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GASTROPRAZOL EQ GRANULADO

FARMACOLOGÍA: La función del omeprazol es inhibir la bomba de protones (suprimir la producción del ácido gástrico), el cual representa una clase de agentes relativamente nueva, llamada benzimidazoles sustituidos. Necesita un ambiente ácido para activarse a un derivado sulfonamida que se une en forma irreversible en la superficie secretora de las células parietales a la enzima H+/K+ATPasa. Inhibe el transporte de los protones dentro del estómago. Actúa tanto en condiciones básales como en situaciones de estímulo. Inhibe al sistema oxidasa citocromo P-450 de función mixta hepático.

INDICACIONES: Indicado en el tratamiento de las enfermedades ulcerativas gastroduodenales, úlcera gástrica recurrente en equinos, para prevenir o tratar las erosiones gástricas por medicamentos, esofagitis y síndrome de gastritis ulcerativa en equinos.

VÍA DE ADMINISTRACIÓN: Oral.

Requerimiento: 4 mg/kg una vez al día durante 4 semanas.

Administrar: 2 sobres de 12 g/500 kg una vez al día durante 4 semanas.

Requerimiento: 2 mg/kg una vez al día durante 4 semanas.

Administrar: 1 sobre de 12 g/500 kg una vez al día durante 4 semanas.

RECOMENDACIONES DE ALMACENAMINENTO: Consérvese en un lugar fresco y seco.

LEYENDAD DE PROTECCIÓN: Su venta requiere receta médica. Para uso exclusivo en medicina veterinaria.

No se deje al alcance de los niños.

PRESENTACIÓN: Caja con 12 sobres de 12 g cada uno.

Hecho en México por:

LABORATORIOS BROVEL, S. A. de C. V.

Tels. (55) 5563-5022, 2337 y 7028

Fax: (55) 5598-9018

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Dr. Naftilan's Overview

Dr. Naftilan graduated from the University of Alabama School of Medicine in 1982. He works in Nashville, TN and specializes in Cardiovascular Disease and Transplant Surgery. Dr. Naftilan is affiliated with Vanderbilt University Medical Center and Williamson Medical Center.

Dr. Naftilan's Experience

Years in Practice: 34

Conditions Treated by Dr. Naftilan

Procedures Performed by Dr. Naftilan

Dr. Naftilan's Specialties

Cardiovascular Disease, Transplant Surgery

Dr. Naftilan's Education & Training

Medical School: University of Alabama School of Medicine; Graduated 1982

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Definition of Asystole:

Cardiac standstill or arrest, absence of a heartbeat.

Synonym: Beau's syndrome.

Drugs associated with Asystole

The following drugs and medications are in some way related to, or used in the treatment of Asystole. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Asystole

Adrenergic bronchodilators

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Adrenergic bronchodilators (specifically beta2-adrenoreceptor agonists) dilate the bronchi by a direct action on the beta2-adrenoreceptors on the bronchial smooth muscle and relax the muscle.

There are two categories of beta2-adrenoreceptor agonists used in asthma. The short acting adrenergic bronchodilators are used on an as needed basis to control symptoms of asthma. The longer acting bronchodilators are used regularly, twice daily, as adjunct therapy in patients whose asthma is poorly controlled by inhaled corticosteroids.

Medical conditions associated with adrenergic bronchodilators:

Adams-Stokes SyndromeAllergic ReactionsAsthmaAsthma, acuteAsthma, MaintenanceAsystoleAV Heart BlockBronchitisBronchospasm During AnesthesiaBronchospasm ProphylaxisCardiac ArrhythmiaCOPDCOPD, AcuteCOPD, MaintenanceElectromechanical DissociationPremature LaborShock Drug List:/tags/epipen-auto-injector/ /tags/isuprel-mistometer/ /tags/serevent/ /tags/xopenex/ /tags/primatene-mist-aerosol/ /tags/bricanyl/ /tags/volmax/ /tags/proventil-hfa-aerosol/ /tags/proventil/ /tags/maxair-autohaler/ /tags/perforomist/ /tags/vospire-er-extended-release-tablets/ /tags/adrenaclick-auto-injector/ /tags/ adrenalin - chloride/ /tags/arcapta/ /tags/brethaire/ /tags/bronkosol/ /tags/epipen-auto-injector/ /tags/epipen-jr-2-pak/ /tags/medihaler-epi/ /tags/metaprel/ /tags/twinject-auto-injector/ Twinject-Auto-Injector-Two-Pack read more

Minims Lidocaine & Fluorescein

Lidocaine and Fluorescein

4% w/v Lidocaine hydrochloride and 0.25% w/v Fluorescein Sodium

About your eye drops

The name of this medicine is Minims Lidocaine & Fluorescein. Each Minims unit contains a solution of 4% w/v Lidocaine hydrochloride with 0.25% w/v fluorescein sodium.

One of the active ingredients in this medicine is lidocaine hydrochloride. This is the new name for lignocaine hydrochloride. The ingredient itself has not changed.

It also contains purified water, povidone and hydrochloric acid. Each Minims unit is a sterile, single-use container which holds approximately 0.5ml of solution. Each carton holds 20 Minims units. Lidocaine is a local anaesthetic which temporarily numbs the surface of the eye. Fluorescein temporarily colours your eyes orange or green and helps your doctor or eye specialist to examine them.

Who makes your eye drops?

Minims Lidocaine and Fluorescein are manufactured by

Laboratoire Chauvin S. A. ZI Ripotier 07200/Aubenas France

The Marketing Authorisations for Minims Lidocaine and Fluorescein (PL 0033/0073 & PA 118/24/1) are held by

Chauvin Pharmaceuticals Ltd. 106 London Road Kingston-Upon-Thames KT2 6TN England What are your eye drops for?

Your eye drops are used to numb and stain the surface of the eye, for a short time only, to allow the doctor or eye specialist to examine your eye.

Most often, your eye drops are used to allow the pressure inside your eyes to be measured.

Before using your eye drops

You should not use this product if you are allergic to fluorescein or Lidocaine and other similar types of local anaesthetic.

This product should be used with care in eyes that are inflamed (red and painful).

Your eye drops are not intended for long term use. Frequent use of local anaesthetic in the eye over long periods of time may affect your eyesight.

Using your eye drops

The doctor or eye specialist will put the drops in for you. You may be asked to press on the inner corners of your eyes for a minute to stop the solution draining into your nose and throat through the tear ducts.

It is important to protect your eye from dust during the time your eye is numb. Your doctor or eye specialist will make sure that your eye is properly protected.

The Minims unit should be thrown away after a single use, even if some solution remains.

It is unlikely that you will suffer an overdose from Minims Lidocaine & Fluorescein, but if you do suddenly feel unwell after receiving the drops, tell your doctor or eye specialist.

Following administration of Minims Lidocaine & Fluorescein you may experience very rare side effects which includes redness and irriatation of the eye, swelling around the eye, rarely difficulty in breathing and symptoms of shock and itchy skin rash with raised red blotches.

After using your eye drops

Tell your doctor or eye specialist if you suffer from any unwanted effects after using Minims Lidocaine & Fluorescein, that are not mentioned in this leaflet.

Storing your eye drops

The expiry date is printed on each Minims unit overwrap and printed on the carton label. Do not use it after this date.

Your eye drops should be stored below 25°C and in original container to protect from light. Do not allow to freeze.

This leaflet applies only to Minims Lidocaine & Fluorescein, but does not contain all the

If you have any questions or are not sure about anything, ask a doctor, eye specialist or pharmacist.

Date of (Partial) Revision of Text:

Chauvin Pharmaceuticals Ltd. 106 London Road Kingston-Upon-Thames KT2 6TN England Tel:020 8781 2900 Fax:020 8781 2901

Art. 76441 0504128/4

Iodopengha

Iodopengha may be available in the countries listed below.

Ingredient matches for Iodopengha Eugenol

Eugenol is reported as an ingredient of Iodopengha in the following countries:

Lidocaine is reported as an ingredient of Iodopengha in the following countries:

International Drug Name Search

Petco Lidocaine

Dosage Form: FOR ANIMAL USE ONLY Drug Facts

Itch Relief Spray

PETCO Itch Relief is a colorless, odorless, non-sticky, non-staining, water based formula containing the following ingredients which provide temporary relief of pain and itching from minor skin problems:

Lidocaine - An anesthectic to instantly calm pain and itching Aloe Vera and Allantoin - To soothe irritated skin Glycerin - A humectant to help moisturize the skin Denatonium Benzoate - A non-toxic bittering agent to deter chewing and licking of skin irritations Active Ingredients

2% Lidocaine HCL, 0.01% Benzalkonium Chloride

Uses Provides temporary relief of pain and itching from minor skin problems such as insect bites, cuts, scrapes, and burns. Warnings

Should irritation develop, persist or increase, discontinue use and consult a veterinarian. Keep this product out of reach of children and pets to avoid unintended consumption.

For use on dogs over six weeks old. Hold sprayer 6-8 inches from animal and thoroughly wet affected area making sure spray contacts the skin. Avoid spraying in eyes, nose, ears or mouth.

Store at 20-25C (68-77F)

Water, glycerin, Aloe Vera, Allantoin, Denatonium Benzoate.

FOR QUESTIONS CALL 1-877-473-8465

PETCO Itch Relief Spray For Dogs Medicated Spray Helpstemporarily relieve itching Helps aid in the temporary relief of minor skin problems Veterinarian Approved NET 8 FL. OZ. (236mL) PETCO lidocaine hydrochloride liquid Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 27102-806 Route of Administration TOPICAL DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength LIDOCAINE HYDROCHLORIDE ( LIDOCAINE ) LIDOCAINE HYDROCHLORIDE 4.72 g in 236 g Inactive Ingredients Ingredient Name Strength Water GLYCERIN ALOE VERA LEAF ALLANTOIN DENATONIUM BENZOATE BENZALKONIUM CHLORIDE Product Characteristics Color Score Shape Size Flavor Imprint Code Contains Packaging # NDC Package Description Multilevel Packaging 1 27102-806-07 236 g In 1 BOTTLE, SPRAY None Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date unapproved drug other 01/01/2001 Labeler - PETCO (028364727) Registrant - United Pet Group (931135730) Establishment Name Address ID/FEI Operations JUNGLE LABORATORIES CORPORATION 032615270 manufacture Revised: 03/2010PETCO

Pro Pet Dr Jeff

Dosage Form: FOR ANIMAL USE ONLY Drug Facts Active Ingredient

2% Lidocaine HCL

Uses: Provides temporary relief of pain and itching from minor skin problems. For use on dogs and cats.

Warnings Should irritation develop, persist, or increase, discontinue use and consult a veterinarian. Do not apply to wounds or damaged skin Do not bandage tightly Keep this product out of reach of children and pets to avoid unintended consumption Directions For use on dogs over six weeks old Hold sprayer 6-8 inches from animal and thoroughly wet affected area making sure spray contacts the skin Avoid spraying in eyes, nose ears or mouth. Other Information

Store at 20C-25C (68F-77F)

Water, Glycerin, Aloe Vera, Allantoin, Denatonium Benzoate.

Relieves minor pain, itching and other skin discomfort With Lidocaine and Aloe Vera Veterinarian Approved Dr. Jeff Werber, D. V.M. Net Wt. 8 Fl. oz. (236 ml)

Skin Relief Medicated Spray

Provides temporary relief from skin discomfort associated with scrapes, insect bites, minor cuts, burns, skin irritations, and sunburn. With Lidocaine. an anesthetic to calm itching and minor pain, and moisturizing conditioners to nourish skin. Bitter taste discourages chewing and licking of irritated area. PRO PET DR. JEFF anti itch spray spray Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 24730-626 Route of Administration TOPICAL DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength LIDOCAINE HYDROCHLORIDE ( LIDOCAINE ) LIDOCAINE HYDROCHLORIDE 4.72 g in 236 g Inactive Ingredients Ingredient Name Strength Water ALLANTOIN ALOE VERA LEAF BENZALKONIUM CHLORIDE GLYCERIN DENATONIUM BENZOATE Product Characteristics Color Score Shape Size Flavor Imprint Code Contains Packaging # NDC Package Description Multilevel Packaging 1 24730-626-07 236 g In 1 BOTTLE, SPRAY None Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date unapproved drug other 01/01/2001 Labeler - United Pet Group (931135730) Establishment Name Address ID/FEI Operations JUNGLE LABORATORIES CORPORATION 032615270 manufacture Revised: 01/2010United Pet Group

Asthma, acute Medications

Drugs associated with Asthma, acute

The following drugs and medications are in some way related to, or used in the treatment of Asthma, acute. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Asthma, acute

UAD Caine

Generic Name: lidocaine injection (LYE doe kane) Brand Names: Anestacaine, UAD Caine, Xylocaine HCl, Xylocaine-MPF

What is UAD Caine ( lidocaine injection)?

Lidocaine is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.

Lidocaine injection is used to numb an area of your body to help reduce pain or discomfort caused by invasive medical procedures such as surgery, needle punctures, or insertion of a catheter or breathing tube.

Lidocaine injection is also given in an epidural (spinal block) to reduce the discomfort of contractions during labor.

Lidocaine injection is sometimes used to treat irregular heart rhythms that may signal a possible heart attack.

Lidocaine injection may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about UAD Caine ( lidocaine injection)? You should not receive this medication if you are allergic to lidocaine or any other type of numbing medicine.

Before you receive lidocaine injection, tell your doctor if you have liver or kidney disease, heart disease, coronary artery disease, circulation problems, or a history of malignant hyperthermia.

To treat irregular heart rhythms, your doctor may prescribe a LidoPen auto-injector. This is a prefilled automatic injection device to be used in an emergency. Keep the device with you at all times.

Your doctor will describe the signs and symptoms to watch for when deciding when it's time to use lidocaine injection at home. Never use the LidoPen auto-injector without first calling your doctor.

With the LidoPen auto-injector you will also receive a CardioBeeper to transmit your heart rate and rhythm to your doctor over a telephone. Read all provided instructions and practice using the CardioBeeper.

Lidocaine can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after using this medication What should I discuss with my healthcare provider before receiving UAD Caine ( lidocaine injection)? You should not receive this medication if you are allergic to lidocaine or any other type of numbing medicine.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use lidocaine injection:

liver disease; kidney disease;

coronary artery disease, circulation problems; or

a history of malignant hyperthermia.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether lidocaine injection passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How is lidocaine injection given?

Lidocaine is given as an injection through a needle placed into a vein or directly into the body area to be numbed. Your doctor, nurse, or other healthcare provider will give you this injection.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving lidocaine injection in a hospital setting.

To treat irregular heart rhythms, you may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles and other items used in giving the medicine.

The LidoPen auto-injector is a prefilled automatic injection device to be used in an emergency. Keep the device with you at all times. Your doctor will describe the signs and symptoms to watch for when deciding when it's time to use the injection.

Never use the LidoPen auto-injector without first calling your doctor.

Do not use the auto-injector in or near a vein or into your buttocks. Inject the medication only in your upper thigh or upper arm.

With the LidoPen auto-injector you will also receive a CardioBeeper. This device is used to transmit your heart rate and rhythm to your doctor over a telephone. Read all provided instructions and practice using the CardioBeeper so you will be able to quickly use it in an emergency.

Store the LidoPen auto-injector at room temperature away from moisture and extreme hot or cold. What happens if I miss a dose?

Since lidocaine injection is used only when needed, you are not likely to be on a dosing schedule.

Never use the LidoPen auto-injector without first calling your doctor.

What happens if I overdose? Seek emergency medical attention if you think you have received too much of this medicine.

Overdose symptoms may include drowsiness, confusion, nervousness, ringing in your ears, blurred vision, feeling hot or cold, numbness, muscle twitches, uneven heartbeats, seizure (convulsions), slowed breathing, or respiratory failure (breathing stops).

What should I avoid while receiving UAD Caine ( lidocaine injection)? Lidocaine can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after using this medication

Avoid eating or chewing within 1 hour after lidocaine injection is used to numb your mouth or throat. You may have trouble swallowing which could lead to choking. You may also accidentally bite the inside of your mouth if you are still numb an hour after treatment with lidocaine injection.

UAD Caine ( lidocaine injection) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have any of these serious side effects:

feeling anxious, shaky, dizzy, restless, or depressed;

drowsiness, vomiting, ringing in your ears, blurred vision;

confusion, twitching, seizure (convulsions);

fast heart rate, rapid breathing, feeling hot or cold;

weak or shallow breathing, slow heart rate, weak pulse; or

feeling like you might pass out.

Less serious side effects include:

mild bruising, redness, itching, or swelling where the medication was injected;

numbness in places where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect UAD Caine ( lidocaine injection)?

There may be other drugs that can interact with lidocaine injection. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More UAD Caine resources UAD Caine Side Effects (in more detail) UAD Caine Use in Pregnancy & Breastfeeding UAD Caine Drug Interactions UAD Caine Support Group 0 Reviews for UAD Caine - Add your own review/rating Lidocaine Aerosol MedFacts Consumer Leaflet (Wolters Kluwer) lidocaine Intradermal Advanced Consumer (Micromedex) - Includes Dosage Information Lidocaine Prescribing Information (FDA) Lidocaine Hydrochloride Monograph (AHFS DI) Lidocaine Hydrochloride (Local Anesthetic) Monograph (AHFS DI) Compare UAD Caine with other medications Anesthesia Arrhythmia Ventricular Fibrillation Ventricular Tachycardia Where can I get more information? Your doctor or pharmacist can provide more information about lidocaine injection.

See also: UAD Caine side effects (in more detail)

Lidocaine Hydrochloride BP Laryngojet 4% (International Medication Systems)

Lidocaine Hydrochloride BP

Please read this leaflet. It contains important information about your medicine. If you have any questions, please ask your doctor or nurse.

What is this medicine?

This medicine is called Lidocaine Hydrochloride BP Laryngojet 4% w/v. It is a sterile solution which comes in a glass vial and contains 160mg lidocaine hydrochloride in 4ml as the active ingredient. It also contains sodium hydroxide and water.

The active ingredient in this medicine is Lidocaine hydrochloride. This is the new name for Lidocaine (Lignocaine) hydrochloride. The ingredient itself has not changed.

There is one 4ml vial in each carton.

It is a local anaesthetic. It numbs the area it is applied to.

Who makes it? Marketing Authorisation Holder: International Medication Systems (UK) Limited 208 Bath Road Slough Berkshire SL1 3WE UK Manufacturer: International Medication Systems (UK) Ltd. Unit 14 Foster Avenue Woodside Park Dunstable Beds LU5 5TA UK What is it used for?

It is used to numb parts of the body, such as the mouth, throat and lungs, before some medical procedures which would otherwise be uncomfortable or painful. Examples of the kind of procedures lidocaine is used for are putting a breathing tube in during an operation, putting a tube into the lungs to examine them (bronchoscopy), or taking a specimen from the mouth, throat or lungs.

Before you are given lidocaine You should not be given lidocaine and should tell your doctor immediately if: You suffer from porphyria You are allergic to any of the ingredients or to other local anaesthetics You should tell your doctor if: You have epilepsy, any heart problems including heart failure, slow heart beat or delayed heart signals (heart block), very poor breathing, myasthenia gravis, shock, low oxygen levels or low blood volume The area to be anaesthetised is infected or cut You are pregnant, likely to become pregnant, or breast feeding You are taking any other medicines at all, especially ones for your heart (eg. propranolol, and medicines to treat an irregular heartbeat) or ulcers (eg. cimetidine) You are going to have a general anaesthetic where suxamethonium will be used. How much is given?

The lowest dose possible will be given. The usual adult dose is 4ml (160mg). The elderly may need a lower dose. Children can be given up to 3mg for every kg they weigh (so if they weigh 10kg, they could have 3 x 10 = 30mg).

The solution can be sprayed, instilled or applied with a swab to the area to be numbed. It usually works within 5 minutes.

Since this medicine will usually be given to you by a doctor it is unlikely that you will be given too much.

However, if you are worried that you have been given too much, please tell the doctor.

Are there any side effects?

Very rarely, a patient may have an allergic reaction including rashes, swelling (particularly of the lips, face, eyelids, tongue and throat), breathlessness and collapse.

If applied in the mouth it may be difficult to swallow properly until the effect has worn off.

Other side effects may include light headedness, drowsiness, dizziness, mood changes, ringing in your ears, fear, vision difficulties such as blurred or double vision or quivering eyeballs, sickness, sensations of heat, cold or numbness, twitching, fits, shaking, unconsciousness, shallow breathing, stopping breathing, low blood pressure (feeling faint), slow heart beat, collapse including the heart stopping.

If you feel drowsy, dizzy or suffer from blurred or double vision after having lidocaine. do not drive or operate machinery.

The doctor treating you will be watching to see if these effects occur and will have the equipment to treat them.

If you think this medicine has upset you in ANY way, please tell your doctor.

How to store this medicine

Do not use this medicine after the expiry date shown on the carton and vial label.

Do not store above 25°C.

KEEP THIS AND ALL MEDICINES OUT OF THE REACH AND SIGHT OF CHILDREN

Date of preparation: January 2004

This leaflet does not contain all the information about your medicine. If you have any questions or are not sure about anything, ask your doctor (or pharmacist), who will have access to further information.

YOU MAY WANT TO READ THIS LEAFLET AGAIN. PLEASE DO NOT THROW IT AWAY IMMEDIATELY.

This leaflet only applies to Lidocaine Hydrochloride BP Laryngojet 4%w/v

Lidocaine Injection BP with Preservative 1 %

Read all of this leaflet carefully before you start taking this medicine. Keep this leaflet. You may need to read it again. If you have further questions, please ask your doctor or your pharmacist. This medicine has been prescribed for you personally and you should not pass it on to others. It may harm them, even if their symptoms are the same as yours. In this leaflet: 1. What your medicine is and what it is used for 2. Before you receive it 3. How it is administered 4. Possible side effects 5. Storing it

Lidocaine Injection with Preservative 1%

The active ingredient in this medicine is lidocaine hydrochloride. This is the new name for lignocaine hydrochloride. The ingredient itself has not changed.

This injection contains the active ingredient lidocaine hydrochloride 1%. Each ml contains 10 mg of lidocaine hydrochloride.

This injection also contains the following inactive ingredients:

Sodium chloride, methylhydroxybenzoate (E218), propylhydroxybenzoate (E216) and water for injections.

Holder of the Marketing Authorisation: hameln pharmaceuticals ltd Gloucester United Kingdom Manufacturer: hameln pharmaceuticals gmbh Langes Feld 13 31789 Hameln Germany What your medicine is and what it is used for

Lidocaine Injection with Preservative 1% is a clear, colourless, sterile and isotonic solution supplied in 20 and 50 ml clear glass vials, only intended to be given by injection under your skin (subcutaneously or SC).

Lidocaine is a local anaesthetic of the amide group. When injected into the skin, it causes loss of feeling before or during surgery. Lidocaine allows doctors to sew up cuts in the skin and to undertake operations without any pain even though the patient is awake.

Before you receive your medicine You should tell your doctor if: you think you are allergic to either lidocaine or the preservatives used in this injection. The preservatives are often known just as benzoates or hydroxy-benzoates. (See also section 4. Possible side effects for further information). you suffer from epilepsy or have fits you suffer from heart, lung or breathing disorders you have kidney or liver disease you suffer from myasthenia gravis (loss of muscle function and weakness) you are pregnant, likely to become pregnant or breast-feeding you have inflammation or infection in the area to be injected you are taking cimetidine (for stomach ulcer or heartburn) or beta-blockers, for example, propranolol (for angina, high blood pressure or other heart problems)

Please inform your doctor or pharmacist if you are taking or have recently taken any other medicines, even those not prescribed.

Driving and operating machinery: Depending on where and how lidocaine is used, it may affect your ability to drive or operate machinery. Ask your doctor about when it would be safe to drive or operate machines.

How your medicine is administered

The dose of a local anaesthetic will be different for different patients. Your healthcare professional will decide on the right amount for you, depending on:

Your age; your general physical condition; the reason the local anaesthetic is being given and other medicines you are taking or will receive before or after the local anaesthetic is given.

Adults: As a guide, 20 ml (equivalent to 200 mg) of Lidocaine Injection with Preservative 1% is the usual maximum dose. Your doctor will decide on the most appropriate dose for you. A smaller dose may be used if you are elderly or weak.

Children: A smaller dose is usually used for children depending on their age, physical condition and the procedure to be performed.

Possible side effects

Like all medicines, Lidocaine Injection with Preservative 1% can have side effects:

Lidocaine is generally well tolerated, but along with its needed effects, all medicine can cause unwanted effects. Lidocaine may occasionally cause the following side effects:

pain, inflammation or numbness at the site of injection after the effects of the injection should have worn off nervousness tremor blurred or double vision dizziness or drowsiness convulsions (seizures) nausea or vomiting breathing problems slowed heart beat or low blood pressure

Allergic reactions to lidocaine hydrochloride are rare, but tell your doctor immediately if you get any difficulty with your breathing, a rash or itchy skin.

Methylhydroxybenzoate (E218) and propylhydroxybenzoate (E216) may cause allergic reactions (possibly delayed), and exceptionally, bronchospasm.

If you notice any side effects not mentioned in this leaflet, please inform your doctor or pharmacist.

For patients going home before the numbness or loss of feeling caused by a local anaesthetic wears off:

During the time that the injected area feels numb, serious injury can occur without your knowing about it. Be especially careful to avoid injury until the anaesthetic wears off or feeling returns to the area.

Storing your medicine

Your doctor will store the vials in the outer carton in order to protect from light, between 10°C and 25°C and out of reach and sight of children.

Your doctor will not use the drug after the expiry date shown on the vial and carton.

This leaflet was last updated on July 13th, 2004.

Lidocaine Ointment

Pronunciation: LIE-doe-cane Generic Name: Lidocaine Brand Name: Generic only. No brands available. Lidocaine Ointment is used for:

Relieving pain in the mouth and throat. It is also used to temporarily relieve pain and itching associated with minor cuts and skin scrapes, minor burns (including sunburn), minor skin irritation, and insect bites. It may also be used for certain medical procedures or other conditions as determined by your doctor.

Lidocaine Ointment is an anesthetic. It works by preventing nerves from transmitting painful impulses to the brain.

Do NOT use Lidocaine Ointment if: you are allergic to any ingredient in Lidocaine Ointment or other similar medicines (eg, amide-type anesthetics)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lidocaine Ointment:

Some medical conditions may interact with Lidocaine Ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a blood infection or severe injury of the mouth, throat, or other area where you are applying Lidocaine Ointment if you have heart, liver, or kidney problems if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any anesthetic medicine

Some MEDICINES MAY INTERACT with Lidocaine Ointment. Tell your health care provider if you are taking any other medicines, especially any of the following:

Amiodarone, beta-adrenergic blockers (eg, metoprolol), cimetidine, or mexiletine because side effects, such as confusion, dizziness, lightheadedness, or tiredness, may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lidocaine Ointment may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lidocaine Ointment:

Use Lidocaine Ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Do not get Lidocaine Ointment in your eyes. Apply a small amount of Lidocaine Ointment to the affected area. Gently rub the medicine in until it is evenly distributed. If applying to broken skin, use a sterile gauze pad to apply the medicine. Wash your hands immediately after using Lidocaine Ointment unless your hands are part of the treated area. If you miss a dose of Lidocaine Ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Lidocaine Ointment.

Important safety information: Lidocaine Ointment may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Lidocaine Ointment with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Tell your doctor or dentist that you take Lidocaine Ointment before you receive any medical or dental care, emergency care, or surgery. Lidocaine Ointment may make it difficult for you to swallow. Do not eat anything for at least 1 hour after Lidocaine Ointment has been applied in the mouth or throat area. Numbness of the tongue may cause you to bite the inside of your mouth accidentally. Do not eat any food or chew gum while your mouth or throat area is numb. Lidocaine Ointment may cause a numbing effect at the application site. Do not scratch, rub, or expose the area to extreme hot or cold temperature until the numbness is gone. Use caution when applying Lidocaine Ointment over large areas. Do not use more medicine, apply it more often, or use it for longer than prescribed. Your condition will not improve faster, but the risk of side effects may be increased. PREGNANCY and BREAST-FEEDING: It is not known if Lidocaine Ointment can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lidocaine Ointment while you are pregnant. It is not known if Lidocaine Ointment is found in breast milk after topical use. If you are or will be breast-feeding while you use Lidocaine Ointment, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Lidocaine Ointment:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness or swelling at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); choking; confusion; dizziness or lightheadedness; fast breathing; fast, slow, or irregular heartbeat; fever; mood or mental changes; ringing in the ears or hearing changes; seizures; shortness of breath; swelling of the throat; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include apprehension; blurred vision; confusion; difficulty breathing; nervousness; ringing in the ears; seizures; sensations of heat, cold, or numbness; severe dizziness, drowsiness, or lightheadedness; slow or irregular heartbeat; tremor; twitching; unconsciousness; vomiting.

Proper storage of Lidocaine Ointment:

Store Lidocaine Ointment at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Keep Lidocaine Ointment out of the reach of children and away from pets.

General information: If you have any questions about Lidocaine Ointment, please talk with your doctor, pharmacist, or other health care provider. Lidocaine Ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lidocaine Ointment. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Lidocaine resources Lidocaine Use in Pregnancy & Breastfeeding Lidocaine Support Group 22 Reviews for Lidocaine - Add your own review/rating Compare Lidocaine with other medications Anal Itching Anesthesia Burns, External Hemorrhoids Pain Persisting Pain, Shingles Pruritus Sunburn read more

Anbesol Teething Gel

1. Name Of The Medicinal Product

Anbesol Teething Gel

2. Qualitative And Quantitative Composition

Emla

Generic Name: lidocaine and prilocaine topical (LY doh kayn and PRIL oh kayn TOP ik al) Brand Names: Emla

What is lidocaine and prilocaine topical?

Lidocaine and prilocaine topical is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.

Lidocaine and prilocaine topical is used to numb the skin, or surfaces of the penis or vagina, in preparation for a medical procedure or to lessen the pain of inserting a medical instrument such as a tube or speculum.

Lidocaine and prilocaine topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about lidocaine and prilocaine? An overdose of numbing medications can cause fatal side effects if too much of the medicine is absorbed through your skin and into your blood. This is more likely to occur when using a numbing medicine without the advice of a medical doctor (such as during a cosmetic procedure like laser hair removal). However, overdose has also occurred in women treated with a numbing medicine before having a mammography. Overdose symptoms may include uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops). Your body may absorb more of this medication if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.

Use the smallest amount of this medication needed to numb the skin or relieve pain. Do not use large amounts of lidocaine and prilocaine topical, or cover treated skin areas with a bandage or plastic wrap without medical advice. Be aware that many cosmetic procedures are performed without a medical doctor present.

Do not use lidocaine and prilocaine topical if you have had an allergic reaction to a numbing medicine in the past.

Before lidocaine and prilocaine topical is applied, tell your doctor if you have liver disease, a history of allergic reaction to lidocaine or prilocaine, or a personal or family history of methemoglobinemia, or any genetic enzyme deficiency.

Lidocaine and prilocaine topical is for use only on the surface of your body. Avoid getting this medication in your eyes.

Avoid accidentally injuring treated skin areas while they are numb. Avoid coming into contact with very hot or very cold surfaces.

What should I discuss with my health care provider before using lidocaine and prilocaine topical? An overdose of numbing medications can cause fatal side effects if too much of the medicine is absorbed through your skin and into your blood.

Overdose is more likely to occur when using a numbing medicine without the advice of a medical doctor (such as during a cosmetic procedure like laser hair removal). However, overdose has also occurred in women treated with a numbing medicine before having a mammography. Symptoms may include uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).

Do not use lidocaine and prilocaine topical if you have a blood cell disorder called methemoglobinemia.

Before lidocaine and prilocaine topical is applied, tell your doctor if you have:

a history of allergic reaction to lidocaine or prilocaine; or

a personal or family history of methemoglobinemia, or any genetic enzyme deficiency.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use lidocaine and prilocaine topical.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Lidocaine and prilocaine topical can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I use lidocaine and prilocaine topical?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended.

Your body may absorb more of this medication if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.

Use the smallest amount of medicine needed to numb the skin or relieve pain. Do not use large amounts of lidocaine and prilocaine topical, or cover treated skin areas with a bandage or plastic wrap without medical advice. Be aware that many cosmetic procedures are performed without a medical doctor present.

This medication comes with instructions for safe and effective application. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

You should be lying down when lidocaine and prilocaine topical cream is applied.

Your medicine may have been supplied with bandages to cover the cream when it is applied to a small area on your skin. If using a bandage dressing, first apply a thick layer of the cream to the skin, taking care not to spread the cream out. Place the bandage over the cream and smooth down the edges until it is completely sealed around the cream.

Lidocaine and prilocaine topical is usually applied 1 to 2 hours before the start of a procedure that requires the treated area to be numb. Follow your doctor's instructions about the length of time the cream should be left on the skin.

Store lidocaine and prilocaine topical at room temperature away from moisture and heat. Do not allow the cream to freeze. What happens if I miss a dose?

Since lidocaine and prilocaine topical is used as needed, it is not likely that you will be on a dosing schedule.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. An overdose of lidocaine and prilocaine topical applied to the skin can cause life-threatening side effects such as uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops). What should I avoid while taking lidocaine and prilocaine topical? Lidocaine and prilocaine topical is for use only on the surface of your body. Avoid getting this medication in your eyes.

Avoid accidentally injuring treated skin areas while they are numb. Avoid coming into contact with very hot or very cold surfaces.

Lidocaine and prilocaine topical side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using lidocaine and prilocaine topical and call your doctor at once if you have any of these serious side effects:

severe burning, stinging, or sensitivity where the medicine is applied;

swelling or redness;

sudden dizziness or sleepiness after medicine is applied;

bruising or purple appearance of the skin; or

unusual sensations of temperature.

Less serious side effects may include:

mild burning where the medicine is applied;

skin redness; or

changes in skin color where the medicine was applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect lidocaine and prilocaine topical?

Before this medication is applied, tell your doctor if you are using any of the following drugs:

heart rhythm medication such as mexiletine (Mexitil);

nitrates or nitrites such as Imdur, Isordil, Monoket;

nitrofurantoin (Furadantin, Macrodantin, Macro-Bid);

phenobarbital (Luminal, Solfoton);

a sulfa drug (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others).

This list is not complete and there may be other drugs that can interact with lidocaine and prilocaine topical. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Emla resources Emla Side Effects (in more detail) Emla Use in Pregnancy & Breastfeeding Emla Support Group 0 Reviews for Emla - Add your own review/rating Emla Topical Advanced Consumer (Micromedex) - Includes Dosage Information Emla Consumer Overview EMLA Prescribing Information (FDA) EMLA Cream MedFacts Consumer Leaflet (Wolters Kluwer) Compare Emla with other medications Anesthesia Where can I get more information? Your pharmacist can provide more information about lidocaine and prilocaine topical.

See also: Emla side effects (in more detail)

Adrenalin Injection

Generic Name: epinephrine (Injection route)

Commonly used brand name(s)

Adrenaclick Adrenalin Adrenalin Chloride Epipen Epipen Jr Twinject

Available Dosage Forms:

Therapeutic Class: Anaphylaxis Agent

Pharmacologic Class: Adrenergic

Chemical Class: Alkylarylamine

Uses For Adrenalin

Epinephrine injection is used for emergency treatment of severe allergic reactions (including anaphylaxis) to insect bites or stings, medicines, foods, or other substances. It is also used to treat anaphylaxis caused by unknown substances or triggered by exercise.

This medicine is available only with your doctor's prescription.

Before Using Adrenalin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

No information is available on the relationship of age to the effects of epinephrine injection in the pediatric population. Safety and efficacy have not been established.

No information is available on the relationship of age to the effects of epinephrine injection in geriatric patients. However, elderly patients are more likely to have age-related heart disease which may require caution in patients receiving epinephrine injection.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Dihydroergotamine Isocarboxazid Linezolid Phenelzine Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amitriptyline Amoxapine Bucindolol Carteolol Carvedilol Clomipramine Desipramine Dilevalol Dothiepin Doxepin Entacapone Halothane Imipramine Levobunolol Lofepramine Metipranolol Nadolol Nortriptyline Opipramol Oxprenolol Penbutolol Pindolol Propranolol Protriptyline Rasagiline Sotalol Tertatolol Timolol Trimipramine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Labetalol Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Angina pectoris (severe chest pain) or Blood vessel problems or Diabetes mellitus (sugar diabetes) or Heart attack or Heart disease or Heart rhythm problems or Hypertension (high blood pressure) or Overactive thyroid or Parkinson's disease—Use with caution. May make these conditions worse. Proper Use of epinephrine

This section provides information on the proper use of a number of products that contain epinephrine. It may not be specific to Adrenalin. Please read with care.

Use this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

If you are using this medicine at home, make sure you or any of your family members understand exactly how to give them. Also, tell your doctor if you or your caregiver has severe arthritis of the hands. If you have any questions about this, check with your doctor.

This medicine is injected under your skin or into the muscle of your outer thigh only . Do not inject this medicine into a vein or into the muscle of your buttocks. To do so, may increase the chance of having serious side effects.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

This medicine comes in an auto-injector syringe and needle kit that contains the correct dose of medicine your doctor has prescribed.

You may need to use more than one injection if your allergic reaction does not get better after the first shot.

Carry this medicine with you at all times for emergency use in case you have a severe allergic reaction.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For injection dosage form: For allergic reactions: Adults and children weighing above 30 kilograms (66 pounds)—0.3 milligram (mg) injected under the skin or into the muscle of your thigh. Adults and children weighing 15 to 30 kilograms (33 to 66 pounds)—0.15 milligram (mg) injected under the skin or into the muscle of your thigh. Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Store the injection kits at room temperature, away from heat, moisture, and direct light. Do not store the medicine in the refrigerator or freezer. Keep the auto-injector in its case or tube.

Check the injection kits regularly to make sure that the liquid has not changed its color. Do not use this medicine if the liquid has changed its color, or if there are solids in the liquid.

Do not reuse the remaining portion of the medicine that is left in the auto-injector. Throw away the auto-injector after you have used it.

Precautions While Using Adrenalin

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Anaphylaxis is a life-threatening reaction and requires immediate medical attention. Check with your doctor right away, or go to an emergency room as soon as possible, even if you feel better after using this medicine.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

Do not inject this medicine into your hands or feet. There is already less blood flow to the hands and feet, and epinephrine could make that worse and cause damage to these tissues. If you accidentally inject epinephrine into your hands or feet, check with your doctor or go to the hospital emergency room right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Adrenalin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known Abnormal or decreased touch sensation arm, back or jaw pain bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site blurred vision chest pain or discomfort chest tightness or heaviness dizziness fainting fast, irregular, pounding, or racing heartbeat or pulse fear or nervousness headache nausea or vomiting paleness of the skin pounding in the ears restlessness shakiness in the legs, arms, hands, or feet shortness of breath slow or fast heartbeat stroke sweating trembling or shaking of the hands or feet troubled breathing unusual tiredness or weakness wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose Agitation coldness of the skin coma confusion decreased urine output depression drowsiness hostility irritability lethargy lightheadedness, dizziness, or fainting muscle twitching pounding, slow heartbeat rapid weight gain rapid, deep breathing seizures stomach cramps stupor swelling of the face, ankles, or hands

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Adrenalin Injection side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs. com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs. com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Adrenalin Injection resources Adrenalin Injection Side Effects (in more detail) Adrenalin Injection Use in Pregnancy & BreastfeedingAdrenalin Injection Drug InteractionsAdrenalin Injection Support Group0 Reviews for Adrenalin Injection - Add your own review/rating Compare Adrenalin Injection with other medications Adams-Stokes SyndromeAllergic ReactionsAsthma, acuteAsystoleAV Heart BlockCOPD, AcuteElectromechanical DissociationShock read more

MEDIJEL GEL

1. Name Of The Medicinal Product

2. Qualitative And Quantitative Composition Lidocaine Hydrochloride BP 0.66% w/w Aminoacridine Hydrochloride BP 1968 0.05% w/w 3. Pharmaceutical Form

4. Clinical Particulars 4.1 Therapeutic Indications

The quick, effective relief from the pain of common mouth ulcers, soreness of gums and denture rubbing. Medijel Gel is administered directly onto the affected area with a clean finger or small pad of cotton wool.

4.2 Posology And Method Of Administration

The gel should be applied directly to the affected area(s) with a clean finger or small pad of cotton wool. If necessary application may be repeated after 20 minutes.

Each dose is approximately 300mg, i. e. 2mg of Lidocaine Hydrochloride and 0.15mg of Aminoacridine Hydrochloride. Medijel Gel can be used as directed for adults and children.

Hypersensitivity to the active substances or to any other of the ingredients.

Contains sucrose. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.

4.4 Special Warnings And Precautions For Use

If symptoms persist longer than 7 days following the use of the product a doctor or dentist should be consulted.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

4.6 Pregnancy And Lactation

The safety of Medijel Gel during pregnancy and lactation has not been established, but is considered not to constitute a hazard.

4.7 Effects On Ability To Drive And Use Machines

4.8 Undesirable Effects

Hypersensitivity reactions to Lidocaine have been reported on rare occasions.

Maximum safe dosage for a 70kg adult is 750mg for Lidocaine (Goodman & Gilman, page 313). A tube of Medijel Gel contains 82.5mg of Lidocaine hydrochloride - overdose is not a problem.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Lidocaine Hydrochloride is well documented in Martindale 28th Edition Page 900-904 and Goodman & Gilman, Chapter 15 and pages 767-770.

Lidocaine Hydrochloride was first introduced in 1948 and is one of the most widely used local anaesthetics, producing more prompt, more intense, longer lasting and more extensive anaesthesia than does an equal concentration of procaine (Peak anaesthesia within 2-5 minutes). Local anaesthetics are drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They have good powers of penetration and their action is reversible. Their use is followed by complete recovery in nerve function with no evidence of structural damage to nerve fibres or cells.

Aminoacridine Hydrochloride is a slow acting disinfectant. It exerts germicidal action against bacteria and fungi. It is also used as a surgical and endodontic irrigant and to treat local infections of the ear, mouth and throat. Its exact mode of action is not known but it involves disruption of certain metabolic pathways.

5.2 Pharmacokinetic Properties

Lidocaine is readily absorbed through mucous membranes. They exert their effects in the form of the non-ionised base. Lidocaine undergoes first-pass metabolism in the liver and bioavailability is low after administration by mouth. It is rapidly de-ethylated to the active metabolite monoethylglycinexylidide and then hydrolysed by amidases to various compounds, including glycineexylidide which has reduced activity but a longer elimination half-life. Less than 10% of a dose is excreted unchanged via the kidneys. The metabolic products are excreted in the urine.

Aminoacridine Hydrochloride if administered systematically is rapidly eliminated through the kidney (0.2 grams being eliminated from the blood in 30 minutes). (Medijel Gel dose 0.15mg Aminoacridine hydrochloride).

5.3 Preclinical Safety Data

There are no pre-clinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Glycerol. Hydroxypolyethoxydodecane HSE, Alcohol 96% v/v, Carbomer, Sucrose, Saccharin Sodium, Peppermint Oil, Ethyl vanillin, Di-isopropanolamine 90% aqueous, Purified Water

6.4 Special Precautions For Storage

Do not store above 25°C.

6.5 Nature And Contents Of Container

Aluminium tube with membrane seal and spiked polyethylene cap.

6.6 Special Precautions For Disposal And Other Handling

7. Marketing Authorisation Holder

94, Rickmansworth Road, Watford, Hertfordshire, United Kingdom, WDI8 7JJ.

8. Marketing Authorisation Number(S)

Legal Status: GSL

9. Date Of First Authorisation/Renewal Of The Authorisation

Date of last renewal: 20/05/03

10. Date Of Revision Of The Text

Available Dosage Forms:

Therapeutic Class: Anesthetic, Amino Amide Combination

Chemical Class: Amino Amide

Uses For lidocaine

Lidocaine and prilocaine periodontal (gingival) gel is used on the gums to cause numbness or loss of feeling during dental procedures. lidocaine contains a mixture of two topical local anesthetics (numbing medicines). It deadens the nerve endings in the gum.

lidocaine is available only with your dentist's prescription.

Before Using lidocaine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lidocaine. the following should be considered:

Tell your doctor if you have ever had any unusual or allergic reaction to lidocaine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of lidocaine and prilocaine periodontal gel in the pediatric population. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific proble

Buy azitrolit - azithromycin - online without prescriptions, azitrolit

Zithromax (Azitrolit)

Zithromax is used for treating mild to moderate infections caused by certain bacteria. It may also be used alone or with other medicines to treat or prevent certain infections in persons with advanced HIV infection. Zithromax is a macrolide antibiotic. It slows the growth of, or sometimes kills, sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.

Use Zithromax as directed by your doctor.

Take Zithromax by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Do not take an antacid that has aluminum or magnesium in it within 1 hour before or 2 hours after you take Zithromax.

Zithromax works best if it is taken at the same time each day.

To clear up your infection completely, use Zithromax for the full course of treatment. Keep using it even if you feel better in a few days.

If you miss a dose of Zithromax, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zithromax.

Store Zithromax below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zithromax out of the reach of children and away from pets.

Active Ingredient: Azithromycin.

Do NOT use Zithromax if:

you are allergic to any ingredient in Zithromax, to other macrolide antibiotics (eg, erythromycin), or to ketolide antibiotics (eg, telithromycin)

you are taking dofetilide, nilotinib, pimozide, propafenone, or tetrabenazine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Zithromax. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver or kidney problems, myasthenia gravis, or abnormal heart rhythms.

Some medicines may interact with Zithromax. Tell your health care provider if you are taking any other medicines, especially any of the following:

Antiarrhythmics (eg, disopyramide, dofetilide ), arsenic, astemizole, cisapride, domperidone, maprotiline, methadone, paliperidone, pimozide, propafenone, quinolone antibiotics (eg, levofloxacin), terfenadine, or tetrabenazine because the risk of heart problems, including irregular heartbeat, may be increased

Nelfinavir because it may increase the risk of Zithromax's side effects

Rifampin because it may decrease Zithromax's effectiveness

Anticoagulants (eg, warfarin), carbamazepine, cyclosporine, digoxin, ergot derivatives (eg, ergotamine), nilotinib, phenytoin, rifampin, theophylline, triazolam, or tyrosine kinase receptor inhibitors (eg, dasatinib) because the risk of their side effects may be increased by Zithromax.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zithromax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Zithromax may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Zithromax with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Zithromax may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zithromax. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Tell your doctor or dentist that you take Zithromax before you receive any medical or dental care, emergency care, or surgery.

Long-term or repeated use of Zithromax may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Be sure to use Zithromax for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Zithromax only works against bacteria; it does not treat viral infections (eg, the common cold).

Zithromax should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zithromax while you are pregnant. It is not known if Zithromax is found in breast milk. If you are or will be breast-feeding while you use Zithromax, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; headache; loose stools; nausea; stomach pain; upset stomach; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; changes in hearing or hearing loss; chest pain; eye or vision problems; irregular heartbeat; muscle weakness; pounding in the chest; red, swollen, blistered, or peeling skin; ringing in the ears; seizure; severe diarrhea; stomach cramps/pain; trouble speaking or swallowing; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Isosorbide mononitrate 20mg tablets - summary of product characteristics (spc), isosorbide mononitra

4.2 Posology and method of administration

The usual dose of Isosorbide mononitrate is 1 tablet of Isosorbide mononitrate 20 mg, taken asymmetrically (to allow a nitrate low period) 2 to 3 times daily. If result is not adequate, the dose may be increased to 1 tablet of Isosorbide mononitrate 40 mg, 2 to 3 times daily.

The dosage may be increased to 120mg per day.

Dosage regime should be designed according to the clinical response of the patient.

The lowest effective dose should be used.

In patients taking isosorbide mononitrate twice daily, the second dose should be taken 8 hours after the 1st dosage. If the dose is one three times daily, take one every 6 hours. This provides a nitrate-free period of 6 – 8 hours.

The maximum dose is 3 tablets isosorbide mononitrate 40 mg per day.

In order to prevent possible initial undesirable effect, it may be adequate to initiate treatment with possible lowest dose and slowly increase to the required dose.

To prevent tolerance, it is recommended that the dosage be kept as low as possible and that a sufficiently long nitrate-free interval is ensured to restore sensitivity (first dose in the morning and last dose late in the afternoon, e. g. at 8 am and 15 pm).

The duration of application is decided by the treating physician.

Treatment with isosorbide mononitrate, as with any other nitrate, should not be stopped suddenly. Both the dosage and frequency should be tapered gradually (see section 4.4).

There is no evidence to suggest that an adjustment of the dosage is necessary in elderly.

There is as yet no data on the safety and efficacy of isosorbide mononitrate in children.

For oral administration.

Method of administration

The tablet should be swallowed whole, taken after meals. It should be unchewed with little fluid.

Hypersensitivity to the isosorbide mononitrate or to to any of the excipients listed in section 6.1.

Isosorbide mononitrate should not be used in cases of acute myocardial infarction with low filling pressure, acute circulatory failure (shock, vascular collapse), or hypertrophic obstructive cardiomyopathy (HOCM), constrictive pericarditis, low cardiac filling pressures, aortic/mitral valve stenosis and diseases associated with a raised intra-cranial pressure e. g following a head trauma and including cerebral haemorrhage.

Isosorbide mononitrate should not be used in patients with severe anaemia, severe hypotension, closed angle glaucoma or severe hypovolaemia.

Phosphodiesterase type-5 inhibitors (eg sildenafil, tadalafil and vardenafil) have been shown to potentiate the hypotensive effects of nitrates, and their co-administration with nitrates or nitric oxide donors is therefore contraindicated (see section 4.5)

4.4 Special warnings and precautions for use

Isosorbide mononitrate may give rise to postural hypotension and syncope in some patients. Severe postural hypotension with light-headedness and dizziness is frequently observed after the consumption of alcohol.

Vascular dilatation can precipitate venous pooling with decreased return to the heart, hypotension and reflex tachycardia. Therefore, oral nitrates should not be used by patients who are sensitive to the effects of hypotension, such as those with pre-existing hypotension, shock, vascular collapse or significant cerebrovascular disease, significant anaemia or hypothyroidism. Isosorbide mononitrate should be used with caution in patients who have a recent history of myocardial infarction low filling pressures e. g. in acute myocardial infraction, impaired left ventricular function (left ventricular failure), or orthostatic dysfunction. Reducing systolic blood-pressure below 90mmHg must be avoided.

It should also be used with caution in patients who are suffering from hypothermia, malnutrition and severe liver or renal disease. For the same reason, Oral nitrates should also be used with caution in patients with angina due to other causes, or pre-existing hyperdynamic (abnormally increased blood circulatory volume) conditions.

Symptoms of circulatory collapse may arise after first dose, particularly in patients with labile circulation.

Hypotension induced by nitrates may be accompanied by paradoxical bradycardia and increased angina.

Since oral nitrates cause venous dilatation they should not be used in patients with increased intracranial pressure. (With high dose i. v. administration of Glyceroltrinitrate a further increase in pressure was observed)

Isosorbide mononitrate tablets contain lactose and therefore patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

In the event of an acute angina attack, a sublingual treatment such as a GTN spray or tablet should be used instead of Isosorbide mononitrate. The onset of action of isosorbide mononitrate is not sufficiently rapid to be useful to treat an acute anginal attack.

Development of tolerance and cross tolerance to other nitrates was described. A continuous administration of high doses should be avoided. The lowest effective dose should be used.

Treatment with Isosorbide mononitrate, as with any other nitrate, should not be stopped suddenly. Both the dosage and frequency should be tapered gradually. (See section 4.2)

In patients with decreased gastrointestinal transit time, a decrease in release of the active ingredient may occur.

Patients who undergo a maintenance treatment with isosorbide mononitrate should be informed that they must not use phosphodiesterase inhibitor-containing products (e. g. sildenafil, tadalafil, vardenafil).

Isosorbide mononitrate therapy should not be interrupted to take phosphodiesterase inhibitor-containing products (e. g. sildenafil, tadalafil, vardenafil), because the risk of inducing an attack of angina pectoris could increase by doing so (see section 4.3 & 4.5).

4.5 Interaction with other medicinal products and other forms of interaction

The antihypertensive effect of Isosorbide mononitrate will increase when it is used concomitantly with phosphodiesterase type 5 inhibitors, which are used in erectile dysfunction. This can lead to life-threatening vascular complications. Patients treated with isosorbide mononitrate must not use phosphodiesterase type 5 inhibitors (e. g. sildenafil, tadalafil, vardenafil)(section 4.3).

Concomitant use of drugs with an antihypertensive action, e. g. beta blockers, calcium antagonists, vasodilators (including neuroleptics and tricyclic antidepressants), alprostadil, aldesleukin, antihypertensives, diuretics, angiotensin II receptor antagonists etc. and / or alcohol can potentiate the hypotensive effect of Isosorbide mononitrate. This can also occur with neuroleptics and tricyclic antidepressant

Reports suggest that concomitant use of Isosorbide mononitrate increases the blood levels of dihydroergotamine and that the hypertensive effect is potentiated.

Sapropterine (Tetrahydrobiopterine, BH4) is a cofactor for nitric oxide synthetase. Caution is recommended during concomitant use of sapropterine-containing medicine with all agents that cause vasodilation by affecting nitric oxide (NO) metabolism or action, including classical NO donors (e. g. glyceryl trinitrate (GTN), isosorbide dinitrate (ISDN), isosorbide 5-mononitrate (5-ISMN) and others).

There are no data available on the interaction with food.

4.6 Fertility, pregnancy and lactation:

Data on the use of isosorbide mononitrate during pregnancy are insufficient to be able to assess the possible harmful effect. Limited data from animal studies indicate no adverse effects on the pregnancy or the unborn child. As precautionary measure, it is preferable to avoid the use of isosorbide mononitrate during pregnancy.

There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. The effects of this exposure on a nursing infant are unknown. As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate.

Animal data do not suggest an effect of the treatment of isosorbide mononitrate on male and female fertility. Human data are lacking.

Therefore isosorbide monohydrate should only be used in pregnancy and during lactation if, in the opinion of the physician, the possible benefits of treatment outweigh the hazards.

4.7 Effects on ability to drive and use machines

Isosorbide mononitrate may occasionally trigger a drop in blood pressure, which can cause dizziness. Dizziness, tiredness or blurred vision might occur at the start of treatment or increasing doses. If affected do not drive or operate machinery. This effect may be increased by alcohol.

4.8 Undesirable effects

Most undesirable effects are pharmacologically mediated and are dose dependent. Headache occurs in approximately 25% of patients at the start of treatment and can be attributed to the vasodilatory effect of the preparation; The headache usually disappears within about one week. Hypotension (with dizziness and nausea) has been reported, but this disappears with continued treatment.

The frequencies of adverse events are ranked according to the following:

Very common (≥1/10)

Common (≥1/100 to <1/10)

Uncommon (≥1/1,000 to <1/100)

Rare (≥1/10,000 to <1/1,000)

Very rare (<1/10,000),

Not known (cannot be estimated from the available data)

Exfoliative dermatitis, flushing, allergic skin reactions**

* Most likely due to a nitrate induced sphincter relaxation

The frequency of headache can be reduced by starting treatment with 30 mg during the first 2-4 days and gradually titrating the dose upwards as necessary. A drop in blood pressure can lead to reflex tachycardia, dizziness and fainting.

Severe hypotensive responses have been reported for organic nitrates and include nausea, vomiting, restlessness, pallor and excessive perspiration.

During treatment with isosorbide mononitrate, a temporary hypoxemia may occur due to a relative redistribution of the blood flow in hypoventilated alveolar areas. Particularly in patients with coronary artery disease this may lead to a myocardial hypoxia.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme Website: www. mhra. gov. uk/yellowcard.

In rats and mice, significant lethality at oral doses of 1965mg/kg and 2581mg/kg, respectively, was observed.

Signs and symptoms .

- Hypotension (fall in blood pressure ≤ 90 mmHg

- Light-headedness of standing

- hot and red skin

An increase in intracranial pressure with confusion and neurological deficit occurs uncommonly. In very high doses the intracranial pressure may be increased. This may lead to cerebral symtoms. Methaemoglobinaemia (cyanosis, hypoxaemia, agitation, respiratory depression, convulsions, cardiac arrhythmias, circulatory insufficiency, increased intracranial pressure) occurs rarely.

Methaemoglobinaemia has been reported in patients receiving other organic nitrates. During isosorbide mononitrate biotransformation nitrite ions are released, which may induce methaemoglobinaemia and cyanosis with subsequent tachypnoea, anxiety, loss of consciousness and cardiac arrest. It cannot be excluded that an overdose of isosorbide mononitrate may cause this adverse reaction.

The following treatments are intended only as guidelines and are at the discretion of the treating physician.

• Stop using isosorbide mononitrate.

• Consider absorption-reducing therapy (administration of activated charcoal) and in case of suspected severe intoxication consider flushing of the stomach (where practicable within one hour after ingestion).

• General procedure in case of incident of nitrate-related low blood pressure:

- Put the patient in horizontal position with the legs up and lower the head.

Expand plasma volume (I. V. fluids)

- Specific treatment for shock (admit patient to intensive care unit).

• Raising the blood pressure if the blood pressure is very low.

• Treatment of methaemoglobinaemia

- Reduction therapy of choice with vitamin C, methylene-blue or toluidine-blue

- Administer oxygen (if necessary)

- Initiate artificial ventilation

- Hemodialysis (if necessary)

• Resuscitation measures

In case of persistent hypotension

• Administration of norepinephrine HCl or dopamine.

Treatment for methemoglobinemia

• Administration of antidote:

- methylene blue: up to 50 ml of a 1% solution i. v.;

- vitamin C: 1 g p. o. or as sodium salt i. v;

- toluidine blue: initially 2 - 4 mg/kg body weight strictly i. v.; if necessary repeated several times with a time lag of one hour with 2 mg/kg body weight.

• If necessary, apply artificial respiration.

• In severe refractory methemoglobinemia (metHEB> 70%) consider hemodialysis, exchange transfusion.

In case of signals of a respiratory and circulatory arrest, start reanimation immediately.

5. Pharmacological properties

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: VASODILATORS USED IN CARDIAC DISEASES; Organic nitrates ATC code: C01DA14

Isosorbide mononitrate is an organic nitrate which in common with other cardioactive nitrates is a vasodilator. It produces decreased left and right ventricular end-diastolic pressures to a greater extent than the decrease in systemic arterial pressure, thereby reducing afterload and especially the preload of the heart. This preparation is a prolonged release form of Isosorbide mononitrate, an active metabolite of isosorbide dinitrate. Nitro-compounds cause a dose-dependent relaxation of smooth muscle. The therapeutic effect is dependent on dose and individual sensitivity.

Isosorbide mononitrate influences the oxygen supply to ischaemic myocardium by causing the redistribution of blood flow along collateral channels and from epicardial to endocardial regions by selective dilation of large epicardial vessels. Low doses cause dilatation of the veins and a decreased venous return to the heart (reduced preload). High doses also cause arterial dilatation and decreased vascular resistance (reduced afterload). Isosorbide mononitrate reduces the load on the heart by venous and arterial dilatation and can have a direct vasodilatory effect on the coronary arteries. By reducing end-diastolic pressure and volume, it lowers the pressure inside the ventricle and thus improves the subendocardial blood flow. The net effect of isosorbide mononitrate is a reduced load on the heart and better oxygen supply to the myocardium.

Isosorbide mononitrate is intended for use in the prophylactic treatment of angina pectoris.

Mechanism of action:

Like all organic nitrates, isosorbide mononitrate acts as a donor of nitric oxide (NO). NO causes a relaxation of vascular smooth muscle via the stimulation of guanylyl cyclase and the subsequent increase of intracellular cyclic guanosine monophosphate (cGMP) concentration. A cGMP-dependent protein kinase is thus stimulated, with resultant alteration of the phosphorylation of various proteins in the smooth muscle cell. This eventually leads to the dephosphorylation of the light chain of myosin and the lowering of smooth muscle tone.

Continuous treatment with nitro-preparations is associated with the development of tolerance. For this reason, the tablets should be taken once a day in order to obtain an interval with low nitrate concentration.

5.2 Pharmacokinetic properties

Isosorbide mononitrate is rapidly absorbed and peak plasma levels are reached approximately 1 hour after oral dosing.

Following oral administration, bioavailability of Isosorbide mononitrate is 100%. It does not undergo a first-pass effect.

Isosorbide mononitrate is eliminated from plasma with a half-life of approximately 5.1 hours. It is metabolised to isosorbide-5-MN-glucuronide, which has a half-life of approximately 2.5 hours. It is also excreted unchanged in the urine.

After multiple oral doses, plasma levels are consistent with predictions based on the kinetic parameters of a single dose.

5.3 Preclinical safety data

Studies on acute toxicity in mice and rats with different routes of administration indicate a low acute toxicity (LD50 oral approximately 2,000 - 2,500 mg/kg b. w.).

Long term toxicity has been tested in rats for 78 weeks and in dogs for 52 weeks. First toxic reactions occurred in dosages of 90 mg/kg (dog) and 405 mg/kg (rat), respectively. Thus taking into account the recommended dosage of 20 to 30 mg/d in humans, the therapeutic index can be stated as high.

These studies included a fertility and breeding study over two generations in rats; teratology studies in rats and rabbits; and a rat peri-postnatal study. The dosage levels used were generally high and produced maternal toxic effects at the highest dose. No teratogenic effects of isosorbide mononitrate were observed.

Isosorbide mononitrate was tested in different studies both in vitro and in vivo (Ames test, Human peripheral lymphocytes, Bone marrow of rats and hamsters, V 79 test, SCE test) on possible mutagenic effects. As all tests were negative the mutagenic risk in humans is considered low.

Neither the long term toxicity studies in rats and dogs nor a special carcinogenicity study, performed in rats over 125 weeks (males) and 138 weeks (females), indicated neoplastic properties of isosorbide mononitrate. Therefore, it can be concluded that the carcinogenic risk in humans is low.

6. Pharmaceutical particulars

6.1 List of excipients

21st century, calciumcitrate petites d3, 200 coated tablets, super citracal 667mg

Expiration Date. Dec 2018

Shipping Weight: 0.71 lbs (0.32 kg)

Product Code: CEN-27709

UPC Code: 740985277096

Package Quantity: 200 Coated Tablets

Dimensions: 2.5 x 2.5 x 5.1 in, 0.6 lbs (0.27 kg)

Compare Active Ingredients to Citracal® +D Petites†

Calcium Supplement

Highly Absorbable to Support Bone Health

Smaller, Easy to Swallow Tablets

Guaranteed Quality - Laboratory Tested

Calcium Citrate is a highly absorbable form of Calcium, an important mineral for supporting bone health. Calcium also works to support muscle and nerve function. Vitamin D3 is added to assist with Calcium absorption and as support for healthy immune function.

As a calcium supplement, take two (2) tablets twice daily with any meal or as directed by your healthcare provider. Do not exceed recommended dosage. Individual results may vary.

Cellulose, stearic acid, magnesium stearate, silicon dioxide, croscarmellose sodium, polyvinyl alcohol, talc, PEG, polysorbate.

No added sugar, yeast, preservatives, artificial flavors or colors. Gluten free.

†Citracal® is a registered trademark of Bayer HealthCare.

Consult a healthcare provider prior to use if: pregnant, nursing, on medications, have a medical condition or are planning a medical procedure. Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children. Do not use if product appears to be tampered with or seal is broken. Store at room temperature.

The length of time for the expiration date or "best used before" date depends on the type of product, as well as the brand.

Perishable items (such as flax oils or certain probiotics) generally have shorter expiration dates. Although our warehouse is fully air-conditioned, these more fragile items are put in cold storage (freezer or refrigeration unit) for maximum freshness.

Our receiving department does its best to verify and then enter the correct expiration dates for all incoming products. However, discrepancies do occur from time to time. This being said, the exceptionally high turnover at iHerb ensures that our inventory is among the freshest in the industry.

The Shipping Weight includes the product, protective packaging material and the actual shipping box. In addition, the Shipping Weight may be adjusted for the Dimensional Weight (e. g. length, width & height) of a package. It is important to note that certain types of products (e. g. glass containers, liquids, fragile, refrigerated or ice packed) will often require protective packaging material. As such, these products will reflect a higher Shipping Weight compared to the unprotected product.

- Loyalty Credit equals 10% of the final shopping cart price, excluding shipping charges, and is available to be used toward your next order once your current (last) order has shipped.

- Each time you place a new order, a Loyalty Credit equal to 10% of the value of your order will be given to you.

- Loyalty Credits expire 60 days after your last purchase with iHerb.

Difflam % spray, diaflam

DIFFLAM 0.15% SPRAY

Transcript

NAME OF THE MEDICINAL PRODUCT Difflam 0.15% w/v Spray

QUALITATIVE AND QUANTITATIVE COMPOSITION Each metered dose pump spray delivers Benzydamine hydrochloride 0.15% w/v, approximately 175 microlitres per puff.

Contains methyl parahydroxybenzoate and Ethanol. For a full list of excipients, see section 6.1.

PHARMACEUTICAL FORM Difflam 0.15% Spray is a metered dose pump throat spray.

Therapeutic indications Difflam 0.15% Spray is a locally acting analgesic and anti-inflammatory treatment for the throat and mouth. It is used to treat various painful oropharyngeal conditions such as mouth ulcers, sore throat, sore mouth or gums, dental pain.

Posology and method of administration Posology Adults, adolescents and elderly: 4 to 8 puffs every 1?-3 hourly. Children(6-12): 4 puffs every 1?-3 hourly. Children under 6: One puff to be administered per 4 kg body weight, up to a maximum of 4 puffs, 1?-3 hourly. Elderly: Because of the small amount of drug applied, elderly patients can receive the

same dose as adults.

Method of administration For oral administration 4.3

Contraindications Difflam 0.15% w/v Spray is contra-indicated in patients with known hypersensitivity to the active substance benzydamine hydrochloride or to any of the excipients listed in section 6.1.

Special warnings and precautions for use Benzydamine use is not advisable in patients with hypersensitivity to acetylsalicylic acid or other NSAIDs. Bronchospasm may be precipitated in patients suffering from or with a previous history of bronchial asthma. Caution should be exercised in these patients. Avoid contact with the eyes.

If the condition is aggravated or not improved use should cease. This medicinal product contains 10 vol % ethanol. Methyl hydroxybenzoate may cause allergic reactions (possibly delayed) 4.5

Interaction with other medicinal products and other forms of interaction None known.

Fertility, pregnancy and lactation Pregnancy Difflam 0.15% w/v Spray should not be used in pregnancy unless considered essential by the physician. There is no evidence of a teratogenic effect in animal studies. Breast-feeding Difflam 0.15% w/v Spray should not be used in lactation unless considered essential

by the physician.

Effects on ability to drive and use machines None.

Undesirable effects Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness The following rate values have been used: Very common (? 1/10), Common (? 1/100 to Yes No

Drugs. com Mobile Apps

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Kop mittoval (uroxatral) utan recept, mittoval

Kopa Mittoval (Uroxatral) Natet Utan Recept

Mittoval (Uroxatral) Forklaring

Mittoval ar definitivt en alfa-blockerare. Funktioner genom att blockera smarta i reducerad urin: systemet, vilket leder till snygg muskelvavnad i blasan hals och prostata varva ner. Denna speciella resten forbattrar urinflodet och minskar de yttre symptom i samband med BPH.

Allmant titeln i samband med Mittoval ar faktiskt Alfuzosin.

Brand i samband med Mittoval ar faktiskt Mittoval.

Mittoval (Uroxatral) Dose

Mittoval kommer in:

10mg Regular Dos friktionsmaterial

Get Mittoval oralt tillsammans med maltider. Bar middag varje dag.

Konsumera Mittoval hela. Vanligtvis inte spricka, slipa, eller ens tugga upp fore intag.

Get Mittoval pa en mer regelbunden rutin for att fa majoriteten av dra nytta av detta.

Om du vill astadkomma basta resultaten brukar inte sluta anvanda Mittoval helt plotsligt.

Mittoval (Uroxatral) I brist forknippas med doserings

Vanligtvis far inte dubbel dos. Om du hoppar over dosen du behover for att bara den nar du kom ihag nar det galler din saknas. Nar det ar dags for dosering du behover bara pa din egen normal dosering rutin.

Mittoval (Uroxatral) Overdosering

Om du overdoserar Mittoval och du undviker ocksa stor att du behover kolla din lakare eller ens lakare omedelbart.

Mittoval (Uroxatral) Lagringsutrymme

Shop i rymden temperaturer mellan 10 och 30 nivaer D (59 samt 86 nivaer F) fran fukt, belysning samt temperatur. Starka nagon form av orord medicinering efter utgangen dagen. Behall fran uppna av barn inom en textruta som smabarn inte kan oppna.

Mittoval (Uroxatral) Negativa effekter

Mittoval erbjuder de negativa effekterna. Den mest typiska tenderar att vara:

trotthet friktionsmaterial

somnighet friktionsmaterial

huvudvark friktionsmaterial

tappt i nasan omrade friktionsmaterial

Mycket mindre typiska och allvarliga negativa effekter i hela anvander Mittoval:

allergiska reaktion reaktioner (urtikaria, andas in och andas problem, allergi, liksom som utslag) friktionsmaterial

smarta i nedre ryggen friktionsmaterial

hjartproblem friktionsmaterial

minskad intima kapacitet friktionsmaterial

svimning friktionsmaterial

snabb eller onormal hjartrytm friktionsmaterial

smartfriktionsmaterial

obehagligt, kontinuerlig erektion friktionsmaterial

allvarliga eller till och med langre trotthet friktionsmaterial

mage eller ens magen obehag friktionsmaterial

ovanlig trotthet eller ens nagra svaghet friktionsmaterial

Negativa effekter indikationer ar beroende av medicinering du kanske anvander men dessutom lita pa ditt valbefinnande villkor och annan aspekter.

Mittoval (Uroxatral) Kontraindikationer

Vanligtvis inte far Mittoval om du ar kanslig for att Mittoval element.

Vanligtvis inte far Mittoval om du vantar annars du tanker ha ett barn, annars ar du verkligen en medicinsk mamma. Mittoval skadar ditt barn.

Vanligtvis inte far Mittoval for dem som har rimliga for att allvarliga sjukdomar i levern.

Vanligtvis inte far Mittoval om du anvander en bra alfa-blockerare (e. Gary gadget kille. Prazosin), en bra azol svampdodande (e. Gary gadget kille. Ketokonazol), eller ens en bra HIV-proteashammare (t. ex. ritonavir).

Sitt rakt upp eller till och med forbli gradvis, sarskilt tidigt pa morgonen.

Forhindra omstandigheter genom vilka skador kan handa pa grund av svimning.

Forhindra alkoholhaltiga drycker.

Underhall Mittoval fran barn och gor inte detta nagra andra enskilda vid att anvanda.

Vanligtvis inte sluta anvanda Mittoval helt plotsligt.

Mittoval (Uroxatral) Vanliga fragor

Queen: Vad exakt ar Mittoval?

Mittoval anvands nar det galler att hantera i samband med ofarlig prostataforstoring (BPH) inom hanar som har en storre prostata. Detta kan ocksa leverera for sarskilda omstandigheter. Mittoval ar definitivt en alfa-blockerare. Funktioner genom att blockera smarta i reducerad urin: systemet, vilket leder till snygg muskelvavnad i blasan hals och prostata varva ner. Denna speciella resten forbattrar urinflodet och minskar de yttre symptom i samband med BPH. A

Queen: Vad exakt ar allmanna och varumarken som forknippas med Mittoval?

Allman titeln i samband med Mittoval ar faktiskt Alfuzosin. Brand i samband med Mittoval ar faktiskt Mittoval. A

Queen: Kan man verkligen konsumera alkohol?

Absolut ingen, det ar verkligen oacceptabelt uppskattar alkoholhaltiga beverages. A

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Sok

Clostrin by glaxo laboratories ltd, clostrin

CLOSTRIN - 188789

TRADEMARK DETAILS Owner:

Glaxo Laboratories Ltd

Type:

Word

Description:

CLOSTRIN

CLOSTRIN with trademark number 188789 was lodged on 08/07/1964 and has a status of Removed - Not Renewed. The applicant/owner of the trademark is registered as Glaxo Laboratories Ltd.

Australian trademark 188789 is one of over a million that we feature on IP in Australia which covers the entire spectrum of trademarks in Australia. Glaxo Laboratories Ltd is also one of thousands of applicants we’ve analysed. We also understand who are the most prolific inventors in Australia with details on all the trademarks attributed to individuals.

Because we have insights into all the attorney firms that have been used across Australia including which specific trademark attorney worked on each trademark, we have access to unique analytics on the best attorney to use if you have specific trademark needs.

Filing trademarks is a time consuming and expensive exercise which is why care needs to be taken ensuring that you’re working with the right individual.

Because we’re an independent third party we can give you unbiased insights and recommendations on the right partner to choose. For more information contact us

Elkridge skilled nursing, lorien

Welcome to Lorien Elkridge

Thank you for considering Lorien Elkridge to take care of you and your loved ones. Our Lorien Elkridge Skilled Nursing Center is located in the established community of Elkridge, just 14 miles south of Baltimore. As you approach Lorien Elkridge, you will see our beautiful new facility conveniently located off of I-95 between route 100 and route 175.

New residents are greeted by our skilled staff dedicated to providing quality nursing and rehabilitation care for your changing personal and health care needs, because we're here to help you reach your goals!

Lorien Elkridge encompasses a wide array of services all under one roof to serve all of your needs. A Long-term Care Unit is provided for those who may need a longer stay with the ability to handle complex medical needs. Our Skilled Nursing and Rehabilitation Unit provides short-term rehabilitation with physical, occupational and speech therapy. In addition, our experienced interdisciplinary staff provides IV therapy, wound care, medication management, hospice and respite care as well as having a dietician to help with dietary needs and education. The comprehensive program is designed to promote healing and provide the highest quality of life.

These transitions can be difficult for both the patient and their family and our staff is here to help.

Care Provided at Lorien Elkridge

"Just a note to thank you for all your efforts to improve the quality of my mother's life. I appreciate your openness to suggestions and willingness to try different things that might work for Mom. The extra effort was immediately apparent after our phone call last week. When I spoke to Mom a couple of days later, she said she didn't know what happened, but she is being treated like a queen! You can't ask for more than that."

7615 Washington Blvd. Elkridge, MD 21075

Lorien Health Systems 3300 North Ridge Road, Suite 390 Ellicott City, MD 21043 • 410-750-7500

Lorien Health Systems guarantees equal opportunity in receiving employment, admission treatment, participation in its programs, services and activities, regardless of race, color, religion, ancestry or national origin, sex, age, marital status, sexual orientation, gender identity, disability, or genetic information. For further information about this policy, contact: Section 504 Coordinator, 410-750-7500, TTY# 1-800-735-2258. Compliance# 1-855-859-0809 Available 24/7

Codeine side effects, codeine

Codeine Side Effects

For the Consumer

Applies to codeine: oral solution, oral syrup, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by codeine. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking codeine:

Incidence not known:

Bloating

blurred vision

chills

cold, clammy skin

confusion

constipation

darkened urine

difficult or troubled breathing

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fainting

fast, irregular, pounding, or racing heartbeat or pulse

fast, weak pulse

feeling of warmth

fever

indigestion

irregular, fast or slow, or shallow breathing

lightheadedness

loss of appetite

nausea

no blood pressure or pulse

no breathing

pains in the stomach, side, or abdomen, possibly radiating to the back

pale or blue lips, fingernails, or skin

redness of the face, neck, arms, and occasionally, upper chest

shortness of breath

stopping of the heart

sweating

unconsciousness

unusual tiredness or weakness

vomiting

wheezing

yellow eyes or skin

If any of the following symptoms of overdose occur while taking codeine, get emergency help immediately:

Symptoms of overdose:

Bluish lips or skin

change in consciousness

chest pain or discomfort

constricted, pinpoint, or small pupils (black part of the eye)

decreased awareness or responsiveness

extreme sleepiness or unusual drowsiness

loss of consciousness

no blood pressure or pulse

severe sleepiness

slow or irregular heartbeat

Minor Side Effects

Some of the side effects that can occur with codeine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Drowsiness

relaxed and calm

Incidence not known:

Abdominal or stomach pain or cramps

blurred or loss of vision

diarrhea

disturbed color perception

double vision

dry mouth

false or unusual sense of well-being

fear or nervousness

feeling of constant movement of self or surroundings

halos around lights

headache

hives or welts

itching skin

night blindness

overbright appearance of lights

redness of the skin

sensation of spinning

shakiness

skin rash

sleeplessness

trouble sleeping

tunnel vision

unable to sleep

weight loss

For Healthcare Professionals

Applies to codeine: compounding powder, injectable solution, oral solution, oral tablet

General

The most frequently observed adverse reactions include drowsiness lightheadedness, dizziness, sedation, shortness of breath, nausea, vomiting, sweating, and constipation. [Ref ]

Respiratory

Uncommon (0.1% to 1%): Bronchospasm, laryngospasm, respiratory depression Frequency not reported: Respiratory arrest, dyspnea Postmarketing reports: Deaths due to respiratory depression [Ref ]

Respiratory depression resulting in death has been reported in children who received codeine postoperatively following tonsillectomy and/or adenoidectomy. These children had evidence of being ultra-rapid metabolizers of codeine. Death has also been reported in nursing infants exposed to high levels of morphine in breast milk due to their breastfeeding mother being an ultra-rapid metabolizer of codeine. [Ref ]

Cardiovascular

Uncommon (0.1% to 1%): Heartbeat irregularities, blood pressure changes, syncope Frequency not reported: Flushing, hypotension, palpitations, circulatory depression, shock, cardiac arrest, circulatory depression, bradycardia, tachycardia, edema [Ref ]

Nervous system

Common (1% to 10%): Drowsiness, dizziness Uncommon (0.1% to 1%): Headache, lightheadedness, feeling faint, paradoxical CNS stimulation (especially in children), disorientation, restlessness, shakiness, somnolence, weakness Frequency not reported: Seizures [Ref ]

Other

Frequency not reported: Fatigue, vertigo, malaise, hypothermia, fever, addiction, tolerance, dependence, withdrawal reactions upon discontinuation of chronically administered drug included diarrhea, sweating, vomiting, insomnia, agitation, tremor, body aches, gooseflesh, loss of appetite, nervousness or restlessness, runny nose, sneezing, shivering, stomach cramps, nausea, sleep disturbances, yawning, weakness, tachycardia, fever, irritability, mydriasis [Ref ]

Hypersensitivity

Uncommon (0.1% to 1%): Itching, facial swelling, pruritus, urticaria, histamine release (hypotension, sweating, flushing of the face, tachycardia, breathlessness) Frequency not reported: Allergic reactions including maculopapular rash [Ref ]

Gastrointestinal

Common (1% to 10%): Constipation Uncommon (0.1% to 1%): Dry mouth, loss of appetite, nausea, vomiting, paralytic ileus, toxic megacolon, anorexia, stomach cramps Frequency not reported: Gastrointestinal distress, anorexia, diarrhea, pancreatitis [Ref ]

Hepatic

Frequency not reported: Biliary spasm [Ref ]

Genitourinary

Uncommon (0.1% to 1%): Urinary retention or hesitance, ureteric spasm, reduced libido and/or potency [Ref ]

Dermatologic

Uncommon (0.1% to 1%): Rash Frequency not reported: Sweating, urticaria, pruritus [Ref ]

Ocular

Uncommon (0.1% to 1%): Miosis, blurred or double vision Frequency not reported: Visual disturbances [Ref ]

Endocrine

Uncommon (0.1% to 1%): Antidiuretic effect Frequency not reported: Decreased libido or potency, erectile dysfunction, sexual dysfunction [Ref ]

Psychiatric

Uncommon (0.1% to 1%): Euphoria, dysphoria, unusual dreams, hallucinations, insomnia, anxiety Frequency not reported: Mood changes, restlessness, confusion, mental depression [Ref ]

Metabolic

Frequency not reported: Hyperglycemia, anorexia [Ref ]

References

1. "Multum Information Services, Inc. Expert Review Panel"

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Codeine Sulfate (codeine)." Roxane Laboratories Inc, Columbus, OH.

4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for codeine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

Haemoproct for the local treatment of haemorrhoids - online pharmacy, haemoproct

Haemoproct Cream, Ointment, Suppositories For the local treatment of haemorrhoids

Cream: Each 1 g contains: ActiveIngredients. Tribenoside 5% w/w

Lidocaine HCl 2% w/w

Excipients :Cetyl alcohol, Stearic acid, Liquid paraffin, Isopropyl palmitate, Cetomacrogol 1000, Sorbitan monostearate, Methyl and propyl para bens, Sorbitol 70% and Purified water Ointment: Each 1 g contains: Active Ingredients :Tribenoside 5% w/w

Lidocaine 2% w/w Excipients :White soft paraffin, Liquid paraffin and Micro - crystalline wax.

Suppositories :Each suppository contains:

Active Ingredients. Tribenoside 400 mg Lidocaine 40 mg Excipients. Glycerol esters of saturated fatty acids and caprylic/capric triglyceride.

Haemoproct provides prompt relief of pain, itching, discomfort and otherunpleasant symptoms due to haemorrhoids. Tribeno - side has local anti-inflammatory properties and is also known to reduce capillary permeability and improve vascular tone, whereas lidocaine as a localanesthetic assures rapid sympto - matic relief.

Haemoproct is effective in treating both external and internal haemorrhoids.

Dosage and Application:

A thin film of the cream or ointment or one suppository should be applied morning and evening until there is disappearance of the acute symptoms; thereafter, the dosage can be reduced to one application per day.

If you miss a dose: – Apply as soon as possible. – If it is almost time for your next regular dose, skip the missed dose and carry on with your dosing regimen. – Do not take two doses at the same time.

Patients with hypersensitivity to the preparation should not use it.

As with other forms of drug therapy, Haemoproct should be given cautiously during pregnancy, especially in the first trimester. Caution is also recommended during breast feeding.

Haemoproct is generally well-tolerated. Some minor side effects have been occasionally reported such as burning sen - sation, and increased intestinal motility.

Cream :Tubes of 30 g. Ointment :Tubes of 30 g. Suppositories :Packs of 10 suppositories. * Store below 30°C, protect from heat.

-Medicament is a product which affects your health, and its consumption contrary to instructions is dangerous for you. – Follow strictly the doctor’s prescription, the method of use and the instructions of the pharmacist who sold the medicament. – The doctor and the pharmacist are experts in medicines, their benefits and risks. – Do not by yourself interrupt the period of treatment prescribed for you. – Do not repeat the same prescription without consulting your doctor. – Keep all medicaments out of the reach of children.

Iulphar Gulf Pharmaceutical Industries, Ras AI Khaimah, U. A. E.

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What is Irbesartan and Hydrochlorothiazide?

Irbesartan and Hydrochlorothiazide is a combination medicine for hypertension (high blood pressure) that contains two active ingredients, Irbesartan and Hydrochlorothiazide. Irbesartan is an angiotensin II receptor antagonist that prevents the blood vessels from narrowing which improves blood flow and lowers blood pressure. Hydrochlorothiazide is a thiazide diuretic (water pill) that stops the body from absorbing too much salt which can lead to fluid retention. High levels of salt in the body can lead to high blood pressure. This medicine is available under several brands, some of which are Avalide, Irovel H (made by Sun Pharma), and CoAprovel (made by Sanofi).

Important Information about Irbesartan and Hydrochlorothiazide

Do not take Irbesartan and Hydrochlorothiazide (Avalide, Irovel H, CoAprovel) if you are allergic to Irbesartan or Hydrochlorothiazide, or if you are unable to urinate. To make sure that this medicine is safe for you, inform your doctor in advance if you have any of these conditions: heart disease or congestive heart failure, kidney disease (or if you are on dialysis), liver disease, lupus, gout, glaucoma diabetes, asthma, or an allergy to sulfa drugs or penicillin. Irbesartan and Hydrochlorothiazide is a pregnancy category D drug. Do not take this medicine if you are a pregnant woman. If you become pregnant during the treatment with this medicine, stop taking it and contact your doctor immediately. Irbesartan and Hydrochlorothiazide can cause injury or death of an unborn baby if pregnant women take it in second or third trimester. Use of effective birth control is recommended while taking this medicine. It is not known whether Irbesartan and Hydrochlorothiazide can pass into breast milk and harm a nursing baby. Consult your doctor about safely taking this medicine if you are breast feeding a baby. Irbesartan and Hydrochlorothiazide may increase your potassium levels. Hence, avoid potassium supplements or salt substitutes that contain potassium while taking this medicine, unless or otherwise directed by your doctor. In rare cases, Irbesartan and Hydrochlorothiazide can lead to a condition which results in the breakdown of skeletal muscle tissue, causing in kidney failure. Seek medical attention right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual fatigue, and dark colored urine.

Before taking Irbesartan and Hydrochlorothiazide

Before taking Irbesartan and Hydrochlorothiazide (Avalide, Irovel H, CoAprovel), take care of all precautions mentioned above. Discuss them with your doctor and clear all doubts which you may have about this drug.

How should I take Irbesartan and Hydrochlorothiazide?

Take Irbesartan and Hydrochlorothiazide strictly according to your doctor’s direction or according to the instructions on the medication label. Do not alter the dosage unless your doctor advises you to do so. Also, do not take this medication after the prescribed period is over. All medications come with a patient leaflet. Refer the instructions in them for detailed information on that particular medication. It may take up to 4 weeks of regular intake (as directed) for Irbesartan and Hydrochlorothiazide to reign in your blood pressure. You have to take this medicine even if look fine for the rest of your life. High blood pressure doesn’t have any outwardly signs. Always store this medicine in a cool and dry place. While taking Irbesartan and Hydrochlorothiazide, watch out for vomiting, diarrhea, or excessive sweating. These can lead to severe dehydration which can further lower your blood pressure. Low blood pressure can be a dangerous and fatal condition. Contact your doctor immediately if you experience any of these conditions while taking this medicine.

What if I miss a dose?

If you miss a dose of Irbesartan and Hydrochlorothiazide, take it as soon as you remember. Don’t take the missed dose if the time to take the next dose is almost up. Taking multiple doses near to each other can lead to excess medication in your body which can be harmful.

What if I overdose?

In case of an overdose of Irbesartan and Hydrochlorothiazide, get emergency medical attention or call the Doctor Immediately. Overdose may result in nausea, weakness, dizziness, dry mouth, thirst, muscle pain or weakness, or feeling like you might pass out.

Things and Activities to avoid while taking Irbesartan and Hydrochlorothiazide

Avoid or limit the consumption of alcohol. Do not become overheated or dehydrated during exercise and hot weather. Follow your doctor’s directions about the type and amount of fluids you should drink. Irbesartan and Hydrochlorothiazide may increase your potassium levels. Hence, avoid potassium supplements or regular use of salt substitutes that contain potassium while taking this medicine.

Irbesartan and Hydrochlorothiazide Side Effects

Some common side effects of Irbesartan and Hydrochlorothiazide are dizziness, light headedness, swelling in ankles or feet, or flushing. If any of these effects persist or deteriorate, get medical attention right away. A serious side effect is unlikely. However, if you get any serious side effect like fast, irregular or rapid heartbeat, or fainting, or any other serious side effect, seek medical attention immediately. The side effects mentioned above are not the only ones that you may experience or witness due to Irbesartan and Hydrochlorothiazide. If you get any serious side effects due to this medication, contact your doctor right away.

Irbesartan and Hydrochlorothiazide Dosing Information

Irbesartan and Hydrochlorothiazide dosage may depend on a range of factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage will be determined by your doctor after examining you properly. Remember to follow your doctor’s advice properly for best results.

Interaction with other drugs

Many other drugs can interact with Irbesartan and Hydrochlorothiazide. Let your doctor know in advance if you use any other drugs or related products (OTC vitamin pills or other medicines, or herbal products), especially gold injections for arthritis, lithium, NSAIDs (ibuprofen, naproxen, or others), steroids, cholestyramine, colestipol, insulin, oral diabetes medicines, a potassium supplement such as K-Dur, Klor-Con, salt substitutes that contain potassium, or a diuretic. However, these are not the only drugs that can interact with Irbesartan and Hydrochlorothiazide. There may be others. Never start a new medication without proper medical advice.

Please note that not all medications, including any referenced on this page, are dispensed from our affiliated Indian pharmacy. The medications in your order may be filled and shipped from an approved International fulfilment center located in a country other than India. In addition to dispensing medications from our Indian pharmacy, medication orders are also filled and shipped from international fulfilment centers that are approved by the regulatory bodies from their respective countries.

Medication orders are filled and shipped from approved fulfilment centers around the world including, but not limited to, India, United Kingdom, New Zealand, Mauritius and the United States. The items in your order may be filled and shipped from any one of the above jurisdictions. The products are sourced from various countries as well as those listed above. All of our affiliated fulfilment centers have been approved by the regulatory bodies from their respective countries.

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The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine.

This PIL is in PDF format and so you must have a PDF reader installed on your device to read it.

Text only version for the visually impaired Below is a text only representation of the Patient Information leaflet. The original may contain images or tables and can be viewed in PDF format using the link above. This PIL may be available from the RNIB in large print, Braille or audio CD. For further information please call the RNIB Medicine Leaflet line on 0800 198 5000. The product code(s) for this leaflet is/are: EU/1/98/086/004, EU/1/98/086/005, EU/1/98/086/006, EU/1/98/086/008, EU/1/98/086/010.

CoAprovel 300/12.5mg film coated tablets (Sanofi)

Package leaflet: Information for the patient

COAPROVEL ® 300 mg/12,5 mg

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

Keep this leaflet. You may need to read it again.

If you have any further questions, ask your doctor or pharmacist.

This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet

1. What CoAprovel is and what it is used for 2. What you need to know before you take CoAprovel 3. How to take CoAprovel 4. Possible side effects 5. How to store CoAprovel 6. Contents of the pack and other information

1. WHAT COAPROVEL IS AND WHAT IT IS USED FOR

CoAprovel is a combination of two active substances, irbesartan and hydrochlorothiazide.

Irbesartan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body that binds to receptors in blood vessels causing them to tighten. This results in an increase in blood pressure. Irbesartan prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax and the blood pressure to lower.

Hydrochlorothiazide is one of a group of medicines (called thiazide diuretics) that causes increased urine output and so causes a lowering of blood pressure.

The two active ingredients in CoAprovel work together to lower blood pressure further than if either was given alone.

CoAprovel is used to treat high blood pressure . when treatment with irbesartan or hydrochlorothiazide alone did not provide adequate control of your blood pressure.

2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE COAPROVEL

Do not take CoAprovel

if you are allergic to irbesartan or any of the other ingredients of this medicine (listed in section 6)

if you are allergic to hydrochlorothiazide or any other sulfonamide-derived medicines

if you are more than 3 months pregnant . (It is also better to avoid CoAprovel in early pregnancy – see pregnancy section)

if you have severe liver or kidney problems

if you have difficulty in producing urine

if your doctor determines that you have persistently high calcium or low potassium levels in your blood

if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren

Warnings and precautions

Talk to your doctor before taking CoAprovel and if any of the following apply to you :

if you get excessive vomiting or diarrhoea

if you suffer from kidney problems or have a kidney transplant

if you suffer from heart problems

if you suffer from liver problems

if you suffer from diabetes

if you suffer from lupus erythematosus (also known as lupus or SLE)

if you suffer from primary aldosteronism (a condition related to high production of the hormone aldosterone, which causes sodium retention and, in turn, an increase in blood pressure).

if you are taking any of the following medicines used to treat high blood pressure

an ACE-inhibitor (for example enalapril, lisinopril, ramipril), in particular if you have diabetes-related kidney problems.

aliskiren.

Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e. g. potassium) in your blood at regular intervals

See also information under the heading “Do not take CoAprovel”.

You must tell your doctor if you think you are ( or might become ) pregnant. CoAprovel is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).

You should also tell your doctor:

if you are on a low-salt diet

if you have signs such as abnormal thirst, dry mouth, general weakness, drowsiness, muscle pain or cramps, nausea, vomiting . or an abnormally fast heart beat which may indicate an excessive effect of hydrochlorothiazide (contained in CoAprovel)

if you experience an increased sensitivity of the skin to the sun with symptoms of sunburn (such as redness, itching, swelling, blistering) occurring more quickly than normal

if you are going to have an operation (surgery) or be given anaesthetics

if you have changes in your vision or pain in one or both of your eyes while taking CoAprovel. This could be a sign that you are developing glaucoma, increased pressure in your eye(s). You should discontinue CoAprovel treatment and seek medical attention.

The hydrochlorothiazide contained in this medicine could produce a positive result in an anti-doping test.

Children and adolescents

CoAprovel should not be given to children and adolescents (under 18 years).

Other medicines and CoAprovel

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Diuretic agents such as the hydrochlorothiazide contained in CoAprovel may have an effect on other medicines. Preparations containing lithium should not be taken with CoAprovel without close supervision by your doctor.

Your doctor may need to change your dose and/or to take other precautions:

If you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not take CoAprovel” and “Warnings and precautions”).

You may need to have blood checks if you take:

potassium supplements

salt substitutes containing potassium

potassium sparing medicines or other diuretics (water tablets)

some laxatives

medicines for the treatment of gout

therapeutic vitamin D supplements

medicines to control heart rhythm

medicines for diabetes (oral agents or insulins)

carbamazepine (a medicine for the treatment of epilepsy).

It is also important to tell your doctor if you are taking other medicines to reduce your blood pressure, steroids, medicines to treat cancer, pain killers, arthritis medicines, or colestyramine and colestipol resins for lowering blood cholesterol.

CoAprovel with food and drink

CoAprovel can be taken with or without food.

Due to the hydrochlorothiazide contained in CoAprovel, if you drink alcohol while on treatment with this medicine, you may have an increased feeling of dizziness on standing up, specially when getting up from a sitting position.

Pregnancy, breast-feeding and fertility

You must tell your doctor if you think you are ( or might become ) pregnant. Your doctor will normally advise you to stop taking CoAprovel before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of CoAprovel. CoAprovel is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.

Tell your doctor if you are breast-feeding or about to start breast-feeding. CoAprovel is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.

Driving and using machines

No studies on the effects on the ability to drive and use machines have been performed. CoAprovel is unlikely to affect your ability to drive or use machines. However, occasionally dizziness or weariness may occur during treatment of high blood pressure. If you experience these, talk to your doctor before attempting to drive or use machines.

CoAprovel contains lactose. If you have been told by your doctor that you have an intolerance to some sugars (e. g. lactose), contact your doctor before taking this medicine.

3. HOW TO TAKE COAPROVEL

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

The recommended dose of CoAprovel is one tablet a day. CoAprovel will usually be prescribed by your doctor when your previous treatment did not reduce your blood pressure enough. Your doctor will instruct you how to switch from the previous treatment to CoAprovel.

Method of administration

CoAprovel is for oral use . Swallow the tablets with a sufficient amount of fluid (e. g. one glass of water). You can take CoAprovel with or without food. Try to take your daily dose at about the same time each day. It is important that you continue to take CoAprovel until your doctor tells you otherwise.

The maximal blood pressure lowering effect should be reached 6-8 weeks after beginning treatment.

If you take more CoAprovel than you should

If you accidentally take too many tablets, contact your doctor immediately.

Children should not take CoAprovel

CoAprovel should not be given to children under 18 years of age. If a child swallows some tablets, contact your doctor immediately.

If you forget to take CoAprovel

If you accidentally miss a daily dose, just take the next dose as normal. Do not take a double dose to make up for a forgotten dose.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. POSSIBLE SIDE EFFECTS

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Some of these effects may be serious and may require medical attention.

Rare cases of allergic skin reactions (rash, urticaria), as well as localised swelling of the face, lips and/or tongue have been reported in patients taking irbesartan.

If you get any of the above symptoms or get short of breath . stop taking CoAprovel and contact your doctor immediately.

The frequency of the side effects listed below is defined using the following convention:

Common: may affect up to 1 in 10 people

Uncommon: may affect up to 1 in 100 people

Side effects reported in clinical studies for patients treated with CoAprovel were:

Common side effects (may affect up to 1 in 10 people):

nausea/vomiting

abnormal urination

fatigue

dizziness (including when getting up from a lying or sitting position)

blood tests may show raised levels of an enzyme that measures the muscle and heart function (creatine kinase) or raised levels of substances that measure kidney function (blood urea nitrogen, creatinine).

If any of these side effects causes you problems . talk to your doctor.

Uncommon side effects (may affect up to 1 in 100 people):

diarrhoea

low blood pressure

fainting

heart rate increased

flushing

swelling

sexual dysfunction (problems with sexual performance)

blood tests may show lowered levels of potassium and sodium in your blood.

If any of these side effects causes you problems . talk to your doctor.

Side effects reported since the launch of CoAprovel

Some undesirable effects have been reported since marketing of CoAprovel. Undesirable effects where the frequency is not known are: headache, ringing in the ears, cough, taste disturbance, indigestion, pain in joints and muscles, liver function abnormal and impaired kidney function, increased level of potassium in your blood and allergic reactions such as rash, hives, swelling of the face, lips, mouth, tongue or throat. Uncommon cases of jaundice (yellowing of the skin and/or whites of the eyes) have also been reported.

As for any combination of two active substances, side effects associated with each individual component cannot be excluded.

Side effects associated with irbesartan alone

In addition to the side effects listed above, chest pain has also been reported.

Side effects associated with hydrochlorothiazide alone

Loss of appetite; stomach irritation; stomach cramps; constipation; jaundice (yellowing of the skin and/or whites of the eyes); inflammation of the pancreas characterised by severe upper stomach pain, often with nausea and vomiting; sleep disorders; depression; blurred vision; lack of white blood cells, which can result in frequent infections, fever; decrease in the number of platelets (a blood cell essential for the clotting of the blood), decreased number of red blood cells (anaemia) characterised by tiredness, headaches, being short of breath when exercising, dizziness and looking pale; kidney disease; lung problems including pneumonia or build-up of fluid in the lungs; increased sensitivity of the skin to the sun; inflammation of blood vessels; a skin disease characterized by the peeling of the skin all over the body; cutaneous lupus erythematosus, which is identified by a rash that may appear on the face, neck, and scalp; allergic reactions; weakness and muscle spasm; altered heart rate; reduced blood pressure after a change in body position; swelling of the salivary glands; high sugar levels in the blood; sugar in the urine; increases in some kinds of blood fat; high uric acid levels in the blood, which may cause gout.

It is known that side effects associated with hydrochlorothiazide may increase with higher doses of hydrochlorothiazide.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard

You can also report side effects directly via

HPRA Pharmacovigilance Earlsfort Terrace IRL - Dublin 2

Tel: +353 1 6764971

Albuterol inhalers, prohair

©2016 Teva Respiratory, LLC. This site is intended for U. S. Residents only. All Rights Reserved. ProAir ® HFA and ProAir RespiClick ® are registered trademarks of Teva Respiratory, LLC The color red as used on the ProAir ® HFA inhaler is a registered trademark of Teva Respiratory, LLC. PRS-40493

PROAIR ® HFA PROAIR RESPICLICK ® HEALTHCARE PROFESSIONALS

©2016 Teva Respiratory, LLC. This site is intended for U. S. Residents only. All Rights Reserved. ProAir ® HFA and ProAir RespiClick ® are registered trademarks of Teva Respiratory, LLC The color red as used on the ProAir ® HFA inhaler is a registered trademark of Teva Respiratory, LLC. PRS-40493

Antenna - definition of antenna by the free dictionary, anten

antenna

With a frightful qualm, I turned, and I saw that I had grasped the antenna of another monster crab that stood just behind me.

Its arms were fully as slender as its legs, and upon a rather long neck was perched its head -- not unlike the head of a man, except that its nose ended in a curling antenna. or "feeler," and its ears from the upper points bore antennae that decorated the sides of its head like two miniature, curling pig tails.

MTI Wireless Edge maintains three outdoor antenna test ranges, varying in length from 8 meters to 300 meters and one indoor compact range for 2-50GHz.

SAN DIEGO -- Ethertronics, a provider of embedded antenna solutions for wideband and multi-band wireless devices, today announced the introduction of its third-generation quad-band WiFi/WLAN internal antenna solution.

Combining multiple high-gain directional antenna elements and high isolation between each antenna beam, Airgain's new MIMO smart antennas significantly increase the signal strength, range and throughput of 802.

SAN DIEGO -- Ethertronics, a leading provider of embedded antenna solutions for wideband and multi-band wireless devices, today announced that it has shipped more than 25-million of its innovative Isolated Magnetic Dipole(TM) (IMD) antennas in 2006.

Antenna currently has 125,000 users in production and handles 15 million mobile transactions each month.

TEL AVIV, Israel -- MTI Wireless Edge, a leading developer of advanced fixed wireless antenna solutions, announces the serial production of their 900MHz 10dBi Horizontal polarized 180 degrees base station antenna .

8Kg) of this new Low Axial Ratio RFID reader antenna range eases installation making it the ideal solution for a wide range of applications.

SkyCross achieves this flexibility with custom engineering that accommodates the allotted antenna space and other components in these various devices.

SAN DIEGO -- Ethertronics, the internal (embedded) antenna technology leader for wireless devices, today announced that its Isolated Magnetic Dipole(TM) (IMD) antennas have been integrated into multiple Samsung 3G Ultra Edition handsets.

The External Mercury Antenna is approximately 3/4 inch tall, 5 1/2 inches long and five inches wide, offering an excellent solution for taller trucks, trailers and other vehicles that need to consider the height restrictions of overpasses and other covered areas.

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