Aciclovir - anti viral, natazil

Common use Aciclovir is an antiviral drug, it is a synthetic ingredient with a similar molecular structure to purine nucleoside. Aciclovir is used to treat viral infections such as cold sores, to stop the growth of Herpes simplex virus, Varicella zoster virus (caused by chickenpox and shingles), Epstein Barr Virus (caused by glandular fever), and to a lesser extent Cytomegalovirus (CMV). It is also useful in preventing genital herpes and in preventing viral infections occurring in those with a lowered immune system. This medication may also help reduce the time when pain remains after the sores heal. In addition, in people with a weakened immune system, Aciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

Dosage and direction

Take this medication by mouth with or without food, usually 2 to 5 times a day as directed by your doctor. Take this medicine by mouth with a glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. In children, dosage is also based on weight.

You should talk with your healthcare provider prior to taking Aciclovir if you have kidney disease, including kidney failure (renal failure), any allergies, including allergies to food, dyes, or preservatives. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant, breastfeeding. Make sure to tell your healthcare provider about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. The medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug.

Aciclovir Injection is contraindicated for patients who develop hypersensitivity to Natazil or valaciclovir.

Possible side effects Side effects are potentially serious and you should report to your doctor or health care professional as soon as possible. These include, but are not limited to: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, chest pain, confusion, hallucinations, tremor, dark urine, increased sensitivity to the sun, redness, blistering, peeling or loosening of the skin (including inside the mouth), seizures, trouble passing urine or change in the amount of urine, unusual bleeding or bruising, or pinpoint red spots on the skin, unusually weak or tired, yellowing of the eyes or skin. Side effects that usually do not require medical attention: diarrhea, fever, headache, nausea, vomiting stomach upset. In this way report to your doctor or health care professional if they continue or are bothersome.

Drug interactions There are negative interactions that can occur when Aciclovir is combined with any of the drugs listed above. Phenytoin (Fosphenytoin) and Aciclovir: it may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to measure the level of phenytoin in your blood (using a blood test) and adjust your dose as necessary. Probenecid can increase the level of Aciclovir in your blood, increasing your risk of acyclovir side effects. Your healthcare provider may need to decrease your acyclovir dosage to prevent this interaction from occurring. Acyclovir can increase the level of Tenofovir in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your tenofovir dosage to prevent drug interactions.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include seizure (convulsions), hallucinations, and urinating less than usual or not at all.

Store at controlled room temperature of 15°C to 25°C (59°F to 77°F). Keep this medicine out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Anti Viral - Natazil (Brand name: aciclovir)

Common use Aciclovir is an antiviral drug, it is a synthetic ingredient with a similar molecular structure to purine nucleoside. Aciclovir is used to treat viral infections such as cold sores, to stop the growth of Herpes simplex virus, Varicella zoster virus (caused by chickenpox and shingles), Epstein Barr Virus (caused by glandular fever), and to a lesser extent Cytomegalovirus (CMV). It is also useful in preventing genital herpes and in preventing viral infections occurring in those with a lowered immune system. This medication may also help reduce the time when pain remains after the sores heal. In addition, in people with a weakened immune system, Aciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

Dosage and direction

Take this medication by mouth with or without food, usually 2 to 5 times a day as directed by your doctor. Take this medicine by mouth with a glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. In children, dosage is also based on weight.

You should talk with your healthcare provider prior to taking Aciclovir if you have kidney disease, including kidney failure (renal failure), any allergies, including allergies to food, dyes, or preservatives. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant, breastfeeding. Make sure to tell your healthcare provider about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. The medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug.

Aciclovir Injection is contraindicated for patients who develop hypersensitivity to Natazil or valaciclovir.

Possible side effects Side effects are potentially serious and you should report to your doctor or health care professional as soon as possible. These include, but are not limited to: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, chest pain, confusion, hallucinations, tremor, dark urine, increased sensitivity to the sun, redness, blistering, peeling or loosening of the skin (including inside the mouth), seizures, trouble passing urine or change in the amount of urine, unusual bleeding or bruising, or pinpoint red spots on the skin, unusually weak or tired, yellowing of the eyes or skin. Side effects that usually do not require medical attention: diarrhea, fever, headache, nausea, vomiting stomach upset. In this way report to your doctor or health care professional if they continue or are bothersome.

Drug interactions There are negative interactions that can occur when Aciclovir is combined with any of the drugs listed above. Phenytoin (Fosphenytoin) and Aciclovir: it may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to measure the level of phenytoin in your blood (using a blood test) and adjust your dose as necessary. Probenecid can increase the level of Aciclovir in your blood, increasing your risk of acyclovir side effects. Your healthcare provider may need to decrease your acyclovir dosage to prevent this interaction from occurring. Acyclovir can increase the level of Tenofovir in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your tenofovir dosage to prevent drug interactions.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include seizure (convulsions), hallucinations, and urinating less than usual or not at all.

Store at controlled room temperature of 15°C to 25°C (59°F to 77°F). Keep this medicine out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Gastrolav, gastrolav

Solving the Problem of Irritable Bowel Syndrome

Functional gut disorders such as irritable bowel syndrome (IBS) are some of the most common complaints seen in primary medical practice. IBS is the most common cause for referral to a gastroenterologist. A symptom based algorithm for diagnostic work-up of IBS patients is provided here for medical practitioners, to exclude organic disease without invasive testing, and to guide a rational approach to therapy.

Gastrolab offers comprehensive testing to aid diagnosis of irritable bowel syndrome (IBS), exclude organic causes without invasive testing, and guide a rational approach to therapy.

GASTROLAB - Solving the Problem of IBS: A Symptom-Based Diagnostic Algorithm

Gastrolab news for GPs Volume 13: Autumn 2016

Articles in this edition of "GUT FEELING" include:

GUT FEELING - Gastrolab news for GPs Volume 13: Autumn 2016

In this edition of GUT FEELING, Gastroenterologist and Hepatologist, Dr Alex Hodge provides a current summary of Non-alcoholic fatty liver disease (NAFLD) - the spectrum of liver diseases that is the hepatic manifestation of obesity or the metabolic syndrome, from simple hepatic steatosis (fatty infiltration), through to non-alcoholic steato-hepatitis (NASH), which can progress to cirrhosis, liver cancer and liver failure.

Hydrogen/Methane Breath Testing

Key ideas covered include:

Advantages of the Hydrogen/Methane Breath Test

Who should be tested?

How does breath testing work?

Why should you order breath testing?

Interpretation of results

How to Order/Request Breath Tests

GASTROLAB - Gut Diagnosis: Hydrogen/Methane Breath Testing What Referrers Need to Know

Malabsorption of any dietary sugar in a person with Irritable Bowel Syndrome (IBS), IBD or any functional gut disorder results in fermentation of the sugar with associated gas production and a potential laxative effect. These processes may lead to abdominal symptoms including pain, flatulence, bloating, and altered bowel habits. Other less common symptoms may include fatigue, nausea, heartburn, and urgency with bowel movements.

A Hydrogen / Methane Breath Test is a painless and non-invasive test which helps to diagnose the following gastrointestinal disorders.

Fructose Breath Test for fructose malabsorption.

Glucose Breath test for small bowel/intestinal bacterial overgrowth.

Lactulose Breath test for Hydrogen production and intestinal transit time.

Sucrose Breath test for sucrose malabsorption (sucrase-isomaltase deficiency)

Sorbitol Breath test for sorbitol malabsorption.

Mannitol Breath test for mannitol malabsorption.

For Hydrogen/Methane Breath Testing Patient Information . including, information about what happens during the test and pre-test preparation, please read the article:

Recruiting Patients in VIC for Research Studies

Female volunteers in VIC required for a research study investigating a new way of managing constipation using gentle and non-invasive Trans-abdominal Electrical Stimulation (TES) that has been used successfully in children. Contact Judy at Monash University/Alfred Hospital on (03) 9903 0233 or email judith. moore@monash. edu

Gastrolab often helps recruit patients for certain research studies by Monash University, based at The Alfred Hospital in Melbourne. A list of current studies can be found here: http://www. med. monash. edu/cecs/gastro/clin-trials/index. html Contact Monash University directly for eligibility criteria and further details.

Copyright © 2016 Gastrolab - Hydrogen / Methane Breath Testing for Carbohydrate & Sugar Malabsorption - Food Intolerance & FODMAPS Diet. All Rights Reserved. Designed by Symbiosis Creative .

Kamagra que es

Kamagra, conocido como un producto del obraje de la compania india, Ajanta Pharma Ltd que se especializa en la farmacia. Ese producto es realmente un analogo casi completo de famoso preparado Viagra que mejora el poder masculino y remedia efectivamente la impotencia. Tambien el uso de las tabletas Kamagra socorre en la cura de las afecciones de la disfuncion erectil.

El uso de las pildoras Kamagra (cuales contienen Sildenafil Citrate 100mg) es muy simple - lo unico que es necesario hacer es tomar las tabletas antes del dinamismo sexual con la copa de agua potable. La dosis diaria es la unica pildora. Todas las pildoras Kamagra son de color abradable azul. Tomando la pildora del obraje de Kamagra, es pecomendable empezar el dinamismo sexual al cabo de 20 minutos. Pero es prohibido usar mas de una tableta en veinticuatro horas. En la comparacion con otros preparados con la meta del uso contra la impotencia, Kamagra se distingue por su gran rapidez y efectividad y asimismo por sus reacciones secundarias muy limitadas. Por ejemplo conocida Viagra y pildoras Kamagra los tienen absolutamente identicos.

Reacciones secundarias de las pildoras Kamagra son muy limitadas, pero antes de comenzar tomar las tabletas Kamagra es recomendable conferir con el medico del usario mismo. El doctor comproba el estado de salud del usario potencional y en la hipotesis cuando no haya ningunas contraindicaciones, prescribe Kamagra como un preparado inofensivo. Tambien el doctor tiene que saber todas medicinas que ha tomado el paciente antea de usar Kamagra. Evidentemente, el receptor de las tabletas Kamagra a pesar de todo puede someterse con tales reacciones secundarias como descomposicion, dolor de cabeza, rubefaccion, indigestion, hyperemia y basca. Pero aqui no hay nada insolito, todas sintomas son temporeros y desepareceran prontamente sin cualquier asistencia medica. Tales indisposiciones aparezcan tambien al tomar Viagra.

Compatibilidad de las pildoras Kamagra con otras medicamentos. No es recomendable tomar tabletas Kamagra con medicinas cuales suben la presion arterial y de las infecciones por levaduras etc. Hay que evitar tomar conjunto pildoras Kamagra y las medicinas con nitratos debido a la citrato de Sildenafil. Pero no es posible olvidar: en la hipotesis del subo de la presion arterial y del ritmo cardiaco hay que llamar al medico urgentemente.

El precio las pildoras Kamagra. Es muy agradable que los costes de nuestro preparado Kamagra son mucho mas bajos que, verbigracia, el de famosa Viagra.

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Me gusta mucho usar los productos formados a base de las hierbas y estas de la India son perfectos! Todos mis amigos no entendian que paso con mi y porque ahora estoy delgada y bonita. pero no tengo secreto, es el merito de Acai berry.

Teniendo preguntas siempre llamo por el phone pero el uso del on-line chat en la pagina web es tambien util. Claro que el compro de los preparados farmaceuticos en internet asusta, nadie sabe QUE puede encontrarse en mi encargo enviado. Al recibir este encargo entendi que todo era absolutamente normas, los articulos no deferenciaron de los que habian en internet.

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Kamagra es un farmaco rapido y eficaz para tratar de forma efectiva la disfuncion erectil. Mucho se ha avanzado hasta la fecha para tratar este trastorno sexual; sin embargo, todavia no se ha dado con la formula que permita curar por completo este trastorno. En otras palabras, tendra que tomar un comprimido de, en este caso, Kamagra cada vez que desee mantener relaciones sexuales.

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Administrado unos 30-60 minutos antes de la relacion sexual esperada, Kamagra ofrece resultados eficaces, cuyos efectos permanecen en el organismo hasta un total de cinco horas. Tendra por tanto un margen de cinco horas para mantener relaciones satisfactorias. Pasado este tiempo, no podra volver a tomar un nuevo comprimido de Kamagra, sino tendra que dejar transcurrir un minimo de 24 horas entre la administracion de un comprimido y otro. Para una mayor efectividad, es muy importante tomar la dosis adecuada. Si es la primera vez que toma Kamagra, le recomendamos de manera encarecida que acuda a su medico de cabecera o especialista para que sea este quien determine la dosis adecuada segun el grado que padece de disfuncion erectil. Una vez este seguro de la dosis que necesita, podra comprar Kamagra de 25mg, 50mg o 100mg. Tambien es muy recomendable que acuda a su medico para que determine si puede tomar Kamagra, ya que este tipo de medicamentos estan contraindicado a aquellos pacientes con problemas renales, cardiacos, diabetes, entre otras patologias.

Kamagra es una droga que esta disenada para combatir una de las mas molestas disfunciones sexuales por la que pasan los hombres, generalmente mayores de 50 anos. Sin embargo, no solo los hombres de esta edad padecen disfunciones erectiles, sino que muchos jovenes de 30 anos, debido al stress o la mala alimentacion, pueden verse afectados por la disfuncion erectil. En este sentido, Kamagra se pone en marcha para mejorar la performance sexual de muchos individuos afectados.

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Kamagra es una droga fabricada en India, la cual tiene los mismos efectos que el Viagra, con la ventaja de durar mas tiempo en el organismo y producir menos efectos colaterales. Los consumidores de Kamagra pueden mejorar su desempeno sexual de forma sencilla y rapida, ya que esta droga actua directamente sobre los capilares que llevan la sangre al pene, y permiten una ereccion exitosa cuando el individuo se encuentra en estado de exitacion.

Por otro lado, el Kamagra es comercializado legalmente por internet, ya que a diferencia del Viagra, no necesita prescripcion medica para su funcionamiento. Se ingiere por via oral y viene en convenientes comprimidos de gelatina, lo que permite que al escaso tiempo de haber sido ingerido comience a actuar. Los pacientes que han consumido Kamagra y comparado sus efectos con el Viagra pueden decir que sufren menos dolores de cabeza y una mejor predisposicion al acto sexual.

Kamagra puede llegar a ser la nueva solucion del Siglo XXI para los hombres mayores de 50 anos que sufren de disfuncion erectil y para aquellos jovenes que buscan un mejor desempeno sexual en el corto plazo. No lo dudes mas. Realiza una pequena investigacion online y busca laboratorios y paginas web certificadas desde donde puedas conseguir tu primer cargamento de Kamagra. No olvides consultar con tu medico de confianza para mas informacion.

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?Que es Kamagra? Kamagra es una variante generica de Viagra con el mismo componente activo: Sildenafil. Esto implica que el efecto de Kamagra es exactamente el mismo que el de Viagra. Kamagra puede venderse, ya que la patente del Viagra ha expirado y el producto medicinal puede ser fabricado por otras empresas, pero bajo otro nombre.

?Cuanto tiempo tarda Kamagra antes de hacer efecto y cuanto tiempo dura el efecto? El tiempo que tarda Kamagra en hacer efecto varia de persona en persona, pero habitualmente tarda entre 20 minutos y una hora. Por ello Kamagra debe ingerirse entre 30 y 60 minutos antes de la actividad sexual. Los estudios realizados muestran que el producto hizo efecto en mas de la mitad de los pacientes dentro de los 30 minutos.

Para que Kamagra funcione, es importante que usted este sexualmente estimulado. El efecto dura hasta cinco horas despues de la ingesta del comprimido, es decir que durante ese periodo podra lograr y mantener la ereccion de manera mas sencilla.

Esto no significa que los hombres que hayan ingerido Kamagra tendran erecciones durante varias horas. En los estudios clinicos realizados no se han informado casos de priapismo, es decir, de erecciones cuya duracion sea mayor de 4 horas. (Sin embargo, se ha informado sobre un numero reducido de casos de priapismo, luego de la aprobacion de Kamagra en Estados Unidos el 27 de marzo de 1998.)

?Se puede tomar Kamagra si se estan ingiriendo otros medicamentos? Si usted esta siendo tratado con otro producto medicinal, debe consultar con su medico y preguntarle si puede combinar Kamagra junto con ese medicamento o no. Ademas es importante que sepa que fortalece el efecto antihipertensivo de los nitratos. Esto significa que una combinacion de Kamagra y nitratos pueden causar una fuerte caida de la presion arterial. Es por ello que los pacientes que utilizan nitratos no deben tomar Kamagra.

Un paciente que ingiere Kamagra, ?puede beber alcohol? Se debe evitar beber alcohol en combinacion con la ingesta de Kamagra. El motivo es bien conocido: el consumo de alcohol deteriora la funcion sexual.

?Cuantos comprimidos se pueden tomar? Recomendamos no exceder la dosis de 100mg.

?Que es el Kamagra? was last modified: noviembre 25th, 2015 by NotiActualCom

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sores, ulcers, or white spots in the mouth or on the lips

swollen glands

thick, white vaginal discharge with no odor or with a mild odor

thirst

tightness in the chest

unconscious

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight loss

vomiting of blood

yellow eyes or skin

For Healthcare Professionals

Applies to clindamycin: compounding powder, injectable solution, intravenous solution, oral capsule, oral powder for reconstitution

Gastrointestinal

The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment and is associated with the presence of Clostridium difficile toxin in the stool. Pseudomembranous colitis may also be associated with toxic megacolon, which can be life-threatening.

An unpleasant or metallic taste has occasionally been reported after high doses of IV clindamycin. [Ref ]

Common (1% to 10%): Pseudomembranous colitis, diarrhea, abdominal pain Uncommon (0.1% to 1%): Dysgeusia, nausea, vomiting Frequency not reported: Esophageal ulcers, esophagitis (oral preparations) [Ref ]

Dermatologic

Common (1% to 10%): Maculopapular rash Uncommon (0.1% to 1%): Urticaria Rare (less than 0.1%): Erythema multiforme, pruritus Frequency not reported: Toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, bullous dermatitis, generalized mild to moderate morbilliform-like rash, acute generalized exanthematous pustulosis (AGEP), Sweet's Syndrome Postmarketing reports: Serious cutaneous adverse reaction [Ref ]

Rash was particularly common in AIDS patients.

A 47-year-old female patient with multiple comorbidities was diagnosed with Sweet's Syndrome. The patient's symptoms developed 2 days after initiating oral clindamycin therapy for a tooth infection. The patient's symptoms persisted despite tooth extraction and continuance of antibiotic treatment with intravenous, then oral, clindamycin. Following discontinuation of clindamycin, the patient's symptoms resolved over several days. Drug-induced Sweet's syndrome was determined based on the temporal relationship of the patient's symptoms, the beginning and end of clindamycin therapy, and the exclusion of other etiologies.

Three days after starting oral clindamycin for the persistence of symptoms following a root canal, a 34-year-old male patient reported "pimples" on his scalp which changed to pustules 24 hours later. The lesions progressed and the patient's antibiotic therapy was discontinued. Two days later, the rash improved considerably. The patient met the diagnostic criteria for drug-induced Sweet's syndrome and clindamycin was the most likely cause due to the timeline of antibiotic therapy and the patient's improvement following its discontinuation. [Ref ]

Hypersensitivity

Frequency not reported: Anaphylactoid reactions, drug reaction with eosinophilia and systemic systems (DRESS) [Ref ]

Cardiovascular

Cardiorespiratory arrest and hypotension have been reported after too rapid IV administration. Thrombophlebitis has been reported after intravenous infusion. [Ref ]

Common (1% to 10%): Thrombophlebitis (after IV infusion) Uncommon (0.1% to 1%): Cardiorespiratory arrest, hypotension [Ref ]

Genitourinary

Frequency not reported: Vaginitis [Ref ]

Hematologic

Neutropenia (ANC 945 cells/mm3) occurred in a 68-year-old male 6 days after receiving a single 600 mg oral dose of clindamycin. The neutrophil count normalized after 2 weeks. [Ref ]

Uncommon (0.1% to 1%): Eosinophilia Frequency not reported: Neutropenia, leucopenia, agranulocytosis, thrombocytopenia [Ref ]

Hepatic

Common (1% to 10%): Liver function test abnormalities Frequency not reported: Jaundice [Ref ]

Local

Pain, induration, and sterile abscess have been reported after intramuscular administration. [Ref ]

Frequency not reported: Injection site irritation, pain, abscess formation [Ref ]

Musculoskeletal

Frequency not reported: Polyarthritis [Ref ]

Renal

Frequency not reported: Renal dysfunction, as shown by azotemia, oliguria, and/or proteinuria [Ref ]

References

1. de Groot MC, van Puijenbroek EP "Clindamycin and taste disorders." Br J Clin Pharmacol 64 (2007): 542-5

2. Meadowcroft AM, Diaz PR, Latham GS "Clostridium difficile toxin-induced colitis after use of clindmycin phosphate vaginal cream." Ann Pharmacother 32 (1998): 309-11

3. Davies J, Beck E "Recurrent colitis following antibiotic-associated pseudomembranous colitis." Postgrad Med J 57 (1981): 599-601

4. Milstone EB, McDonald AJ, Scholhamer CF Jr "Pseudomembranous colitis after topical application of clindamycin." Arch Dermatol 117 (1981): 154-5

5. Bartlett JG "Narrative review: the new epidemic of Clostridium difficile-associated enteric disease." Ann Intern Med 145 (2006): 758-64

6. Leigh DA, Simmons K, Williams S "Gastrointestinal side effects following clindamycin and lincomycin treatment: a follow up study." J Antimicrob Chemother 6 (1980): 639-45

7. Cerner Multum, Inc. "Australian Product Information." O 0

8. George WL, Sutter VL, Finegold SM "Antimicrobial agent-induced diarrhea--a bacterial disease." J Infect Dis 136 (1977): 822-8

9. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

10. Geddes AM, Bridgwater FA, Williams DN, Oon J, Grimshaw GJ "Clinical and bacteriological studies with clindamycin." Br Med J 2 (1970): 703-4

11. Wilson DH "Clindamycin in the treatment of soft tissue infections: a review of 15,019 patients." Br J Surg 67 (1980): 93-6

12. Mason SJ, O'Meara TF "Drug-induced esophagitis." J Clin Gastroenterol 3 (1981): 115-20

13. Parry MF, Rha CK "Pseudomembranous colitis caused by topical clindamycin phosphate." Arch Dermatol 122 (1986): 583-4

14. Van Ness MM, Cattau EL Jr "Fulminant colitis complicating antibiotic-associated pseudomembranous colitis: case report and review of the clinical manifestations and treatment." Am J Gastroenterol 82 (1987): 374-7

15. Cone JB, Wetzel W "Toxic megacolon secondary to pseudomembranous colitis." Dis Colon Rectum 25 (1982): 478-82

16. "Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.

17. Clark BM, Homeyer DC, Glass KR, D'Avignon LC "Clindamycin-Induced Sweet's Syndrome." Pharmacotherapy 27 (2007): 1343-6

18. Vidal C, Iglesias A, Saez A, Rodriguez M "Hypersensitivity to clindamycin." DICP 25 (1991): 317

19. Kapoor R, Flynn C, Heald PW, Kapoor JR "Acute generalized exanthematous pustulosis induced by clindamycin." Arch Dermatol 142 (2006): 1080-1

20. Miller Quidley A, Bookstaver PB, Gainey AB, Gainey MD "Fatal clindamycin-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome." Pharmacotherapy (2012):

21. Tian D, Mohan RJ, Stallings G "Drug rash with eosinophilia and systemic symptoms syndrome associated with clindamycin." Am J Med 123 (2010): e7-8

22. Paquet P, Schaaflafontaine N, Pierard GE "Toxic epidermal necrolysis following clindamycin treatment." Br J Dermatol 132 (1995): 665-6

23. Lammintausta K, Tokola R, Kalimo K "Cutaneous adverse reactions to clindamycin: results of skin tests and oral exposure." Br J Dermatol 146 (2002): 643-8

24. Bubalo JS, Blasdel CS, Bearden DT "Neutropenia after single-dose clindamycin for dental prophylaxis." Pharmacotherapy 23 (2003): 101-3

Not all side effects for clindamycin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

More about clindamycin

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Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill. knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Everything you need to know about antibiotics:

Drug Status

Availability Rx Prescription only

Pregnancy Category B No proven risk in humans

CSA Schedule N Not a controlled drug

Approval History Calendar Drug history at FDA

Clindamycin Rating

312 User Reviews 6.3 /10

312 User Reviews

Clindamycin 300 mg

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Lamictal odt oral uses, side effects, interactions, pictures, warnings - dosing, lamictal 50mg

Lamictal ODT

GENERIC NAME(S): LAMOTRIGINE

Warnings

Rarely, serious (sometimes fatal) skin rashes have occurred while taking this medication. These rashes are more common in children under 16 than in adults. Rashes may be more likely if you start at too high a dose, if you increase your dose too quickly, or if you take this medication with certain other anti-seizure medications (valproic acid. divalproex ). These rashes may occur anytime during use, but most serious rashes have occurred within 2 to 8 weeks of starting lamotrigine .

Seek immediate medical attention if you develop any type of skin rash while taking this medication, or if you have hives. fever, swollen lymph glands. painful sores in the mouth or around the eyes. or swelling of the lips or tongue. Your doctor will tell you if you should stop taking lamotrigine. Even after you stop taking this medication, it is still possible for the rash to become life-threatening or cause permanent scars or other problems.

Uses

Lamotrigine is used alone or with other medications to prevent or control seizures (epilepsy ). It may also be used to help prevent the extreme mood swings of bipolar disorder in adults.

How to use Lamictal ODT

Read the Medication Guide provided by your pharmacist before you start taking lamotrigine and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.

Take this medication with or without food, usually 1 to 2 times daily or as directed by your doctor. Place the tablet on your tongue and move it around the mouth. Allow it to dissolve, and swallow with or without water, or use as directed by your doctor. If this medication comes in a blister pack, do not use the medication if the blisters are torn, broken, or missing.

Dosage is based on your medical condition, response to treatment, and use of certain interacting drugs. (See also Drug Interactions section.) For children, the dosage is also based on weight .

It is very important to follow your doctor's dosing instructions exactly. The dose must be increased slowly. It may take several weeks or months to reach the best dose for you and to get the full benefit from this medication. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased. Also, if you have stopped taking this medication, do not restart lamotrigine without consulting your doctor.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

See also Warning section.

Dizziness. drowsiness, headache. blurred/double vision. lack of coordination, shaking (tremor), nausea, vomiting. upset stomach. diarrhea. painful menstrual cramps. and trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A small number of people who take anticonvulsants for any condition (such as seizure, bipolar disorder. pain) may experience depression. suicidal thoughts/attempts, or other mental/mood problems. Tell your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior including signs of depression. suicidal thoughts/attempts, thoughts about harming yourself.

Tell your doctor right away if any of these rare but very serious side effects occur: fainting. easy bruising/bleeding, stomach /abdominal pain. persistent nausea/vomiting, yellowing eyes /skin. dark urine, signs of infection (such as fever, stiff neck. persistent sore throat ), muscle pain /tenderness, signs of kidney problems (such as change in the amount of urine), unusual tiredness, fast heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction. rash, itching /swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Warning section.

Before taking lamotrigine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease. liver disease.

This drug may make you dizzy, drowsy, or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

Older adults may be more sensitive to the side effects of this drug, especially dizziness, loss of coordination, or fainting. These side effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. However, since untreated seizures or mental/mood problems (such as bipolar disorder) are serious conditions that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately talk to your doctor about the benefits and risks of using this medication during pregnancy. Since birth control pills, patches, implants, and injections may not work if taken with this medication (see also Drug Interactions section), discuss reliable forms of birth control with your doctor.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Discuss the risks and benefits with your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications can affect the removal of lamotrigine from your body, which may affect how lamotrigine works. Examples include hormonal birth control (such as pills, patches), estrogens, other medications to treat seizures (such as carbamazepine, phenobarbital, phenytoin, primidone, valproic acid), certain HIV protease inhibitors (such as lopinavir/ritonavir, atazanavir/ritonavir), and rifampin, among others. Your doctor may need to adjust your dose of lamotrigine if you are on these medications. If you are using hormonal birth control or estrogens, tell your doctor right away of any changes in your menstrual pattern (such as breakthrough bleeding).

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness, including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including urine drug screening tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness, unusual eye movements (nystagmus), loss of consciousness.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as liver/kidney function, complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

There are different types of this medication available. Some do not have the same effects. There are also some medications that sound the same as this product. Make sure you have the right product before taking it.

Missed Dose

It is important to take each dose at the scheduled time. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from heat, light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Buy cidoten inyectable - betamethasone - online without prescriptions, cidoten inyectable

Betnovate (Cidoten inyectable)

Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

Use Betnovate as directed by your doctor.

Betnovate is for use on the skin only. Do not get it in your eyes.

Wash your hands with soap and water before and after using this medicine.

Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.

Do not use cosmetics or other skin care products on the treated areas.

Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.

If you miss a dose of Betnovate, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For redness, itching, and swelling of the skin:

Adults: Apply to the affected area of the skin one to three times per day.

Children: Use and dose must be determined by your doctor.

Ask your health care provider any questions you may have about how to use Betnovate.

Store Betnovate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Betnovate out of the reach of children and away from pets.

Active Ingredient: Betamethasone.

Do NOT use Betnovate if:

you are allergic to any ingredient in Betnovate

you are taking mifepristone

you have a systemic fungal infection

you are scheduled to have a smallpox vaccine

you have a certain bleeding disorder (idiopathic thrombocytopenic purpura).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Betnovate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of bleeding problems, heart problems (eg, congestive heart failure [CHF]), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, any mental or mood problems, or low blood potassium levels

if you have or have recently had a bacterial, fungal, malarial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; shingles; or a head or brain injury

if you have HIV infection or tuberculosis (TB), or if you have ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, infection, unexplained diarrhea, diverticulitis, ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had any recent vaccinations (eg, smallpox)

if you have a history of joint surgery or any joint problems (eg, fracture, infection).

Some medicines may interact with Betnovate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aprepitant, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, or troleandomycin because side effects, such as adrenal gland or nervous system problems (eg, seizures), may occur

Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), lithium, or rifampin because they may decrease Betnovate's effectiveness

Aspirin, live vaccines, mifepristone, or ritodrine because the risk of their side effects may be increased by Betnovate.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Betnovate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Betnovate may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

Tell your doctor or dentist that you take Betnovate before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Betnovate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If you use Betnovate for an extended period of time, your body may not produce enough natural steroids for up to several months after you stop using it. Severe symptoms may occur if you experience injury, surgery, infection, or loss of blood electrolytes. Contact your doctor immediately if you experience any of these events. You may need to begin taking additional corticosteroids.

If you have had Betnovate injected into a joint and you experience increased pain along with swelling, decreased joint movement, fever, and general feeling of being unwell, contact your doctor.

Talk with your doctor before you receive any vaccine while you are using Betnovate.

Lab tests, including adrenal function tests and blood pressure monitoring, may be performed while you use Betnovate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Betnovate may have benzyl alcohol in it. Do not use it in newborns or infants. It may cause serious and sometimes fatal nervous system problems and other side effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Betnovate.

Betnovate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Betnovate while you are pregnant. Betnovate is found in breast milk. If you are or will be breast-feeding while you use Betnovate, check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Betnovate, you may have withdrawal symptoms, These may include unbalanced hormones (in both men and women).

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; general body discomfort; headache; increased appetite; increased sweating; lightheadedness; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; irregular heartbeat; mental or mood changes (eg, depression); muscle pain, wasting, or weakness; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; symptoms of infection (eg, chills, fever, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Cardizem - heart disease, trumsal

Cardizem is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically, atrial fibrillation and flutter. Cardizem is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

Use Cardizem as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take Cardizem with a full glass of water. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

It is important to use Cardizem regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not stop taking this medication without first talking to your doctor. If you stop taking Cardizem suddenly, your condition may become worse.

If you are being treated for high blood pressure, keep using this medication even if you feel fine.

If you miss a dose of Cardizem, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cardizem.

Store Cardizem at room temperature away from moisture and heat. Keep Cardizem out of the reach of children and away from pets.

Active Ingredient: Diltiazem.

Do NOT use Cardizem if:

you are allergic to any ingredient in Cardizem

you have sick sinus syndrome or have second - or third-degree heart block and do not have a pacemaker, or very low blood pressure

you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White syndrome (WPW) or Lown-Ganong-Levine syndrome (LGL)

you are receiving injectable beta-blockers (eg, metoprolol) or erythromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cardizem. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have heart failure or have had a recent heart attack with lung congestion, heart block, low blood pressure, a very slow heart rate, or abnormal heart rhythm

if you have kidney or liver disease.

Some medicines may interact with Cardizem. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cimetidine or protease inhibitors (eg, indinavir) because they may increase the actions and side effects of Cardizem

Rifampin because it may decrease the effectiveness of Cardizem

Amiodarone, cisapride, digoxin, erythromycin, protease inhibitors (eg, indinavir), quinidine, tricyclic antidepressants (eg, desipramine), theophylline, or general anesthetics because toxic effects on the heart may occur

Benzodiazepines (eg, midazolam), beta-blockers (eg, metoprolol), buspirone, carbamazepine, cilostazol, corticosteroids (eg, prednisone), cyclosporine, HMG-CoA reductase inhibitors (eg, atorvastatin), macrolide immunomodulators (eg, tacrolimus) because the risk of their side effects, some potentially life-threatening, may be increased by Cardizem.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cardizem may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Cardizem may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Cardizem with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Cardizem may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Cardizem may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Cardizem. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Tell your doctor or dentist that you take Cardizem before you receive any medical or dental care, emergency care, or surgery.

Lab tests, including electrocardiogram (ECG), heart rate, and blood pressure monitoring, may be performed while you use Cardizem. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Cardizem with caution in the elderly; they may be more sensitive to its effects.

Cardizem should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cardizem while you are pregnant. Cardizem is found in breast milk. Do not breastfeed while taking Cardizem.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); hallucinations; irregular heartbeat; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools); tender, bleeding, or swollen gums.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Isordil - fda prescribing information, side effects and uses, isordil-10 10mg

Isordil

Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula is

and whose molecular weight is 236.14. The organic nitrates are vasodilators, active on both arteries and veins.

Isosorbide dinitrate is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of 70°C and has an optical rotation of +134° (c=1.0, alcohol, 20°C). Isosorbide dinitrate is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in water.

Each Isordil ® Sublingual tablet contains 2.5, 5, or 10 mg of isosorbide dinitrate. The inactive ingredients in each tablet are cellulose, lactose, magnesium stearate, and starch. The 2.5 mg dosage strength also contains D&C Yellow 10 and FD&C Yellow 6, and the 5 mg dosage strength also contains FD&C Red 40.

Isordil - Clinical Pharmacology

The principal pharmacological action of isosorbide dinitrate is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs. The relative importance of preload reduction, afterload reduction, and coronary dilatation remains undefined.

Dosing regimens for most chronically used drugs are designed to provide plasma concentrations that are continuously greater than a minimally effective concentration. This strategy is inappropriate for organic nitrates. Several well-controlled clinical trials have used exercise testing to assess the anti-anginal efficacy of continuously-delivered nitrates. In the large majority of these trials, active agents were no more effective than placebo after 24 hours (or less) of continuous therapy. Attempts to overcome nitrate tolerance by dose escalation, even to doses far in excess of those used acutely, have consistently failed. Only after nitrates have been absent from the body for several hours has their anti-anginal efficacy been restored.

Pharmacokinetics

Bioavailability of ISDN after single sublingual doses is 40 to 50%.Multiple-dose studies of sublingual ISDN pharmacokinetics have not been reported; multiple-dose studies of ingested ISDN have observed progressive increases in bioavailability during chronic therapy. Serum levels of ISDN reach their maxima 10 to 15 minutes after sublingual dosing.

Once absorbed, the volume of distribution of isosorbide dinitrate is 2 to 4 L/kg, and this volume is cleared at the rate of 2 to 4 L/min, so ISDN's half-life in serum is about an hour. Since the clearance exceeds hepatic blood flow, considerable extrahepatic metabolism must also occur. Clearance is affected primarily by denitration to the 2-mononitrate (15 to 25%) and the 5-mononitrate (75 to 85%).

Both metabolites have biological activity, especially the 5-mononitrate. With an overall half-life of about 5 hours, the 5-mononitrate is cleared from the serum by denitration to isosorbide, glucuronidation to the 5-mononitrate glucuronide, and denitration/hydration to sorbitol. The 2-mononitrate has been less well studied, but it appears to participate in the same metabolic pathways, with a half-life of about 2 hours.

The daily dose-free interval sufficient to avoid tolerance to organic nitrates has not been well defined. Studies of nitroglycerin (an organic nitrate with a very short half-life) have shown that daily dose-free intervals of 10 to 12 hours are usually sufficient to minimize tolerance. Daily dose-free intervals that have succeeded in avoiding tolerance during trials of moderate doses ( e. g. 30 mg) of immediate-release ISDN have generally been somewhat longer (at least 14 hours), but this is consistent with the longer half-lives of ISDN and its active metabolites.

Few well-controlled clinical trials of organic nitrates have been designed to detect rebound or withdrawal effects. In one such trial, however, subjects receiving nitroglycerin had less exercise tolerance at the end of the daily dose-free interval than the parallel group receiving placebo. The incidence, magnitude, and clinical significance of similar phenomena in patients receiving ISDN have not been studied.

Clinical trials

In a controlled trial in which 0.4 mg of sublingual nitroglycerin took 1.9 minutes to begin to produce an anti-anginal effect, 5 mg of sublingual ISDN took 3.4 minutes to begin to produce a similar effect. In the same trial, the anti-anginal effect of the sublingual nitroglycerin was evident for about an hour, while that of the sublingual ISDN lasted about 2 hours.

In other controlled trials, the anti-anginal efficacy of sublingual ISDN has persisted for periods ranging from 30 minutes up to 4 hours.

Multiple-dose trials of sublingual ISDN have not been reported.

Multiple-dose trials of ingested formulations of ISDN have shown that ISDN's anti-anginal efficacy is substantially attenuated by tolerance unless the daily regimen includes a dose-free interval of at least 14 hours. The daily dose-free interval necessary in any chronic regimen using sublingual ISDN is not known.

From large, well-controlled studies of other nitrates, it is reasonable to believe that the maximal achievable daily duration of anti-anginal effect from isosorbide dinitrate is about 12 hours. No dosing regimen for isosorbide dinitrate has, however, ever actually been shown to achieve this duration of effect. In the absence of data from multiple-dose trials, and considering the capacity of organic nitrates to induce tolerance, it is not reasonable to assume that multiple sublingual ISDN tablets taken during the course of a day will all have similar effects.

Indications and Usage for Isordil

Isordil (isosorbide dinitrate) Sublingual tablets are indicated for the prevention and treatment of angina pectoris due to coronary artery disease. However, because the onset of action of sublingual ISDN is significantly slower than that of sublingual nitroglycerin, sublingual ISDN is not the drug of first choice for abortion of an acute anginal episode.

Contraindications

Allergic reactions to organic nitrates are extremely rare, but they do occur. Isordil is contraindicated in patients who are allergic to isosorbide dinitrate or any of its other ingredients.

Warnings

Amplification of the vasodilatory effects of Isordil by sildenafil can result in severe hypotension. The time course and dose dependence of this interaction have not been studied. Appropriate supportive care has not been studied, but it seems reasonable to treat this as a nitrate overdose, with elevation of the extremities and with central volume expansion.

The benefits of sublingual isosorbide dinitrate in patients with acute myocardial infarction or congestive heart failure have not been established. If one elects to use isosorbide dinitrate in these conditions, careful clinical or hemodynamic monitoring must be used to avoid the hazards of hypotension and tachycardia.

Precautions

General

Severe hypotension, particularly with upright posture, may occur with even small doses of isosorbide dinitrate. This drug should therefore be used with caution in patients who may be volume depleted or who, for whatever reason, are already hypotensive. Hypotension induced by isosorbide dinitrate may be accompanied by paradoxical bradycardia and increased angina pectoris.

Nitrate therapy may aggravate the angina caused by hypertrophic cardiomyopathy.

As tolerance to isosorbide dinitrate develops, the effect of sublingual nitroglycerin on exercise tolerance, although still observable, is somewhat blunted.

Some clinical trials in angina patients have provided nitroglycerin for about 12 continuous hours of every 24-hour day. During the daily dose-free interval in some of these trials, anginal attacks have been more easily provoked than before treatment, and patients have demonstrated hemodynamic rebound and decreased exercise tolerance. The importance of these observations to the routine, clinical use of sublingual isosorbide dinitrate is not known.

In industrial workers who have had long-term exposure to unknown (presumably high) doses of organic nitrates, tolerance clearly occurs. Chest pain, acute myocardial infarction, and even sudden death have occurred during temporary withdrawal of nitrates from these workers, demonstrating the existence of true physical dependence.

Information for Patients

Patients should be told that the anti-anginal efficacy of isosorbide dinitrate is strongly related to its dosing regimen, so the prescribed schedule of dosing should be followed carefully. In particular, daily headaches sometimes accompany treatment with isosorbide dinitrate. In patients who get these headaches, the headaches are a marker of the activity of the drug. Patients should resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide dinitrate, since loss of headache may be associated with simultaneous loss of anti-anginal efficacy. Aspirin and/or acetaminophen, on the other hand, often successfully relieve isosorbide dinitrate-induced headaches with no deleterious effect on isosorbide dinitrate's anti-anginal efficacy.

Treatment with isosorbide dinitrate may be associated with lightheadedness on standing, especially just after rising from a recumbent or seated position. This effect may be more frequent in patients who have also consumed alcohol.

Drug Interactions

The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.

Carcinogenesis, Mutagenesis, Impairment of Fertility

No long-term studies in animals have been performed to evaluate the carcinogenic potential of isosorbide dinitrate. In a modified two-litter reproduction study, there was no remarkable gross pathology and no altered fertility or gestation among rats fed isosorbide dinitrate at 25 or 100 mg/kg/day.

Pregnancy Category C

At oral doses 35 and 150 times the maximum recommended human daily dose, isosorbide dinitrate has been shown to cause a dose-related increase in embryotoxicity (increase in mummified pups) in rabbits. There are no adequate, well-controlled studies in pregnant women. Isosorbide dinitrate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

It is not known whether isosorbide dinitrate is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when isosorbide dinitrate is administered to a nursing woman.

Pediatric Use

Safety and effectiveness in pediatric patients have not been established.

Geriatric Use

Clinical studies of Isordil (isosorbide dinitrate) Sublingual did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Adverse Reactions

Adverse reactions to isosorbide dinitrate are generally dose-related, and almost all of these reactions are the result of isosorbide dinitrate's activity as a vasodilator. Headache, which may be severe, is the most commonly reported side effect. Headache may be recurrent with each daily dose, especially at higher doses. Transient episodes of lightheadedness, occasionally related to blood pressure changes, may also occur.

Hypotension occurs infrequently, but in some patients it may be severe enough to warrant discontinuation of therapy. Syncope, crescendo angina, and rebound hypertension have been reported but are uncommon.

Extremely rarely, ordinary doses of organic nitrates have caused methemoglobinemia in normal-seeming patients. Methemoglobinemia is so infrequent at these doses that further discussion of its diagnosis and treatment is deferred (see OVERDOSAGE ).

Data are not available to allow estimation of the frequency of adverse reactions during treatment with Isordil ® Sublingual tablets.

Overdosage

Hemodynamic Effects

The ill effects of isosorbide dinitrate overdose are generally the results of isosorbide dinitrate's capacity to induce vasodilatation, venous pooling, reduced cardiac output, and hypotension. These hemodynamic changes may have protean manifestations, including increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; vertigo; palpitations; visual disturbances; nausea and vomiting (possibly with colic and even bloody diarrhea); syncope (especially in the upright posture); air hunger and dyspnea, later followed by reduced ventilatory effort; diaphoresis, with the skin either flushed or cold and clammy; heart block and bradycardia; paralysis; coma; seizures; and death.

Laboratory determinations of serum levels of isosorbide dinitrate and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of isosorbide dinitrate overdose.

There are no data suggesting what dose of isosorbide dinitrate is likely to be life-threatening in humans. In rats, the median acute lethal dose (LD 50 ) was found to be 1100 mg/kg.

No data are available to suggest physiological maneuvers ( e. g. maneuvers to change the pH of the urine) that might accelerate elimination of isosorbide dinitrate and its active metabolites. Similarly, it is not known which, if any, of these substances can usefully be removed from the body by hemodialysis.

No specific antagonist to the vasodilator effects of isosorbide dinitrate is known, and no intervention has been subject to controlled studies as a therapy for isosorbide dinitrate overdose. Because the hypotension associated with isosorbide dinitrate overdose is the result of venodilatation and arterial hypovolemia, prudent therapy in this situation should be directed toward increase in central fluid volume. Passive elevation of the patient's legs may be sufficient, but intravenous infusion of normal saline or similar fluid may also be necessary.

The use of epinephrine or other arterial vasoconstrictors in this setting is likely to do more harm than good.

In patients with renal disease or congestive heart failure, therapy resulting in central volume expansion is not without hazard. Treatment of isosorbide dinitrate overdose in these patients may be subtle and difficult, and invasive monitoring may be required.

Methemoglobinemia

Nitrate ions liberated during metabolism of isosorbide dinitrate can oxidize hemoglobin into methemoglobin. Even in patients totally without cytochrome b 5 reductase activity, however, and even assuming that the nitrate moieties of isosorbide dinitrate are quantitatively applied to oxidation of hemoglobin, about 1 mg/kg of isosorbide dinitrate should be required before any of these patients manifests clinically significant (≥10%) methemoglobinemia. In patients with normal reductase function, significant production of methemoglobin should require even larger doses of isosorbide dinitrate. In one study in which 36 patients received 2 to 4 weeks of continuous nitroglycerin therapy at 3.1 to 4.4 mg/hr (equivalent, in total administered dose of nitrate ions, to 4.8 to 6.9 mg of bioavailable isosorbide dinitrate per hour), the average methemoglobin level measured was 0.2%; this was comparable to that observed in parallel patients who received placebo.

Notwithstanding these observations, there are case reports of significant methemoglobinemia in association with moderate overdoses of organic nitrates. None of the affected patients had been thought to be unusually susceptible.

Methemoglobin levels are available from most clinical laboratories. The diagnosis should be suspected in patients who exhibit signs of impaired oxygen delivery despite adequate cardiac output and adequate arterial pO 2. Classically, methemoglobinemic blood is described as chocolate brown, without color change on exposure to air.

When methemoglobinemia is diagnosed, the treatment of choice is methylene blue, 1 to 2 mg/kg intravenously.

Isordil Dosage and Administration

As noted under Clinical Pharmacology. multiple-dose studies with ISDN and other nitrates have shown that maintenance of continuous 24-hour plasma levels results in refractory tolerance. Every dosing regimen for ISDN must provide a daily dose-free interval to minimize the development of this tolerance. In the case of sublingual tablets, it is probably true that one of the daily dose-free intervals must be somewhat longer than 14 hours.

As also noted under CLINICAL PHARMACOLOGY. the efficacy of daily doses after the first has never been demonstrated.

Large controlled studies with other nitrates suggest that no dosing regimen with Isordil Sublingual tablets should be expected to provide more than about 12 hours of continuous anti-anginal efficacy per day.

A patient anticipating activity likely to cause angina should take one Isordil Sublingual tablet (2.5 to 5 mg) about 15 minutes before the activity is expected to begin. Isordil Sublingual tablets may be used to abort an acute anginal episode, but its use is recommended only in patients who fail to respond to sublingual nitroglycerin.

How is Isordil Supplied

Isordil ® (isosorbide dinitrate) Sublingual Tablets are available as follows:

2.5 mg, round, yellow tablets imprinted "2.5" on one side and "W" on reverse side: NDC 0008-4139-01, bottles of 100.

5 mg, round, pink tablets imprinted "5" on one side and "W" on reverse side: NDC 0008-4126-01, bottles of 100.

Store at room temperature, approximately 25° C (77° F) Protect from light Keep bottles tightly closed Dispense in a light-resistant, tight container Use carton to protect blisters from light

10 mg, round, white tablets imprinted "10" on one side and "Wyeth" on reverse side: NDC 0008-4161-01, bottles of 100.

Store at room temperature, approximately 25° C (77° F) Keep tightly closed Dispense in a tight container

ALSO AVAILABLE Oral Titradose ® Tablets in the following dosage strengths:

5 mg, NDC 0008-4152, in bottles of 100 or 1,000.

10 mg, NDC 0008-4153, in bottles of 100 or 1,000.

20 mg, NDC 0008-4154, in bottles of 100 or 500.

30 mg, NDC 0008-4159, in bottles of 100.

40 mg, NDC 0008-4192, in bottles of 100.

Wyeth Laboratories A Wyeth-Ayerst Company Philadelphia, PA 19101

Deltafluorene, deltafluorene

Deltafluorene

An anti-inflammatory 9-fluoro-glucocorticoid. [PubChem]

Pharmacology of Deltafluorene

Deltafluorene and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS. dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.

Deltafluorene for patients

Patients should be warned not to discontinue the use of corticosteroids abruptly or without medical supervision. As prolonged use may cause adrenal insufficiency and make patients dependent on corticosteroids, they should advise any medical attendants that they are taking corticosteroids and they should seek medical advice at once should they develop an acute illness including fever or other signs of infection. Following prolonged therapy, withdrawal of corticosteroids may result in symptoms of the corticosteroid withdrawal syndrome including, myalgia. arthralgia. and malaise. Persons who are on corticosteroids should be warned to avoid exposure to chickenpox or measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.

Deltafluorene Interactions

Aminoglutethimide: Aminoglutethimide may diminish adrenal suppression by corticosteroids.

Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents (e. g. amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. In addition, there have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure.

Antibiotics: Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance.

Anticholinesterases: Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy.

Anticoagulants, oral: Co-administration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports. Therefore, coagulation indices should be monitored frequently to maintain the desired anticoagulant effect.

Antidiabetics: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required.

Antitubercular drugs: Serum concentrations of isoniazid may be decreased. Cholestyramine: Cholestyramine may increase the clearance of corticosteroids. Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. Convulsions have been reported with this concurrent use.

Dexamethasone suppression test (DST): False-negative results in the dexamethasone suppression test (DST) in patients being treated with indomethacin have been reported. Thus, results of the DST should be interpreted with caution in these patients.

Digitalis glycosides: Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia.

Ephedrine: Ephedrine may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and lessened physiologic activity, thus requiring an increase in corticosteroid dosage.

Estrogens, including oral contraceptives: Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.

Hepatic Enzyme Inducers, Inhibitors and Substrates: Drugs which induce cytochrome P450 3A4 (CYP 3A4) enzyme activity (e. g. barbiturates, phenytoin, carbamazepine, rifampin) may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased. Drugs which inhibit CYP 3A4 (e. g. ketoconazole, macrolide antibiotics such as erythromycin) have the potential to result in increased plasma concentrations of corticosteroids. Dexamethasone is a moderate inducer of CYP 3A4. Co-administration with other drugs that are metabolized by CYP 3A4 (e. g. indinavir, erythromycin) may increase their clearance, resulting in decreased plasma concentration.

Ketoconazole: Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60%, leading to increased risk of corticosteroid side effects. In addition, ketoconazole alone can inhibit adrenal corticosteroid synthesis and may cause adrenal insufficiency during corticosteroid withdrawal.

Nonsteroidal anti-inflammatory agents (NSAIDS): Concomitant use of aspirin (or other nonsteroidal antiinflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. The clearance of salicylates may be increased with concurrent use of corticosteroids.

Phenytoin: In post-marketing experience, there have been reports of both increases and decreases in phenytoin levels with dexamethasone co-administration, leading to alterations in seizure control.

Skin tests: Corticosteroids may suppress reactions to skin tests.

Thalidomide: Co-administration with thalidomide should be employed cautiously, as toxic epidermal necrolysis has been reported with concomitant use.

Vaccines: Patients on corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response. Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines. Routine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possible.

Deltafluorene Contraindications

Systemic fungal infections.

DECADRON tablets are contraindicated in patients who are hypersensitive to any components of this product.

Additional information about Deltafluorene

Deltafluorene Indication: Injection: for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.

Ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.

Ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus

Topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

Oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy

Intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps Mechanism Of Action: Deltafluorene is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. This results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A 2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Drug Interactions: Ambenonium The corticosteroid decreases the effect of anticholinesterases Aminoglutethimide Aminogluthetimide decreases the effect of dexamethasone Amobarbital The barbiturate decreases the effect of the corticosteroid Anisindione The corticosteroid alters the anticoagulant effect Aprepitant Aprepitant increases the effect and toxicity of dexamethasone Aprobarbital The barbiturate decreases the effect of the corticosteroid Aspirin The corticosteroid decreases the effect of salicylates Butabarbital The barbiturate decreases the effect of the corticosteroid Butalbital The barbiturate decreases the effect of the corticosteroid Butethal The barbiturate decreases the effect of the corticosteroid Dicumarol The corticosteroid alters the anticoagulant effect Dihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroid Edrophonium The corticosteroid decreases the effect of anticholinesterases Ethotoin The enzyme inducer decreases the effect of the corticosteroid Fosphenytoin The enzyme inducer decreases the effect of the corticosteroid Heptabarbital The barbiturate decreases the effect of the corticosteroid Hexobarbital The barbiturate decreases the effect of the corticosteroid Imatinib Decreases levels of imatinib Mephenytoin The enzyme inducer decreases the effect of the corticosteroid Methohexital The barbiturate decreases the effect of the corticosteroid Methylphenobarbital The barbiturate decreases the effect of the corticosteroid Midodrine Increased arterial pressure Neostigmine The corticosteroid decreases the effect of anticholinesterases Pentobarbital The barbiturate decreases the effect of the corticosteroid Phenobarbital The barbiturate decreases the effect of the corticosteroid Phenytoin The enzyme inducer decreases the effect of the corticosteroid Primidone The barbiturate decreases the effect of the corticosteroid Pyridostigmine The corticosteroid decreases the effect of anticholinesterases Quinidine barbiturate The barbiturate decreases the effect of the corticosteroid Rifampin The enzyme inducer decreases the effect of the corticosteroid Secobarbital The barbiturate decreases the effect of the corticosteroid Sunitinib Possible decrease in sunitinib levels Talbutal The barbiturate decreases the effect of the corticosteroid Warfarin The corticosteroid alters the anticoagulant effect Bismuth The corticosteroid decreases the effect of salicylates Acenocoumarol The corticosteroid alters the anticoagulant effect Salicylate-magnesium The corticosteroid decreases the effect of salicylates Salsalate The corticosteroid decreases the effect of salicylates Food Interactions: Avoid alcohol. Take with food to reduce irritation. Avoid taking with grapefruit juice. Generic Name: Dexamethasone Synonyms: Desametasone [Dcit]; Desametasone; Desamethasone; DEX; Dexametasona [Inn-Spanish]; Dexamethasone Acetate; Dexamethasone Alcohol; Dexamethasone Base; Dexamethasone Sodium Phosphate; Dexamethasonum [Inn-Latin]; Dexamethazone; DXM; Dxms; Fluormethylprednisolone Drug Category: Antineoplastic Agents, Hormonal; Glucocorticoids; Antiemetics; Anti-inflammatory Agents; Adrenergic Agents Drug Type: Small Molecule; Approved; Investigational Other Brand Names containing Dexamethasone: Adexone; Aeroseb-D; Aeroseb-Dex; Anaflogistico; Aphtasolon; Aphthasolone; Auxiron; Azium; Bisu Ds; Calonat; Corson; Corsone; Cortisumman; Decacort; Decacortin; Decaderm; Decadron; Decadron Tablets, Elixir; Decadron-La; Decagel; Decalix; Decasone; Decaspray; Dectancyl; Dekacort; Deltafluorene; Dergramin; Deronil; Desadrene; Desameton; Deseronil; Dex-Ide; Dexa; Dexa Mamallet; Dexa-Cortidelt; Dexa-Cortisyl; Dexa-Mamallet; Dexa-Scheroson; Dexa-Sine; Dexacen-4; Dexacidin; Dexacort; Dexacortal; Dexacortin; Dexadeltone; Dexafarma; Dexair; Dexalona; Dexaltin; Dexameth; Dexamethasone Intensol; Dexamonozon; Dexapolcort; Dexapos; Dexaprol; Dexason; Dexasone; Dexinolon; Dexinoral; Dexone; Dexone 0.5; Dexone 0.75; Dexone 1.5; Dexone 4; Dexonium; Dextelan; Dezone; Dinormon; Fluormone; Fluorocort; Fortecortin; Gammacorten; Hexadecadrol; Hexadrol; Hexadrol Elixir; Hexadrol Tablets; Hl-Dex; Isopto-Dex; Lokalison F; Loverine; Luxazone; Maxidex; Maxitrol; Mediamethasone; Mexidex; Millicorten; Mymethasone; Ocu-Trol; Oradexon; Pet Derm Iii; Pet-Derm Iii; Policort; Prednisolon F; Prednisolone F; Sk-Dexamethasone; Spoloven; Sunia Sol D; Superprednol; Turbinaire; Visumetazone; Absorption: 80-90% Toxicity (Overdose): Oral, rat LD 50 . >3 gm/kg. Signs of overdose include retinal toxicity, glaucoma. subcapsular cataract. gastrointestinal bleeding, pancreatitis, aseptic bone necrosis, osteoporosis. myopathies, obesity, edemas, hypertension, proteinuria, diabetes, sleep disturbances, psychiatric syndromes, delayed wound healing, atrophy and fragility of the skin, ecchymosis, and pseudotumor cerebri. Protein Binding: 70% Biotransformation: Hepatic. Half Life: 36-54 hours Dosage Forms of Deltafluorene: Solution Intravenous Liquid Intravenous Tablet Oral Solution Ophthalmic Solution / drops Ophthalmic Liquid Oral Elixir Oral Ointment Ophthalmic Liquid Intramuscular Chemical IUPAC Name: (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one Chemical Formula: C22H29FO5 Dexamethasone on Wikipedia: http://en. wikipedia. org/wiki/Dexamethasone Organisms Affected: Humans and other mammals

Buy rabigal

RABETAL DSR TABLET

This medication is an antidopaminergic agent, used in treating nausea, vomiting, gastrointestinal problems and Parkinson? s disease.

How does Domperidone work:

Domperidone helps the stomach get rid of food and lowers signs of an upset stomach, throwing up, heartburn, and fullness.

How should Domperidone be used:

Adult: Oral - Nausea and vomiting - 10-20 mg 4-8 hourly. Max: 80 mgday. Non ulcer dyspepsia - 10-20 mg 3 timesday and at night. Migraine - 20 mg 4 hourly. Max: 4 doses24 hour. Rectal - Nausea and vomiting - 60 mg twice daily. It is available in various forms like tablet, drop, suspension, capsule to take by mouth, on an empty stomach.

Common side effects of Domperidone :

Headache. Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. See a dentist often

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Domperidone :

Alert your doctor if you have stomach problems (such as stomach bleeding or intestinal blockage) or prolactinoma (a tumour that releases a hormone called prolactin). - Alert your doctor if you have heart, liver or kidney disease, or if you have breast cancer. - Alert your doctor if you are pregnant or breastfeeding. Do not breastfeed while being treated with Domperidone.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. A fast heartbeat. Very bad dizziness or passing out. Seizures. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Domperidone with other medicines:

Alert your doctor quickly if you are taking any of the following medications: - bromocriptine - heart medicines, especially those used to control irregular heartbeat. - antidepressants known as MAOI, such as phenelzine, isocarboxazid. - other mood medicines such as mesoridazine, thioridazine. - painkillers such as codeine, morphine. - Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription.

Are there any food restrictions

How do I store Domperidone :

Oral: Store it at controlled room temperature (15-30?C).

Pregnancy Category

Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Therapeutic Classification

Antiemetics, GIT Regulators & Anti-Inflammatories

This medication is an antidopaminergic agent, used in treating nausea, vomiting, gastrointestinal problems and Parkinson? s disease.

Welcome to Abigail’s Bakery. We offer a variety of New England organic breads that are sure to please. What could be more nurturing and satisfying than a freshly baked loaf of whole grain bread delivered directly to your door. Abigail’s Bakery, nestled in the hills of East Weare, New Hampshire, has been producing one of New England’s finest quality breads since 1976. Each loaf is hand shaped from all natural ingredients and baked in our time worn ovens .

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Active component . Rabeprazole Sodium

Availability . In Stock!

Payment method . Visa

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Medical form: piller

Prescription required: No Prescription Required for Generic Aciphex Rated 93% based on 511 user reviews.

Thumbnail sketch . Generic Aciphex is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

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Clotrimazole cream - fda prescribing information, side effects and uses, clotrima

Clotrimazole Cream

DESCRIPTION

Clotrimazole Cream USP, 1% contains clotrimazole, a synthetic antifungal agent having the chemical name ; the molecular formula C 22 H 17 ClN 2 ; a molecular weight of 344.84; and the structural formula:

Clotrimazole USP is an odorless, white crystalline substance. It is practically insoluble in water, sparingly soluble in ether and very soluble in polyethylene glycol 400, ethanol and chloroform.

Each gram of Clotrimazole Cream USP contains 10 mg clotrimazole USP, dispersed in a vanishing cream base of sorbitan monostearate, polysorbate 60, cetyl esters wax, cetostearyl alcohol, octyldodecanol, purified water, and benzyl alcohol (1%) as preservative.

CLINICAL PHARMACOLOGY

Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. The primary action of clotrimazole is against dividing and growing organisms.

In vitro, clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes. Epidermophyton floccosum, Microsporum canis and Candida species including Candida albicans. In general, the in vitro activity of clotrimazole corresponds to that of tolnaftate and griseofulvin against the mycelia of dermatophytes ( Trichophyton, Microsporum, and Epidermophyton ), and to that of the polyenes (amphotericin B and nystatin) against budding fungi ( Candida ). Using an in vivo (mouse) and an in vitro (mouse kidney homogenate) testing system, clotrimazole and micronazole were equally effective in preventing the growth of the pseudomycelia and mycelia of Candida albicans .

Strains of fungi having a natural resistance to clotrimazole are rare. Only a single isolate of Candida guilliermondi has been reported to have primary resistance to clotrimazole.

No single-step or multiple-step resistance to clotrimazole has developed during successive passages of Candida albicans and Trichophyton mentagrophytes. No appreciable change in sensitivity was detected after successive passage of isolates of C. albicans, C krusei. or C. pseudotropicalis in liquid or solid media containing clotrimazole. Also, resistance could not be developed in chemically induced mutant strains of polyene-resistant isolates of C. albicans. Slight, reversible resistance was noted in three isolates of C. albicans tested by one investigator. There is a single report that records the clinical emergence of C. albicans strain with considerable resistance to flucytosine and micronazole, and with cross-resistance to clotrimazole, the strain remained sensitive to nystatin and amphotericin B.

In studies of the mechanism of action, the minimum fungicide concentration of clotrimazole caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. Both these events began rapidly and extensively after addition of the drug.

Clotrimazole appears to be well absorbed in humans following oral administration and is eliminated mainly as inactive metabolites. Following topical and vaginal administration, however, clotrimazole appears to be minimally absorbed.

Six hours after the application of radioactive clotrimazole 1% cream and 1% solution onto intact and acutely inflamed skin, the concentration of clotrimazole varied from 100 mcg/cm 3 in the stratum corneum to 0.5 to 1 mcg/cm 3 in the stratum reticulare, and 0.1 mcg/cm 3 in the subcutis. No measurable amount of radioactivity (≤0.001 mcg/mL) was found in the serum within 48 hours after application under occlusive dressing of 0.5 mL of the solution or 0.8 g of the cream. Only 0.5% or less of the applied radioactivity was excreted in the urine.

Following intravaginal administration of 100 mg 14 C-clotrimazole vaginal tablets to nine adult females, an average peak serum level, corresponding to only 0.03 μg equivalent/mL of clotrimazole, was reached one to two days after application. After intravaginal administration of 5 g of 1% 14 C-clotrimazole vaginal cream containing 50 mg active drug, to five subjects (one with candidal colpitis), serum levels corresponding to approximately 0.01 μg equivalents/mL were reached between 8 and 24 hours after application.

INDICATIONS AND USAGE

Clotrimazole Cream USP is indicated for the topical treatment of candidiasis due to Candida albicans and tinea versicolor due to Malassezia furfur.

Clotrimazole is also available as a nonprescription item which is indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes. Epidermophyton floccosum. and Microsporum canis.

CONTRAINDICATIONS

Clotrimazole Cream is contraindicated in individuals sensitive to its components.

Casicot, casicot

Bactrim consists of two medications: sulfamethoxazole and trimethoprim. The first inhibits synthesis of dihydrofolic acid (the substance important for human and bacterial metabolism) while the last blocks next stage of its biochemical cycle: formation of tetrahydrofolic acid which occurs only in microorganisms. This medication is effective against streptococci, staphylococci, pneumococci, bacillus dysentery, typhoid fever, E. coli, Proteus, and ineffective against Mycobacterium tuberculosis, spirochetes, Pseudomonas aeruginosa. Bactrim is applied in treatment of pneumonia and other diseases of respiratory, gastrointestinal systems, urogenital systems caused by bacterial infections which develop after surgery and others.

Dosage and directions

Bactrim can be taken two or three times a day with or without a meal. Dosage depends on the type and severity of infection. Take with a glass of water. Patients with severe kidney failure require correction of Bactrim dosage.

Precautions Avoid exposure to sunlight or getting tanned. Antibiotic medicines can cause diarrhea, inform your doctor if you have it, it can mask other infection. Warn your doctor if you suffer from asthma or have severe kidney or liver disorders.

Contraindications Do not take Bactim if you are allergic to components of the medication, if you are pregnant, breastfeeding, have anemia caused by folic acid deficiency. This medication should not be administered to premature babies and newborns.

Possible side effect

If you have such signs of allergic reaction as hives, difficulty breathing, swelling of your face, lips, tongue, or throat or more serious signs of poor health as fever, sore throat, and headache with a severe blistering, pale skin, easy bruising or bleeding, diarrhea that is watery or bloody, hallucinations, slow heart rate, weak pulse, nausea, stomach pain, urinating less than usual or not at all then seek for immediate medical attention.

Drug interaction Bactim should be co-administered with dofetilide or methenamine. Bactrim is able to change effects of certain anti-diabetic medications, "blood thinners", cyclosporine, digoxin, drugs which can increase potassium levels, live vaccines, tricyclic antidepressants, some "water pills". So inform your doctor about all prescription and nonprescription/herbal products you may use.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose If you took too much of Bactim you may feel dizziness, drowsiness, nausea, vomiting, loss of appetite, stomach pain, headache, yellowing of your skin or eyes, blood in your urine, fainting. In case of serious side effects seek for immediate medical help.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Fosval, fosval

Paraguay

FOSVAL 70mg

Inhibidor selectivo de la resorciпїЅn пїЅsea mediada por osteoclastos.

ComposiciпїЅn.

Cada comprimido contiene 70mg de alendronato sпїЅdico.

Propiedades.

El alendronato es un bifosfonato de tercera generaciпїЅn anпїЅlogo del pirofosfato, recientemente aprobado por la F. D.A. para el tratamiento de la osteoporosis. Es un inhibidor altamente selectivo de la resorciпїЅn пїЅsea mediada por los osteoclastos, que no altera la mineralizaciпїЅn del hueso, por lo que su uso a largo plazo carece de este riesgo. Estudios experimentales en animales, indican que las dosis para inhibir la mineralizaciпїЅn пїЅsea son 6.000 veces mayores que las dosis antirresortivas. Los bifosfonatos son una clase de compuestos sintпїЅticos usados en el tratamiento de diversas enfermedades metabпїЅlicas de los huesos. Se caracterizan por un nпїЅcleo con enlaces P-CP, el que es resistente a la hidrпїЅlisis enzimпїЅtica. Al igual que los pirofosfatos, el alendronato se adhiere fuertemente a la hidroxiapatita. La firme afinidad por el fosfato de calcio, explica en general la rпїЅpida y sostenida uniпїЅn al hueso. AbsorciпїЅn, distribuciпїЅn y metabolismo: es pobremente absorbido desde el tracto gastrointestinal (1% a 5% de la dosis) y la absorciпїЅn es disminuida con comidas que contengan hierro y calcio. Bajo las mejores condiciones el rango de biodisponibilidad va de 1% a 10%. MпїЅs aпїЅn, la vida media circulatoria de estos agentes es sпїЅlo entre 15-60 minutos con grandes variabilidades individuales. DespuпїЅs de un corto perпїЅodo en la circulaciпїЅn, el alendronato es removido rпїЅpidamente. Se estima que un 20% a 50% de la absorciпїЅn oral va a los sitios de mineralizaciпїЅn пїЅsea y el resto es excretado en la orina. En contraste con la circulaciпїЅn, la vida media del alendronato en el hueso es de alrededor de 10 aпїЅos. El alendronato disminuye los marcadores bioquпїЅmicos de recambio пїЅseo en mujeres posmenopпїЅusicas, por lo tanto la densidad пїЅsea se incrementa significativamente despuпїЅs de su uso. Numerosa evidencia clпїЅnica avala que el uso de 10mg diarios de alendronato incrementa la densidad пїЅsea, medida en cadera, columna lumbar y corporal total.

Indicaciones.

FOSVAL estпїЅ indicado en el tratamiento y prevenciпїЅn de la osteoporosis en mujeres posmenopпїЅusicas.

DosificaciпїЅn.

Se administra en forma oral. La dosis recomendada para el tratamiento de la osteoporosis en mujeres posmenopпїЅusicas es de 70mg a la semana. Para facilitar su absorciпїЅn, FOSVAL debe ser tomado con un vaso lleno de agua pura, al menos 30 minutos antes de la primera comida, bebida o medicamento. No es necesario ajustar la dosis en pacientes de edad avanzada o con insuficiencia renal leve a moderada (clearance de creatinina: 35 - 60ml/minuto). En pacientes con falla renal severa (clearance de creatinina

Galepsi, galepsi

Neurontin is used for treating seizures associated with epilepsy. Neurontin is an anticonvulsant.

Use Neurontin as directed by your doctor.

Take Neurontin by mouth with or without food.

Do not take an antacid containing aluminum or magnesium within 2 hours before you take Neurontin.

If you are taking half of a scored tablet as your dose, take the other half of that tablet as your next dose. Throw away any half-tablets not used within several days of breaking a scored tablet.

Do not suddenly stop taking Neurontin. You may have an increased risk of side effects (eg, seizures). If you need to stop Neurontin or add a new medicine, your doctor will gradually lower your dose.

If you miss a dose of Neurontin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Neurontin.

Store Neurontin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neurontin out of the reach of children and away from pets.

Active Ingredient: Gabapentin.

Do NOT use Neurontin if:

you are allergic to any ingredient in Neurontin.

Some medical conditions may interact with Neurontin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems and are on dialysis

if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions.

Some medicines may interact with Neurontin. Tell your health care provider if you are taking any medicines, especially any of the following:

Morphine because it may increase the risk of Neurontin's side effects, including drowsiness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Neurontin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Neurontin may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Neurontin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Patients who take Neurontin may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Neurontin closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Diabetes patients - Neurontin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Neurontin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Neurontin.

Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Neurontin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Neurontin with caution in the elderly; they may be more sensitive to its effects.

Neurontin may cause emotional or behavioral side effects in children 3 to 12 years. If the following side effects occur, notify your doctor immediately: emotional "swings", hostile or aggressive behavior, problems concentrating, decreased performance at school, an increase in restlessness or hyperactivity.

Neurontin should be used with extreme caution in children younger 3 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Neurontin while you are pregnant. Neurontin is found in breast milk. If you are or will be breast-feeding while you use Neurontin, check with your doctor. Discuss any possible risks to your baby.

If you stop taking Neurontin suddenly, you may have withdrawal symptoms. These may include dizziness, drowsiness, clumsiness, hostility, hyperactivity, mood swings, nausea, tiredness, or vomiting.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; changes in vision (double or blurred vision); clumsiness; constipation; diarrhea; dizziness; drowsiness; dry mouth; nausea; stomach upset; tiredness; vomiting; weight gain.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thoughts; back and forth eye movements; behavioral problems; change in school performance; chest pain; confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hyperactivity; loss of coordination; memory loss; new or worsening mental or mood changes (eg, depression, agitation, anxiety, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, inability to sit still); new or worsening seizures; numbness of an arm or leg; one-sided weakness; severe headache or dizziness; shortness of breath; speech changes; suicidal thoughts or actions; swelling of the hands, legs, or feet; tremor; trouble concentrating; twitching.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Neurontin is used for treating seizures associated with epilepsy. Neurontin is an anticonvulsant.

Use Neurontin as directed by your doctor.

Take Neurontin by mouth with or without food.

Do not take an antacid containing aluminum or magnesium within 2 hours before you take Neurontin.

If you are taking half of a scored tablet as your dose, take the other half of that tablet as your next dose. Throw away any half-tablets not used within several days of breaking a scored tablet.

Do not suddenly stop taking Neurontin. You may have an increased risk of side effects (eg, seizures). If you need to stop Neurontin or add a new medicine, your doctor will gradually lower your dose.

If you miss a dose of Neurontin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Neurontin.

Store Neurontin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neurontin out of the reach of children and away from pets.

Active Ingredient: Gabapentin.

Do NOT use Neurontin if:

you are allergic to any ingredient in Neurontin.

Some medical conditions may interact with Neurontin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems and are on dialysis

if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions.

Some medicines may interact with Neurontin. Tell your health care provider if you are taking any medicines, especially any of the following:

Morphine because it may increase the risk of Neurontin's side effects, including drowsiness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Neurontin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Neurontin may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Neurontin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Patients who take Neurontin may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Neurontin closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Diabetes patients - Neurontin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Neurontin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Neurontin.

Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Neurontin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Neurontin with caution in the elderly; they may be more sensitive to its effects.

Neurontin may cause emotional or behavioral side effects in children 3 to 12 years. If the following side effects occur, notify your doctor immediately: emotional "swings", hostile or aggressive behavior, problems concentrating, decreased performance at school, an increase in restlessness or hyperactivity.

Neurontin should be used with extreme caution in children younger 3 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Neurontin while you are pregnant. Neurontin is found in breast milk. If you are or will be breast-feeding while you use Neurontin, check with your doctor. Discuss any possible risks to your baby.

If you stop taking Neurontin suddenly, you may have withdrawal symptoms. These may include dizziness, drowsiness, clumsiness, hostility, hyperactivity, mood swings, nausea, tiredness, or vomiting.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; changes in vision (double or blurred vision); clumsiness; constipation; diarrhea; dizziness; drowsiness; dry mouth; nausea; stomach upset; tiredness; vomiting; weight gain.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thoughts; back and forth eye movements; behavioral problems; change in school performance; chest pain; confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hyperactivity; loss of coordination; memory loss; new or worsening mental or mood changes (eg, depression, agitation, anxiety, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, inability to sit still); new or worsening seizures; numbness of an arm or leg; one-sided weakness; severe headache or dizziness; shortness of breath; speech changes; suicidal thoughts or actions; swelling of the hands, legs, or feet; tremor; trouble concentrating; twitching.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Bullen middle school - kenosha, wisconsin, edulen

Welcome to Bullen

Middle School

Click our "Calendar" Tab to see upcoming dates and events!

KUSD will begin piloting Kajeet at Bradford, Indian Trail and Tremper high schools, as well as Bullen, Lance, Lincoln, Mahone and Washington middle schools in January 2016 . Kajeet is a mobile hotspot that offers internet usage to students at home with the same filters and protections they would have while at school. This service will be FREE for our families

Visit your school library media teacher for specific program details or kajeet. net to learn more.

Make sure to be asking your student everyday:

What are you learning today?

© 2016 John Bullen Middle School 2804 39th Avenue Kenosha, Wisconsin 53144 Phone: (262) 359-4460

Cytoxan (cyclophosphamide) side effects, interactions, warning, dosage & uses, endoxan

Cytoxan (cyclophosphamide) is a synthetic antineoplastic drug chemically related to the nitrogen mustards. The chemical name for cyclophosphamide is 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate, and has the following structural formula:

Cyclophosphamide has a molecular formula of C 7 H 15 Cl 2 N 2 O 2 P•H 2 O and a molecular weight of 279.1. Cyclophosphamide is soluble in water, saline, or ethanol.

Cyclophosphamide for Injection, USP is a sterile white cake available as 500 mg, 1 g, and 2 g strength vials.

500 mg vial contains 534.5 mg cyclophosphamide monohydrate equivalent to 500 mg cyclophosphamide and 375 mg mannitol

1 g vial contains 1069.0 mg cyclophosphamide monohydrate equivalent to 1 g cyclophosphamide and 750 mg mannitol

2 g vial contains 2138.0 mg cyclophosphamide monohydrate equivalent to 2 g cyclophosphamide and 1500 mg mannitol

Cyclophosphamide Tablets, USP are for oral use and contain 25 mg or 50 mg cyclophosphamide (anhydrous). Inactive ingredients in Cyclophosphamide Tablets are: acacia, FD&C Blue No. 1, D&C Yellow No. 10 Aluminum Lake, lactose, magnesium stearate, starch, stearic acid and talc.

What are the possible side effects of cyclophosphamide (Cytoxan, Neosar)?

Get emergency medical help if you have any of these signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

blood in your urine or stools, pain or burning when you urinate;

pale skin, feeling light-headed, rapid heart rate, trouble concentrating;

sudden chest pain or discomfort, wheezing, dry cough or hack, feeling short of breath on exertion;

fever, chills, body aches, flu symptoms, sores in your mouth and.

What are the precautions when taking cyclophosphamide (Cytoxan)?

Before taking cyclophosphamide, tell your doctor or pharmacist if you are allergic to it; or to other chemotherapy drugs (e. g. busulfan, chlorambucil); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: decreased bone marrow function (e. g. anemia, leukopenia, thrombocytopenia).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, surgery to remove your adrenal glands.

Cyclophosphamide can make you more likely to get.

Last reviewed on RxList: 6/13/2013 This monograph has been modified to include the generic and brand name in many instances.

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