Betagan, betagan

Betagan

Betagan is a type of eye drop used to treat high eye pressure or chronic open angle glaucoma. This medication is only available by prescription and is typically used in the affected eye(s) once or twice a day. Although most people tolerate it well, side effects are possible and may include burning, stinging, or inflammation of the lining of the eye and eyelid.

What Is Betagan?

Betagan ® (levobunolol hydrochloride) is a prescription eye drop approved to lower eye pressure in people with chronic open angle glaucoma or high eye pressure (ocular hypertension ).

(Click Betagan Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Brand-name Betagan is manufactured by Allergan, Inc.

How Does Betagan Work?

Betagan belongs to a group of drugs called beta-adrenergic blocking agents, more often known as beta blockers. As the name implies, these medications block beta receptors in the body. Beta receptors are located in a number of places within the body, including the eyes. Beta blockers lower the pressure in the eye by decreasing the amount of fluid produced by the eye (known as aqueous humor).

When and How to Take It

Some general considerations include the following:

This medication comes in the form of an eye drop. It is used in the affected eye(s) once or twice a day.

In order to prevent contamination of the drops, do not touch the tip of the dropper to any surface, including the surface of the eye.

For the medication to work properly, it must be taken as directed.

Acne treatment with benzoyl peroxide-topic overview, benzoyl peroxide

Acne: Treatment With Benzoyl Peroxide - Topic Overview

Benzoyl peroxide is a medicine you use to treat acne. It comes in different strengths in lotions, gels, soaps, and liquids.

How does benzoyl peroxide treat acne ?

Benzoyl peroxide unclogs skin pores. It also helps stop bacteria from growing and causing acne pimples and cystic lesions.

At first, acne may get worse. Your skin may get red and peel. It’s not a quick fix. You may need to use the product for as long as 4 to 6 weeks before your acne starts improving.

Does it have side effects?

Side effects of benzyl peroxide for some people include:

Dry or peeling skin.

Skin that feels warm.

Tingling or slight stinging.

While using a product that contains benzoyl peroxide, call a doctor if you develop:

Who should not use this product?

Talk to a doctor before allowing a child younger than 12 to use a product that contains benzoyl peroxide.

Where can I get benzoyl peroxide?

You can buy products that contain benzoyl peroxide in the grocery store or pharmacy. Look at the outside package to find products that have benzoyl peroxide as the active ingredient. Strengths range from 2.5% to 10% benzoyl peroxide. Start with the lowest strength to see how your skin reacts. Brand names include Brevoxyl and Triaz .

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

WebMD Medical Reference from Healthwise

This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information. © 1995-2015 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

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RANITIDINE 150 MG TABLETS

Transcript

RANITIDINE 150 mg AND 300 mg TABLETS PACKAGE LEAFLET: INFORMATION FOR THE USER Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. ? Keep this leaflet. You may need to read it again. ? If you have any further questions, ask your doctor or pharmacist. ? This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. ? If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. What is in this leaflet: 1. What Ranitidine is and what it is used for 2. What you need to know before you take Ranitidine 3. How to take Ranitidine 4. Possible side effects 5. How to store Ranitidine 6. Contents of the pack and other information 1.

What Ranitidine is and what it is used for

Ranitidine belongs to a group of medicines called histamine H2-antagonists which reduce the amount of acid in your stomach. Ranitidine is used: ? to treat ulcers of the stomach and duodenum (portion of the small intestine) ? to treat Zollinger-Ellison Syndrome, a condition where the stomach produces too much acid ? to treat a condition called reflux oesophagitis which causes heartburn ? to treat other problems such as indigestion or heartburn where a reduction in stomach acid is required ? to prevent ulcers in the small intestine which are sometimes caused as a side effect of taking nonsteroidal anti-inflammatory drugs (sometimes used to treat arthritis e. g. aspirin, ibuprofen, naproxen) ? to prevent bleeding of existing ulcers and gastrointestinal bleeding from stress ulceration in seriously ill patients ? before administration of a general anaesthetic to patients considered to be at risk of Mendelson’s syndrome (e. g. patients during labour), a condition where acid fluid from the stomach is brought up into the windpipe and passes into the lungs. 2.

What you need to know before you take Ranitidine

DO NOT take Ranitidine if you: ? if you are allergic (hypersensitive) to ranitidine or any of the other ingredients of ranitidine (listed in section 6). Warnings and precautions Tell your doctor before you start to take this medicine if you: ? have ever suffered from porphyria, a deficiency of specific enzymes within the body, causing an increase of substances called porphyrins

suffer from severe kidney problems suffer from any chronic lung disease have diabetes have a weakened immune system (e. g. due to disease, or due to other medical treatments).

If you are middle aged or older and you have new or recently changed symptoms, you should speak to your doctor, as these may be a sign of a more serious underlying condition requiring different treatment. If you are taking non-steroidal anti-inflammatory (NSAID) medicines (see “Taking other medicines”), your doctor should monitor you regularly, particularly if you are elderly, or have a history of peptic ulcer. Other medicines and Ranitidine Tell your doctor if you are taking any of the following: ? non-steroidal anti-inflammatory (NSAID) medicines, for pain or inflammation, such as aspirin, ibuprofen, or diclofenac ? medicines to thin your blood e. g. warfarin ? procainamide or N-acetylprocainamide (used to treat abnormal heart rhythms) ? triazolam, midazolam (sedative medicines) ? glipizide (used to treat diabetes) ? ketoconazole (used to treat fungal infections) ? atazanavir, delaviridine (used to treat HIV infection) ? gefitnib (used to treat certain types of cancer) ? sucralfate (used to treat certain conditions caused by too much acid being produced in the stomach) Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Pregnancy and breast-feeding ? If you are pregnant, planning to become pregnant or are breast-feeding, you should not take this medicine unless your doctor advises it is essential. Driving and using machines ? Ranitidine is not known to affect your ability to drive or operate machinery. 3.

How to take Ranitidine

Always take Ranitidine exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. The tablets should be swallowed preferably with a drink of water. The usual dose is Adults (including the elderly) and adolescents (12 years and over) ? To treat ulcers, reflux oesophagitis, indigestion, dyspepsia or heartburn 150 mg twice a day, taken in the morning and evening. Sometimes your doctor may advise a single daily dose of 300 mg taken in the evening. The exact dose and length of treatment will depend on the condition you are being treated for.

Zollinger-Ellison Syndrome The usual starting dose is 150 mg three times a day. Your doctor may increase this, if necessary, up to a maximum dose of 6 g per day.

Mendelson’s Syndrome 150 mg the evening before and a further dose of 150 mg 2 hours before administration of a general anaesthetic.

Children from 3 to 11 years of age and over 30 kg of weight Children require a reduced dosage depending on how much they weigh. ? To treat stomach or duodenal (small intestine) ulcer 2 - 4 mg for each kg of body weight, taken twice a day for 4 weeks. If necessary another 4 weeks of treatment can be given. The maximum dose is 300 mg ranitidine each day. ? To treat reflux oesophagitis, indigestion, dyspepsia or heartburn 2.5 - 5 mg for each kg of body weight, taken twice a day. The maximum dose is 600 mg each day. Children under 3 years of age Ranitidine is not recommended for use in children under 3 years of age. Patients with severe kidney problems 150 mg at bedtime for four to eight weeks. Your doctor may increase this if necessary. If you take more Ranitidine than you should If you (or someone else) swallow a lot of the tablets all together, or if you think a child has swallowed any of the tablets, contact your nearest hospital casualty department or your doctor immediately. Please take this leaflet, any remaining tablets, and the container with you to the hospital or doctor so that they know which tablets were consumed. If you forget to take Ranitidine If you forget to take a tablet, take one as soon as you remember, unless it is nearly time to take the next one. DO NOT take a double dose to make up for a forgotten dose. If you stop taking Ranitidine DO NOT stop taking your medicine without talking to your doctor first even if you feel better. If you have any further questions on the use of this product, ask your doctor or pharmacist. 4.

Possible side effects

Like all medicines, Ranitidine can cause side effects, although not everybody gets them. Stop taking the tablets and tell your doctor immediately or go to the casualty department at your nearest hospital if the following happens: ? an allergic reaction; signs of this may include swelling of the lips, face or neck leading to severe difficulty in breathing or wheezing, severe skin rash or hives, fever, low blood pressure or chest pain. This is a very serious but rare side effect. You may need urgent medical attention or hospitalisation. Tell your doctor immediately if you notice any of the following serious side effects:

? severe pain in the abdomen and back, which may be a sign of inflammation of the pancreas ? yellowing of the skin or whites of the eyes, which may be a sign of inflammation of the liver These are serious but very rare side effects. You may need urgent medical attention. The following side effects have been reported at the approximate frequencies shown: Uncommon (may affect upto 1 in 100 users) ? abdominal pain ? constipation ? feeling sick (these effects usually diminish with continued treatment. Rare (may affect upto 1 in 1000 users) ? skin rash ? blood tests may show changes in results of liver function tests, or increased levels of creatinine. Very Rare (may affect upto 1 in 10000 users) ? headache ? dizziness ? blurred vision ? slower or faster heart beat ? involuntary movements ? reduction in the number of white blood cells, which makes infections more likely ? reduction in blood platelets, which increases risk of bleeding or bruising ? mental confusion, depression, hallucinations (seeing or hearing things which are not real) ? inflammatory skin eruptions ? hair loss ? inflammation in the kidneys ? inflammation of the blood vessels; symptoms may include fever, swelling and a general sense of feeling ill ? joint and muscle pain ? men may experience inability to get or maintain an erection (impotence) ? men may experience swelling or discomfort of the breasts ? shortness of breath ? diarrhoea Reporting of side effects If you get side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side www. mhra. gov. uk/yellowcard

By reporting side effects you can help provide more information on the safety of this medicine. 5.

How to store Ranitidine

Keep this medicine out of the sight and reach of children. Do not store the tablets above 25oC. Store the tablets in the original container.

Do not use Ranitidine after the expiry date that is stated on the outer packaging. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment. 6.

Contents of the pack and other information

What Ranitidine Tablets contain(s): ? The active ingredient is ranitidine (as hydrochloride) 150 or 300mg. ? The other ingredients are microcrystalline cellulose (E460), croscarmellose sodium, magnesium stearate and colloidal silicon dioxide. ? The tablet coating contains: polyethylene glycol, hypromellose (E464), polydextrose (E1200), vanillin, titanium dioxide (E171) and carnauba wax (E903). What Ranitidine Tablets look(s) like and contents of the pack: ? Ranitidine 150 mg Tablets are white, round, biconvex, film-coated tablets engraved with ‘5C1’ ? Ranitidine 300 mg Tablets are white, capsule shaped, biconvex, film-coated tablets engraved with ‘5C3’ ? The tablets are available in blister packs of 28, 30, 56, 60, 84, 112 and 120 tablets and HDPE tablet containers of 100, 250, 500 and 1000 tablets. Not all pack sizes may be marketed. Marketing Authorisation Holder and Manufacturer Marketing Authorisation holder and company responsible for manufacture: TEVA UK Limited, Eastbourne, BN22 9AG This leaflet was last revised: December 2014 PL 00289/0315-0316

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Avapro

Avapro (irbesartan) belongs to a group of drugs called angiotensin II receptor antagonists. Irbesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Avapro is used to treat high blood pressure (hypertension). It is sometimes given together with other blood pressure medications.

Avapro is also used to treat kidney problems caused by type 2 diabetes.

Avapro may also be used for purposes not listed in this medication guide.

Important information

Do not use Avapro if you are pregnant. Stop using and tell your doctor right away if you become pregnant.

If you have diabetes, do not use Avapro together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

Drinking alcohol can further lower your blood pressure and may increase certain side effects of Avapro. Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to.

In rare cases, Avapro can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Before taking this medicine

You should not use Avapro if you are allergic to irbesartan.

If you have diabetes, do not use Avapro together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

You may also need to avoid taking Avapro with aliskiren if you have kidney disease.

To make sure this medicine is safe for you, tell your doctor if you have:

congestive heart failure; or

if you are dehydrated.

FDA pregnancy category D. Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Avapro can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.

It is not known whether irbesartan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take Avapro?

Take Avapro exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Avapro may be taken with or without food.

Your blood pressure will need to be checked often.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of Avapro.

Do not use potassium supplements or salt substitutes while you are taking Avapro, unless your doctor has told you to.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avapro side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Avapro: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, Avapro can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

little or no urinating;

swelling, rapid weight gain; or

confusion, loss of appetite, vomiting, pain in your side or lower back.

Common Avapro side effects may include:

heartburn, upset stomach; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Avapro dosing information

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 150 mg orally once a day with or without food. Maintenance dose: 150 to 300 mg orally once a day.

Usual Adult Dose for Hypertension:

Initial dose: 150 mg orally once a day with or without food. Maintenance dose: 150 to 300 mg orally once a day.

Usual Pediatric Dose for Hypertension:

6 to 12 years: Initial dose: 75 mg once daily. Maintenance dose: 75 mg to 150 mg once daily.

13 to 18 years: Initial dose: 150 mg once daily. Maintenance dose: 150 mg to 300 mg once daily.

What other drugs will affect Avapro?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Avapro, especially:

This list is not complete. Other drugs may interact with irbesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

More about Avapro (irbesartan)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about Avapro.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Avapro only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 7.02. Revision Date: 2014-08-28, 2:40:28 PM.

Drug Status

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PYRIDIATE (PYRIDIUM) INDICATIONS

Pyridiate is a urinary tract analgesic . Pyridiate is indicated for the symptomatic relief of pain, burning, urgency, frequency and other discomforts arising from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters.

PYRIDIATE (PYRIDIUM) INSTRUCTIONS

Use Pyridiate as directed by your doctor.

Take Pyridiate by mouth after meals.

Taking Pyridiate at the same time(s) each day will help you remember to take it.

If you miss a dose of Pyridiate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pyridiate.

PYRIDIATE (PYRIDIUM) STORAGE

Store Pyridiate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pyridiate out of the reach of children and away from pets.

PYRIDIATE (PYRIDIUM) MORE INFO:

Active Ingredient: Phenazopyridine HCl.

Do NOT use Pyridiate if:

you are allergic to any ingredient in Pyridiate

you have decreased kidney function.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Pyridiate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of certain blood problems (eg, hemolysis)

if you have an enzyme deficiency called glucose-6-phosphate dehydrogenase (G-6-PD) deficiency or a family history of this deficiency.

Some medicines may interact with Pyridiate. However, no specific interactions with Pyridiate are known at this time.

Important safety information:

Do NOT take more than the recommended dose or use for longer than 2 days without checking with your doctor.

Do not use Pyridiate for future urinary tract problems without first checking with your doctor.

Pyridiate may change the color of your urine to orange or red. It may also stain fabric. This is normal and not a cause for concern.

Do not wear soft contact lenses while taking Pyridiate; permanent staining of the lenses may occur.

Pyridiate may interfere with certain lab tests including urinalysis. Be sure your doctor and lab personnel know you are taking Pyridiate.

Use Pyridiate with caution in the elderly; they may be more sensitive to its effects.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Pyridiate while you are pregnant. It is not known if Pyridiate is found in breast milk. If you are or will be breast-feeding while you use Pyridiate, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

No common side effects have been reported with Pyridiate.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue or purple skin color; decreased urination; loss of appetite; unusual fatigue; vomiting; weight loss; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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See Also

What should I discuss with my health care provider before taking phenazopyridine?

Do not take this medication if you are allergic to phenazopyridine, or if you have kidney disease.

Before using phenazopyridine, tell your doctor if you are allergic to any drugs, or if you have:

liver disease;

diabetes ; or

a condition called G6PD (glucose-6-phosphate dehydrogenase) deficiency.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take phenazopyridine.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether phenazopyridine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take phenazopyridine?

Take phenazopyridine exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medicine with a full glass of water.

To avoid stomach upset, take phenazopyridine with food.

Phenazopyridine will most likely darken the color of your urine to an orange or red color. This is a normal effect and is not cause for alarm unless you have other symptoms such as pale or yellowed skin, fever, stomach pain, nausea, and vomiting. Darkened urine may also cause stains to your underwear, which may or may not be removed by laundering.

Phenazopyridine can also permanently stain soft contact lenses, and you should not wear them while taking this medicine.

Do not use phenazopyridine for longer than 2 days unless your doctor has told you to.

This medication can cause you to have false results with glucose or ketone urine tests. Tell any doctor who treats you that you are using phenazopyridine.

Store this medication at room temperature away from moisture and heat.

Medical Dictionary

Pyridium

Pyridium is a pain reliever that affects the lower part of your urinary tract (bladder and urethra).

Pyridium is used to treat pain, burning, increased urination, and increased urge to urinate. These symptoms are usually caused by infection, injury, surgery, catheter, or other conditions that irritate the lower urinary tract.

Pyridium will treat the symptoms of a urinary tract infection, but this medication does not treat the actual infection. Take the antibiotic that your doctor prescribes to treat your infection.

Pyridium may also be used for purposes other than those listed.

Important information

Do not take Pyridium if you are allergic to phenazopyridine, or if you have kidney disease. Pyridium will treat the symptoms of a urinary tract infection, but this medication does not treat the actual infection. Take any antibiotic that your doctor prescribes to treat your infection. To avoid stomach upset, take Pyridium with food.

Pyridium will most likely darken the color of your urine to an orange or red color. This is a normal effect and is not cause for alarm unless you have other symptoms such as pale or yellowed skin, fever, stomach pain, nausea, and vomiting. Darkened urine may also cause stains to your underwear, which may or may not be removed by laundering.

Pyridium can also permanently stain soft contact lenses, and you should not wear them while taking this medicine.

Do not use Pyridium for longer than 2 days unless your doctor has told you to.

Stop taking Pyridium and call your doctor at once if you have pale skin, fever, confusion, yellowing of your skin or eyes, increased thirst, swelling, or if you urinate less than usual or not at all.

Before taking this medicine

Do not take Pyridium if you are allergic to phenazopyridine, or if you have kidney disease.

Before using Pyridium, tell your doctor if you are allergic to any drugs, or if you have:

a condition called G6PD (glucose-6-phosphate dehydrogenase) deficiency.

If you have any of these conditions, you may not be able to use Pyridium, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category B. Pyridium is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Pyridium passes into breast milk or if it could harm a nursing baby. Do not use Pyridium without telling your doctor if you are breast-feeding a baby.

How should I take Pyridium?

Take Pyridium exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medicine with a full glass of water. To avoid stomach upset, take Pyridium with food.

Pyridium will most likely darken the color of your urine to an orange or red color. This is a normal effect and is not cause for alarm unless you have other symptoms such as pale or yellowed skin, fever, stomach pain, nausea, and vomiting. Darkened urine may also cause stains to your underwear, which may or may not be removed by laundering.

Pyridium can also permanently stain soft contact lenses, and you should not wear them while taking this medicine.

Do not use Pyridium for longer than 2 days unless your doctor has told you to.

Pyridium can cause you to have false results with glucose or ketone urine tests. Tell any doctor who treats you that you are using Pyridium.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include yellowed skin, fever, confusion, weakness, urinating less than usual, nausea, vomiting, swelling, numbness, or blue-colored skin.

What should I avoid?

Avoid wearing soft contact lenses while you are taking Pyridium. The medication can cause permanent staining of soft contact lenses.

Pyridium side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Pyridium and call your doctor at once if you have any of these serious side effects:

pale skin, fever, confusion or weakness;

jaundice (yellowing of your skin or eyes);

urinating less than usual or not at all;

drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;

swelling, weight gain, feeling short of breath; or

blue or purple coloring in your skin.

Less serious side effects of Pyridium may include:

stomach pain, upset stomach; or

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Pyridium?

There may be other drugs that can affect Pyridium. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More about Pyridium (phenazopyridine)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about Pyridium.

What does my medication look like?

Phenazopyridine is available over-the-counter and with a prescription under many different brand names. Generic forms are also available. Ask your pharmacist any questions you have about Pyridium, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Pyridium only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 3.02. Revision Date: 4/12/2009 4:37:06 PM.

Drug Status

Brand Names: Azo-Gesic, Azo-Standard, Baridium, Phenazo, Prodium, Pyridiate, Pyridium, Re-Azo, Uricalm, Uristat

Generic Name: phenazopyridine (Pronunciation: fen AY zoe PIR i deen)

What is phenazopyridine (Azo-Gesic, Azo-Standard, Baridium, Phenazo, Prodium, Pyridiate, Pyridium, Re-Azo, Uricalm, Uristat)?

Phenazopyridine is a pain reliever that affects the lower part of your urinary tract (bladder and urethra).

Phenazopyridine is used to treat pain, burning, increased urination, and increased urge to urinate. These symptoms are usually caused by infection, injury, surgery, catheter, or other conditions that irritate the lower urinary tract.

Phenazopyridine will treat the symptoms of a urinary tract infection, but this medication does not treat the actual infection . Take any antibiotic that your doctor prescribes to treat your infection.

Phenazopyridine may also be used for other purposes not listed in this medication guide.

Phenazopyridine 100 mg-AMN

round, brown, imprinted with AN 1

Phenazopyridine 100 mg-GG

Phenazopyridine 200 mg-AMN

Phenazopyridine 200 mg-GG

Phenazopyridine 200 mg-QUA

What are the possible side effects of phenazopyridine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using phenazopyridine and call your doctor at once if you have any of these serious side effects:

pale skin, fever. confusion or weakness;

jaundice (yellowing of your skin or eyes);

urinating less than usual or not at all;

drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;

swelling, weight gain, feeling short of breath; or

blue or purple coloring in your skin.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about phenazopyridine?

Do not take this medication if you are allergic to phenazopyridine, or if you have kidney disease .

Phenazopyridine will treat the symptoms of a urinary tract infection, but this medication does not treat the actual infection . Take any antibiotic that your doctor prescribes to treat your infection.

To avoid stomach upset, take phenazopyridine with food.

Phenazopyridine will most likely darken the color of your urine to an orange or red color. This is a normal effect and is not cause for alarm unless you have other symptoms such as pale or yellowed skin, fever, stomach pain, nausea, and vomiting. Darkened urine may also cause stains to your underwear, which may or may not be removed by laundering.

Phenazopyridine can also permanently stain soft contact lenses. and you should not wear them while taking this medicine.

Do not use phenazopyridine for longer than 2 days unless your doctor has told you to.

Stop taking this medication and call your doctor at once if you have pale skin, fever, confusion, yellowing of your skin or eyes, increased thirst, swelling, or if you urinate less than usual or not at all.

Medical Dictionary

Buy woman s health - tromagesic (brand name diclofenac) online - order diclofenac - purchase woman s

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

Take Diclofenac by mouth with or without food. Ask your health care provider any questions you may have about how to use Diclofenac.

Drug Class and Mechanism

Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

If you miss a dose of Diclofenac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Diclofenac at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do not use Diclofenac if:

you are allergic to any ingredient in Diclofenac; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to another NSAID (e. g. ibuprofen, naproxen, celecoxib) or aspirin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Diclofenac may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you start any new medicine, check the label to see if it has Tromagesic or another nonsteroidal anti-inflammatory drug (NSAID) medicine in it too. If it does or if you are not sure, check with your doctor or pharmacist. Diclofenac should not be used in children; safety and effectiveness in children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breast-feed while using Diclofenac.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

burning or stinging; discharge; eye redness, irritation, or itching. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred or distorted vision; eye infection; eyelid swelling or redness; sensitivity to glare or light.

Diclofenac is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Fanfic erisol 2tupid lovve, homestuck, erisol

EriSol Request: Sweet Dreams

Eridan sat up, eyes wide, heart pounding. Everything around him was blurred, like a land dweller opening their eyes underwater. Or like a sea dweller without his glasses. He fumbled around for them, finally grabbing them and throwing them on his face. He clambered out of his recoopracoon, mind still on his dream. As the water washed away the slime, he remembered how damn close his lips had gotten to Captor's before he woke up.

That was always when he woke up. Right before he got anything good. Groaning, he pulled on a shirt, not even bothering with a scarf or cape. He had to end these stupid dreams, and he had to end them now. He slammed open his computer, ignoring Feferi's trolling and going straight to the little yellow bubble on his screen.

caligulasAquarium began trolling twinArmageddons at 6:12 am

CA: captor, are you evven awwake?

TA: damn, let a troll fiinii2h a liine of code, wiill you

TA: what iin the hell do you want, ampora

CA: i need to see you. to talk to you

TA: ii2 iit urgent? ii have code two type

CA: yes it's urgent, wwhen can i come see you?

TA: ii gue22 you could drag your 2orry a22 over here now iif you have two

CA: thank you, i wwill be there soon

caligulasAquarium ceased trolling twinArmageddons at 6:15 am

Sollux stared at the screen, thoughts swimming through his mind. Ampora wanted to see him? Urgently? Maybe… no he couldn't get his hopes up. There was no way Eridan felt anything even remotely red for him. It was completely out of the question.

But that didn't change the fact that Sollux couldn't get him out of his head. He was all he could think about, all he could dream about, all he could code about. That last one didn't make much sense, but when you started replacing sections of code with his name and expecting it to work, you certainly thought it made all the sense on the world.

Sollux glanced around his hive, cursing the mess. There were clothes everywhere, mind honey all over the floor, and an

ATH coding book stuck in the honey combs. Damn. Luckily it took Eridan at least an hour to get to his hive, a fact he hoped to resent later on.

Sighing, Sollux began to gather things up and shove them in sort of correct places, dirty clothes in the drawers, clean ones in the hamper, books in piles shoved in corners, the trash shoved in the linen closet. After an attempt to pry the

ATH book from the honey he gave up, throwing a blanket over the whole sticky mess. The place at least looked presentable, and not a moment too soon. The troll rattling around in his mind was rattling the bell by the door.

Sollux moved aside to let the purple blood in, heart threatening to pound out of his chest. As much as he tried to stop them, he felt his hopes inflate like a balloon, hoping maybe Eridan was interested on filling the same quadrant as he was.

"Tho, uh, what did you want, Ampora?"

"Uh…" The troll suddenly looked very nervous, a purple blush dusting his cheeks. He began to look around, anywhere but at the inwardly hopeful Sollux in front of him.

"Eridan? Man, are you feeling okay?"

"I'm…I'm going to fai-"

Sollux stared down at the royal heap on his floor, wondering what in the heck he was supposed to do now. He decided he should probably move him to a couch or something, seeing as his position on the floor looked rather uncomfortable. Sighing he slid off his glasses, red and blue energy surrounding the purple-bloods body. Blinking, Sollux dumped him on the couch, face first. Oops.

Damn. Was he awake already? Sollux wanted a few more minutes to be rid of the awkwardness hanging in the air.

Sollux blinked slowly, inching closer to Eridan.

"N…no, Fef… don't tell 'im!"

The mustard-blooded troll wasn't sure whether or not he should be laughing or responding. What he could see of Eridan's face was contorted in a kind of cute disdain, attempting to stop his imaginary Feferi to not tell someone something.

"Can't tell Thol what?" Sollux had gotten close enough that he knelt down in front of Eridan without thinking.

"Can't tell Sol…that…I…"

"That you…? Eridan?"

"That I…lovve him…"

"You do!" Sollux jumped back, instantly deadpanning his face, looking over the couch, over in the nutrition block, at the ceiling, at the floor, anywhere but at the confused Eridan lying on his couch.

"Hmm?" Sollux looked at him with what he hoped was innocence.

"You just shouted 'You do'… wwhat do I do?"

Sollux saw his chance. Maybe not to express his feelings for the royal, but to at least rid some of the tension from the room. "One more time, Eri? I can't theem two hear you."

Eridan was silent for a moment, glaring at the lowblood in front of him. He looked like he was ready to explode, taking a shaky breath as he fixed his glasses and smoothed out his shirt. "I…I do not have flushed feelings for my hand."

"What about the other hand?"

"What?" Sollux smirked, "Don't like me making fun of your unfilled quadranth?"

"Oh wait, they're all unfilled. I bet your tho dethperate, you would athk every troll on Alternia two fill a quadrant, exthept apparently for me."

"Haven't you onthe conthidered the fact that you forgot me? Or were you two much of a coward two admit your flushed feelingth two my face?"

"To…your…face?" Eridan looked almost terrified, wringing his hands in a part of his cape.

"Yeth. My face. Thith thing, with the eyeths and the mouth."

"No, I mean, wwhen did I NOT admit them to your face?"

"Just now. You were all thleep talking, "Nooo, Fef, don't tell Thol that I 'lovve' him

A pained look crossed the royals face, but then he seemed to realized something, "Wwell, you don't look disgusted. If I didn't knoww any better, I might say you look almost okay wwith it."

"Why would I be okay with it? That'th just…just…"

Eridan stood, walking over to the mustard blood, and placing his hands on his shoulders. "Let's try a different way. Sollux Captor, wwill you be my matesprit-"

"You wwill? Sol that's-mmph-"

Grinning into Eridan's lips, Sollux slinked his arms around his waist, forcing Eridan's arms to hook behind his neck. After a minute, Sollux pulled back, resting his forehead on Eridan's."

"I lovve you too."

A/N: AAAAAH SO FLUFFY

I HOPE YOU ENJOYED. Requests are still open, info on my DA page which a link to that is on my profile here.

Interflox, interflox

Robocopy is very powerful tools for an admin and especially when you want to migrate from Server to Server.

Then there are some very smart options such as :

*. to select everything /s. It allow to select even subfolder (It won’t copy the empty one) /sec. Copy files with their own security /mov or /move. Move files from source to destination and delete from source /max:<N> Specify to copy files smaller than a value N

I wanna copy the files lower than 10M.

backup copy disk save

Hi guys, today I am going to show some tips to increase the quickness of your machine (Laptop/Desktop) and some software for backing up (in case of you need to restore you favourites files)

So do need wait more, Let’s started…

I. COMMANDS

1. TEMPORY FILE

Go to the folder

It is only temporary files so you can easily delete its.

2. SORT ALL YOUR FILE STORED INSIDE THE DRIVE TO MAKE IT QUICKER

Use the command lines

Go to your browser (firefox, chrome, IE) and check everything.

4. NETWORK

Open a command line and type :

5. STARTUP

Open a run command then type :

Uncheck all services that you do not need.

II. Software

1. DEFRAGMENTATION

Type defrag on the start bar

Then click on the drive that you want to de-fragment.

2. CCLEANER

Use ccleaner to clear everything you don’t need into your computer.

3. GLARY

III. OTHER SOFTWARE

1. WINDOWS DVD

It is really import to keep a copy of Windows in case of some issues apear on your PC.

You can use daemon tools as free tool to mount an ISO to a Virtual drive and

Some software such as :

– Windows Bootable Image

2. ACRONIS

This soft allow you to create/edit/delete and manage your drive and partitions dynamiquelly.

3. BACKUP and RESTORE

Use Windows Backup to create a restoration point to be able to restore your system for any problems.

crash optimisation pc

Here we are…Sometimes you enjoy to have the most reliable webserver because it never crash, however in other moments it is really difficult to find why apache daemon stopped suddenly.

Here is the command line to find where are store the main log :

You should have something like this :

So you should start to see the main log located in this folder (in my case)

Florian Chambard an ITC Sys & Network

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Ciplox is used to treat different types of bacterial infections. It may also be used to prevent or slow anthrax after exposure.

Take Cipro exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Cipro with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking this medicine. Cipro may be taken with or without food, but take it at the same time each day. Shake the oral suspension (liquid) for at least 15 seconds just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

When taking the Cipro oral liquid, swallow it without chewing the medicine beads you may notice in the liquid.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Do not take Cipro with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products as part of a regular meal, but do not use them alone when taking Cipro. They could make the medication less effective.

Take Cipro for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cipro will not treat a viral infection such as the common cold or flu.

Store Cipro at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

If you missed a dose - take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Take exactly as prescribed by your Health Provider.

Store this medicine at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

You should not use Ciplox if you are taking tizanidine (Zanaflex), if you have a history of myasthenia gravis, or if you are allergic to ciprofloxacin or similar antibiotics such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and others.

Before taking Ciplox, tell your doctor if you have a heart rhythm disorder, kidney or liver disease, joint problems, diabetes, muscle weakness or trouble breathing, a condition called pseudotumor cerebri, a history of seizures, a history of head injury or brain tumor, low levels of potassium in your blood, a personal or family history of Long QT syndrome, or if you have ever had an allergic reaction to an antibiotic.

Do not take Ciplox with dairy products such as milk or yogurt, or with calcium-fortified juice. Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 6 hours before or 2 hours after you take Ciplox. Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.

You should NOT take Ciplox if:

you are also taking tizanidine (Zanaflex);

you have a history of myasthenia gravis; or

you are allergic to ciprofloxacin or similar medications such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

To make sure you can safely take Ciplox, tell your doctor if you have any of these other conditions:

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a history of head injury or brain tumor;

a condition called pseudotumor cerebri (high pressure inside the skull that may cause headaches, vision loss, or other symptoms);

a history of allergic reaction to an antibiotic;

joint problems;

kidney or liver disease;

epilepsy or seizures;

diabetes;

muscle weakness or trouble breathing;

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a personal or family history of Long QT syndrome.

FDA pregnancy category C. It is not known whether Ciplox will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using it. Ciprofloxacin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Ciplox may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share Ciplox with another person (especially a child), even if they have the same symptoms you have.

Get emergency medical help if you have any of these signs of an allergic reaction to Ciplox: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Ciplox and call your doctor at once if you have a serious side effect such as:

severe dizziness, fainting, fast or pounding heartbeats;

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diarrhea that is watery or bloody;

confusion, hallucinations, depression, unusual thoughts or behavior;

seizure (convulsions);

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urinating less than usual or not at all;

easy bruising or bleeding;

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Contains per ml.

Enrofloxacin. 100 mg.

Enrofloxacin belongs to the group of quinolones and acts bactericidal against mainly Gram positive and Gram-negative bacteria like Campylobacter, E. coli, Haemophilus, Pasteurella, Salmonella and Mycoplasma spp.

Gastrointestinal infections, respiratory infections and urinary tract infections caused by enrofloxacin sensitive micro-organisms, like Campylobacter, E. coli, Haemophilus, Pasteurella, Salmonella and Mycoplasma spp. in calves, goat, sheep, swine and poultry.

For oral administration:

Calves, goat and sheep :Twice daily 10 ml per 75-150 kg body weight for 3-5 days

Swine :1 litre per 1000 - 3000 litre drinking water for 3 - 5 days.

Poultry :1 litre per 2000 litre drinking water for 3 - 5 days.

Note. for pre-ruminant calves, lambs and kids only

Interflox Oral ® . 1000 ml.

DEPTAN RI No. I. 07073243 PKC

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Often, there are no noticeable symptoms in the early stages of colorectal cancer. That's what makes screenings, such as colonoscopies, even more important. It's in these early stages that this form of cancer is most treatable. although it is preventable, colorectal cancer is the third…

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Leflunomide medlineplus drug information, leflumide

Leflunomide

IMPORTANT WARNING:

Do not take leflunomide if you are pregnant or plan to become pregnant. Leflunomide may harm the fetus. You should not begin taking leflunomide until you have taken a pregnancy test with negative results and your doctor tells you that you are not pregnant. You must use an effective method of birth control before you begin taking leflunomide, during your treatment with leflunomide, and for 2 years after treatment. If your period is late or you miss a period during treatment with leflunomide, call your doctor immediately. Talk to your doctor if you plan to become pregnant within 2 years after stopping treatment with leflunomide. Your doctor can prescribe a treatment that will help to remove this medication more quickly from your body.

Leflunomide may cause liver damage that can be life-threatening and even cause death. The risk for liver damage is greatest in people taking other medications known to cause liver damage, and in people who already have liver disease. Tell your doctor if you have or have ever had hepatitis or any other type of liver disease and if you if you drink or have ever drunk large amounts of alcohol. Tell your doctor and pharmacist if you are taking acetaminophen (Tylenol, in other over-the-counter products), aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs such as ibuprofen [Advil, Motrin] and naproxen [Aleve, Naprosyn], cholesterol-lowering medications (statins), hydroxychloroquine, iron products, isoniazid (Laniazid, in Rifamate, in Rifater), methotrexate (Trexall), niacin (nicotinic acid), or rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). If you experience any of the following symptoms, call your doctor immediately: nausea, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, dark-colored urine, or flu-like symptoms.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to leflunomide.

Talk to your doctor about the risks of taking leflunomide.

Why is this medication prescribed?

Leflunomide is used alone or in combination with other medications to treat rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function). Leflunomide is in a class of medications called disease-modifying antirheumatic drugs (DMARDs). It works by decreasing inflammation and slowing the progress of the condition, which can help improve the physical activity of people with rheumatoid arthritis.

How should this medicine be used?

Leflunomide comes as a tablet to take by mouth. It is usually taken once a day. Your doctor may tell you to take a larger dose of leflunomide for the first 3 days of treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take leflunomide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may need to decrease your dose or stop treatment if you experience certain severe side effects. Be sure to tell your doctor how you are feeling during your treatment.

Leflunomide may help control the symptoms of your rheumatoid arthritis but does not cure it. Continue to take leflunomide even if you feel well. Do not stop taking leflunomide without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking leflunomide,

tell your doctor and pharmacist if you are allergic to leflunomide, teriflunomide (Aubagio), any other medications, or any of the ingredients in leflunomide tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin Jantoven); cholestyramine (Prevalite); gold compounds such as auranofin (Ridaura); medications to treat cancer; other medications that suppress the immune system such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Astagraf, Prograf); penicillamine (Cuprimine, Depen), and tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had serious infections or if you frequently get infections, cancer or other conditions affecting the bone marrow or the immune system (including human immunodeficiency virus [HIV] and acquired immunodeficiency syndrome [AIDS]), diabetes, or kidney disease.

tell your doctor if you are breastfeeding. Do not breastfeed while you are taking leflunomide.

if you are planning to father a child, you should talk to your doctor about stopping leflunomide and receiving a treatment to help to remove this medication from your body more quickly.

ask your doctor about the safe use of alcoholic beverages while you are taking leflunomide.

Taking leflunomide may decrease your ability to fight infection. Tell your doctor if you have an infection now or if you have any signs of infection such as fever, cough, or flu-like symptoms. If you experience any of the following symptoms during your treatment with leflunomide, call your doctor: fever; sore throat; cough; flu-like symptoms; area of warm, red, swollen, or painful skin; painful, difficult, or frequent urination; or other signs of infection. Your treatment with leflunomide may need to be interrupted if you have an infection.

You may already be infected with tuberculosis (TB; a serious lung infection) but not have any symptoms of the disease. In this case, leflunomide may make your infection more serious and cause you to develop symptoms. Tell your doctor if you have or have ever had TB, if you have lived in or visited a country where TB is common, or if you have been around someone who has or has ever had TB. Before you begin your treatment with leflunomide, your doctor will perform a skin test to see if you have TB. If you do have TB, your doctor will treat this infection with antibiotics before you begin taking leflunomide.

do not have any vaccinations without talking to your doctor.

you should know that leflunomide may cause high blood pressure. You should have your blood pressure checked before starting treatment and regularly while you are taking this medication.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Leflunomide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

diarrhea

vomiting

heartburn

headache

dizziness

weight loss

back pain

muscle pain or weakness

pain, burning, numbness, or tingling in the hands or feet

hair loss

leg cramps

dry skin

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS section, call your doctor immediately or get emergency medical treatment:

rash with or without a fever

hives

blisters or peeling of skin

mouth sores

itching

difficulty breathing

new or worsening cough

chest pain

pale skin

Receiving medications which suppress the immune system may increase the risk of developing certain types of cancer. An increase in cancers was not reported in clinical studies with leflunomide to date. Talk to your doctor about the risks of receiving leflunomide.

Leflunomide may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom) and light.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo. gl/c4Rm4p ) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following:

diarrhea

stomach pain

extreme tiredness

weakness

pale skin

fast heartbeat

shortness of breath

What other information should I know?

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

Gris-peg - fda prescribing information, side effects and uses, gris-peg

Gris-PEG

Gris-PEG ® Tablets contain ultramicrosize crystals of griseofulvin, an antibiotic derived from a species of Penicillium .

The chemical name of griseofulvin, USP is 7 - Chloro - 2’,4,6 - trimethoxy - 6’β - methylspiro[benzofuran - 2(3H),1’ - [2]cyclohexene] - 3,4’ - dione. Its structural formula is:

C 17 H 17 ClO 6 M. W. 352.77

Griseofulvin, USP occurs as a white to creamy white, odorless powder which is very slightly soluble in water, soluble in acetone, dimethylformamide, and chloroform and sparingly soluble in alcohol.

Each Gris-PEG tablet contains:

griseofulvin ultramicrosize. 125 mg

Inactive Ingredients: Polyethylene Glycol 8000, Lactose Monohydrate, Colloidal Silicon Dioxide, Crospovidone, Magnesium Stearate, Methylparaben, Polyvinyl Alcohol, Titanium Dioxide, Polyethylene Glycol 3350, and Talc.

Active Ingredient: griseofulvin ultramicrosize. 250 mg

Inactive Ingredients: Polyethylene Glycol 8000, Magnesium Stearate, Sodium Lauryl Sulfate, Methylparaben, Polyvinyl Alcohol, Titanium Dioxide, Polyethylene Glycol 3350, and Talc.

Gris-PEG - Clinical Pharmacology

Microbiology

Griseofulvin is fungistatic with in vitro activity against various species of Microsporum, Epidermophyton and Trichophyton. It has no effect on bacteria or other genera of fungi.

Pharmacokinetics

Following oral administration, griseofulvin is deposited in the keratin precursor cells and has a greater affinity for diseased tissue. The drug is tightly bound to the new keratin which becomes highly resistant to fungal invasions.

The efficiency of gastrointestinal absorption of ultramicrocrystalline griseofulvin is approximately one and one-half times that of the conventional microsize griseofulvin. This factor permits the oral intake of two-thirds as much ultramicrocrystalline griseofulvin as the microsize form. However, there is currently no evidence that this lower dose confers any significant clinical differences with regard to safety and/or efficacy.

In a bioequivalence study conducted in healthy volunteers (N=24) in the fasted state, 250 mg ultramicrocrystalline griseofulvin tablets were compared with 250 mg ultramicrocrystalline griseofulvin tablets that were physically altered (crushed) and administered with applesauce. The 250 mg ultramicrocrystalline griseofulvin tablets were found to be bioequivalent to the physically altered (crushed) 250 mg ultramicro-crystalline griseofulvin tablets (See Table 1 ).

Table 1: Mean (± SD) of the Pharmacokinetic Parameters for Griseofulvin administered in applesauce as a Single Dose of Gris-PEG® 250-mg Tablets Uncrushed and Crushed to fasted Healthy Volunteers (N=24)

250 mg Ultramicrocrystalline Griseofulvin Tablets Unaltered

250 mg Ultramicrocrystalline Griseofulvin Tablets Physically Altered (Crushed and in Applesauce)

9023.71 (± 1911.5)

Indications and Usage for Gris-PEG

Gris-PEG (griseofulvin ultramicrosize) is indicated for the treatment of the following ringworm infections; tinea corporis (ringworm of the body), tinea pedis (athlete's foot), tinea cruris (ringworm of the groin and thigh), tinea barbae (barber's itch), tinea capitis (ringworm of the scalp), and tinea unguium (onychomycosis, ringworm of the nails), when caused by one or more of the following genera of fungi: Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Trichophyton interdigitalis, Trichophyton verrucosum, Trichophyton megnini, Trichophyton gallinae, Trichophyton crateriform, Trichophyton sulphureum, Trichophyton schoenleini, Microsporum audouini, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum. NOTE: Prior to therapy, the type of fungi responsible for the infection should be identified. The use of the drug is not justified in minor or trivial infections which will respond to topical agents alone. Griseofulvin is not effective in the following: bacterial infections, candidiasis (moniliasis), histoplasmosis, actinomycosis, sporotrichosis, chromoblastomycosis, coccidioidomycosis, North American blastomycosis, cryptococcosis (torulosis), tinea versicolor and nocardiosis.

Contraindications

Two cases of conjoined twins have been reported since 1977 in patients taking griseofulvin during the first trimester of pregnancy. Griseofulvin should not be prescribed to pregnant patients. If the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. This drug is contraindicated in patients with porphyria or hepatocellular failure and in individuals with a history of hypersensitivity to griseofulvin.

Warnings

Prophylactic Usage

Safety and efficacy of griseofulvin for prophylaxis of fungal infections have not been established.

Serious Skin Reactions

Severe skin reactions (e. g. Stevens-Johnson syndrome, toxic epidermal necrolysis) and erythema multiforme have been reported with griseofulvin use. These reactions may be serious and may result in hospitalization or death. If severe skin reactions occur, griseofulvin should be discontinued (see ADVERSE REACTIONS section).

Hepatotoxicity

Elevations in AST, ALT, bilirubin, and jaundice have been reported with griseofulvin use. These reactions may be serious and may result in hospitalization or death. Patients should be monitored for hepatic adverse events and discontinuation of griseofulvin considered if warranted (see ADVERSE REACTIONS section).

Animal Toxicology

Chronic feeding of griseofulvin, at levels ranging from 0.5%-2.5% of the diet resulted in the development of liver tumors in several strains of mice, particularly in males. Smaller particle sizes result in an enhanced effect. Lower oral dosage levels have not been tested. Subcutaneous administration of relatively small doses of griseofulvin once a week during the first three weeks of life has also been reported to induce hepatomata in mice. Thyroid tumors, mostly adenomas but some carcinomas, have been reported in male rats receiving griseofulvin at levels of 2.0%, 1.0% and 0.2% of the diet, and in female rats receiving the two higher dose levels. Although studies in other animal species have not yielded evidence of tumorigenicity, these studies were not of adequate design to form a basis for conclusion in this regard. In subacute toxicity studies, orally administered griseofulvin produced hepatocellular necrosis in mice, but this has not been seen in other species. Disturbances in porphyrin metabolism have been reported in griseofulvin-treated laboratory animals. Griseofulvin has been reported to have a colchicine-like effect on mitosis and cocarcinogenicity with methylcholanthrene in cutaneous tumor induction in laboratory animals. Usage in Pregnancy – see CONTRAINDICATIONS section.

Animal Reproduction Studies

It has been reported in the literature that griseofulvin was found to be embryotoxic and teratogenic on oral administration to pregnant rats. Pups with abnormalities have been reported in the litters of a few bitches treated with griseofulvin. Suppression of spermatogenesis has been reported to occur in rats, but investigation in man failed to confirm this.

Precautions

Patients on prolonged therapy with any potent medication should be under close observation. Periodic monitoring of organ system function, including renal, hepatic and hematopoietic, should be done. Since griseofulvin is derived from species of Penicillium. the possibility of cross-sensitivity with penicillin exists; however, known penicillin-sensitive patients have been treated without difficulty. Since a photosensitivity reaction is occasionally associated with griseofulvin therapy, patients should be warned to avoid exposure to intense natural or artificial sunlight. Occasionally slight abnormalities in liver enzymes (irrespective of drug relationship) were reported with an incidence of less than 1%, specifically elevated ALT and/orAST. The majority of subjects with elevated liver enzymes also had concomitant medical conditions and were taking other drugs that may have increased the propensity for elevated values. When follow-up was provided, changes in elevated liver enzymes appeared to be reversible. Lupus erythematosus or lupus-like syndromes have been reported in patients receiving griseofulvin. Griseofulvin decreases the activity of warfarin-type anticoagulants so that patients receiving these drugs concomitantly may require dosage adjustment of the anticoagulant during and after griseofulvin therapy. Barbiturates usually depress griseofulvin activity and concomitant administration may require a dosage adjustment of the antifungal agent. There have been reports in the literature of possible interactions between griseofulvin and oral contraceptives. The effect of alcohol may be potentiated by griseofulvin, producing such effects as tachycardia and flush.

Adverse Reactions

There have been post-marketing reports of severe skin and hepatic adverse events associated with griseofulvin use (see WARNINGS section). When adverse reactions occur, they are most commonly of the hypersensitivity type such as skin rashes, urticaria, erythema multiforme-like drug reactions, and rarely, angioneurotic edema, and may necessitate withdrawal of therapy and appropriate countermeasures. Paresthesia of the hands and feet have been reported after extended therapy. Other side effects reported occasionally are oral thrush, nausea, vomiting, epigastric distress, diarrhea, headache, fatigue, dizziness, insomnia, mental confusion, and impairment of performance of routine activities. Proteinuria and leukopenia have been reported rarely. Administration of the drug should be discontinued if granulocytopenia occurs. When rare, serious reactions occur with griseofulvin, they are usually associated with high dosages, long periods of therapy, or both.

To report SUSPECTED ADVERSE REACTIONS, contact Valeant Pharmaceuticals North America LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www. fda. gov/medwatch.

Gris-PEG Dosage and Administration

Accurate diagnosis of infecting organism is essential. Identification should be made either by direct microscopic examination of a mounting of infected tissue in a solution of potassium hydroxide or by culture on an appropriate medium. Medication must be continued until the infecting organism is completely eradicated as indicated by appropriate clinical or laboratory examination. Representative treatment periods are tinea capitis, 4 to 6 weeks; tinea corporis, 2 to 4 weeks; tinea pedis, 4 to 8 weeks; tinea unguium-depending on rate of growth-fingernails, at least 4 months; toenails, at least 6 months. General measures in regard to hygiene should be observed to control sources of infection or reinfection. Concomitant use of appropriate topical agents is usually required, particularly in treatment of tinea pedis. In some forms of athlete's foot, yeasts and bacteria may be involved as well as fungi. Griseofulvin will not eradicate the bacterial or monilial infection. Gris-PEG ® tablets may be swallowed whole or crushed and sprinkled onto 1 tablespoonful of applesauce and swallowed immediately without chewing.

Adults:

Daily administration of 375 mg (as a single dose or in divided doses) will give a satisfactory response in most patients with tinea corporis, tinea cruris, and tinea capitis. For those fungal infections more difficult to eradicate, such as tinea pedis and tinea unguium, a divided dose of 750 mg is recommended.

Pediatric Use:

Approximately 7.3 mg per kg of body weight per day of ultramicrosize griseofulvin is an effective dose for most pediatric patients. On this basis, the following dosage schedule is suggested:

16-27 kg: 125 mg to 187.5 mg daily

over 27 kg: 187.5 mg to 375 mg daily

Children and infants 2 years of age and younger – dosage has not been established. Clinical experience with griseofulvin in children with tinea capitis indicates that a single daily dose is effective. Clinical relapse will occur if the medication is not continued until the infecting organism is eradicated.

How is Gris-PEG Supplied

Gris-PEG ® (griseofulvin ultramicrosize) Tablets, 125 mg, white scored, elliptical-shaped, embossed “Gris-PEG” on one side and “125” on the other. The 125 mg strength is film-coated and is available in bottles of 100 (NDC 0884-0763-04).

Gris-PEG (griseofulvin ultramicrosize) Tablets, 250 mg, white scored, capsule-shaped, embossed “Gris-PEG” on one side and “250” on the other. The 250 mg strength is film-coated and is available in bottles of 100 (NDC 0884-0773-04).

STORAGE

Store Gris-PEG tablets at controlled room temperature 15° to 30°C (59° to 86°F) in tight, light-resistant containers.

Valeant Pharmaceuticals North America LLC

Bridgewater, NJ 08807 USA

Valeant Pharmaceuticals International, Inc.

Laval, Quebec, Canada, H7L 4A8

Gris-PEG is a trademark of Valeant Pharmaceuticals International, Inc. or its affiliates.

© Valeant Pharmaceuticals North America LLC

PACKAGE LABEL – PRINCIPAL DISPLAY PANEL – 125 mg 100 count NDC 0884-0763-04 Rx only Gris-PEG ® (griseofulvin ultramicrosize) Tablets, USP 125 mg 100 Tablets VALEANT

PACKAGE LABEL – PRINCIPAL DISPLAY PANEL – 250 mg 100 count

NDC 0884-0773-04 Rx only Gris-PEG ® (griseofulvin ultramicrosize) Tablets, USP 250 mg 100 Tablets VALEANT

Dilvas 20mg tablet ( cipla ) - buy dilvas 20mg tablet online at best price in india, dilvas 10mg

DILVAS 20MG TABLET

What is Enalapril for:

This medication is an ACE (angiotensin-converting enzyme) inhibitor, prescribed for high blood pressure either alone or with other medications. It is also used for heart failure. It decreases certain chemicals that tighten the blood vessels.

How does Enalapril work:

Enalapril lowers blood pressure by lowering a strong chemical in the body. It helps the heart work better. It helps kidney function in patients with high blood sugar (diabetes). It helps blood flow.

How should Enalapril be used:

PO - The recommended dose is 5 ? 20mgday, once or twice daily. It comes as a tablet to take by mouth, with or without food.

Common side effects of Enalapril :

Feeling dizzy. Rise slowly over a few minutes when sitting or lying down. Be careful climbing. Headache. Bad taste in your mouth. This most often goes back to normal. Cough.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Enalapril :

If you have an allergy to enalapril or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have any of these health problems: A block in the kidneys arteries or hyperaldosteronism. If you have high blood sugar (diabetes) and are taking aliskiren. If you are pregnant or may be pregnant.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Signs of infection. These include a fever of 100.5?F (38?C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain. Very bad dizziness or passing out. Trouble breathing. Too much sweat, fluid loss, throwing up, or loose stools. May lead to low blood pressure. A big weight gain. Swelling in your legs or belly. Cough that does not go away. Dark urine or yellow skin or eyes. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Enalapril with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

How do I store Enalapril :

Store it at room temperature and protect it from moisture.

Pregnancy Category

Category D. There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

ACE InhibitorsDirect Renin Inhibitors

This medication is an ACE (angiotensin-converting enzyme) inhibitor, prescribed for high blood pressure either alone or with other medications. It is also used for heart failure. It decreases certain chemicals that tighten the blood vessels.

Insomnia symptoms, causes, treatment & cures, insom

Definition and facts about insomnia

Patient Comments Read 15 Comments Share Your Story

Most adults have experienced insomnia or sleeplessness at one time or another in their lives. However, some of the general population have chronic insomnia.

Insomnia is not defined by a specific number of hours of sleep that one gets, since individuals vary widely in their sleep needs and practices. Although most of us know what insomnia is and how we feel and perform after one or more sleepless nights, few seek medical advice. Many people remain unaware of the behavioral and medical options available to treat insomnia.

Insomnia is generally classified based on the duration of the problem. Not everyone agrees on one definition, but generally:

symptoms lasting less than one week are classified as transient insomnia ,

symptoms between one to three weeks are classified as short-term insomnia . and

those longer than three weeks are classified as chronic insomnia .

Insomnia affects all age groups. Among adults, insomnia affects women more often than men. The incidence tends to increase with age.

Insomnia typically more common in people in lower socioeconomic (income) groups, chronic alcoholics, patients with post-traumatic stress disorder or symptoms, and mental health patients.

Stress most commonly triggers short-term or acute insomnia.

Chronic insomnia may develop if it isn't addressed.

Some surveys have shown that about a third of Americans reported difficulty falling asleep during the previous year and a significant percentage reported problems with long standing insomnia.

There seems to be an association between depression. anxiety. and insomnia. Although the nature of this association is unknown, people with depression or anxiety were significantly more likely to develop insomnia.

What is insomnia?

Insomnia is a symptom, not a stand-alone diagnosis or a disease. By definition, insomnia is "difficulty initiating or maintaining sleep. or both" or the perception of poor quality sleep. Insomnia may therefore be due to inadequate quality or quantity of sleep.

Medically Reviewed by a Doctor on 5/25/2016

Read What Your Physician is Reading on Medscape

Medical Dictionary

Buy heart disease - corodrox (brand name cardizem) online - order cheap diltiazem - purchase heart d

Cardizem is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically, atrial fibrillation and flutter. Cardizem is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

Use Cardizem as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take Cardizem with a full glass of water. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

It is important to use Cardizem regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not stop taking this medication without first talking to your doctor. If you stop taking Cardizem suddenly, your condition may become worse.

If you are being treated for high blood pressure, keep using this medication even if you feel fine.

If you miss a dose of Cardizem, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cardizem.

Store Cardizem at room temperature away from moisture and heat. Keep Cardizem out of the reach of children and away from pets.

Active Ingredient: Diltiazem.

Do NOT use Cardizem if:

you are allergic to any ingredient in Cardizem

you have sick sinus syndrome or have second - or third-degree heart block and do not have a pacemaker, or very low blood pressure

you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White syndrome (WPW) or Lown-Ganong-Levine syndrome (LGL)

you are receiving injectable beta-blockers (eg, metoprolol) or erythromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cardizem. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have heart failure or have had a recent heart attack with lung congestion, heart block, low blood pressure, a very slow heart rate, or abnormal heart rhythm

if you have kidney or liver disease.

Some medicines may interact with Cardizem. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cimetidine or protease inhibitors (eg, indinavir) because they may increase the actions and side effects of Cardizem

Rifampin because it may decrease the effectiveness of Cardizem

Amiodarone, cisapride, digoxin, erythromycin, protease inhibitors (eg, indinavir), quinidine, tricyclic antidepressants (eg, desipramine), theophylline, or general anesthetics because toxic effects on the heart may occur

Benzodiazepines (eg, midazolam), beta-blockers (eg, metoprolol), buspirone, carbamazepine, cilostazol, corticosteroids (eg, prednisone), cyclosporine, HMG-CoA reductase inhibitors (eg, atorvastatin), macrolide immunomodulators (eg, tacrolimus) because the risk of their side effects, some potentially life-threatening, may be increased by Cardizem.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cardizem may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Cardizem may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Cardizem with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Cardizem may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Cardizem may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Cardizem. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Tell your doctor or dentist that you take Cardizem before you receive any medical or dental care, emergency care, or surgery.

Lab tests, including electrocardiogram (ECG), heart rate, and blood pressure monitoring, may be performed while you use Cardizem. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Cardizem with caution in the elderly; they may be more sensitive to its effects.

Cardizem should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cardizem while you are pregnant. Cardizem is found in breast milk. Do not breastfeed while taking Cardizem.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); hallucinations; irregular heartbeat; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools); tender, bleeding, or swollen gums.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Clotrimazole - side effects, dosage, interactions, mycelex

Clotrimazole

Clotrimazole is an anti-fungal medication used to treat yeast infections of the vagina, skin, and mouth. It is commonly used for athlete's foot, jock itch, body ringworm. and oral thrush.

Lotrimin is one of the brand names of clotrimazole. There are several other brand names, and this medicine is also used in combination products.

The drug prevents the growth of fungi by interfering with the production of the membrane that surrounds fungal cells.

Clotrimazole comes as a cream, powder, and lotion to apply to the skin. It also comes as a lozenge to dissolve in the mouth and a vaginal tablet and cream to be inserted into the vagina.

Clotrimazole (Lotrimin) Warnings

Clotrimazole cream, lotion, and solution should only be used externally. Do not swallow or let the medication get in your eyes. Also, do not swallow the vaginal tablets or cream.

If you have a vaginal infection, you should avoid sexual intercourse. An ingredient in clotrimazole cream may weaken certain latex products like condoms or diaphragms, so you should not use these products within 72 hours of taking clotrimazole.

Continue to use clotrimazole even if you feel well. You should not stop taking this drug without talking to your doctor. You should also keep taking it during your menstrual period.

Before taking this drug, you should tell your doctor if you have or have ever had liver disease, problems with your immune system, HIV, AIDS, a history of alcohol abuse, or diabetes. You should also tell your doctor if you drink alcohol before taking this medicine.

Studies have shown clotrimazole is poorly absorbed into the blood and body when applied to the skin or vagina. Women in their second or third trimesters of pregnancy have shown no ill effects while taking clotrimazole. It is not known whether this drug is secreted in breast milk.

Clotrimazole (Lotrimin) Side Effects

This should slowly dissolve in the mouth after being placed on the tongue. One troche (lozenge) is typically given five times a day for 14 days.

Cream, lotion, or solution forms:

These are typically applied to the affected area and surrounding skin twice a day, in the morning and evening.

This is inserted through an applicator once daily for seven consecutive days (preferably at bedtime).

The 100-milligram (mg) suppository is inserted once a day for seven consecutive days (preferably at bedtime).

The 200 mg suppository is inserted once a day for three days (preferably at bedtime).

Clotrimazole (Lotrimin) Overdose

If you suspect an overdose, contact a poison control center or emergency room immediately. You can get in touch with a poison control center at (800) 222-1222.

Missed Dose of Clotrimazole (Lotrimin)

If you miss a dose of clotrimazole, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and follow your regular dosing schedule. Do not "double up" to make up for a missed dose.

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Why is this medication prescribed?

Ramipril is used alone or in combination with other medications to treat high blood pressure. It is also used to reduce the risk of heart attack and stroke in patients at risk for these problems and to improve survival in patients with heart failure after a heart attack. Ramipril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

How should this medicine be used?

Ramipril comes as a capsule to take by mouth. It is usually taken once or twice a day with or without food. To help you remember to take ramipril, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ramipril exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsule whole, or open the capsule and sprinkle the contents on a small amount of applesauce (about 4 oz.) or in 4 oz. (about 120 mL) of water or apple juice. Eat or drink the entire mixture. This mixture can be prepared in advance and stored for 24 hours at room temperature or 48 hours in the refrigerator.

Your doctor will probably start you on a low dose of ramipril and gradually increase your dose.

Ramipril controls high blood pressure and heart failure but does not cure them. Continue to take ramipril even if you feel well. Do not stop taking ramipril without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking ramipril,

tell your doctor &nbsp;&nbsp;&nbsp;&nbsp; and pharmacist if you are allergic to ramipril, benazepril (Lotensin), &nbsp;&nbsp;&nbsp;&nbsp; captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), &nbsp;&nbsp;&nbsp;&nbsp; lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), &nbsp;&nbsp;&nbsp;&nbsp; quinapril (Accupril), trandolapril (Mavik), or any other medications.

tell your doctor &nbsp;&nbsp;&nbsp;&nbsp; if you have diabetes (high blood sugar) and you are taking aliskiren &nbsp;&nbsp;&nbsp;&nbsp; (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably &nbsp;&nbsp;&nbsp;&nbsp; tell you not to take ramipril if you have diabetes and you are also taking &nbsp;&nbsp;&nbsp;&nbsp; aliskiren.

tell your doctor &nbsp;&nbsp;&nbsp;&nbsp; and pharmacist what prescription and nonprescription medications, &nbsp;&nbsp;&nbsp;&nbsp; vitamins, nutritional supplements, and herbal products you are taking. Be &nbsp;&nbsp;&nbsp;&nbsp; sure to mention any of the following: aspirin and other nonsteroidal &nbsp;&nbsp;&nbsp;&nbsp; anti-inflammatory medications (NSAIDs) such as indomethacin (Indocin); &nbsp;&nbsp;&nbsp;&nbsp; diuretics ('water pills'); lithium (Eskalith, Lithobid); and potassium &nbsp;&nbsp;&nbsp;&nbsp; supplements. Your doctor may need to change the doses of your medications &nbsp;&nbsp;&nbsp;&nbsp; or monitor you carefully for side effects.

tell your doctor &nbsp;&nbsp;&nbsp;&nbsp; if you have or have ever had heart, liver, or kidney disease; lupus; &nbsp;&nbsp;&nbsp;&nbsp; scleroderma; diabetes; or angioedema, a condition that causes difficulty &nbsp;&nbsp;&nbsp;&nbsp; swallowing or breathing and painful swelling of the the face, throat, &nbsp;&nbsp;&nbsp;&nbsp; tongue, lips, eyes, hands, feet, ankles, or lower legs.

tell your doctor &nbsp;&nbsp;&nbsp;&nbsp; if you plan to become pregnant or are breast-feeding.

if you are &nbsp;&nbsp;&nbsp;&nbsp; having surgery, including dental surgery, tell the doctor or dentist that &nbsp;&nbsp;&nbsp;&nbsp; you are taking ramipril.

you should know &nbsp;&nbsp;&nbsp;&nbsp; that diarrhea, vomiting, not drinking enough fluids, and sweating a lot &nbsp;&nbsp;&nbsp;&nbsp; can cause a drop in blood pressure, which may cause lightheadedness and &nbsp;&nbsp;&nbsp;&nbsp; fainting.

What special dietary instructions should I follow?

Talk to your doctor before using salt substitutes containing potassium. If your doctor prescribes a low-salt or low-sodium diet, follow these directions carefully.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Ramipril may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

headache

dizziness

cough

upset stomach

vomiting

excessive tiredness

weakness

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

swelling of the face, throat, tongue, lips, eyes, &nbsp;&nbsp;&nbsp;&nbsp; hands, feet, ankles, or lower legs

hoarseness

difficulty breathing or swallowing

yellowing of the skin or eyes

fever, sore throat, chills, and other signs of &nbsp;&nbsp;&nbsp;&nbsp; infection

lightheadedness

fainting

Ramipril may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

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Description

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis.

Active Ingredient: diclofenac

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Diclobru diseases

COMPOSITION: Active ingredients: Diclofenac Sodium 75 mg/3 ml Other ingredients: propylene glycol, benzyl alcohol, sodium metabisulfite, mannitol, sodium hydroxyde, water for injection.

PRESENTATION AND PACKAGE: ampoules of 3 ml with clear, colorless liquid free of visible particles, packed in boxes of 5 or 100 ampoules.

PHARMACOLOGICAL PARTICULARS. Non-steroidal anti-inflammatory drug belonging to the group of phenylacetic acid derivatives. It has anti-inflammatory, analgesic and antipyretic effects. It inhibits cyclooxygenase with resulting blockade of the arachidonic cascade reactions and disturbance of synthesis of PGE2, PGF2-alfa, thromboxan A2, prostacycline, leukotrienes and output of lysosomal enzymes: inhibits platelet aggregation, and has a desensitizing effect in long-term using. In course treatment of locomotor system diseases, the drug intensively penetrates the joint cavity, relieves joint pain in rest and movements, improves volume of movements, and decreases morning constraint and edema of joints. It relieves pain in rest and movements, morning constraint, edema of joints, improves their functional activity. In inflammatory processes after operations and traumas, it rapidly relieves both a spontaneous pain and a pain in movements, decreases an inflammatory edema in the wound area. After a course treatment of the patients with polyarthritis, the drug concentration in sinovial liquid and sinovial tissues is higher than that in plasma. By anti-inflammatory activity, diclofenac is better than acetylsalicylic acid, butadione, ibuprofen; there are data of its more significant clinical effect and better tolerance compared to indometacin. By rheumatism and Bechterevs disease it is equivalent to prednisolone.

- The peak plasma concentration is reached 10-20 minutes after intramuscular administration. 99 % of the drug is bound to plasma proteins. It freely penetrates tissues and sinovial liquid where its concentration rises slowly and over 4 hours becomes higher than that in plasma. Diclobru is metabolized in the liver through conjugation and hydroxylation with formation of the pharmacologically inactive metabolites. 35 % of metabolites is eliminated with feces, and 65 % is eliminated via the kidneys as inactive derivatives (less than 1 % is eliminated as unchanged drug). The plasma half-life elimination is 2 hours, sinovial liquid - 3-6 hours.

INDICATIONS: - Locomotor system diseases (rheumatic arthritis, arthroses, gout, bursopathy, entesopathy, deforming osteoarthrosis, synovitis and tendosynovitis, myalgia, myositis) - Spinal diseases (Bechterevs disease, coxarthrosis, ankylosing spondylitis, spondylosis, ischias, osteochondrosis, disorders of the lumbosacral plexus, radiculitis)

- Neurological diseases (neuralgia and neuritis, migraine attacks)

- Posttraumatic pains (sprains, dislocations, contusions, fractures)

- Postoperative pains (after tonsillectomy, operations on the abdominal organs, extraction of teeth)

- Menstrual pains (algodysmenorrhea) and inflammation of ovaritis (salpingitis and oophoritis), inflammatory diseases of the uterus, of vagina and vulva (pathogenetic therapy)

- Renal and bile colicks

- Pathogenetic therapy of the otorhinolaryngologic diseases (inflammation of middle ear, acute pharyngitis, acute tonsillitis [angina], sinusitis, maxillitis)

- Pathogenetic therapy of acute respiratory infections of the upper respiratory tract

- Diseases of the vision organs (blepharoconjunctivitis, conjunctivitis, keratoconjunctivitis, changes in corneal membranes, trauma of the eye and orbit)

POSOLOGY FOR INTRAMUSCULAR INJECTION OR SLOW INFUSION (DROP)

1. Intramuscular injection: Contents of one ampoule to be injected deeply in the buttock. (do never inject under the skin or directly in bolus in a vein), once a day. In some cases the daily dose can be increased up to two ampoules per day (one injection in each buttlock) with interval of minimum 6 hours between two injections. The maximal daily dose is 150 mg. The maximal dose should not be used for more than 5 consecutive days.

2. Slow intravenous drop infusion (fulfilled by a doctor in a hospital only): immediately before infusion, prepare the following solution: to a 100 - 150 ml of 0.9 % NaCl solutions for intravenous drop infusions or to a 100-150 ml of 5 % glucose solutions, add 1ml of a solution for injection of 4.2% of Na Bicarbonate. Add the required quantity of Diclobru in one of the above mentioned solution. Verify that you have obtained a clear solution free of any particles, crystals or precipitate. Use only a clear solution. The intravenous drop infusion may be fulfilled by one of the following schemes: - 25-50 mg of Diclobru for one hour. Then Diclobru may be infused with rate 5 mg/h to maintain a therapeutic effect; 75 mg of Diclobru for two hours. Never exceed the maximal dose of 150 mg/day.

CHILDREN: NOT RECOMMENDED FOR CHIDRENS

CONTRAINDICATIONS: - hypersensitivity to diclofenac and other ingredients of the drug or other NSAIDs - ulcerative disease of the stomach and duodenum - destructive and inflammatory diseases of the intestines in acute phase - haemopoiesis disorders or blood disorders aspirin bronchial asthma - porphyria - last trimester of pregnancy and breast feeding - children under the age of 14 years - renal and liver insufficiency

SIDE-EFFECTS: Gastrointestinal side effects may include in rare cases, nausea, erosive-ulcerative lesions, bleeding and perforation in the gastrointestinal tract, liver dysfunction, elevated transaminase levels, jaundice, hepatitis. Peripheral edema and allergic reactions: rash, pruritus, eczema, bronchospasm, anaphylactic systemic reactions. Central and peripheral nervous system side effects: dizziness, headache, tinnitus, insomnia, nervousness, depression or tiredness, vision disturbances (blurred vision, diplopia). Urinary tract: nephrotic syndrome, renal insufficiency may occur. Haemopoiesis system: leucopenia, thrombocytopenia, aplastic anaemia, erythema multiforme, agranulocytosis, haemolytic anemia. Other systems: edema in the injection site, local pain and induration, particularly in elderly diabetics.

PRECAUTIONS: The drug should be used with caution in diseases of liver, kidneys, gastrointestinal tract in anamnesis, in dyspeptic symptoms, bronchial asthma, arterial hypertension, heart failure, recent serious operative interventions, as well as for elderly patients. Patients suffering from impairment of hepatic, cardiac, or renal function should be carefully monitored. Dosage may have to be reduces in the elderly.

During prolonged treatment, it is recommended to control hepatic function, peripheral blood contents, occult blood in feces. In case of known allergic reactions on NSAIDs or sulfites, diclofenac may be used only in emergency cases. During the firs 6 months of pregnancy, the drug should be used by strict indications and in least dosage. During the treatment alcohol is not recommended. Effects on the ability to drive or operate machinery: During the treatment, decrease in speed of psychomotor reactions is possible. OVERDOSAGE. Symptoms: acute headache, motor excitation, dizziness, cramps, convulsions; nausea, vomiting, blood vomiting, diarrhoea, gastrointestinal erosion, ulceration or bleeding in gastrointestinal tract; liver disorders; renal insufficiency. Treatment: Forced diuresis. Symptomatic therapy directed on the blood pressure normalization. In case of convulsions - diazepam, phenobarbital. Hemodialysis is ineffective.

INTERACTIONS WITH OTHER DRUGS

- Concurrent use of diclofenac with potassium-sparing diuretics may increase blood potassium level; concurrent use with loop diuretics may reduce their diuretic effects It increases blood lithium level

- Concurrent use of digoxin and lithium with diclofenac can provoke increasing of digoxin and lithium plasma concentrations.

- Methotrexate. NSAIDs may decrease protein binding and/or renal elimination of methotrexate, resulting in increased and prolonged methotrexate plasma concentrations and increased risk of toxicity; it is recommended to withdraw NSAID therapy before and after infusions of methotrexate in high doses.

- Cyclosporine: Risk of toxicity may increased

- Concurrent use with aspirin is not recommended because administration of two or more NSAIDs may increase the risk of gastrointestinal toxicity and bleeding Concurrent administration of two or more NSAIDs may alter the pharmacokinetic profile of at least one of the medications, which may alter the therapeutic effect and/or increase the risk of adverse effect; specifically, aspirin decreases the bioavailability of diclofenac [by 50 %] with lowering plasma diclofenac level.

- Anticoagulants, coumarin-or indandione-derivative or heparin or thrombolytic agents: Inhibition of platelet aggregation by NSAIDs, and the possibility of NSAID-induced gastrointestinal ulceration or bleeding may be hazardous to patients receiving anticoagulant or thrombolytic therapy; although with usual doses, diclofenac less likely than other NSAIDs may significantly alter platelet aggregation

- It increases risk of side effects of glucocorticoids (gastrointestinal bleeding)

- Antidiabetic agents, oral or insulin: NSAIDs may increase the effect of these medications; dosage adjustments of the antidiabetic agent may be necessary

- It increases the blood level of quinoline derivatives

- Bone marrow depressants. Leukopenic and/or thrombocytopenic effects of these medications may be increased with concurrent or recent therapy with NSAID; if necessary, dosage adjustment of the bone marrow depressant should be based on blood counts

- Cefamandole, cefoperazone, plicamycin, valproive acid, colchicin: Concurrent use with NSAID may increase risk of gastrointestinal bleeding and bleeding in other sites.

SHELF LIFE :Shelf-life is 3 years.

DELIVERY CONDITIONS. On medical prescription.

STORAGE INSTRUCTIONS: Store below 25°C. Protect from light.

KEEP OUT OF REACH OF CHILDREN.

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Product description

Safety information

Side effects

Diclofenac is used primarily for the treatment of inflammation and pain caused by conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also effective in treating soft tissue inflammations due to tendinitis and bursitis, and treating dysmenorrhea (menstrual cramps). Diclofenac is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Diclofenac as directed by your doctor!

Take Diclofenac by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Diclofenac with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Diclofenac, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac.

Store Diclofenac at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do NOT use Diclofenac if:

you are allergic to any ingredient in Diclofenac or to bovine (cow) protein

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you have severe kidney problems

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if this applies to you.

Some medical conditions may interact with Diclofenac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you smoke, drink alcohol, or have a history of alcohol abuse

if you are taking an antibiotic or an anti-seizure medicine. The risk of liver problems may be increased with some of these medicines.

Some medicines may interact with Diclofenac. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin and other blood thinners (eg, dalteparin), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Acetaminophen because the risk of liver problems may be increased

Probenecid because it may increase the risk of Diclofenac's side effects

Cyclosporine, lithium, metformin, methotrexate, oral NSAIDs (eg, ibuprofen), or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Diclofenac

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Diclofenac.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Diclofenac may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Diclofenac. Taking it in high doses, for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Diclofenac with food will NOT reduce the risk of these effects. If you have severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling, contact your doctor or emergency room right away.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Diclofenac is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Diclofenac unless your doctor tells you to.

Check with your doctor or pharmacist before you take acetaminophen while you are taking Diclofenac. The risk of liver problems may be increased.

Do not switch between different forms of Diclofenac (eg, enteric-coated tablets, immediate-release tablets, capsules) unless your doctor tells you to. They may not provide the same amount of medicine to your body.

Lab tests, including kidney function, liver function, blood electrolyte levels, complete blood cell counts, and blood pressure, may be performed while you use Diclofenac. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Diclofenac with caution in the elderly; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.

Diclofenac should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Diclofenac may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breastfeed while taking Diclofenac.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; mild stomach pain or heartburn; nausea; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; persistent flu-like symptoms; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting or diarrhea; shortness of breath; sudden or unexplained weight gain; swelling of the hands, legs, or feet; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, yellowing of the skin or eyes); unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Diclobru diseases

BRUPHARMEXPORT S. P.R. L. is a Belgian family owned company founded in 1983 by the pharmacist Mr Eric Vandecauter (actual C. E.O. of the company) and his mother the pharmacist Mrs Marcel Bingen. The company began its activity in CIS countries very soon after the end of USSR in 1992 and is now known as a reference in central Asia, Caucasus and Ukraine, being on the market without interruption for more than 20 years. Brupharmexport s. p.r. l. is contract manufacturing European quality made product aiming to provide quality health solution to everyone in Central Asia, Caucasus and Ukraine. Therefore Brupharmexport s. p.r. l. has the pleasure to sell their own products on the market such as a wide range of cardiologist products, generics such as Diclofenac (Diclobru) tablets and injectable, Butyl-Scopolamine (Spasmobru) tablets and injectable, Domperidone (Brulium Linguatabs). Brupharmexport s. p.r. l. is also the exclusive representative of European partners by selling their products.

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A dietary food and nutritious means; Agents from intestinal disorders and gastric agents; Agents on care of a body; Agents on care of a skin and hair; Agents on care of the child; Generics; Infusions & standard injections solutions; OTC Products; Sports medicine;

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Main article: Systemic circulation Systemic circulation is the circulation of the blood to all parts of the body except the lungs. Systemic circulation is the portion of the cardiovascular system which transports oxygenated blood away from the heart through the aorta from the left ventricle where the blood has been previously deposited from pulmonary circulation, to the rest of the body, and returns oxygen-depleted blood back to the heart. Systemic circulation is, distance-wise, much longer than pulmonary circulation, transporting blood to every part of the body.[7] Oxygen transportation An animation of a typical human red blood cell cycle in the circulatory system. This animation occurs at real time (20 seconds of cycle) and shows the red blood cell deform as it enters capillaries, as well as changing color as it alternates in states of oxygenation along the circulatory system. Main article: Blood § Oxygen transport About 98.5% of the oxygen in a sample of arterial blood in a healthy human breathing air at sea-level pressure is chemically combined with hemoglobin molecules. About 1.5% is physically dissolved in the other blood liquids and not connected to hemoglobin. The hemoglobin molecule is the primary transporter of oxygen in mammals and many other species.

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