in each nostril) once a day may be effective.

Use: Treatment of symptoms of seasonal and perennial allergic rhinitis

What other drugs will affect fluticasone nasal?

Tell your doctor about all your current medicines and any you start or stop using, especially:

antifungal medicine; or

antiviral medicine to treat hepatis C or HIV/AIDS.

This list is not complete. Other drugs may interact with fluticasone nasal, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

More about fluticasone nasal

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about fluticasone nasal.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 8.02. Revision Date: 2015-08-28, 7:34:31 AM.

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Co-enac hexal, co-enac hexal

Co-Enac Hexal - Tabletten

Enalapril gehort zur Arzneimittelgruppe der sog. Angiotensin-Converting-Enzym-Hemmer (ACE-Hemmer) und senkt den Blutdruck, indem es die Blutgefa?e erweitert.

Hydrochlorothiazid gehort zur Arzneimittelgruppe der sog. Diuretika („Wassertabletten”) und senkt den Blutdruck, indem es die Urinausscheidung steigert.

Co-Enac Hexal enthalt eine Kombination von Enalapril und Hydrochlorothiazid. Es wird zur Behandlung von Bluthochdruck eingesetzt, wenn sich die Behandlung mit Enalapril allein als unzureichend erwiesen hat.

Ihr Arzt wird Ihnen Co-Enac Hexal auch an Stelle von separaten Tabletten mit denselben Dosen von Enalapril und Hydrochlorothiazid verordnen.

Fur die Erstbehandlung eignet sich diese fixe Dosiskombination nicht.

2 Was mussen Sie vor dem Gebrauch beachten?

Co-Enac Hexal darf nicht eingenommen werden

wenn Sie allergisch gegen Enalaprilmaleat oder andere ACE-Hemmer, Hydrochlorothiazid oder einen der in Abschnitt 6. genannten sonstigen Bestandteile dieses Arzneimittels sind (siehe „Was Co-Enac Hexal enthalt“)

wenn Sie allergisch gegen Sulfonamide und deren Abkommlinge (= bestimmte Antibiotika und bestimmte orale Antidiabetika) sind

wenn nach Einnahme eines ACE-Hemmers schon einmal eine schwere allergische Reaktion, ein sogenanntes Angioodem aufgetreten ist. Zu den Anzeichen gehoren Juckreiz, Nesselausschlag (Urticaria), rote Flecken an Handen, Fu?en und Hals, Schwellungen von Gesicht, Lippen, Zunge und/oder Rachen, mit Schluck und Atemproblemen.

wenn Sie an einem angeborenen Angioodem leiden, bzw. wenn dessen Ursache nicht bekannt ist

bei Verengung der Herzklappen der linken Herzkammer bzw. anderen Ausflussbehinderungen der linken Herzkammer, wenn diese bereits die Kreislauffunktion beeintrachtigen

wenn Sie schwerwiegende Probleme mit den Nieren haben

wenn Sie keinen Harn lassen konnen

wenn Sie schwerwiegende Probleme mit der Leber haben

wenn Sie an einer bestimmten Erkrankung der Nebennieren (primarer Hyperaldosteronismus) leiden

wenn Sie Diabetes mellitus oder eine eingeschrankte Nierenfunktion haben und mit einem blutdrucksenkenden Arzneimittel, das Aliskiren enthalt, behandelt werden

ab dem 3. Monat der Schwangerschaft (es wird empfohlen, Co-Enac Hexal auch in der fruhen Schwangerschaft nicht einzunehmen - siehe Abschnitt „Schwangerschaft und Stillzeit")

Warnhinweise und Vorsichtsma?nahmen

Bitte sprechen Sie mit Ihrem Arzt oder Apotheker, bevor Sie Co-Enac Hexal einnehmen, wenn

Ihre Arterien verengt sind (Atherosklerose), wenn Sie Probleme wie z. B. Schlaganfall oder vorubergehende Minderdurchblutung des Gehirns (transitorische ischamische Attacke – TIA – oder „Mini-Schlaganfall“) haben

Sie an Herzschwache leiden

Sie uber langere Zeit gro?e Mengen an Korpersalzen oder - flussigkeiten verloren haben (durch Erbrechen, Durchfall, eine salzarme Diat oder die Einnahme von Entwasserungstabletten)

Ihr Flussigkeits-/Elektrolythaushalt gestort ist (veranderter Flussigkeits-/Salzhaushalt in Ihrem Korper)

Sie an einer Herzmuskelerkrankung (hypertrophe Kardiomyopathie), einer Verengung der Hauptschlagader (Aortenstenose), bei dem das Blut nicht ungehindert aus dem Herzen ausstromen kann, oder einem sonstigen Herzproblem leiden

bei Ihnen eine sog. LDL-Apherese (maschinelle Entfernung von Cholesterin aus dem Blut) durchgefuhrt wird

sich unter Behandlung mit Co-Enac Hexal das Blutbild (die Anzahl der wei?en und roten Blutkorperchen oder der Blutplattchen) verandert

bei Ihnen eine Desensibilisierungsbehandlung mit Insektengift (z. B. Bienen - oder Wespengift) durchgefuhrt wird

Sie Diabetiker (zuckerkrank) sind. Wenn Sie an Diabetes mellitus leiden und dagegen Arzneimittel zum Einnehmen oder Insulin verwenden, muss vor allem wahrend des ersten Monats der Behandlung mit Co-Enac Hexal der Blutzuckerspiegel engmaschig uberwacht werden.

Sie an Gicht leiden oder hohe Harnsaurespiegel im Blut haben

Sie sich einer umfassenden Operation (auch beim Zahnarzt) unterziehen oder bei Ihnen Narkosemittel angewendet werden mussen

Sie schwarze Hautfarbe haben, da ACE-Hemmer bei Patienten mit schwarzer Hautfarbe eine geringere blutdrucksenkende Wirkung haben konnen

bei Ihnen eine Funktionsprufung der Nebenschilddrusen geplant ist

Sie Leber - oder Nierenprobleme haben oder hatten, wenn Ihre Nierenarterien verengt sind (Nierenarterienstenose), wenn Sie nur eine funktionierende Niere haben oder wenn Sie Dialysepatient sind

Sie eine Kollagenkrankheit (der Blutgefa?e) haben wie z. B. systemischer Lupus erythematosus

Sie zu Allergien neigen oder an Asthma leiden

ein anhaltender trockener Reizhusten auftritt

Sie zur Behandlung einer psychischen Erkrankung Lithium einnehmen

Sie eines der folgenden Arzneimittel zur Behandlung von hohem Blutdruck einnehmen:

einen Angiotensin-II-Rezeptor-Antagonisten (diese werden auch als Sartane bezeichnet – z. B. Valsartan, Telmisartan, Irbesartan), insbesondere wenn Sie Nierenprobleme aufgrund von Diabetes mellitus haben

Aliskiren Ihr Arzt wird gegebenenfalls Ihre Nierenfunktion, Ihren Blutdruck und die Elektrolytwerte (z. B. Kalium) in Ihrem Blut in regelma?igen Abstanden uberprufen. Siehe auch Abschnitt „Co-Enac Hexal darf nicht eingenommen werden“.

Sie einen erniedrigten Kalium-, Natrium-, Magnesium-, Kalzium - oder Chloridspiegel im Blut haben (ersichtlich an den Blutwerten und kann zu Schwachegefuhl, Muskelkrampfen, Mudigkeit, Herzjagen und sonstigen Beschwerden fuhren)

bei Ihnen plotzlich eine Sehschwache oder Schmerzen der Augen auftreten

Co-Enac Hexal wird grundsatzlich nicht empfohlen bei:

Patienten, bei denen kurz vorher eine Nierentransplantation durchgefuhrt wurde

Patienten mit hohem Kaliumspiegel im Blut

Sie mussen Ihrem Arzt mitteilen, wenn Sie vermuten, schwanger zu sein (oder schwanger werden konnten). Co-Enac Hexal wird in der fruhen Schwangerschaft nicht empfohlen, und darf nicht mehr nach dem dritten Schwangerschaftsmonat eingenommen werden, da die Einnahme in diesem Stadium Ihrem Kind ernsthaft schaden kann (siehe „Schwangerschaft und Stillzeit“).

Die Anwendung von Co-Enac Hexal kann bei Dopingkontrollen zu positiven Ergebnissen fuhren. Sprechen Sie mit Ihrem Arzt, wenn Sie Sportler sind und ein Dopingtest bei Ihnen durchgefuhrt werden soll.

Bei alteren Patienten und Patienten in schlechtem Ernahrungszustand sollte Co-Enac Hexal mit besonderer Vorsicht angewendet werden.

Kinder und Jugendliche

Die Wirksamkeit und Sicherheit von Co-Enac Hexal wurde bei Kindern und Jugendlichen nicht untersucht. Daher wird die Anwendung bei Patienten unter 18 Jahren nicht empfohlen.

Wahrend der Einnahme von Co-Enac Hexal:

Wenn Sie eines der folgenden Symptome bemerken, mussen Sie sofort Ihren Arzt informieren:

Schwindel oder Benommenheit nach der ersten Dosis Manche Menschen reagieren auf die erste Dosis oder auf eine Dosissteigerung mit Schwindel, Schwache, Ohnmacht und Ubelkeit.

plotzliches Anschwellen von Lippen, Gesicht, Hals, moglicherweise auch Handen und Fu?en, oder keuchende Atmung und Heiserkeit Diese Beschwerden werden als Angioodem bezeichnet. Sie konnen jederzeit wahrend der Behandlung auftreten. Bei dunkelhautigen Patienten kommt es unter einer ACE-Hemmer - Behandlung haufiger zu einem Angioodem als bei Patienten anderer Hautfarbe.

hohe Korpertemperatur, Halsschmerzen oder Geschwure in der Mundhohle (dabei kann es sich um Symptome einer Infektion als Folge der niedrigen Zahl wei?er Blutkorperchen handeln)

Gelbfarbung von Haut und Augenwei? (Gelbsucht) als Zeichen einer Lebererkrankung

uber langere Zeit anhaltender trockener Husten Husten kann als Nebenwirkung von ACE-Hemmern auftreten, aber auch Symptom einer anderen Erkrankung der oberen Atemwege sein.

Einnahme von Co-Enac Hexal zusammen mit anderen Arzneimitteln

Informieren Sie Ihren Arzt oder Apotheker, wenn Sie andere Arzneimittel einnehmen/ anwenden, kurzlich andere Arzneimittel eingenommen/angewendet haben oder beabsichtigen, andere Arzneimittel einzunehmen/anzuwenden.

Sie sollten Co-Enac Hexal nicht zur selben Zeit einnehmen wie die folgenden Arzneimittel:

Arzneimittel, die den Kaliumgehalt des Blutes erhohen konnen (z. B. Spironolacton, Triamteren, Amilorid, Kaliumpraparate, kaliumhaltige Salze und Heparin)

andere blutdrucksenkende oder gefa?erweiternde Arzneimittel

Narkosemittel und Medikamente zur Behandlung von psychischen Storungen oder Depressionen, wie Lithium und Psychosen, trizyklische Antidepressiva oder Beruhigungsmittel

Diuretika (Entwasserungstabletten)

Schmerzmittel und Medikamente gegen Entzundungen, z. B. Ibuprofen, Indometacin und Acetylsalicylsaure (>300 mg/Tag)

Natriumaurothiomalat (Gold), ein injizierbares Medikament gegen rheumatische Arthritis

Sympathomimetika, Medikamente wie Ephedrin, Noradrenalin und Adrenalin, verwendet fur die Behandlung von niedrigem Blutdruck, Schock, Herzinsuffizienz, Asthma oder Allergien

Arzneimittel, die eine bestimmte EKG-Veranderung (QT-Verlangerung) auslosen konnen (z. B. Chinidin, Amiodaron - fragen Sie Ihren Arzt um Rat)

Procainamid (Arzneimittel gegen Herzrhythmusstorungen)

Sotalol (Arzneimittel zur Behandlung von unregelma?igem Herzschlag und hohem Blutdruck)

Medikamente zur Senkung des Blutzuckerspiegels wie z. B. Insulin oder orale Antidiabetika

Cholestyramin - oder Colestipol-Ionenaustauscher zur Senkung der Blutfette

Kortikosteroide: hormonartige, entzundungshemmende Substanzen

Corticotropin (ACTH), wird hauptsachlich zur Prufung der Nebennierenfunktion angewendet

Muskelrelaxanzien: Arzneimittel, die wahrend einer Operation die Muskeln entspannen (z. B. Tubocurarin-Chlorid)

Anasthetika (Betaubungsmittel z. B. im Rahmen von Operationen)

Allopurinol, Probenecid, Sulfinpyrazon und andere Gicht-Medikamente

Krebsmedikamente wie Cyclophosphamid oder Methotrexat

Medikamente zur Unterdruckung des korpereigenen Immunsystems bzw. zur Verhinderung von Absto?ungsreaktionen nach einer Organ - oder Knochenmarktransplantation

Ciclosporin, zur Verhinderung von Absto?ungsreaktionen nach einer Organ - oder Knochenmarktransplantation

Herzglykoside: Medikamente zur Starkung des Herzens (z. B. Digoxin)

Medikamente, die als Nebenwirkung zu Storungen der Reizleitung am Herzen fuhren: z. B. Medikamente gegen Herzrhythmusstorungen, manche Medikamente zur Behandlung von Psychosen und weitere Medikamente wie z. B. Medikamente zur Behandlung bakterieller Infektionen

sonstige Arzneimittel zur Behandlung des Bluthochdrucks

Ihr Arzt muss unter Umstanden Ihre Dosierung anpassen und/oder sonstige Vorsichtsma?nahmen treffen: Wenn Sie einen Angiotensin-II-Rezeptor-Antagonisten oder Aliskiren einnehmen (siehe auch Abschnitte „Co-Enac Hexal darf nicht eingenommen werden“ und „Warnhinweise und Vorsichtsma?nahmen“).

Amphotericin B und andere Medikamente gegen Pilzinfektionen

Arzneimittel, die den Kaliumgehalt des Blutes vermindern konnen, wie Laxantien (Arzneimittel gegen Verstopfung), Diuretika (Entwasserungstabletten), steroidhaltige Arzneimittel gegen Entzundungen (z. B. Prednisolon), ACTH (zur Prufung der ordnungsgema?en Funktion der Nebennieren)

jodhaltige Kontrastmittel, die bei Rontgenuntersuchungen die Gefa?e und Organe besser sichtbar machen

Alkohol

Einnahme von Co-Enac Hexal zusammen mit Nahrungsmitteln und Getranken

Co-Enac Hexal kann unabhangig von den Mahlzeiten eingenommen werden.

Der Genuss von Alkohol zusammen mit diesem Arzneimittel kann die blutdrucksenkende Wirkung verstarken (und u. a. zu Schwindel beim Aufstehen fuhren).

Schwangerschaft und Stillzeit

Wenn Sie schwanger sind oder stillen, oder wenn Sie vermuten, schwanger zu sein oder beabsichtigen, schwanger zu werden, fragen Sie vor der Einnahme dieses Arzneimittels Ihren Arzt oder Apotheker um Rat.

Sie mussen Ihren Arzt informieren, wenn Sie glauben, dass Sie schwanger sind (oder es werden konnten). Normalerweise wird Ihr Arzt Ihnen raten, die Einnahme von Co-Enac Hexal zu beenden bevor oder sobald eine Schwangerschaft eintritt und wird Ihnen raten, anstatt Co-Enac Hexal ein anderes Arzneimittel einzunehmen. Co-Enac Hexal wird in der Fruhschwangerschaft nicht empfohlen und darf nicht eingenommen werden, wenn Sie das dritte Schwangerschaftsmonat uberschritten haben, da es Ihrem Kind ab dem dritten Schwangerschaftsmonat ernsthaft schaden kann.

Wenn Sie stillen oder beabsichtigen zu stillen, fragen Sie vor der Einnahme dieses Arzneimittels Ihren Arzt um Rat. Dieses Arzneimittel wird fur stillende Mutter nicht empfohlen. Ihr Arzt wird eine andere Behandlung fur Sie wahlen, wenn Sie stillen mochten, insbesondere, wenn Sie ein neu - oder fruhgeborenes Baby haben.

Verkehrstuchtigkeit und Fahigkeit zum Bedienen von Maschinen

Achtung: Dieses Arzneimittel kann die Reaktionsfahigkeit und Verkehrstuchtigkeit beeintrachtigen.

Wie bei vielen anderen blutdrucksenkenden Arzneimitteln kann bei der Einnahme von Co - Enac Hexal durch Blutdruckabfall, Schwindel und Benommenheit die Fahigkeit zur aktiven Teilnahme am Stra?enverkehr oder zum Bedienen von Maschinen beeintrachtigt werden. Dies gilt in verstarktem Ma?e bei Behandlungsbeginn, bei Dosisanderungen oder bei gleichzeitiger Einnahme von Alkohol. Ob das der Fall ist, hangt von der individuellen Empfindlichkeit ab. Wenn Sie davon betroffen sind, durfen Sie sich nicht ans Steuer eines Fahrzeugs setzen und keine Maschinen bedienen.

Co-Enac Hexal enthalt Lactose

Dieses Arzneimittel enthalt Lactose. Bitte nehmen Sie Co-Enac Hexal erst nach Rucksprache mit Ihrem Arzt ein, wenn Ihnen bekannt ist, dass Sie unter einer Zuckerunvertraglichkeit leiden.

3 Wie wird es angewendet?

Nehmen Sie dieses Arzneimittel immer genau nach Absprache mit Ihrem Arzt oder Apotheker ein. Fragen Sie bei Ihrem Arzt oder Apotheker nach, wenn Sie sich nicht sicher sind.

Die ubliche Dosis ist einmal taglich 1 Tablette.

Ihr Arzt wird die Enalapril - und die Hydrochlorothiazid-Dosis sorgfaltig anpassen, unter bestimmten Umstanden wird empfohlen, mit einer halben Tablette taglich die Behandlung zu beginnen.

Patienten mit Nierenproblemen

Ihr Arzt wird die Enalapril - und die Hydrochlorothiazid-Dosis sorgfaltig anpassen.

Wenn Sie gerade andere Diuretika („Wassertabletten") einnehmen, sollten Sie die Einnahme 2 - 3 Tage vor Beginn der Behandlung mit Co-Enac Hexal beenden.

Art der Anwendung

Die Tabletten konnen vor, wahrend oder nach den Mahlzeiten mit Flussigkeit eingenommen werden.

Zur Erleichterung der Einnahme bei Schluckbeschwerden konnen die Tabletten an der Bruchrille geteilt werden.

Teilen der Tablette:

Legen Sie die Tablette auf einen harten, flachen Untergrund mit der Bruchkerbe nach oben. Drucken Sie mit dem Finger in die Mitte der Tablette und die Tablette bricht in zwei gleiche Teile.

Wenn Sie eine gro?ere Menge von Co-Enac Hexal eingenommen haben als Sie sollten

Wenn Sie (oder jemand anders) viele Tabletten auf einmal geschluckt haben oder wenn Sie glauben, dass ein Kind eine oder mehrere der Tabletten geschluckt hat, wenden Sie sich unverzuglich an einen Arzt. Bei einer Uberdosierung sind folgende Beschwerden zu erwarten: niedriger Blutdruck, extrem schneller oder extrem langsamer Herzschlag, Herzklopfen, Schock, rasche Atmung, Husten, Ubelkeit und Erbrechen, Krampfe, Schwindel, Schlafrigkeit und Verwirrtheit oder Angst, stark vermehrtes Wasserlassen oder Unfahigkeit zum Wasserlassen. Bitte nehmen Sie diese Packungsbeilage, die verbliebenen Tabletten und das Behaltnis mit zum Krankenhaus oder zum Arzt, damit sie dort wissen, was fur Tabletten Sie eingenommen haben.

Wenn Sie die Einnahme von Co-Enac Hexal vergessen haben

Nehmen Sie nicht die doppelte Menge ein, um eine versaumte Tablette auszugleichen, sondern nehmen Sie einfach die nachste Dosis zum normalen Zeitpunkt ein.

Wenn Sie die Einnahme von Co-Enac Hexal abbrechen

Die Behandlung des Bluthochdrucks ist eine Langzeitbehandlung und das Abbrechen der Behandlung muss mit Ihrem Arzt besprochen werden. Eine Unterbrechung oder Beendigung der Behandlung kann zu einem Anstieg Ihres Blutdrucks fuhren.

Wenn Sie weitere Fragen zur Einnahme dieses Arzneimittels haben, wenden Sie sich an Ihren Arzt oder Apotheker.

4 Was sind mogliche Nebenwirkungen?

Wie alle Arzneimittel kann auch dieses Arzneimittel Nebenwirkungen haben, die aber nicht bei jedem auftreten mussen.

Die Nebenwirkungen konnen mit folgenden Haufigkeiten auftreten:

(Haufigkeit auf Grundlage der verfugbaren Daten nicht abschatzbar)

Wenn Sie die folgenden Veranderungen bei sich bemerken, nehmen Sie Co-Enac Hexal nicht mehr ein und informieren Sie unverzuglich Ihren Arzt oder suchen Sie die Notaufnahme des nachsten Krankenhauses auf:

eine schwere allergische Reaktion, die als Angioodem bezeichnet wird (und mit Hautausschlag, Juckreiz, Schwellungen von Gliedma?en, Gesicht, Lippen, Mundhohle oder Rachen einhergeht sowie Schluckbeschwerden und Atemproblemen) Hierbei handelt es sich um eine schwerwiegende und haufige Nebenwirkung. Wenn diese Symptome auftreten, benotigen Sie dringend arztliche Hilfe oder eine Behandlung im Krankenhaus.

Gelbsucht (Gelbfarbung von Haut und Augenwei?) Diese potenziell schwerwiegende, aber seltene Nebenwirkung ist Ausdruck einer Leberentzundung. Wenn dieses Symptom auftritt, benotigen Sie dringend arztliche Hilfe oder eine Behandlung im Krankenhaus.

Co-Enac Hexal verursacht haufig niedrigen Blutdruck, der mit Schwindel - und Schwachegefuhl verbunden sein kann. Bei manchen Patienten treten diese Beschwerden nach der ersten Dosis oder nach einer Dosissteigerung auf. Wenn Sie diese Symptome bemerken, wenden Sie sich bitte unverzuglich an Ihren Arzt.

Co-Enac Hexal kann eine Abnahme der wei?en Blutkorperchen bewirken. Dadurch wird Ihre Widerstandsfahigkeit gegen Infektionen geschwacht. Wenn Sie an einer Infektion mit Symptomen wie Fieber und starker Beeintrachtigung Ihres Allgemeinzustandes erkranken oder wenn bei Ihnen Fieber mit Symptomen einer lokal begrenzten Infektion wie Halsschmerzen, Schmerzen im Mund - und Rachenraum oder Probleme beim Wasserlassen auftreten, sollten Sie unverzuglich Ihren Arzt aufsuchen. Er wird einen Bluttest durchfuhren, um zu prufen, ob die Zahl Ihrer wei?en Blutkorperchen stark zuruckgegangen ist (Agranulozytose). Es ist wichtig, dass Sie Ihren Arzt daruber informieren, welche Medikamente Sie einnehmen.

Sehr haufig klagen die Patienten, die mit Co-Enac Hexal oder anderen ACE-Hemmern behandelt werden, uber einen trockenen Husten, der uber lange Zeit andauert. Dies kann eine Nebenwirkung des Medikaments, aber auch das Symptom einer anderen Erkrankung der oberen Atemwege sein. Sie sollten sich an Ihren Arzt wenden, wenn dieses Symptom bei Ihnen auftritt.

Auch uber die folgenden Nebenwirkungen wurde berichtet:

verschwommenes Sehen

Schwindel/Benommenheit

Ubelkeit

Schwache/Kraftlosigkeit

trockener Reizhusten

Kopfschmerzen, Depressionen, Ohnmachtsanfalle, Geschmacksstorungen

erniedrigte oder erhohte Kaliumwerte im Blut, erhohte Cholesterin - oder Fettwerte im Blut, erhohte Harnsaure-Werte im Blut

Blutdruckabfall, Blutdruckabfall bei Veranderung der Korperhaltung (z. B. Schwindelgefuhl oder Schwache beim Aufstehen aus dem Liegen), Brustschmerzen, abnormer Herzrhythmus, abnorm beschleunigter Herzschlag (Tachykardie)

Kurzatmigkeit, Atemnot

Schmerzen im Brustkorb

Durchfall, Bauchschmerzen

Hautausschlag, allergische Reaktionen mit Schwellung von Armen und Beinen, Gesicht, Lippen, Zunge und/oder Rachen zusammen mit Schluck - oder Atembeschwerden

Mudigkeit

hohe Kaliumspiegel im Blut, die einen abnormen Herzrhythmus verursachen konnen; Anstieg des Kreatininspiegels im Blut, Anstieg von Cholesterin und Triglyzeriden

Angina pectoris

Muskelkrampfe**

Depression

Blutarmut (Anamie) und dadurch Schwache oder Atemnot

niedrige Blutzucker-Werte (Hypoglykamie), niedrige Magnesium-Werte (Hypomagnesiamie) oder niedrige Natrium-Werte (Hyponatriamie) im Blut, Gicht*

Verwirrtheit, Schlafrigkeit, Schlaflosigkeit, Nervositat, Kribbelgefuhl, Ameisenlaufen oder Taubheitsgefuhl, Schwindel

Blutdruckabfall bei Veranderung der Korperhaltung

Klingeln in den Ohren (Tinnitus)

Herzklopfen

Herzinfarkt oder Schlaganfall (zerebrovaskularer Insult): vor allem bei Patienten mit niedrigem Blutdruck

laufende Nase, Halsschmerzen, Heiserkeit, Atembeschwerden, keuchende Atmung

Darmverschluss, Bauchspeicheldrusenentzundung (Pankreatitis) mit starken Bauch - und Ruckenschmerzen, Erbrechen, Verdauungsstorungen, Verstopfung, Appetitlosigkeit, Magenreizung, Mundtrockenheit, Magengeschwur, Blahungen*

Vermehrtes Schwitzen, Juckreiz, Quaddelbildung, Haarausfall

Nierenprobleme, Eiwei? im Urin

Impotenz, vermindertes sexuelles Verlangen*

Unwohlsein, Fieber, Gelenksschmerzen*

Anstieg des Harnstoffspiegels im Blut

Abnahme der roten Blutkorperchen mit der Folge von Hautblasse

Abnahme der wei?en Blutkorperchen und, daraus folgend, Zunahme des Infektionsrisikos; Abnahme anderer Blutzellen, Veranderungen der Blutzusammensetzung, verminderte Aktivitat des Knochenmarks, Erkrankung der Lymphknoten, Autoimmunkrankheiten (Krankheiten, bei denen der Korper sich selbst angreift)

abnorme Traume, Schlafstorungen, Taubheitsgefuhl

Raynaud-Syndrom: Erkrankung der Blutgefa?e, bei der die Finger und Zehen zuerst prickeln, dann blass werden und sich dann blaulich und schlie?lich rotlich verfarben

Lungenprobleme einschlie?lich Lungenentzundung; Entzundung der Nasenschleim - haut, laufende Nase (Rhinitis)

Geschwure in der Mundhohle, Entzundung der Zunge und der Mundschleimhaut

Erhohung der Leberwerte und des Bilirubins im Blut, Leberentzundung (Hepatitis), Leberversagen (auch mit todlichem Verlauf), Gelbverfarbung der Augen und der Haut (Gelbsucht), Entzundung der Gallenblase (insbesondere bei Patienten mit Gallensteinen)

Hautausschlag, starke Blasenbildung, Rotung der Haut, Stevens-Johnson-Syndrom (Blasenbildung der Haut an Mund, Augen und Genitalien), Hauterkrankung mit roten, schuppigen Flecken uber der Nase und den Wangen (Lupus erythematodes), Pemphigus (eine Krankheit mit Blasenbildung) und andere umschriebene Hautveranderungen, die normalerweise im Mund beginnen, Nesselausschlag, Haarausfall und Juckreiz Manchmal sind die Hautprobleme von Fieber, schwerwiegenden Entzundungen, Gefa?entzundungen, Muskelschmerzen und/oder Gelenksschmerzen, Veranderungen der Blutzusammensetzung und einer beschleunigten Blutsenkungsgeschwindigkeit (Bluttest zum Nachweis von Entzundungen) begleitet.

verminderte Harnausscheidung (Oligurie), Blut im Urin als mogliches Anzeichen fur Nierenprobleme (interstitielle Nephritis)

Anstieg des Blutzuckers

Brustvergro?erung bei Mannern

Schwellungen im Darm

erhohter Kalziumspiegel im Blut

Speicheldrusenentzundung

Erkrankungen des Hormonhaushalts (Syndrom der inadaquaten antidiuretischen Hormon Sekretion)

Zuckerausscheidung im Urin; niedrige Kaliumspiegel im Blut, die zu Muskelschwache, Muskelzucken oder Herzrhythmusstorungen fuhren konnen; die zu Bauchschmerzen, Ubelkeit und Erbrechen, Verstopfung, Appetitlosigkeit, uberma?igem Durst, vermehrtem Wasserlassen und Gewichtsverlust fuhren konnen

nekrotisierende Angiitis (Krankheit mit Entzundung von Blutgefa?en)

uberma?ige Lichtempfindlichkeit der Haut, schwere allergische Reaktionen, Wiederauftreten von Hauterkrankung mit roten, schuppigen Flecken uber der Nase und den Wangen (Lupus erythematodes; bei Patienten, die bereits an einer solchen Hautkrankheit leiden, kann sich diese verschlimmern)

Gelbsucht

Ruhelosigkeit

Gelbsehen, akute Kurzsichtigkeit, akutes Engwinkelglaukom

Beobachtet nur bei Hydrochlorothiazid-Dosen von 12,5 mg und 25 mg.

Haufig traten Muskelkrampfe nur bei Hydrochlorothiazid-Dosen von 12,5 mg und 25 mg auf, gelegentlich bei Hydrochlorothiazid-Dosen von 6 mg.

Meldung von Nebenwirkungen

Wenn Sie Nebenwirkungen bemerken, wenden Sie sich an Ihren Arzt oder Apotheker. Dies gilt auch fur Nebenwirkungen, die nicht in dieser Packungsbeilage angegeben sind.

Sie konnen Nebenwirkungen auch direkt uber das nationale Meldesystem anzeigen.

Bundesamt fur Sicherheit im Gesundheitswesen Traisengasse 5

1200 WIEN OSTERREICH

Fax: + 43 (0) 50 555 36207 Website: http://www. basg. gv. at/

Indem Sie Nebenwirkungen melden, konnen Sie dazu beitragen, dass mehr Informationen uber die Sicherheit dieses Arzneimittels zur Verfugung gestellt werden.

5 Wie soll es aufbewahrt werden?

Nicht uber 30°C lagern.

Bewahren Sie dieses Arzneimittel fur Kinder unzuganglich auf.

Sie durfen dieses Arzneimittel nach dem auf dem Umkarton nach „verwendbar bis:“ und am Blister nach „verw bis:“ angegebenen Verfalldatum nicht mehr verwenden. Das Verfalldatum bezieht sich auf den letzten Tag des angegebenen Monats.

Entsorgen Sie Arzneimittel nicht im Abwasser oder Haushaltsabfall. Fragen Sie Ihren Apotheker, wie das Arzneimittel zu entsorgen ist, wenn Sie es nicht mehr verwenden. Sie tragen damit zum Schutz der Umwelt bei.

6 Weitere Informationen

Was Co-Enac Hexal enthalt

Die Wirkstoffe sind Enalapril und Hydrochlorothiazid (HCT).

1 Tablette enthalt 20 mg Enalaprilmaleat und 12,5 mg Hydrochlorothiazid.

Die sonstigen Bestandteile sind:

Natriumhydrogencarbonat, Maisstarke, Lactose-Monohydrat, Calciumhydrogenphosphat - Dihydrat, Talk, Magnesiumstearat

Wie Co-Enac Hexal aussieht und Inhalt der Packung

Wei?e, ovale, bikonvexe Snap-tap Tablette mit einseitiger Bruchrille und auf der anderen Seite mit dem Aufdruck „E H“.

Die Tablette kann in gleiche Dosen geteilt werden. Packungsgro?e: 30 Stuck

Pharmazeutischer Unternehmer und Hersteller

Hexal Pharma GmbH, 1020 Wien, Osterreich

Salutas Pharma GmbH, 39179 Barleben, Deutschland

Biclopan (diclofenac sodium) drug & pharmaceuticals, biclopan

Medication: Biclopan

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Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products:

Biclopan available forms, composition, doses:

Biclopan destination | category:

Human:

Analgesics (non-opioid) and antipyretics

Cyclooxygenase-2 (COX-2) inhibitors

Dermatologicals

Mouth / throat preparations

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Nonsteroidal antiimflammatory agents

Ophthalmic decongestants, anesthetics, anti-inflammatories

Indications and usages, anatomical therapeutic chemical and diseases classification codes:

Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers:

Reviews:

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Biaxin (Klarexyl)

Biaxin is used for treating infections caused by certain bacteria. Biaxin is a macrolide antibiotic. It works by stopping the growth of or killing sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.

Use Biaxin as directed by your doctor.

Take Biaxin by mouth with or without food.

Biaxin works best if it is taken at the same time each day.

Continue to take Biaxin even if you feel well.

Do not miss any dose. If you miss a dose of Biaxin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Biaxin.

Store Biaxin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Biaxin out of the reach of children and away from pets.

Active Ingredient: Clarithromycin.

Do NOT use Biaxin if:

you are allergic to any ingredient in Biaxin or to any other macrolide (eg, erythromycin)

you are taking cisapride, cyclosporine, dofetilide, eletriptan, an ergot alkaloid (eg, dihydroergotamine, ergotamine), an H 1 antagonist (eg, astemizole, terfenadine), pimozide, a QT-prolonging agent (eg, quinidine, sotalol, thioridazine), a quinolone (eg, ciprofloxacin), or sumatriptan.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Biaxin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, a blood disorder, severe kidney problems, or liver problems.

Some medicines may interact with Biaxin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aldosterone blockers (eg, spironolactone), anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam), buspirone, carbamazepine, cilostazol, cisapride, colchicine, corticosteroids (eg, hydrocortisone), cyclosporine, digoxin, disopyramide, eletriptan, ergot alkaloids (eg, ergotamine, dihydroergotamine), H 1 antagonists (eg, astemizole, terfenadine), HMG-CoA reductase inhibitors (eg, simvastatin), imatinib, macrolide immunosuppressants (eg, tacrolimus), macrolides and ketolides (eg, azithromycin, erythromycin), phosphodiesterase type 5 inhibitors (eg, sildenafil), rifampin, sumatriptan, theophyllines, or verapamil because their actions and the risk of their side effects may be increased by Biaxin

Dofetilide, macrolides and ketolides (eg, azithromycin, erythromycin), pimozide, QT-prolonging agents (eg, quinidine, sotalol, thioridazine), quinolones (eg, ciprofloxacin), or streptogramins (eg, mikamycin) because serious, possibly life-threatening side effects on the heart or irregular heartbeat may occur

Rifampin because it may decrease Biaxin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Biaxin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Biaxin only works against bacteria; it does not treat viral infections (eg, the common cold).

Long-term or repeated use of Biaxin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Be sure to use Biaxin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Lab tests, including complete blood cell counts, may be performed while you use Biaxin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Biaxin should not be used in children younger 6 months; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Biaxin has been shown to cause harm to the fetus. Biaxin is not recommended for use during pregnancy except when no other antibiotics can be used. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Biaxin while you are pregnant. It is not known if Biaxin is found in breast milk. If you are or will be breast-feeding while you use Biaxin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Abnormal taste; diarrhea; headache; indigestion; nausea; stomach discomfort; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; decreased urination; depression; emotional or mood changes; hallucinations; nightmares; severe diarrhea; severe stomach pain/cramps; trouble sleeping.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Buy dolocort diclofenac online without prescriptions, dolocort

Diclofenac is used primarily for the treatment of inflammation and pain caused by conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also effective in treating soft tissue inflammations due to tendinitis and bursitis, and treating dysmenorrhea (menstrual cramps). Diclofenac is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Diclofenac as directed by your doctor!

Take Diclofenac by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Diclofenac with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Diclofenac, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac.

Store Diclofenac at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do NOT use Diclofenac if:

you are allergic to any ingredient in Diclofenac or to bovine (cow) protein

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you have severe kidney problems

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if this applies to you.

Some medical conditions may interact with Diclofenac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you smoke, drink alcohol, or have a history of alcohol abuse

if you are taking an antibiotic or an anti-seizure medicine. The risk of liver problems may be increased with some of these medicines.

Some medicines may interact with Diclofenac. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin and other blood thinners (eg, dalteparin), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Acetaminophen because the risk of liver problems may be increased

Probenecid because it may increase the risk of Diclofenac's side effects

Cyclosporine, lithium, metformin, methotrexate, oral NSAIDs (eg, ibuprofen), or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Diclofenac

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Diclofenac.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Diclofenac may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Diclofenac. Taking it in high doses, for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Diclofenac with food will NOT reduce the risk of these effects. If you have severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling, contact your doctor or emergency room right away.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Diclofenac is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Diclofenac unless your doctor tells you to.

Check with your doctor or pharmacist before you take acetaminophen while you are taking Diclofenac. The risk of liver problems may be increased.

Do not switch between different forms of Diclofenac (eg, enteric-coated tablets, immediate-release tablets, capsules) unless your doctor tells you to. They may not provide the same amount of medicine to your body.

Lab tests, including kidney function, liver function, blood electrolyte levels, complete blood cell counts, and blood pressure, may be performed while you use Diclofenac. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Diclofenac with caution in the elderly; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.

Diclofenac should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Diclofenac may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breastfeed while taking Diclofenac.

Glevo 750mg; tablet, glenmark pharmaceuticals limited, glevo 750mg

GLEVO 750mg - Tablet, Glenmark Pharmaceuticals Limited

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Cefaclor 500mg, cefaclor 500mg

FORMA FARMACпїЅUTICA Y FORMULACIпїЅN:

Cada cпїЅpsula contiene:

Cefaclor monohidratado equivalente a. 250 mg de cefaclor

Excipiente, c. b.p. 1 cпїЅpsula.

CEFACLOR es un antibiпїЅtico cefalosporпїЅnico semisintпїЅtico de segunda generaciпїЅn. La acciпїЅn bactericida de las cefalosporinas se debe a la inhibiпїЅciпїЅn de la sпїЅntesis de pared celular.

CEFACLOR estпїЅ indicado para el tratamiento de las siguientes infecciones cuando son causadas por пїЅcepas susceptibles de los microorganismos designados:

Otitis media: Causada por S. pneumoniae, H. influenzae estafilococos y M. catarrhalis.

Sinusitis aguda y crпїЅnica: Por S. pneumoniae, H. influenzae y M. catarrhalis.

Infecciones del aparato respiratorio inferior incluyendo bronquitis aguda, exacerbaciones agudas de bronquitis crпїЅnica y neumonпїЅa: Por S. pneumoniae H. influenzae S. pyogenes (estreptococos betahemolпїЅticos del grupo A) y M. catarrhalis.

Infecciones del aparato respiratorio superior incluyendo faringitis y amigdalitis: Por S. pyogenes (estreptococos betahemolпїЅticos del grupo A).

Infecciones del aparato urinario incluyendo pielonefritis cistitis y uretritis: Por E. coli P. mirabilis especies de Klebsiella y estafilococos coagulasa-negativos.

Infecciones de la piel y tejido subcutпїЅneo: Por Staphylococcus aureus y S. pyogenes (estreptococos betahemolпїЅticos del grupo A).

Se deben hacer cultivos y estudios de susceptibilidad adecuados para determinar la susceptibilidad a CEFACLOR de las bacterias causales. El CEFACLOR es inactivo contra los estafilococos resistentes a la meticilina. Pseudomonas spp, Acinetobacter calcoaceticus, la mayorпїЅa de las cepas de enterococos, Enterobacter spp, Morganella morganii, Providencia rettgeri, H. Influenzae, betalactamasa negativo-resistente a ampicilina Proteus indol-positivos, Serratia spp, son resistentes a CEFACLOR.

CONTRAINDICACIONES: Hipersensibilidad a las cefalosporinas.

CEFACLOR debe administrarse con cautela a los pacientes con marcada insuficiencia renal. Debido a que la vida media de CEFACLOR en la anuria es de 2.3 a 2.8 horas, no suele ser necesario hacer ajuste de dosis en los enfermos con insuficiencia renal moderada o severa. La experiencia clпїЅnica con CEFACLOR en estas condiciones es limitada; por tanto, se debe hacer una observaciпїЅn clпїЅnica cuidadosa y los estudios de laboratorio necesarios. Antes de instituir el tratamiento con CEFACLOR, es preciso hacer un interrogatorio minucioso para determinar si el paciente ha tenido reacciones previas de hipersensibilidad a cefalosporinas, penicilinas u otros medicamentos. En caso de que este producto se vaya a administrar en pacientes sensibles a la penicilina, es preciso proceder con cautela, ya que se ha documentado claramente hipersensibilidad cruzada, incluyendo anafilaxia entre antibiпїЅticos betalactпїЅmicos.

RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA:

La seguridad de CEFACLOR durante el embarazo no se ha establecido. La evaluaciпїЅn de estudios experimentales en animales, no indica efectos daпїЅinos directos o indirectos en lo que respecta al desarrollo del embriпїЅn o feto en el curso de la gestaciпїЅn y el desarrollo peri y posnatal. CEFACLOR debe ser utilizado durante el embarazo sпїЅlo si es estrictamente necesario, valorando el riesgo/beneficio y bajo responsabilidad del mпїЅdico tratante.

No se han realizado estudios con CEFACLOR en mujeres que amamantan; sin embargo, CEFACLOR se excreta en la leche materna despuпїЅs de la administraciпїЅn de dosis пїЅnicas de 500 mg. La concentraciпїЅn promedio fue de 0.18, 0.20, 0.21 y 0.16 пїЅg/ml a las 2, 3, 4 y 5 horas, respectivamente. A la hora se identificaron huellas del medicamento. Se desconoce cuпїЅl sea el efecto en los niпїЅos lactantes. Se debe ser cauteloso al administrar CEFACLOR a una mujer que estпїЅ amamantando.

REACCIONES SECUNDARIAS Y ADVERSAS:

Gastrointestinales: Ictericia colestпїЅsica, diarrea, nпїЅusea, colitis seudomembranosa, vпїЅmito.

HematolпїЅgicas: Agranulocitosis, eosinofilia, anemia hemolпїЅtica, neutropenia, trombocitopenia.

Renales: Nefritis intersticial, alteraciпїЅn de las pruebas de funciпїЅn renal.

DermatolпїЅgicas: Eritema multiforme, reacciones de hipersensibilidad, prurito, erupciпїЅn cutпїЅnea, reacciones semejantes a la enfermedad del suero, sпїЅndrome de Stevens-Johnson, necrпїЅlisis tпїЅxica epidпїЅrmica, пїЅurticaria.

Otras: Angioedema, artralgia, artritis, fiebre, moniliasis.

Se ha informado de casos raros de reacciones similares a la enfermedad del suero caracterizadas por erupciпїЅn cutпїЅnea, tпїЅpicamente urticaria o eritema multiforme, y una alteraciпїЅn articular como artritis o artralgia. Muy rara vez se han reportado linfadenopatпїЅa y afecciпїЅn renal en contraste con las descripciones clпїЅsicas de la enfermedad del suero.

No se ha identificado un patrпїЅn de asociaciпїЅn con medicamentos previos o concomitantes.

Los sпїЅntomas suelen aparecer a los siete dпїЅas despuпїЅs de indicado el tratamiento y durante 1 y 2 semanas. Ocasionalmente, la hospitalizaciпїЅn es necesaria para tratamiento de soporte. Generalmente, la recuperaciпїЅn es completa.

INTERACCIONES MEDICAMENTOSAS Y DE OTRO GпїЅNERO:

Han habido reportes raros de aumento en el efecto anticoagulante con la administraciпїЅn concomitante de CEFACLOR y anticoagulantes orales.

PRECAUCIONES EN RELACIпїЅN CON EFECTOS DE CARCINOGпїЅNESIS, MUTAGпїЅNESIS, TERATOGпїЅNESIS Y SOBRE LA FERTILIDAD:

No se han realizado estudios para determinar el potencial carcinogпїЅnico o mutagпїЅnico. Se han realizado estudios de reproducciпїЅn en ratones y ratas a dosis hasta de 12 veces la dosis en humanos y en hurones hasta 3 veces la dosis mпїЅxima en humanos sin que se observaran evidencias de deterioro en la fertilidad o daпїЅo al feto debido a CEFACLOR.

DOSIS Y VпїЅA DE ADMINISTRACIпїЅN:

Adultos: La dosis recomendada para adultos es de 250 mg cada 8 horas. Para infecciones mпїЅs severas (como neumonпїЅa) o aquпїЅllas causadas por organismos menos sensibles, la dosis se debe duplicar (500 mg cada 8 horas).

La dosis total diaria no debe exceder 4 g/dпїЅa por 28 dпїЅas. Para sinusitis, se recomienda una dosis de 500 mg cada 8 horas por 10 dпїЅas. En el traпїЅtaпїЅmiento de la uretritis gonocпїЅcica aguda, en hombres y mujeres, se administra una dosis пїЅnica de 3 g en combinaciпїЅn con 1 g de probenecid.

Lactantes menores: La seguridad y eficacia de CEFACLOR en menores de un mes de edad no se ha establecido.

Tratamiento opcional de 2 veces al dпїЅa: Para el tratamiento de la otitis media y faringitis, la dosis total diaria puede ser fraccionada y administrada cada 12 horas.

Insuficiencia renal: Por lo general, no se requiere ajuste de la dosis en presencia de insuficiencia renal moderada o severa. En el tratamiento de las infecciones por estreptococos betahemolпїЅticos, se debe administrar una dosis terapпїЅutica de CEFACLOR por lo menos durante 10 dпїЅas.

MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACIпїЅN O INGESTA ACCIDENTAL:

NпїЅusea, vпїЅmito, malestar epigпїЅstrico y diarrea. La sobredosis de cefalosporinas puede causar convulsiones. El manejo general consiste en terapia de apoyo.

Se puede disminuir la absorciпїЅn con la administraciпїЅn del carbпїЅn activado en lugar de o en adiciпїЅn al lavado gпїЅstrico.

A menos que se haya ingerido 5 veces la dosis normal de CEFACLOR, el lavado gпїЅstrico no serпїЅ necesario.

RECOMENDACIONES SOBRE ALMACENAMIENTO:

ConsпїЅrvese a temperatura ambiente a no mпїЅs de 30пїЅC y en lugar seco.

LEYENDAS DE PROTECCIпїЅN:

Literatura exclusiva para mпїЅdicos. No se deje al alcance de los niпїЅos. Su venta requiere receta mпїЅdica. La administraciпїЅn de este medicamento durante el embarazo, queda bajo responsabilidad del mпїЅdico.

NOMBRE Y DOMICILIO DEL LABORATORIO:

VпїЅase PresentaciпїЅn o Presentaciones.

PRESENTACIпїЅN O PRESENTACIONES:

Fuente: S. S.A. CatпїЅlogo de Medicamentos GenпїЅricos Intercambiables para farmacias y pпїЅblico en general al 3 de agosto de 2007. Con el objeto de demostrar la intercambiabilidad a que se refiere el artпїЅculo 75 del reglamento de Insumos para la Salud, los medicamentos que integran el CatпїЅlogo de Medicamentos GenпїЅricos Intercambiables han sido comparados, siguiendo los lineamientos indicados por la NOM-177SSA1-1998, contra los productos innovadores o de referencia enlistados en las pпїЅgs. 11 a 22 donde usted lo podrпїЅ consultar.

Home - de nederlandse zo?technische vereniging, klenzit

for English click here

Deze zal dit jaar voor het eerst uitgereikt worden door NZV om studenten en pas afgestudeerden te motiveren innovatieve ideeën te ontwikkelen en te delen met geïnteresseerden uit de sector. NZV wil hiermee innovatie in de agrarische sector bevorderen.

Facebook, Uber, Plant-E en andere startups hebben een aantal dingen met elkaar gemeen: vernieuwend voor hun ‘sector’, begonnen op een ‘zolderkamer', vaak gestart door studenten of pas-afgestudeerden en binnen een paar jaar impact op lokaal - of zelfs wereldniveau! De van oudsher nog wat traditionele veehouderij is ook toe aan vernieuwende ideeën om in te spelen op de vraag naar lokale, biologische of authentieke producten, de wereldbevolking te blijven voeden, de vraag naar vlees en zuivel te kunnen voldoen, een verantwoorde bijdrage te leveren aan milieu en economie, antibioticagebruik te reduceren, Big-Data in de keten in te zetten, enz. enz.

Heb jij een idee hoe? Of heb je met je jaarclub, commissie of ondervereniging wel eens gebrainstormd over hoe het anders kan? Deel je idee, draag bij aan de toekomst van de veehouderij en wie weet, win je die Award! >> Lees meer

Inspiration dinner - Vitaliseer de varkenshouderij

Naar aanleiding van het 'Actieplan vitalisering varkenshouderij' organiseerde NZV op 6 september 2016 een Inspiration Dinner.

Het Actieplan is opgesteld door de Regiegroep Vitale Varkenshouderij, waar het Ministerie Economische Zaken, Rabobank en de Producenten Organisatie Varkenshouderij (POV) een positie hebben.

Terugblik Social Evening ism De Veetelers - 8 juni 2016

Ieder jaar organiseren NZV en de Social Evening commissie van studievereniging ''De Veetelers'' uit Wageningen een gezamenlijke Social Evening met inleidingen en discussie over een actueel thema. Thema dit keer: Dierlijk vs. plantaardig eiwit: wat heeft de toekomst? Ga voor een verslag van de bijeenkomst, foto's en presentaties naar deze webpagina .

Terugblik NZV-Lustrum - 5 november 2015

De Nederlandse Zoötechnische Vereniging vierde op 5 november 2015 haar 85-jarig bestaan. Waar de NZV ooit begon als vereniging om inhoudelijke kennis uit te wisselen over veeteelt zien we nu de kracht van het netwerk, inmiddels wereldwijd. Het lustrumthema was daarom: ‘De rol van de veetelers over de hele wereld’.

Het programma ter gelegenheid van het 85-jarig bestaan van de NZV gaf een indruk van de kansen en vraagstukken die wereldwijd spelen en de rol die de dierwetenschapper kan spelen bij de aanpak van deze vraagstukken. Deze invalshoek bood een mooie kans om diepgaand met elkaar kennis te delen en in debat te gaan. Klik hier voor het programma, presentaties en foto's

Inloggen voor leden van de NZV

Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices, zok-zid

Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices

Abstract

The aim of this study was to develop a multilayer (core/coat) dosage form via co-extrusion, the core providing sustained drug release and the coat immediate drug release. In this study polymers were selected which can be combined in a co-extruded dosage form. Several thermoplastic polymers were hot-melt extruded and evaluated for processability and macroscopic properties (surface smoothness, die swell). Metoprolol tartrate (MPT) and hydrochlorothiazide (HCT) were incorporated as sustained and immediate release model drugs, respectively. Based on the polymer screening experiments a combination of polycaprolactone (core) and polyethylene oxide (coat) was selected for co-extrusion trials, taking into account their drug release profiles and extrusion temperature (70 °C). This combination (containing 10% HCT in the coat and 45% MPT in the core) was successfully co-extruded (diameter core: 3 mm/thickness coat: 0.5 mm). Adhesion between the two polymer layers was good. HCT release from the coat was complete within 30 min, while MPT release was sustained over 24 h (55%, 70%, 85% and 100% after 4, 8, 12 and 24 h, respectively). DSC, XRD and Raman spectroscopy revealed that MPT remained crystalline during extrusion, whereas HCT was dissolved in the polyethylene oxide matrix. The in vivo study revealed no significant differences between the experimental formulation and the reference formulation (Zok-Zid® tablet). Fixed-dose combination mini-tablets with good in vitro and in vivo performance were successfully developed by means of co-extrusion, using a combination of polycaprolactone and polyethylene oxide.

Graphical abstract

Production and characterization of co-extruded formulation

Keywords

Co-extrusion ;

Hot-melt extrusion ;

Multiple-unit dosage form ;

Polycaprolactone ;

Polyethylene oxide ;

Sustained release

Corresponding author. Ghent University, Laboratory of Pharmaceutical Technology, Harelbekestraat 72, 9000 Ghent, Belgium. Tel. +32 9 264 80 54; fax: +32 9 222 82 36.

Copyright © 2012 Elsevier B. V. All rights reserved.

Aquacel hydrofiber dressings, aquacil

AQUACEL Ag Hydrofiber Wound Dressings - 4in x 4.7in

Description

Aquacel ag 4" x 4.7" antimicrobial hydrofiber dressing with ionic silver. Sold by the box of 10. AQUACEL Ag dressing incorporating unique Hydrofiber Technology with 1.2% (w/w) silver combines the favorable gelling characteristics of Hydrofiber Technology with the broad-spectrum antimicrobial properties of ionic silver (Ag+). It is a versatile primary dressing indicated for moderate to highly exuding chronic and acute wounds where there is an infection* or an increased risk of infection. * when used in a comprehensive protocol of care. Also available in ribbon form, with stichbonding for added strength.

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Reviews

Displaying all 3 reviews

I have utilized the AQUACEL Ag Dressings in the past. It is an outstanding product!

Posted by Bruce T. Kowalski on Aug 19, 2015

I have utilized the AQUACEL Ag Dressings in the past. It is an outstanding product!

I have used this product and it has reduced my incidents of infection and kept my wound clean.

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I have used this product and it has reduced my incidents of infection and kept my wound clean.

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Used for healing large or small wounds

Cefzil - fda prescribing information, side effects and uses, cefzil 500mg

Cefzil

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefzil ® and other antibacterial drugs, Cefzil should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Cefzil Description

Cefzil (cefprozil) is a semi-synthetic broad-spectrum cephalosporin antibiotic.

Cefprozil is a cis and trans isomeric mixture (≥90% cis). The chemical name for the monohydrate is (6 R ,7 R )-7-[( R )-2-Amino-2-( p - hydroxyphenyl)acetamido] - 8 - oxo - 3 - propenyl - 5 - thia - 1 - azabicyclo[4.2.0]oct - 2 - ene - 2 - carboxylic acid monohydrate, and the structural formula is:

Cefprozil is a white to yellowish powder with a molecular formula for the monohydrate of C 18 H 19 N 3 O 5 S•H 2 O and a molecular weight of 407.45.

Cefzil Tablets and Cefzil for Oral Suspension are intended for oral administration.

Cefzil Tablets contain cefprozil equivalent to 250 mg or 500 mg of anhydrous cefprozil. In addition, each tablet contains the following inactive ingredients: cellulose, hypromellose, magnesium stearate, methylcellulose, simethicone, sodium starch glycolate, polyethylene glycol, polysorbate 80, sorbic acid, and titanium dioxide. The 250 mg tablets also contain FD&C Yellow No. 6.

Cefzil for Oral Suspension contains cefprozil equivalent to 125 mg or 250 mg anhydrous cefprozil per 5 mL constituted suspension. In addition, the oral suspension contains the following inactive ingredients: aspartame, cellulose, citric acid, colloidal silicone dioxide, FD&C Red No. 3, flavors (natural and artificial), glycine, polysorbate 80, simethicone, sodium benzoate, sodium carboxymethylcellulose, sodium chloride, and sucrose.

Cefzil - Clinical Pharmacology

The pharmacokinetic data were derived from the capsule formulation; however, bioequivalence has been demonstrated for the oral solution, capsule, tablet, and suspension formulations under fasting conditions.

Following oral administration of cefprozil to fasting subjects, approximately 95% of the dose was absorbed. The average plasma half-life in normal subjects was 1.3 hours, while the steady-state volume of distribution was estimated to be 0.23 L/kg. The total body clearance and renal clearance rates were approximately 3 mL/min/kg and 2.3 mL/min/kg, respectively.

Average peak plasma concentrations after administration of 250 mg, 500 mg, or 1 g doses of cefprozil to fasting subjects were approximately 6.1, 10.5, and 18.3 µg/mL, respectively, and were obtained within 1.5 hours after dosing. Urinary recovery accounted for approximately 60% of the administered dose. (See Table .)

*Data represent mean values of 12 healthy volunteers.

During the first 4-hour period after drug administration, the average urine concentrations following 250 mg, 500 mg, and 1 g doses were approximately 700 µg/mL, 1000 µg/mL, and 2900 µg/mL, respectively.

Administration of Cefzil tablet or suspension formulation with food did not affect the extent of absorption (AUC) or the peak plasma concentration (C max ) of cefprozil. However, there was an increase of 0.25 to 0.75 hours in the time to maximum plasma concentration of cefprozil (T max ).

The bioavailability of the capsule formulation of cefprozil was not affected when administered 5 minutes following an antacid.

Plasma protein binding is approximately 36% and is independent of concentration in the range of 2 µg/mL to 20 µg/mL.

There was no evidence of accumulation of cefprozil in the plasma in individuals with normal renal function following multiple oral doses of up to 1000 mg every 8 hours for 10 days.

In patients with reduced renal function, the plasma half-life may be prolonged up to 5.2 hours depending on the degree of the renal dysfunction. In patients with complete absence of renal function, the plasma half-life of cefprozil has been shown to be as long as 5.9 hours. The half-life is shortened during hemodialysis. Excretion pathways in patients with markedly impaired renal function have not been determined. (See PRECAUTIONS and DOSAGE AND ADMINISTRATION .)

In patients with impaired hepatic function, the half-life increases to approximately 2 hours. The magnitude of the changes does not warrant a dosage adjustment for patients with impaired hepatic function.

Healthy geriatric volunteers (≥65 years old) who received a single 1-g dose of cefprozil had 35% to 60% higher AUC and 40% lower renal clearance values compared with healthy adult volunteers 20 to 40 years of age. The average AUC in young and elderly female subjects was approximately 15% to 20% higher than in young and elderly male subjects. The magnitude of these age - and gender-related changes in the pharmacokinetics of cefprozil is not sufficient to necessitate dosage adjustments.

Adequate data on CSF levels of cefprozil are not available.

Comparable pharmacokinetic parameters of cefprozil are observed between pediatric patients (6 months to 12 years) and adults following oral administration of selected matched doses. The maximum concentrations are achieved at 1 to 2 hours after dosing. The plasma elimination half-life is approximately 1.5 hours. In general, the observed plasma concentrations of cefprozil in pediatric patients at the 7.5, 15, and 30 mg/kg doses are similar to those observed within the same time frame in normal adult subjects at the 250, 500, and 1000 mg doses, respectively. The comparative plasma concentrations of cefprozil in pediatric patients and adult subjects at the equivalent dose level are presented in the table below.

a n=11; b n=5; c n=9; d n=11.

Indications and Usage for Cefzil

Cefzil is indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the conditions listed below:

UPPER RESPIRATORY TRACT

Pharyngitis/tonsillitis caused by Streptococcus pyogenes .

NOTE: The usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever, is penicillin given by the intramuscular route. Cefprozil is generally effective in the eradication of Streptococcus pyogenes from the nasopharynx; however, substantial data establishing the efficacy of cefprozil in the subsequent prevention of rheumatic fever are not available at present.

Otitis Media caused by Streptococcus pneumoniae. Haemophilus influenzae (including β-lactamase-producing strains), and Moraxella (Branhamella) catarrhalis (including β-lactamase-producing strains). (See CLINICAL STUDIES .)

NOTE: In the treatment of otitis media due to β-lactamase producing organisms, cefprozil had bacteriologic eradication rates somewhat lower than those observed with a product containing a specific β-lactamase inhibitor. In considering the use of cefprozil, lower overall eradication rates should be balanced against the susceptibility patterns of the common microbes in a given geographic area and the increased potential for toxicity with products containing β-lactamase inhibitors.

Acute Sinusitis caused by Streptococcus pneumoniae. Haemophilus influenzae (including β-lactamase-producing strains), and Moraxella (Branhamella) catarrhalis (includingβ-lactamase-producing strains).

LOWER RESPIRATORY TRACT

Secondary Bacterial Infection of Acute Bronchitis and Acute Bacterial Exacerbation of Chronic Bronchitis caused by Streptococcus pneumoniae. Haemophilus influenzae (including β-lactamase-producing strains), and Moraxella (Branhamella) catarrhalis (includingβ-lactamase-producing strains).

SKIN AND SKIN STRUCTURE

Uncomplicated Skin and Skin-Structure Infections caused by Staphylococcus aureus (including penicillinase-producing strains) and Streptococcus pyogenes. Abscesses usually require surgical drainage.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefzil and other antibacterial drugs, Cefzil should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Contraindications

Cefzil (cefprozil) is contraindicated in patients with known allergy to the cephalosporin class of antibiotics.

Warnings

BEFORE THERAPY WITH Cefzil IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO Cefzil, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. IF THIS PRODUCT IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-SENSITIVITY AMONG β-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. IF AN ALLERGIC REACTION TO Cefzil OCCURS, DISCONTINUE THE DRUG. SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED.

Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Cefzil, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile .

C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin-producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile. and surgical evaluation should be instituted as clinically indicated.

Precautions

General

Prescribing Cefzil in the absence of proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

In patients with known or suspected renal impairment (see DOSAGE AND ADMINISTRATION ), careful clinical observation and appropriate laboratory studies should be done prior to and during therapy. The total daily dose of Cefzil (cefprozil) should be reduced in these patients because high and/or prolonged plasma antibiotic concentrations can occur in such individuals from usual doses. Cephalosporins, including Cefzil, should be given with caution to patients receiving concurrent treatment with potent diuretics since these agents are suspected of adversely affecting renal function.

Prolonged use of Cefzil may result in the overgrowth of nonsusceptible organisms. Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken.

Cefprozil should be prescribed with caution in individuals with a history of gastrointestinal disease particularly colitis.

Positive direct Coombs’ tests have been reported during treatment with cephalosporin antibiotics.

Information for Patients

Phenylketonurics: Cefzil for oral suspension contains phenylalanine 28 mg per 5 mL (1 teaspoonful) constituted suspension for both the 125 mg/5 mL and 250 mg/5 mL dosage forms.

Patients should be counseled that antibacterial drugs including Cefzil should only be used to treat bacterial infections. They do not treat viral infections (eg, the common cold). When Cefzil is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Cefzil or other antibacterial drugs in the future.

Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.

Drug Interactions

Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics. Concomitant administration of probenecid doubled the AUC for cefprozil.

The bioavailability of the capsule formulation of cefprozil was not affected when administered 5 minutes following an antacid.

Drug/Laboratory Test Interactions

Cephalosporin antibiotics may produce a false positive reaction for glucose in the urine with copper reduction tests (Benedict’s or Fehling’s solution or with Clinitest ® tablets), but not with enzyme-based tests for glycosuria (eg, Clinistix ® ). A false negative reaction may occur in the ferricyanide test for blood glucose. The presence of cefprozil in the blood does not interfere with the assay of plasma or urine creatinine by the alkaline picrate method.

Clinitest® and Clinistix® are registered trademarks of the Bayer HealthCare LLC.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Long term in vivo studies have not been performed to evaluate the carcinogenic potential of cefprozil.

Cefprozil was not found to be mutagenic in either the Ames Salmonella or E. coli WP2 urvA reversion assays or the Chinese hamster ovary cell HGPRT forward gene mutation assay and it did not induce chromosomal abnormalities in Chinese hamster ovary cells or unscheduled DNA synthesis in rat hepatocytes in vitro. Chromosomal aberrations were not observed in bone marrow cells from rats dosed orally with over 30 times the highest recommended human dose based upon mg/m 2 .

Impairment of fertility was not observed in male or female rats given oral doses of cefprozil up to 18.5 times the highest recommended human dose based upon mg/m 2 .

Pregnancy

Teratogenic Effects: Pregnancy Category B

Reproduction studies have been performed in rabbits, mice, and rats using oral doses of cefprozil of 0.8, 8.5, and 18.5 times the maximum daily human dose (1000 mg) based upon mg/m 2. and have revealed no harm to the fetus. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Labor and Delivery

Cefprozil has not been studied for use during labor and delivery. Treatment should only be given if clearly needed.

Nursing Mothers

Small amounts of cefprozil (<0.3% of dose) have been detected in human milk following administration of a single 1 gram dose to lactating women. The average levels over 24 hours ranged from 0.25 to 3.3 µg/mL. Caution should be exercised when Cefzil is administered to a nursing woman, since the effect of cefprozil on nursing infants is unknown.

Pediatric Use

The safety and effectiveness of cefprozil in the treatment of otitis media have been established in the age groups 6 months to 12 years. Use of Cefzil for the treatment of otitis media is supported by evidence from adequate and well-controlled studies of cefprozil in pediatric patients. (See CLINICAL STUDIES .)

The safety and effectiveness of cefprozil in the treatment of pharyngitis/tonsillitis or uncomplicated skin and skin-structure infections have been established in the age groups 2 to 12 years. Use of Cefzil for the treatment of these infections is supported by evidence from adequate and well-controlled studies of cefprozil in pediatric patients.

The safety and effectiveness of cefprozil in the treatment of acute sinusitis have been established in the age groups 6 months to 12 years. Use of Cefzil in these age groups is supported by evidence from adequate and well-controlled studies of cefprozil in adults.

Safety and effectiveness in pediatric patients below the age of 6 months have not been established for the treatment of otitis media or acute sinusitis, or below the age of 2 years for the treatment of pharyngitis/tonsillitis or uncomplicated skin and skin-structure infections. However, accumulation of other cephalosporin antibiotics in newborn infants (resulting from prolonged drug half-life in this age group) has been reported.

Geriatric Use

Of the more than 4500 adults treated with Cefzil in clinical studies, 14% were 65 years and older, while 5% were 75 years and older. When geriatric patients received the usual recommended adult doses, their clinical efficacy and safety were comparable to clinical efficacy and safety in nongeriatric adult patients. Other reported clinical experience has not identified differences in responses between elderly and younger patients, but greater sensitivity of some older individuals to the effects of Cefzil cannot be excluded (see CLINICAL PHARMACOLOGY ).

Cefzil is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function. See DOSAGE AND ADMINISTRATION for dosing recommendations for patients with impaired renal function.

Adverse Reactions

The adverse reactions to cefprozil are similar to those observed with other orally administered cephalosporins. Cefprozil was usually well tolerated in controlled clinical trials. Approximately 2% of patients discontinued cefprozil therapy due to adverse events.

The most common adverse effects observed in patients treated with cefprozil are:

Gastrointestinal: Diarrhea (2.9%), nausea (3.5%), vomiting (1%), and abdominal pain (1%).

Hepatobiliary: Elevations of AST (SGOT) (2%), ALT (SGPT) (2%), alkaline phosphatase (0.2%), and bilirubin values (<0.1%). As with some penicillins and some other cephalosporin antibiotics, cholestatic jaundice has been reported rarely.

Hypersensitivity: Rash (0.9%), urticaria (0.1%). Such reactions have been reported more frequently in children than in adults. Signs and symptoms usually occur a few days after initiation of therapy and subside within a few days after cessation of therapy.

CNS: Dizziness (1%), hyperactivity, headache, nervousness, insomnia, confusion, and somnolence have been reported rarely (<1%). All were reversible.

Hematopoietic: Decreased leukocyte count (0.2%), eosinophilia (2.3%).

Renal: Elevated BUN (0.1%), serum creatinine (0.1%).

Other: Diaper rash and superinfection (1.5%), genital pruritus and vaginitis (1.6%).

The following adverse events, regardless of established causal relationship to Cefzil, have been rarely reported during postmarketing surveillance: anaphylaxis, angioedema, colitis (including pseudomembranous colitis), erythema multiforme, fever, serum-sickness like reactions, Stevens-Johnson syndrome, and thrombocytopenia.

Cephalosporin class paragraph

In addition to the adverse reactions listed above which have been observed in patients treated with cefprozil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Aplastic anemia, hemolytic anemia, hemorrhage, renal dysfunction, toxic epidermal necrolysis, toxic nephropathy, prolonged prothrombin time, positive Coombs’ test, elevated LDH, pancytopenia, neutropenia, agranulocytosis.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment, when the dosage was not reduced. (See DOSAGE AND ADMINISTRATION and OVERDOSAGE .) If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Overdosage

Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weanling, or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.

Cefprozil is eliminated primarily by the kidneys. In case of severe overdosage, especially in patients with compromised renal function, hemodialysis will aid in the removal of cefprozil from the body.

Cefzil Dosage and Administration

Cefzil is administered orally.

a In the treatment of infections due to Streptococcus pyogenes. Cefzil should be administered for at least 10 days.

Store at 59°–77° F (15°–25° C) prior to constitution.

U. S. Patent No. 4,520,022

Clinical Studies

Study One:

In a controlled clinical study of acute otitis media performed in the United States where significant rates of β-lactamase-producing organisms were found, cefprozil was compared to an oral antimicrobial agent that contained a specific β-lactamase inhibitor. In this study, using very strict evaluability criteria and microbiologic and clinical response criteria at the 10 to 16 days post-therapy follow-up, the following presumptive bacterial eradication/clinical cure outcomes (ie, clinical success) and safety results were obtained:

U. S. Acute Otitis Media Study

Cefprozil vs β-lactamase inhibitor-containing control drug

Study Two:

In a controlled clinical study of acute otitis media performed in Europe, cefprozil was compared to an oral antimicrobial agent that contained a specific β-lactamase inhibitor. As expected in a European population, this study population had a lower incidence of β-lactamase-producing organisms than usually seen in U. S. trials. In this study, using very strict evaluability criteria and microbiologic and clinical response criteria at the 10 to 16 days post-therapy follow-up, the following presumptive bacterial eradication/clinical cure outcomes (ie, clinical success) were obtained:

European Acute Otitis Media Study

Cefprozil vs β-lactamase inhibitor-containing control drug

% of Cases with Pathogen (n=47)

cefprozil equivalent to control

cefprozil equivalent to control

cefprozil equivalent to control

cefprozil equivalent to control

cefprozil equivalent to control

The incidence of adverse events in the cefprozil arm was comparable to the incidence of adverse events in the control arm (agent that contained a specific β-lactamase inhibitor).

REFERENCES

National Committee for Clinical Laboratory Standards. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically —Third Edition. Approved Standard NCCLS Document M7-A3, Vol. 13, No. 25, NCCLS, Villanova, PA, December 1993.

National Committee for Clinical Laboratory Standards. Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria —Third Edition. Approved Standard NCCLS Document M11-A3, Vol. 13, No. 26, NCCLS, Villanova, PA, December 1993.

National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Disk Susceptibility Tests —Fifth Edition. Approved Standard NCCLS Document M2-A5, Vol. 13, No. 24, NCCLS, Villanova, PA, December 1993.

Bristol-Myers Squibb Company Princeton, New Jersey 08543 USA

Cefzil cefprozil tablet, film coated

HUMAN PRESCRIPTION DRUG LABEL

Item Code (Source)

Route of Administration

Active Ingredient/Active Moiety

Basis of Strength

sodium starch glycolate

100 TABLET, FILM COATED (100 TABLET) in 1 BOTTLE

Cefzil cefprozil tablet, film coated

HUMAN PRESCRIPTION DRUG LABEL

Item Code (Source)

Route of Administration

Active Ingredient/Active Moiety

Basis of Strength

sodium starch glycolate

50 TABLET, FILM COATED (50 TABLET) in 1 BOTTLE

100 TABLET, FILM COATED (100 TABLET) in 1 BOTTLE

Cefzil cefprozil powder, for suspension

HUMAN PRESCRIPTION DRUG LABEL

Item Code (Source)

Route of Administration

Active Ingredient/Active Moiety

Basis of Strength

colloidal silicone dioxide

flavors (natural and artificial)

50 mL (50 MILLILITER) in 1 BOTTLE

75 mL (75 MILLILITER) in 1 BOTTLE

100 mL (100 MILLILITER) in 1 BOTTLE

Cefzil cefprozil powder, for suspension

HUMAN PRESCRIPTION DRUG LABEL

Item Code (Source)

Route of Administration

Active Ingredient/Active Moiety

Basis of Strength

colloidal silicone dioxide

flavors (natural and artificial)

50 mL (50 MILLILITER) in 1 BOTTLE

75 mL (75 MILLILITER) in 1 BOTTLE

100 mL (100 MILLILITER) in 1 BOTTLE

Labeler - Bristol-Myers Squibb

More about Cefzil (cefprozil)

Consumer resources

Professional resources

Related treatment guides

Drug Status

Availability Rx Prescription only

Pregnancy Category B No proven risk in humans

CSA Schedule N Not a controlled drug

Approval History Calendar Drug history at FDA

FDA Consumer Updates

Cefzil Rating

9 User Reviews 7.3 /10

Cefzil (cefprozil) 250 mg

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Benoxuric (Zyloprim) Description

Benoxuric is used for treating gout caused by excessive levels of uric acid in the blood (hyperuricemia). Hyperuricemia occurs when the body produces more uric acid than it can eliminate. The uric acid forms crystals in joints (gouty arthritis) and tissues, causing inflammation and pain. Elevated blood uric acid levels also can cause kidney disease and stones. Benoxuric prevents the production of uric acid by blocking the activity of the enzyme that converts purines to uric acid.

Benoxuric prevents the production of uric acid by blocking the activity of the enzyme that converts purines to uric acid.

Benoxuric is also known as Allopurinol, Allohexal, Allosig, Progout, Zyloric, Puricos.

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Benoxuric (Zyloprim) Dosage

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Benoxuric (Zyloprim) Missing of dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Benoxuric (Zyloprim) Overdose

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Benoxuric (Zyloprim) Storage

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Benoxuric (Zyloprim) Side effects

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Lactulose solution

Treating constipation. It may also be used for other conditions as determined by your doctor.

Lactulose solution is a colonic acidifier. It works by drawing water into the colon, which softens the stool and helps to produce a bowel movement.

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Antacids because they may decrease lactulose solution's effectiveness

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Tell your doctor or dentist that you take lactulose solution before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Lactulose solution may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.

LAB TESTS, including blood electrolyte levels, may be performed while you use lactulose solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use lactulose solution with caution in the ELDERLY; they may be more sensitive to its effects.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using lactulose solution while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use lactulose solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of lactulose solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Belching; gas; nausea; stomach cramps; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include diarrhea; stomach cramps.

Proper storage of lactulose solution:

Store lactulose solution at room temperature between 68 and 77 degrees F (20 and 25 degrees C). A normal darkening of the solution may occur under normal storage conditions. This will not affect the product. Exposure to temperatures above 86 degrees F (30 degrees C) will cause extreme darkening of the solution. Do not use the medicine if this occurs. Store away from heat, moisture, and light. Do not store in the bathroom. Keep lactulose solution out of the reach of children and away from pets.

General information:

If you have any questions about lactulose solution, please talk with your doctor, pharmacist, or other health care provider.

Lactulose solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take lactulose solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about lactulose solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to lactulose solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using lactulose solution.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about lactulose

Cetapred ophthalmic uses, side effects, interactions, pictures, warnings - dosing, cetapred

Cetapred ophthalmic

Uses

This medication is used to prevent or treat eye infections and to treat swelling in the eye. This product contains an antibiotic (sulfacetamide) that stops the growth of bacteria and a corticosteroid (prednisolone ) that reduces inflammation .

This medication treats only bacterial eye infections. It will not work for other types of eye infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

How to use Cetapred ophthalmic

Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to manufacturer's directions and check with your doctor before using them.

Apply eye ointment to the affected eye(s) as follows: Wash hands first. To avoid contamination, be careful not to touch the tube tip or let it touch your eye. Tilt your head back, look upward and pull down your lower eyelid to make a pouch. Place a 1/2 inch (1.3 centimeters) strip of ointment into the pouch by squeezing the tube gently. Look downward and gently close your eyes for 1 to 2 minutes. Roll your eyeball in all directions to spread the medication. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed. Apply as often as directed by your doctor.

Wipe the tip of the ointment tube with a clean tissue to remove excess medication before recapping it.

If you are using another kind of eye medication (e. g. drops or ointments), wait at least 10 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. Continue using it for the full time prescribed even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Do not use this medication for longer than prescribed. If you use it regularly for an extended period of time, do not suddenly stop using it without consulting your doctor. Your dosage may need to be gradually decreased.

Inform your doctor if your condition does not improve after 2 days.

Side Effects

This medication may temporarily sting or burn your eyes for a minute or two when applied. Blurred vision. sensitivity to light, eye discomfort, dry eyes. tearing, itching. or redness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Use of this medication for prolonged or repeated periods may result in a new type of eye infection (e. g. viral, fungal). Do not use it for longer than prescribed. Contact your doctor if you notice new or worsening symptoms.

Tell your doctor right away if any of these unlikely but serious side effects occur: vision changes, eye pain. staining of the eyes.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing. signs of infection (e. g. fever, persistent sore throat ), easy bleeding/bruising, yellowing of the eyes/skin. dark urine.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using sulfacetamide/prednisolone, tell your doctor or pharmacist if you are allergic to it; or to sulfa drugs (e. g. sulfamethoxazole ), corticosteroids (e. g. hydrocortisone. prednisone ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: eye problems (e. g. glaucoma. severely dry eyes ), eye surgeries (e. g. cataract surgery), diabetes .

Your vision may be temporarily blurred or unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if the medications in this product pass into breast milk. Consult your doctor before breast - feeding.

Interactions

Your healthcare professionals (e. g. doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur: gentamicin. certain local anesthetics (e. g. tetracaine), preparations that contain silver.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Throw away the unused portion after therapy is completed. Do not use it later for another infection or give it to someone else. A different medication may be necessary in those cases.

With prolonged use (more than 10 days), laboratory and/or medical tests (e. g. eye exams ) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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