Hydromet, hydromet

WARNINGS/PRECAUTIONS

May be habit forming and has potential for abuse. Psychic/physical dependence and tolerance may develop upon repeated administration; use w/ caution. May produce dose-related respiratory depression; may be antagonized by the use of naloxone HCl and other supportive measures when indicated. Respiratory depression effects and the capacity to elevate CSF pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions, or preexisting increased intracranial pressure (ICP). May obscure clinical course of head injuries and acute abdominal conditions. Carefully consider benefit to risk ratio, especially in pediatric patients w/ respiratory embarrassment (eg, croup). Before prescribing medication to suppress/modify cough, it is important to ascertain the underlying cause of cough, that the modification of cough does not increase the risk of clinical or physiological complications, and that appropriate therapy for the primary disease is provided. Caution in elderly, debilitated, severe hepatic/renal impairment, hypothyroidism, Addison's disease, prostatic hypertrophy or urethral stricture, asthma, and narrow-angle glaucoma.

ADVERSE REACTIONS

Sedation, drowsiness, lethargy, mental/physical impairment, anxiety, fear, dizziness, psychic dependence, N/V, ureteral spasm, urinary retention, respiratory depression, skin rash, pruritus.

DRUG INTERACTIONS

May exhibit additive CNS depression w/ other narcotics, antihistamines, antipsychotics, antianxiety agents, or other CNS depressants (including alcohol); reduce dose of 1 or both agents. May increase effects of either antidepressants or hydrocodone w/ MAOIs or TCAs.

PREGNANCY AND LACTATION

Buy gastac - ranitidine - online without prescriptions, gastac

Ranitidine (Gastac)

Ranitidine is used for treating certain conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It is also used to treat ulcers of the small intestine that have not responded to other treatment. It may be used as a short-term alternative to oral ranitidine, in patients who are not able to take medicine by mouth. Ranitidine is an H 2 - receptor blocker. It works by blocking the action of histamine in the stomach. This reduces the amount of acid the stomach makes. Reducing stomach acid helps to reduce heartburn, heal irritation of the esophagus, and heal ulcers of the stomach or intestines.

Use Ranitidine as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You may take antacids while you are using Ranitidine if you are directed to do so by your doctor.

Continue to use Ranitidine even if you feel well. Do not miss any dose.

If you miss a dose of Ranitidine, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranitidine.

Store Ranitidine between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranitidine out of the reach of children and away from pets.

Do NOT use Ranitidine if:

you are allergic to any ingredient in Ranitidine

you have a history of the blood disease porphyria

you are taking dasatinib.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Ranitidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems

if you have abnormal blood electrolyte levels or a history of irregular heartbeat.

Some medicines may interact with Ranitidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Certain benzodiazepines (eg, midazolam, triazolam), glipizide, procainamide, or warfarin because the risk of their side effects may be increased by Ranitidine

Dasatinib, delavirdine, gefitinib, certain HIV protease inhibitors (eg, atazanavir), itraconazole, or ketoconazole because their effectiveness may be decreased by Ranitidine.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Ranitidine may rarely cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranitidine with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Ranitidine may interfere with certain lab tests, including urine protein tests. Be sure your doctor and lab personnel know you are taking Ranitidine.

Lab tests, including liver function, may be performed while you use Ranitidine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ranitidine should be used with extreme caution in children younger than 1 month old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranitidine while you are pregnant. Ranitidine is found in breast milk. Do not breastfeed while taking Ranitidine.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; headache; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced; confusion; dark urine; depression; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucinations; severe or persistent headache or stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Duomycin

In some countries, this medicine may only be approved for veterinary use.

Found in: Switzerland

Duomycin is NOT known to be marketed in the USA. Duomycin may be available in the countries listed above.

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Clonnirit drug & pharmaceuticals, clonnirit

Medication: Clonnirit

Clonnirit - Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonnirit may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for Clonnirit include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonnirit also exhibits some peripheral activity.

Indication: May be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD).

Clonnirit is an α-adrenergic agent that acts specifically on α2-receptors. α2-receptors regulate a number of signaling pathways mediated by multiple Gi proteins, Gαi1, Gαi2, and G&alphai3. Stimulation of α2-receptors mediates effects such as inhibition of adenylyl cyclase, stimulation fo phospholipase D, stimulation of mitogen-activated protein kinases, stimulation of K+ currents and inhibition of Ca2+ currents. Three G-protein coupled α2-receptor subtypes have been identified: α2A, α2B, and α2C. Each subtype has a unique pattern of tissue distribution in the central nervous system and peripheral tissues. The α2A-receptor is widely distributed throughout the central nervous system; it is found in the locus coeruleus, brain stem nuclei, cerebral cortex, septum, hypothalamus, and hippocampus. α2A-receptors are also expressed in the kidneys, spleen, thymus, lung and salivary glands. The α2C-receptor is primarily expressed in the central nervous system, including the striatum, olfactory tubercle, hippocampus and cerebral cortex. Low levels of the α2C-subtype are also found in the kidneys. The α2B-receptor is located primarily in the periphery (kidney, liver, lung and heart) with low levels of expression in the thalamic nuclei of the central nervous system. The α2A - and α2C-receptors are located presynaptically and inhibit the released of noradrenaline from sympathetic nerves. Stimulation of these receptors decreases sympathetic tone, resulting in decreases in blood pressure and heart rate. Sedation and analgesia is mediated by centrally located α2A-receptors, while peripheral α2B-receptors mediate constriction of vascular smooth muscle. α2A-Receptors also mediate essential components of the analgesic effect of nitrous oxide in the spinal cord. Clonnirit stimulates all three α2-receptor subtypes with similar potency. Its actions in the nervous system decreases blood pressure in patients with hypertension and decreases sympathetic overactivity in patients undergoing opioid withdrawal. Clonnirit is also a potent sedative and analgesic and can prevent post-operative shivering in intensive and post-operative care. Its use in differential diagnosis of pheochromocytoma owes to the fact that hypertension in patients with pheochromocytoma is refractory to antihypertensive treatment with clonidine.

Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products:

Clonnirit available forms, composition, doses:

Tablets; Oral; Clonidine Hydrochloride 0.025 mg

Clonnirit destination | category:

Human:

Antihypertensives

Central alpha-agonists

Indications and usages, anatomical therapeutic chemical and diseases classification codes:

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Bonamina, bonamina

DOSIS Y ADMINISTRACIÓN

Adultos y niños sobre 6 años: Para profilaxis y alivio sintomático de náuseas, vómitos y vértigo, la dosis es de 25-100 mg diarios, en dosis divididas, dependiendo de la respuesta clínica.

La dosis recomendada de BONAMINA para indicaciones específicas es: Mareo del movimiento: Una dosis única de 25 a 50 mg de BONAMINA proporciona protección contra el mareo por aproximadamente 24 horas. La dosis inicial debe ser tomada una hora antes de embarcarse para asegurar la absorción de la droga, debido a que la retención del medicamento es incierta en aquellos individuos que ya están sufriendo los efectos del mareo.

Después se indica la repetición de la dosis cada 24 horas durante la duración del viaje. Con esta dosis, la incidencia de efectos laterales, con la excepción de somnolencia, es aproximadamente la misma que la que se encuentra en grupos de control que han recibido placebos.

Náuseas y vómitos del embarazo: Una dosis diaria de 25 a 50 mg es generalmente efectiva.

Perturbaciones vestibulares y laberínticas: La dosis óptima es generalmente 25 a 100 mg diarios, dependiendo de la respuesta clínica.

Enfermedad por radiación: 50 mg administrados 2 a 12 horas antes de la terapia con radiación.

Cada TABLETA MASTICABLE contiene: Clorhidrato de meclizina 25 mg.

CONTRAINDICACIONES: Hipersensibilidad conocida a la droga.

Profilaxis y alivio sintomático de náuseas, vómitos y vértigo.

PRESENTACIÓN: Envase de 20 y 100 tabletas con sabor a piña.

PFIZER DE CHILE S. A.

Av. Las Américas 173 - Cerrillos

Telf. 241-2000 Fax: 557-5766

DOSIS Y ADMINISTRACIÓN

Adultos y niños sobre 6 años: Para profilaxis y alivio sintomático de náuseas, vómitos y vértigo, la dosis es de 25-100 mg diarios, en dosis divididas, dependiendo de la respuesta clínica.

La dosis recomendada de BONAMINA para indicaciones específicas es: Mareo del movimiento: Una dosis única de 25 a 50 mg de BONAMINA proporciona protección contra el mareo por aproximadamente 24 horas. La dosis inicial debe ser tomada una hora antes de embarcarse para asegurar la absorción de la droga, debido a que la retención del medicamento es incierta en aquellos individuos que ya están sufriendo los efectos del mareo.

Después se indica la repetición de la dosis cada 24 horas durante la duración del viaje. Con esta dosis, la incidencia de efectos laterales, con la excepción de somnolencia, es aproximadamente la misma que la que se encuentra en grupos de control que han recibido placebos.

Náuseas y vómitos del embarazo: Una dosis diaria de 25 a 50 mg es generalmente efectiva.

Perturbaciones vestibulares y laberínticas: La dosis óptima es generalmente 25 a 100 mg diarios, dependiendo de la respuesta clínica.

Enfermedad por radiación: 50 mg administrados 2 a 12 horas antes de la terapia con radiación.

Cada TABLETA MASTICABLE contiene: Clorhidrato de meclizina 25 mg.

CONTRAINDICACIONES: Hipersensibilidad conocida a la droga.

Profilaxis y alivio sintomático de náuseas, vómitos y vértigo.

PRESENTACIÓN: Envase de 20 y 100 tabletas con sabor a piña.

PFIZER DE CHILE S. A.

Av. Las Américas 173 - Cerrillos

Telf. 241-2000 Fax: 557-5766

Clotrix, clotrix

Clotrix

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Amaryl - 1 (tablets); amaryl - 2 (tablets); amaryl - 4 (tablets), glamaryl

PROPRIETARY NAME (and dosage form):

COMPOSITION: Per tablet: Glimepiride 1 mg Glimepiride 2 mg Glimepiride 4 mg

PHARMACOLOGICAL CLASSIFICATION: A 21.2 Oral hypoglycaemics

PHARMACOLOGICAL ACTION: AMARYL ® is a sulfonylurea. AMARYL ® decreases blood glucose concentrations mainly by stimulating insulin release from pancreatic beta cells. This effect is based predominantly on an improved responsiveness of the pancreatic beta cells to the physiological glucose stimulus. Glimepiride also has extra pancreatic (insulin-sensitizing and insulin-mimetic) effects. The effect of glimepiride is dose-dependent over the dose range of 1 to 6 mg. The physiological response to acute physical exercise, i. e. reduction of insulin secretion, is still present with glimepiride. There was no significant difference in effect regardless of whether the drug was given 30 minutes or immediately before a meal. In diabetic patients, metabolic control over 24 hours can be achieved with a single dose. The absolute bioavailability of glimepiride is complete. Food intake has no relevant influence on absorption. Maximum serum concentrations are reached approximately 2,5 hours after oral intake and there is a linear relationship between dose and both maximum concentrations and area under the time/concentration curve. Glimepiride has a high protein binding (>99%). Mean dominant serum half-life, which is of relevance for the serum concentrations under multiple-dose conditions, is about 5 to 8 hours. After single dose radio labelled glimepiride, 58% of the radioactivity was recovered in the urine, and 35% in the faeces. No unchanged substance was detected in the urine. Pharmacokinetics was similar in males and females, as well as in young and elderly patients.

INDICATIONS: AMARYL ® is indicated as an adjunct to diet and exercise to lower the blood glucose in patients with non-insulin-dependent (Type II) diabetes mellitus (NIDDM) whose hyperglycaemia cannot be controlled by diet and exercise alone. AMARYL ® is not suitable for the treatment of insulin-dependent (type I) diabetes mellitus (e. g. for the treatment of diabetics with a history of ketoacidosis, of diabetic ketoacidosis, or of diabetic precoma or coma).

CONTRA-INDICATIONS: AMARYL ® must not be used in patients hypersensitive to glimepiride, other sulphonylureas, other sulfonamides, or any of the excipients (risk of hypersensitivity reactions), in pregnant or breast-feeding women as safety has not been shown impaired liver function and moderate to more severe impaired renal function, and children.

WARNINGS: SPECIAL WARNING ON INCREASED RISK OF CARDIOVASCULAR MORTALITY. The administration of oral hypoglycaemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin. This warning is based on the study conducted by the University Group Diabetes Program (UGDP), a long-term, prospective clinical trial designed to evaluate the effectiveness of glucose-lowering drugs in preventing or delaying vascular complications in patients with non-insulin-dependent diabetes. The study involved 823 patients who were randomly assigned to one of four treatment groups (Diabetes, 19 supp.2: 747-830.1970). UGDP reported that patients treated for 5 to 8 years with diet plus a fixed dose of tolbutamide (1,5 grams per day) had a rate of cardiovascular mortality approximately 2 -1/2 times that of patients treated with diet alone. A significant increase in total mortality was not observed, but the use of tolbutamide was discontinued based on the increase in cardiovascular mortality, thus limiting the opportunity for the study to show an increase in overall mortality. Despite controversy regarding the interpretation of these results, the findings of the UGDP study provide an adequate basis for this warning. The patient should be informed of the potential risks and advantages of AMARYL ® (glimepiride tablets) and of alternative modes of therapy. Although only one drug in the sulfonylurea class (tolbutamide) was included in this study, it is prudent from a safety standpoint to consider that this warning may also apply to other oral hypoglycaemic drugs in this class. In view of their close similarities in mode of action and chemical structure.

DOSAGE AND DIRECTIONS FOR USE: The dosage of AMARYL ® is determined by the desired blood glucose level. The dosage of glimepiride must be the lowest which is sufficient to achieve the desired metabolic control. During treatment with AMARYL ® glucose levels in blood and urine must be measured regularly. In addition, it is recommended that regular determinations of the proportion of glycated haemoglobin be carried out.

If a patient forgets to take a dose, this must never be corrected by subsequently taking a larger dose. Measures for dealing with such situations (in particular forgetting a dose or skipping a meal) where a dose cannot be taken at the prescribed time must be discussed and agreed between physician and patient beforehand.

If it is discovered that too high a dose or an extra dose of AMARYL ® has been taken, a physician must be notified immediately. Initial dose and dose titration: The usual initial dose is 1 mg AMARYL ® once daily. If necessary, the daily dose can be increased. It is recommended that the increase be guided by regular blood glucose monitoring, and that the dose be increased gradually, i. e. at intervals of one to two weeks and according to the following dose steps: 1 mg - 2 mg - 3 mg - 4 mg - 6 mg. Daily doses of more than 6 mg are more effective only in a minority of patients. A maximum of 8 mg per day may not be exceeded. Dose range in patients with well controlled diabetes: Usual daily doses in patients with well controlled diabetes are 1 to 4 mg AMARYL ® . Distribution of doses: Timing and distribution of doses are to be decided by the physician, taking into consideration the patient's current life-style. Normally a single daily dose of AMARYL ® is sufficient. It is recommended that this dose be taken immediately before a substantial breakfast or - if none is taken - immediately before the first main meal. It is very important not to skip meals after the tablet(s) have been taken. Secondary dosage adjustment: An improvement in the control of diabetes is associated with higher insulin sensitivity, therefore glimepiride requirements may fall as treatment proceeds. To avoid hypoglycaemia, dose reduction or cessation of AMARYL ® therapy must therefore be considered, in time. Correction of dosage must also be considered, whenever the patient's weight changes, the patient's lifestyle changes or other factors arise which cause an increased susceptibility to hypoglycaemia or hyperglycaemia (refer to "Special Precautions"). Duration of treatment: Treatment with AMARYL ® is normally long-term therapy. Change-over from other oral antidiabetics to AMARYL ® : There is no exact dosage relationship between AMARYL ® and other oral antidiabetics. When substituting AMARYL ® for other oral antidiabetics, it is recommended that the procedure be the same as for initial dosage, starting with daily doses of 1 mg. This applies even in cases where the patient is being switched from the maximum dose of another oral antidiabetic. Administration: AMARYL ® tablets must be swallowed whole with approximately ½ glass of water.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS: Side-effects Hypoglycaemia Hypoglycaemia (sometimes life-threatening) may occur as a result of the blood-glucose-lowering action of AMARYL ®. This happens when there is an imbalance between AMARYL ® dosage, carbohydrate intake (diet), physical exercise and other factors influencing metabolism. Possible symptoms of hypoglycaemia include headache, ravenous hunger, nausea, vomiting, lassitude, sleepiness, sleep disorders, restlessness, aggressiveness, impaired concentration, impaired alertness and reactions, depression, confusion, speech disorders, aphasia, visual disorders, tremor, paresis, sensory disturbances, dizziness, helplessness, loss of self-control, delirium, cerebral convulsions, somnolence and loss of consciousness up to and including coma, shallow respiration and bradycardia. In addition, signs of adrenergic counter-regulation may be present such as sweating, clammy skin, anxiety, tachycardia, hypertension, palpitations, angina pectoris, and cardiac arrhythmias. The clinical picture of a severe hypoglycaemic attack may resemble that of a stroke. The symptoms of hypoglycaemia may persist if hypoglycaemia is corrected. Eyes Especially at the start of treatment, there may be temporary visual impairment due to the change in blood glucose levels. The cause is a temporary alteration in the turgidity and hence the refractive index of the lens, this being dependent on blood glucose level. Digestive tract Occasionally, gastrointestinal symptoms such as nausea, vomiting, sensations of pressure or fullness in the epigastrium, abdominal pain and diarrhoea may occur. In isolated cases, there may be elevation of liver enzyme levels, impairment of liver function (e. g. with cholestasis and jaundice) and hepatitis which may also lead to life-threatening liver failure. Blood Potentially life-threatening changes in the blood picture may occur, such as thrombocytopenia and, in isolated cases, leucopenia. AMARYL ®. in addition to the above, may cause haemolytic anaemia or erythrocytopenia, granulocytopenia, agranulocytosis and (e. g. due to myelosuppression) pancytopenia. Allergic or pseudoallergic reactions may occur such as itching, urticaria or rashes. These mild reactions may develop into serious and even life-threatening reactions with dyspnoea and a fall in blood pressure, sometimes progressing to shock. In the event of urticaria a physician must therefore be notified immediately. In isolated cases, a decrease in serum sodium concentration has been seen and allergic vasculitis or hypersensitivity of the skin to light may occur. If any of these reactions occur a doctor should be consulted. Alertness and reactions may be impaired due to hypo - or hyperglycaemia, especially when beginning or after altering treatment, or when AMARYL ® is not taken regularly. This may, for example, affect the ability to drive or to operate machinery. Special precautions Treatment with AMARYL ® must be initiated and monitored by a physician. The patient must take AMARYL ® at the times and in the doses prescribed by the doctor, normally at the same time every day. To achieve the goal of treatment of AMARYL ® - optimal control of blood glucose - adherence to correct diet, regular and sufficient physical exercise and, if necessary, reduction of body weight are just as necessary as regular ingestion of AMARYL ® . Clinical signs of a still insufficiently lowered blood glucose (hyperglycaemia) are e. g. increased urinary frequency (polyuria), intense thirst, dryness of the mouth and dry skin. In the initial weeks of treatment, the risk of hypoglycaemia may he increased and necessitates especially careful monitoring. Factors favouring hypoglycaemia include: unwillingness or (more commonly in older patients) incapacity of the patient to co-operate Undernourishment, irregular meal times, or skipped meals. Imbalance between physical exertion and carbohydrate intake. Alteration of diet. Consumption of alcohol, especially in combination with skipped meals. Impaired renal function. Severe impairment of liver function. Overdosage with AMARYL ® . Certain uncompensated disorders of the endocrine system affecting carbohydrate metabolism or counter-regulation of hypoglycaemia (as for example in certain disorders of thyroid function and in anterior pituitary or corticoadrenal insufficiency). Concurrent administration of certain other medicines (refer to "Interactions"). Treatment with AMARYL ® in the absence of any indication. The patient must inform the physician about such factors and about hypoglycaemic episodes since they may indicate the need for particularly careful monitoring. If such risk factors for hypoglycaemia are present, it may be necessary to adjust the dosage of AMARYL ® or the entire therapy. This also applies whenever illness occurs during therapy or the patient's life-style changes. Those symptoms of hypoglycaemia which reflect the body's adrenergic counter-regulation (refer to "Adverse effects") may be milder or absent where hypoglycaemia develops gradually, in the elderly, and where there is autonomic neuropathy or where the patient is receiving concurrent treatment with beta-blockers, clonidine, reserpine, guanethidine or other sympatholytic drugs. Hypoglycaemia can almost always be promptly controlled by immediate intake of carbohydrates (glucose or sugar, e. g. in the form of sugar lumps, sugar sweetened fruit juice or sugar sweetened tea). For this purpose patients must carry a minimum of 20 grams of glucose with them at all times. They may require the assistance of other persons to avoid complications. Artificial sweeteners are ineffective in controlling hypoglycaemia. It is known from other sulfonylureas that, despite initially successful countermeasures, hypoglycaemia may recur. Patients must, therefore, remain under close observation. Severe hypoglycaemia further requires immediate treatment and follow-up by a physician and, in some circumstances, in-patient hospital care. In exceptional stress situations (e. g. trauma, surgery, febrile infections) blood glucose regulation may deteriorate, and a temporary change to insulin may be necessary to maintain good metabolic control. Insulin is the treatment of choice for non-insulin-dependent diabetes mellitus (NIDDM) with renal and hepatic dysfunction. No experience has been gained concerning the use of AMARYL ® in patients with impairment of liver function. In patients with severe impairment of renal function, change-over to insulin is indicated, to achieve optimal metabolic control. (See contra-indications) Interactions: Patients who take or discontinue taking certain other medicines while undergoing treatment with AMARYL ® may experience changes in blood glucose control. The following interactions must be considered: Potentiation of the blood-glucose-lowering effect and, thus, in some instances hypoglycaemia may occur when one of the following drugs is taken, for example: - insulin and other oral antidiabetics - MAO inhibitors - ACE inhibitors - miconazole - anabolic steroids and male sex hormones - para-aminosalicyclic acid - chloramphenicol - pentoxifylline (high dose parenteral) - coumarin derivatives - phenylbutazone, azapropazone, oxyphenbutazone - cyclophosphamide - probenecid - disopyramide - quinolones - fenfluramine - salicylates - fenyramidol - sulphinpyrazone - fibrates - sulfonamide antibiotics - fluoxetine - tetracyclines - guanethidine - tritoqualine - ifosfamide - trofosfamide Weakening of the blood-glucose-lowering effect and, thus raised glucose levels may occur when one of the following drugs is taken, for example: - acetazolamide - laxatives (after protracted use) - barbiturates - nicotinic acid (in high doses) - corticosteroids - oestrogens and progestogens - diazoxide - phenothiazines - diuretics - phenytoin - epinephrine (adrenaline) and other sympathomimetic agents - rifampicin - glucagon - thyroid hormones H 2 receptor antagonists, beta-blockers, clonidine and reserpine may lead to either potentiation or weakening of the blood-glucose-lowering effect. Under the influence of sympatholytic drugs such as beta-blockers, clonidine, guanethidine and reserpine, the signs of adrenergic counter-regulation to hypoglycaemia may be reduced or absent. Both acute and chronic alcohol intake may potentiate or weaken the blood-glucose-lowering action of AMARYL ® in an unpredictable fashion. The effect of coumarin derivatives may be potentiated or weakened.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: Please refer to Special Precautions and Side-Effects Treatment is symptomatic and supportive.

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Content and information on Pharmapacks. com is provided for informational purposes only. It is not meant to substitute the advice provided by one's physician or any other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing medication. If you have or suspect that you have a medical problem, immediately contact your health care provider. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. While we work extremely hard to ensure that all product information is correct, manufacturers sometimes change their logos, packaging and products. You should use our site as a reference, carefully read all product packaging, and contact the manufacturer with any questions before using a product. We are not liable for inaccuracies or misstatements about products. Customer reviews are provided for informational purposes only. Customer reviews reflect the individual reviewer's results and experiences only and are not verified or endorsed by Pharmapacks. com. Actual results may vary among users.

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Cetro in english, cetro

Durante la coronacion, el rey llevaba la corona y portaba el cetro en su mano derecha. During the coronation, the king would wear the crown and bear the scepter in his right hand.

b. sceptre (United Kingdom)

Tradicionalmente, el arzobispo entrega la corona, el orbe y el cetro al monarca. Traditionally, the archbishop delivers the crown, the orb, and the sceptre to the monarch.

El cetro del soberano fue duro y opresivo, por eso el pueblo apoyo al usurpador. The monarch's reign was harsh and oppressive, which is why the people supported the usurper.

a. crown (in contests)

La cantante perdio su cetro tras haber estado seis meses en el numero uno de las listas. The singer lost her crown after being at the top of the charts for six months.

b. title (in sports)

Si el test de drogas da positivo, el luchador no podra mantener su cetro. If he fails the drug test, the wrestler won't keep his title.

Imped - definition of imped by the free dictionary, imped

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1. a small devil or wicked spirit. kwelgees ??????? дяволче diabrete certik, skritek das Teufelchen lille dj?vel; trold ????????? diablillo kuradike ??? ??? ?????? pikkupiru diablotin ??????? ???? ????? ?? ????? vrazicak kisordog setan kecil puki diavoletto ??? ????? velniukstis velnens anak syaitan duiveltje smadjevel. djevelunge chochlik ????? ?????? ???? ?????? ??? diabrete dracusor чертёнок skriatok vrazic vragolan smadjavul ???????; ?????????; ??????????? kucuk seytan ??? чортеня, бісеня ????? ti?u yeu ???

2. a mischievous child. Her son is a little imp. kwajong ?????? ????? ? ??????? пакостник diabrete rarasek, nezbeda der Schelm spilopmager ?????????, ?????? ????? diablillo. pillo vorukael ??? ??? vintio petit diable ???? ?????, ????? ????? nestasko huncut kolyok anak nakal o?ekktarangi diavoletto ?????? ?? velniukstis draiskulis; nebednis budak nakal deugniet trollunge. skoyer diabelek ???? ????? diabrete drac impielitat озорник nezbednik porednez obesenjak satunge ????????? yaramaz cocuk ?? пустун ???? ??? d?a tr? tinh quai ??

ondeund ????????? ???? даволит endiabrado rozpustily schelmisch gavtyveagtig ?????????????? travieso. endiablado uleannetu ?????? ???? vintiomainen espiegle ???? ????? ???? vragolast, nestasan pajkos, huncut seperti setan hrekkjottur; glettinn sbarazzino ????? ?????? valiugiskas draiskuligs; nebednigs nakal duivels. ondeugend skjelmsk. skoyeraktig. ondskapsfull psotny ????? endiabrado neastamparat озорной nezbedny vrazji vragolast okynnig, smajaklig ?? cin gibi, afacan, yaramaz ?? пустотливий; злий ???? tinh quai ???,????

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Cyklokapron oral uses, side effects, interactions, pictures, warnings - dosing, cyklokapron

Cyklokapron

Uses

This medication is used to treat heavy bleeding during your menstrual period. Tranexamic acid works by slowing the breakdown of blood clots. which helps to prevent prolonged bleeding. It belongs to a class of drugs known as antifibrinolytics.

Tranexamic acid is not a hormone. It does not treat other menstrual or pre-menstrual symptoms. It does not stop your period. It is not a form of birth control and does not protect against sexually transmitted diseases .

How to use Cyklokapron

Read the Patient Information Leaflet if available from your pharmacist before you start taking tranexamic acid and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually 2 tablets 3 times a day (morning, afternoon, bedtime ). Swallow this medication whole. Do not crush or chew. Wait until your period has started before taking your first dose. Do not take tranexamic acid for more than 5 days in a row.

Dosage is based on your medical condition and response to treatment. Do not take more than 3 doses (6 tablets) in 24 hours. Stop taking tranexamic acid and see your doctor right away if you have any eye problems or change in vision .

Tell your doctor if there is a change in your bleeding pattern or heavy bleeding persists or worsens.

Side Effects

See also How to use section.

Nausea. vomiting. diarrhea. and muscle pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: eye /eyelid problems.

Although unlikely, this medication may cause serious blood clot problems. Stop taking tranexamic acid and get medical help right away if any of these unlikely but serious side effects occur: coughing up blood. fainting. pain/swelling/warmth in the groin/calf. swelling/weakness /redness/pain in the arms/legs, signs of a stroke (such as weakness on one side of the body, slurred speech, sudden vision changes, confusion), change in the amount of urine, vision changes (such as color vision changes, decreased vision/blindness).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking tranexamic acid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding in the brain (subarachnoid hemorrhage), history of blood clots (such as in the legs, lung. brain. eye ), certain heart diseases (irregular heartbeat. heart valve problems), blood clotting problems, kidney problems (including blood in the urine ), irregular menstrual bleeding of unknown cause.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is usually used during your menstrual period. Therefore, it is unlikely to be used during pregnancy. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: "blood thinners " (anticoagulants such as warfarin. heparin ), drugs that prevent bleeding (including factor IX complex, anti-inhibitor coagulant concentrates), tretinoin. estrogens. hormonal birth control (such as pills, patch, ring).

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, naproxen) that may increase your risk of bleeding. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Ask your doctor or pharmacist for more details.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, vomiting.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as kidney tests, eye examinations) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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No data available at this time.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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QUETIAPINE (kwe TYE a peen) is an antipsychotic. It is used to treat schizophrenia and bipolar disorder, also known as manic-depression.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

They need to know if you have any of these conditions: - brain tumor or head injury - breast cancer - cataracts - diabetes - difficulty swallowing - heart disease - kidney disease - liver disease - low blood counts, like low white cell, platelet, or red cell counts - low blood pressure or dizziness when standing up - Parkinson's disease - previous heart attack - seizures - suicidal thoughts, plans, or attempt by you or a family member - thyroid disease - an unusual or allergic reaction to quetiapine, other medicines, foods, dyes, or preservatives - pregnant or trying to get pregnant - breast-feeding

Take this medicine by mouth. Swallow it with a drink of water. Follow the directions on the prescription label. If it upsets your stomach you can take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on the advice of your doctor or health care professional. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 10 years for selected conditions, precautions do apply. Patients over age 65 years may have a stronger reaction to this medicine and need smaller doses.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Do not take this medicine with any of the following medications: - certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole - cisapride - dofetilide - dronedarone - droperidol - grepafloxacin - halofantrine - phenothiazines like chlorpromazine, mesoridazine, thioridazine - pimozide - sparfloxacin - ziprasidone This medicine may also interact with the following medications: - alcohol - antiviral medicines for HIV or AIDS - certain medicines for blood pressure - certain medicines for depression, anxiety, or psychotic disturbances like haloperidol, lorazepam - certain medicines for diabetes - certain medicines for Parkinson's disease - certain medicines for seizures like carbamazepine, phenobarbital, phenytoin - cimetidine - erythromycin - other medicines that prolong the QT interval (cause an abnormal heart rhythm) - rifampin - steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Your health care provider may suggest that you have your eyes examined prior to starting this medicine, and every 6 months thereafter. If you have been taking this medicine regularly for some time, do not suddenly stop taking it. You must gradually reduce the dose or your symptoms may get worse. Ask your doctor or health care professional for advice. Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of antidepressant treatment or after a change in dose, call your health care professional. You may get dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks. Do not treat yourself for colds, diarrhea or allergies. Ask your doctor or health care professional for advice, some ingredients may increase possible side effects. This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

Side effects that you should report to your doctor or health care professional as soon as possible: - allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue - difficulty swallowing - fast or irregular heartbeat - fever or chills, sore throat - increased hunger or thirst - increased urination - problems with balance, talking, walking - seizures - stiff muscles - suicidal thoughts or other mood changes - uncontrollable head, mouth, neck, arm, or leg movements - unusually weak or tired Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): - change in sex drive or performance - constipation - drowsy or dizzy - dry mouth - stomach upset - weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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QUETIAPINE 25MG TABLETS

Transcript

PACKAGE LEAFLET: INFORMATION FOR THE USER ®

Seroquel 25mg Tablets / Quetiapine 25mg Tablets Seroquel® 200mg Tablets / Quetiapine 200mg Tablets Seroquel® 300mg Tablets / Quetiapine 300mg Tablets (quetiapine fumarate) This product is available as any of the above names but will be referred to as Seroquel throughout the following leaflet. Please note that the leaflet also contains information about other strengths (Seroquel 100mg and 150mg Tablets). Read all of this leaflet carefully before you start taking this medicine. Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. If you get any side effects talk to your doctor or pharmacist. This includes any side effects not listed in this leaflet. See Section 4. In this leaflet: 1. What Seroquel is and what it is used for 2. What you need to know before you take Seroquel 3. How to take Seroquel 4. Possible side effects 5. How to store Seroquel 6. Contents of the pack and other information 1. What Seroquel is and what it is used for Seroquel contains a substance called quetiapine. This belongs to a group of medicines called anti-psychotics. Seroquel can be used to treat several illnesses, such as: ? Bipolar depression: where you feel sad. You may find that you feel depressed, feel guilty, lack energy, lose your appetite or can’t sleep. ? Mania: where you may feel very excited, elated, agitated, enthusiastic or hyperactive or have poor judgment including being aggressive or disruptive. ? Schizophrenia: where you may hear or feel things that are not there, believe things that are not true or feel unusually suspicious, anxious, confused, guilty, tense or depressed. Your doctor may continue to prescribe Seroquel even when you are feeling better. 2. What you need to know before you take Seroquel Do not take Seroquel: ? If you are allergic (hypersensitive) to quetiapine or any of the other ingredients of Seroquel (see Section 6: Further information). ? If you are taking any of the following medicines: - some medicines for HIV - azole medicines (for fungal infections) - erythromycin or clarithromycin (for infections) - nefazodone (for depression). Do not take Seroquel if the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Seroquel. Warnings and Precautions Talk to your doctor or pharmacist before taking Seroquel if: ? You, or someone in your family, have or have had any heart problems, for example heart rhythm problems, weakening of the heart muscle or inflammation of the heart or if you are taking any medicines that may have an impact on the way your heart beats. ? You have low blood pressure. ? You have had a stroke, especially if you are elderly. ? You have problems with your liver. ? You have ever had a fit (seizure). ? You have diabetes or have a risk of getting diabetes. If you do, your doctor may check your blood sugar levels while you are taking Seroquel. ? You know that you have had low levels of white blood cells in the past (which may or may not have been caused by other medicines). ? You are an elderly person with dementia (loss of brain function). If you are, Seroquel should not be taken because the group of medicines that Seroquel belongs to may increase the risk of stroke, or in some cases the risk of death, in elderly people with dementia. ? You or someone else in your family has a history of blood clots, as medicines like these have been associated with formation of blood clots. ? You have or have had a condition where you stop breathing for short periods during your normal nightly sleep (called “sleep apnoea”) and are taking medicines that slow down the normal activity of the brain (“depressants”). ? You have or have had a condition where you can’t completely empty your bladder (urinary retention), have an enlarged prostate, a blockage in your intestines, or increased pressure inside your eye. These conditions are sometimes caused by medicines (called “anti-cholinergics”) that affect the way nerve cells function in order to treat certain medical conditions. Tell your doctor immediately if you experience any of the following after taking Seroquel: ? A combination of fever, severe muscle stiffness, sweating or a lowered level of consciousness (a disorder called “neuroleptic malignant syndrome”). Immediate medical treatment may be needed. ? Uncontrollable movements, mainly of your face or tongue. ? Dizziness or a severe sense of feeling sleepy. This could increase the risk of accidental injury (fall) in elderly patients. ? Fits (seizures). ? A long-lasting and painful erection (Priapism). These conditions can be caused by this type of medicine. Tell your doctor as soon as possible if you have: ? A fever, flu-like symptoms, sore throat, or any other infection, as this could be a result of a very low white blood cell count, which may require Seroquel to be stopped and/or treatment to be given. ? Constipation along with persistent abdominal pain, or constipation which has not responded to treatment, as this may lead to a more serious blockage of the bowel. Thoughts of suicide and worsening of your depression If you are depressed you may sometimes have thoughts of harming or killing yourself. These may be increased when first starting treatment, since these medicines all take time to work, usually about two weeks but sometimes longer.

These thoughts may also be increased if you suddenly stop taking your medication. You may be more likely to think like this if you are a young adult. Information from clinical trials has shown an increased risk of suicidal thoughts and/or suicidal behaviour in young adults aged less than 25 years with depression. If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed, and ask them to read this leaflet. You might ask them to tell you if they think your depression is getting worse, or if they are worried about changes in your behaviour. Weight gain Weight gain has been seen in patients taking Seroquel. You and your doctor should check your weight regularly. Children and Adolescents Seroquel is not for use in children and adolescents below 18 years of age. Other medicines and Seroquel Tell your doctor if you are taking or have recently taken any other medicines. Do not take Seroquel if you are taking any of the following medicines: ? Some medicines for HIV. ? Azole medicines (for fungal infections). ? Erythromycin or clarithromycin (for infections). ? Nefazodone (for depression). Tell your doctor if you are taking any of the following medicines: ? Epilepsy medicines (like phenytoin or carbamazepine). ? High blood pressure medicines. ? Barbiturates (for difficulty sleeping). ? Thioridazine or Lithium (other anti-psychotic medicines). ? Medicines that have an impact on the way your heart beats, for example, drugs that can cause an imbalance in electrolytes (low levels of potassium or magnesium) such as diuretics (water pills) or certain antibiotics (drugs to treat infections). ? Medicines that can cause constipation. ? Medicines (called “anti-cholinergics”) that affect the way nerve cells function in order to treat certain medical conditions. Before you stop taking any of your medicines, please talk to your doctor first. Seroquel with food, drink and alcohol ? Seroquel can be taken with or without food. ? Be careful how much alcohol you drink. This is because the combined effect of Seroquel and alcohol can make you sleepy. ? Do not drink grapefruit juice while you are taking Seroquel. It can affect the way the medicine works. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or planning to have a baby ask your doctor for advice before taking Seroquel. You should not take Seroquel during pregnancy unless this has been discussed with your doctor. Seroquel should not be taken if you are breast-feeding. The following symptoms which can represent withdrawal may occur in newborn babies of mothers that have used Seroquel in the last trimester (last three months of their pregnancy): shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty in feeding. If your baby develops any of these symptoms you may need to contact your doctor. Driving and using machines Your tablets may make you feel sleepy. Do not drive or use any tools or machines until you know how the tablets affect you. Seroquel contains lactose Seroquel contains lactose which is a type of sugar. If you have been told by your doctor that you have an intolerance to some sugars, talk to your doctor before taking this medicine. Effect on Urine Drug Screens If you are having a urine drug screen, taking Seroquel may cause positive results for methadone or certain drugs for depression called tricyclic antidepressants (TCAs) when some test methods are used, even though you may not be taking methadone or TCAs. If this happens, a more specific test can be performed. 3. How to take Seroquel Always take Seroquel exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Your doctor will decide on your starting dose. The maintenance dose (daily dose) will depend on your illness and needs but will usually be between 150 mg and 800 mg. ? You will take your tablets once a day, at bedtime or twice a day, depending on your illness. ? Swallow your tablets whole with a drink of water. ? You can take your tablets with or without food. ? Do not drink grapefruit juice while you are taking Seroquel. It can affect the way the medicine works. ? Do not stop taking your tablets even if you feel better, unless your doctor tells you. Liver problems If you have liver problems your doctor may change your dose. Elderly people If you are elderly your doctor may change your dose. Use in children and adolescents Seroquel should not be used by children and adolescents aged under 18 years. If you take more Seroquel than you should If you take more Seroquel than prescribed by your doctor, you may feel sleepy, feel dizzy and experience abnormal heart beats. Contact your doctor or nearest hospital straight away. Keep the Seroquel tablets with you. If you forget to take a dose of Seroquel If you forget to take a dose, take it as soon as you remember. If it is almost time to take the next dose, wait until then. Do not take a double dose to make up for a forgotten tablet. If you stop taking Seroquel If you suddenly stop taking Seroquel, you may be unable to sleep (insomnia), or you may feel sick (nausea), or you may experience headache, diarrhoea, being sick (vomiting), dizziness or irritability. Your doctor may suggest you reduce the dose gradually before stopping treatment. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects Like all medicines, Seroquel can cause side effects, although not everybody gets them. Very common side effects (may affect more than 1 in 10 people): ? Dizziness (may lead to falls), headache, dry mouth. ? Feeling sleepy (this may go away with time, as you keep taking Seroquel) (may lead to falls). ? Discontinuation symptoms (symptoms which occur when you stop taking Seroquel) include not being able to sleep (insomnia), feeling sick (nausea), headache, diarrhoea, being sick (vomiting), dizziness and irritability. Gradual withdrawal over a period of at least 1 to 2 weeks is advisable. ? Putting on weight. ? Abnormal muscle movements. These include difficulty starting muscle movements, shaking, feeling restless or muscle stiffness without pain. ? Changes in the amount of certain fats (triglycerides and total cholesterol). Common side effects (may affect up to 1 in 10 people): ? Rapid heartbeat. ? Feeling like your heart is pounding, racing or has skipped beats. ? Constipation, upset stomach (indigestion). ? Feeling weak. ? Swelling of arms or legs. ? Low blood pressure when standing up. This may make you feel dizzy or faint (may lead to falls). ? Increased levels of sugar in the blood. ? Blurred vision. ? Abnormal dreams and nightmares. ? Feeling more hungry. ? Feeling irritated. ? Disturbance in speech and language. ? Thoughts of suicide and worsening of your depression. ? Shortness of breath. ? Vomiting (mainly in the elderly). ? Fever. ? Changes in the amount of thyroid hormones in your blood. ? Decreases in the number of certain types of blood cells. ? Increases in the amount of liver enzymes measured in the blood. ? Increases in the amount of the hormone prolactin in the blood. Increases in the hormone prolactin could in rare cases lead to the following: Men and women to have swelling breasts and unexpectedly produce breast milk. Women to have no monthly periods or irregular periods. Uncommon side effects (may affect up to 1 in 100 people): ? Fits or seizures. ? Allergic reactions that may include raised lumps (weals), swelling of the skin and swelling around the mouth. ? Unpleasant sensations in the legs (also called restless legs syndrome). ? Difficulty swallowing. ? Uncontrollable movements, mainly of your face and tongue. ? Sexual dysfunction. ? Diabetes. ? Change in electrical activity of the heart seen on ECG (QT prolongation). ? A slower than normal heart rate which may occur when starting treatment and which may be associated with low blood pressure and fainting. ? Difficulty in passing urine. ? Fainting (may lead to falls). ? Stuffy nose. ? Decrease in the amount of red blood cells. ? Decrease in the amount of sodium in the blood. ? Worsening of pre-existing diabetes. Rare side effects (may affect up to 1 in 1,000 people): ? A combination of high temperature (fever), sweating, stiff muscles, feeling very drowsy or faint (a disorder called “neuroleptic malignant syndrome”). ? Yellowing of the skin and eyes (jaundice). ? Inflammation of the liver (hepatitis). ? A long-lasting and painful erection (priapism). ? Swelling of breasts and unexpected production of breast milk (galactorrhoea). ? Menstrual disorder. ? Blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing. If you notice any of these symptoms seek medical advice immediately. ? Walking, talking, eating or other activities while you are asleep. ? Body temperature decreased (hypothermia). ? Inflammation of the pancreas. ? A condition (called “metabolic syndrome”) where you have a combination of 3 or more of the following: an increase in fat around your abdomen, a decrease in “good cholesterol” (HDL?C), an increase in a type of fat in your blood called triglycerides, high blood pressure and an increase in your blood sugar. ? Combination of fever, flu-like symptoms, sore throat, or any other infection with very low white blood cell count, a condition called agranulocytosis. ? Bowel obstruction. ? Increased blood creatine phosphokinase (a substance from the muscles). Very rare side effects (may affect up to 1 in 10,000 people): ? Severe rash, blisters, or red patches on the skin. ? A severe allergic reaction (called anaphylaxis) which may cause difficulty in breathing or shock. ? Rapid swelling of the skin, usually around the eyes, lips and throat (angioedema). ? A serious blistering condition of the skin, mouth, eyes and genitals (StevensJohnson syndrome). ? Inappropriate secretion of a hormone that controls urine volume. ? Breakdown of muscle fibers and pain in muscles (rhabdomyolysis). Not known (frequency cannot be estimated from the available data): ? Skin rash with irregular red spots (erythema multiforme). ? Serious, sudden allergic reaction with symptoms such as fever and blisters on the skin and peeling of the skin (toxic epidermal necrolysis). ? Symptoms of withdrawal may occur in newborn babies of mothers that have used Seroquel during their pregnancy. The class of medicines to which Seroquel belongs can cause heart rhythm problems, which can be serious and in severe cases may be fatal.

Some side effects are only seen when a blood test is taken. These include changes in the amount of certain fats (triglycerides and total cholesterol) or sugar in the blood, changes in the amount of thyroid hormones in your blood, increased liver enzymes, decreases in the number of certain types of blood cells, decrease in the amount of red blood cells, increased blood creatine phosphokinase (a substance in the muscles), decrease in the amount of sodium in the blood and increases in the amount of the hormone prolactin in the blood. Increases in the hormone prolactin could in rare cases lead to the following: ? Men and women to have swelling of the breasts and unexpectedly produce breast milk. ? Women to have no monthly period or irregular periods. Your doctor may ask you to have blood tests from time to time. Side effects in children and adolescents The same side effects that may occur in adults may also occur in children and adolescents. The following side effects have been seen more often in children and adolescents or have not been seen in adults: Very Common side effects (may affect more than 1 in 10 people): ? Increase in the amount of a hormone called prolactin, in the blood. Increases in the hormone prolactin could in rare cases lead to the following: - boys and girls to have swelling of breasts and unexpectedly produce breast milk - girls to have no monthly period or irregular periods. ? Increased appetite. ? Vomiting. ? Abnormal muscle movements. These include difficulty starting muscle movements, shaking, feeling restless or muscle stiffness without pain. ? Increase in blood pressure. Common side effects (may affect up to 1 in 10 people): ? Feeling weak, fainting (may lead to falls). ? Stuffy nose. ? Feeling irritated. Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme (Website: www. mhra. gov. uk/yellowcard). By reporting side effects you can help provide more information on the safety of this medicine. 5. How to store Seroquel ? Do not store above 30°C. Store in their original package. ? Keep all medicines out of the sight and reach of children. ? Do not use after the expiry date printed on the carton label or blister strip. The expiry date refers to the last day of that month. ? If the tablets become discoloured or show any other signs of deterioration, you should ask your doctor or pharmacist for advice. ? Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment. 6. Contents of the pack and other information What Seroquel contains Your medicine is called Seroquel. Each film-coated tablet contains quetiapine fumarate equivalent to 25mg, 200mg and 300mg quetiapine. Seroquel also contains the following inactive ingredients: lactose monohydrate, hypromellose, povidone, calcium hydrogen phosphate, sodium starch glycollate, macrogol, microcrystalline cellulose, magnesium stearate, titanium dioxide (E171). Seroquel 25mg tablets also contain red iron oxide (E172) and yellow iron oxide (E172). What Seroquel looks like and contents of the pack Seroquel 25mg Tablets are round, peach coloured, film-coated tablets marked ‘SEROQUEL 25’ on one side and a plain reverse. They are supplied as blister packs of 30 and 6 tablets. Seroquel 200mg Tablets are round, white, film-coated tablets marked ‘SEROQUEL 200’ on one side and plain on the reverse. They are supplied as blister packs of 60 tablets. Seroquel 300mg Tablets are oblong, white, film-coated tablets marked ‘SEROQUEL’ on one side and ‘300’ on the reverse. They are supplied as blister packs of 60 tablets. Manufacturer Manufacturer by AstraZeneca UK Limited, Silk Road Business Park, Macclesfield, Cheshire and procured from within the EU and repackaged by the PL holder: O. P.D. Laboratories Ltd. Unit 6 Colonial Way, Watford, Herts WD24 4PR. POM 25mg PL No: 15814/0727 200mg PL No: 15814/0763 300mg PL No: 15814/0769 Leaflet revision and issue date (Ref.): 19.01.2016. Seroquel is a registered trade mark of AstraZeneca group of companies. To request a copy of this leaflet in Braille, large print or audio please call 01923 332 796. You can also get information on mental health from the following national organisations: ? MIND (National Association for Mental Health). MindinfoLine: 0845 766 0163. ? RETHINK (Formerly the National Schizophrenia Fellowship). Advice Service: 0208 974 6814. ? National Schizophrenia Fellowship (Scotland): 0131 662 4359. ? SANELINE Helpline: 0845 767 8000.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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Espercil para que sirve, espercil

ESPERCIL

Tenga especial cuidado durante el embarazo .

Revise siempre que no sea alergico a ninguno de los componentes de ESPERCIL . podria poner en peligro su salud

Recuerda antes de tomar este medicamento consultar siempre con su medico, la informacion que ofrecemos es orientativa y no sustituye en ningun caso la de su medico u otro profesional de la salud.

Prospecto e indicaciones

Composicion:

Comprimidos:

cada comprimido contiene: Acido Tranexamico 500 mg.

Capsulas:

cada capsula contiene: Acido Tranexamico 250 mg.

Ampolla Inyectable I. V. 1.000 mg:

cada ampolla inyectable contiene: Acido Tranexamico 1.000 mg.

Indicaciones:

Tratamiento de hemorragias: menorragia primaria o inducida por D. I.U. herorragia durante el embarazo y post-parto, hemorragia digestiva, epistaxis recurrente, hemoptisis, hemorragia post-extraccion dental. Prevencion de hemorragias: en cirugia o trauma: conizacion, cirugia prostatica, hifema traumatico y quirurgico. En hemofilicos y enfermos tratados con anticoagulantes. En extraccion dentaria y otros procedimientos odontologicos. Reversion de hiperfibrinolisis: fibrinolisis inducida por medicamentos activadores de plasminogeno, tales como estreptokinasa y urokinasa.

Accion Terapeutica:

Presentaciones:

Comprimidos 500 mg:

envase conteniendo 20 comprimidos.

Capsulas 250 mg:

envase conteniendo 32 capsulas.

Inyectable I. V. 1.000 mg:

envase conteniendo 3 ampollas de 10 ml.

Posologia:

30-50 mg/kg/dia, fraccionados cada 6-8 horas. La duracion del tratamiento es variable entre 3-7 dias dependiendo de la indicacion. Espercil se administra por las vias I. V. y oral. La administracion por via I. V. puede hacerse en forma directa y lenta (1 g en 5 minutos) o en infusion 1-2 g en 500 ml de solucion glucosada o salina en 20 a 30 min. cada 8 horas.

Ejemplos:

Hemorragia digestiva alta: 1 g I. V. cada 8 horas durante 2 dias y luego, 1 cada 8 horas por via oral por 5 dias. Menorragia: 500 mg cada 8 horas por via oral y durante 3 o 4 dias. Prostatectomia: 1 g I. V. cada 8 horas desde el comienzo de la intervencion y por 24 horas. Luego, 1 g cada 8 horas por via renal y por 7 dias. Epistaxis: impregnar tapones con el contenido de 1 ampolla I. V. Extraccion dentaria en hemofilicos y en enfermos con tratamiento anticoagulante: irrigar el campo con 500 mg de Espercil (? ampolla de Espercil 1.000 I. V.) antes de la sutura y al termino del procedimiento quirurgico. Instruir al enfermo para hacer un enjuagatorio bucal 4 veces al dia durante 7 dias con una solucion de Espercil al 50% (1 ampolla bebible de 10 ml diluida en 10 ml de agua, ocupando cada vez la mitad de la solucion resultante) manteniendola en la boca durante 2 minutos.

Funcion renal alterada:

la dosis diaria de Espercil se ajusta en enfermos insuficientes renales de acuerdo al siguiente esquema: si la creatinina serica fuera de 1.4 - 2.9 mg/100 ml, la dosis de acido tranexamico seria de 10 mg/kg cada 12 horas. Si la creatinina serica fuera de 3.0 - 5.7 mg/100 ml, la dosis de acido tranexamico seria de 10 mg/kg cada 24 horas. Si la creatinina serica fuera de 5.8 y mas mg/100 ml, la dosis de acido tranexamico seria de 10 mg/kg cada 48 horas.

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Alendronate oral uses, side effects, interactions, pictures, warnings - dosing, alendromet

alendronate

Uses

Alendronate is used to prevent and treat certain types of bone loss (osteoporosis ) in adults. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases as you age, after menopause. or if you are taking corticosteroid medications (such as prednisone ) for a long time.

This medication works by slowing bone loss. This effect helps maintain strong bones and reduce the risk of broken bones (fractures ). Alendronate belongs to a class of drugs called bisphosphonates.

How to use alendronate

Read the Medication Guide provided by your pharmacist before you start taking alendronate and each time you get a refill. Follow the instructions very closely to make sure your body absorbs as much drug as possible and to reduce the risk of injury to your esophagus. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth once a day, after getting up for the day and before taking your first food, beverage, or other medication. Take it with a full glass (6-8 ounces or 180-240 milliliters) of plain water. Swallow the tablet whole. Do not chew or suck on it. Then stay fully upright (sitting, standing, or walking) for at least 30 minutes and do not lie down until after your first food of the day. Alendronate works only if taken on an empty stomach. Wait at least 30 minutes (preferably 1 to 2 hours) after taking the medication before you eat or drink anything other than plain water.

Do not take this medication at bedtime or before rising for the day. It may not be absorbed and you may have side effects.

Calcium or iron supplements. vitamins. antacids, coffee, tea, soda, mineral water, calcium - enriched juices, and food can decrease the absorption of alendronate. Do not take these for at least 30 minutes (preferably 1 to 2 hours) after taking alendronate.

Take this medication regularly to get the most benefit from it. Remember to use it at the same time each morning. Talk to your doctor about the risks and benefits of long-term use of this medication.

Side Effects

Stomach pain. constipation. diarrhea. gas, or nausea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: jaw pain. increased or severe bone/joint/muscle pain. new or unusual hip/thigh/groin pain, swelling of joints/hands/ankles /feet, black/tarry stools, vomit that looks like coffee grounds.

This medication may rarely cause serious irritation and ulcers of the esophagus. If you notice any of the following unlikely but very serious side effects, stop taking alendronate and talk to your doctor or pharmacist right away: new or worsening heartburn. chest pain. pain or difficulty when swallowing.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking alendronate, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: disorders of the esophagus (such as esophageal stricture or achalasia ), trouble swallowing, trouble standing or sitting upright for at least 30 minutes, low calcium levels, kidney problems, stomach /intestinal disorders (such as ulcers).

Some people taking alendronate may have serious jawbone problems. Your doctor should check your mouth before you start this medication. Tell your dentist that you are taking this medication before you have any dental work done. To help prevent jawbone problems, have regular dental exams and learn how to keep your teeth and gums healthy. If you have jaw pain. tell your doctor and dentist right away.

Before having any surgery (especially dental procedures), tell your doctor and dentist about this medication and all other products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor or dentist may tell you to stop taking alendronate before your surgery. Follow all instructions about stopping or starting this medication.

This drug is not recommended for use in children. Studies have shown that many children who took this drug had severe side effects such as vomiting. fever, and flu - like symptoms.

Caution is advised if you are pregnant or planning to become pregnant in the future. Alendronate may stay in your body for many years. Its effects on an unborn baby are unknown. Discuss the risks and benefits with your doctor before starting treatment with alendronate.

It is unknown if this medication passes into breast milk. Consult your doctor before breast - feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe stomach pain, painful heartburn, pain in the esophagus (chest pain), muscle weakness/cramps, mental/mood changes.

Notes

Do not share this medication with others.

Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, stopping smoking, limiting alcohol, and eating well-balanced meals that contain adequate calcium and vitamin D. You may also need to take calcium and vitamin D supplements. Consult your doctor for specific advice.

Laboratory and/or medical tests (X-rays, height measurement, blood mineral levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, skip the missed dose. Resume your usual dosing schedule the following day. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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